What is the rate-determining step of RuAAC?

A. Step B

B. Step D

C. Step A

D. Step C

What factors affect the outcome of the RuAAC reaction? (multiple answers)

A. The order of azides

B. The substituents on the alkyne

C. Type of catalysts

D. Aprotic or protic solvent

The mechanism of RuAAC reaction was proposed by:

A. The experiment of Sharpless

B. Density functional theory

C. Huigen’s proposal
D. DFI calculations

The regioselectivity is determined by the oxidative coupling step, which can also be viewed as a
nucleophilic attack of the activated alkyne at the electrophilic terminal nitrogen of the azide.

True

False

The C – N bond formed between the alkyne and the azide at which step?

A. Oxidative

B. Making the activated complex

C. Forming the metal-triazole complex

D. Reductive elimination