ASSIGNMENT LABORATORY PRACTICE

Department of Pharmacology and Therapy

Faculty of Medicine, Universitas Gadjah Mada

Name of student : Day, Date :

Student ID Number : Time :
Group : Instructor :
__________________________________________________________________________________________

Answering the questions

(score max. 100)
Title : Administration of Parenteral Dosage Form
……………………………………

Questions :

Individual assignment

1. Mention the different kinds of dosage form of injectable drugs and explain their characteristic? (5)

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2. Explain the reasons of administering drugs parenterally? (5)

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3. Describe how to reconstitute/dissolve dry powder medication vial using a diluent in a vial ? (10)

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4. What are the advantages and disadvantages of parenteral dosage form? Explain! (5)

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5. Mention the advantages and disadvantages of intravenous bolus? (5)

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6. Mention the advantages and disadvantages of intravenous intermittent and continuous infusion?

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7. Mention 3 examples of parenteral injection for antibiotics stated in National Formulary of Indonesia
Republic (name, strength of the dose unit, type of pharmaceutical form, container, route of administration) (10)

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Group assignment

Paracetamol (Case A)
A 19-year-old man with fever come to emergency room of a hospital. He has had high fever in the last 2 days
ago. His temperature is 39,5C. Paracetamol infusion is given to relieve the fever.

Questions:
A. What is the mechanism of action, indications, contraindications and adverse effects of paracetamol?
B. What is the form of paracetamol infusion? (powder/solution/suspension/emulsion)
C. Describe the concentration and container of paracetamol infusion!
D. What is the mode of intravenous infusion for this paracetamol?
E. If the paracetamol given is 1 g over 15 minutes intravenously, and the dropper of infusion set is
calibrated to deliver 20 drops per mL, how many drops per minute the flow rate should be adjusted?
F. Mention the devices used to administer paracetamol infusion (include the sizes)?
G. Mention the number of medicine and devices needed if paracetamol will be prescribed for a day!

References:

Furosemide (Case B)
A 60-year-old woman suffering renal failure is treated with furosemide injection to manage his hypertension
and edema

A. What is the mechanism of action, indications, contraindications and adverse effects of furosemide?
B. What is the form of furosemide injection? (powder/solution/suspension/emulsion)
C. Describe advantages and disadvantages of those form!
D. Describe the concentration and container of furosemide injection!
E. What is the mode of administration for this furosemide?
F. Dosage of furosemide is 20-40 mg as a single IV injection (bolus), given once or twice daily. If the
preparation is available in 10 mg/mL and 2 ml per ampule, how many ml will you administer? What size
syringe is best to administer this dose?
G. Mention the number of medicine and devices needed if furosemide will be prescribed for 3 days!

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Infusion Ringer lactate (Case C)
A dengue fever patient is treated with RL infusion.

A. What is the indications, contraindications and adverse effects of Ringer Lactate?

B. What is the form of RL infusion? (powder/solution/suspension/emulsion)
C. Describe the concentration and container of RL infusion!
D. What is the mode of administration for this fluid?
E. If the RL infusion given is 1500 mL per day, and the dropper of infusion set is calibrated to deliver 20
drops per mL, how many drops per minute the flow rate should be adjusted?
F. Mention the devices used to administer RL infusion (include the sizes)?
G. Mention the number of medicine and devices needed if Ringer Lactate will be prescribed for 3 day!

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Ceftriaxone-Na (Case D)
A man with gonorrhea is treated with combination of ceftriaxone injection and azythromycine orally.

Note: The displacement volume of 1 g of Ceftriaxone Hexpharm is 0.71 ml

Lidocaine is used as a solvent for ceftriaxone IM injection

A. What is the mechanism of action, indications, contraindications and adverse effects of Ceftriaxone-Na?
B. What is the form of ceftriaxone-Na? (powder/solution/suspension/emulsion)
C. Describe advantages and disadvantages of powder form!
D. How to reconstitute/dissolve it?
E. Describe the concentration and container of ceftriaxone-Na!
F. What is the mode of administration for ceftriaxone-Na?
G. If the dose given is 250 mg single dose, how many mL of ceftriaxone-Na should be administered ?
H. Mention the devices used to administer ceftriaxone-Na (include the sizes)?
I. Mention the number of medicine and devices needed if Ceftriaxone-Na will be prescribed for a single
dose!
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Depo progestin IM (Case E)
The doctor plans to give Mrs N (32 y.o.) depo progestin injection IM

A. What is the mechanism of action, indications, contraindications and adverse effects of

medroxyprogesterone/depo progestin?
B. What is the form of depo progestin? (powder/solution/suspension/emulsion)
C. Describe advantages and disadvantages of suspension form!
D. Describe the concentration and container of depo progestin!
E. If the dose given is 150 mg, how many mL of depo progestin should be administered?
F. How is the dosing schedule of depo progestin for family planning programme?
G. Mention the devices used to administer depo progestin (include the sizes)?
H. Mention the number of medicine and devices needed if Depo Progestin will be prescribed for a single
dose!

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