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Uveitis & Ocular Immunology: Introductory Lecture Series
Uveitis & Ocular Immunology: Introductory Lecture Series
Intermediate Uveitis
• Main Features:
– Sine equa non: Vitreous Cells
• May or may not have:
– Snow Balls
– Snow Banking
• If all three present the diagnosis is likely either
Pars Planitis “syndrome” which is often
associated to multiple sclerosis or rarely CNS
lymphoma.
Clinical Findings
Complications
• CME
• Cataracts
• Glaucoma
• Optic Disk Edema
• Optic Neuritis
• Retinal Detachment
• Venous Sheathing (may not have vasculitis)
• Vasculitis (may not have venous sheething)
• Retinal Neovascularization
• Vasoproliferative Tumor of the Retinal Periphery
Complications: CME
• Up to 50% of patients
• Most common cause
of visual loss in
intermediate uveitis
patients.
• Prevalence increases
with the severity of
inflammation.
Complications: Cataracts
• Disk Edema
– Up to 20% of eyes
– Most often secondary to intraocular
inflammation.
– If bilateral consider MRI
• Optic Neuritis:
– 7.5 % of patients
– Patients may or may not have multiple sclerosis
– Treat as in ONTT.
Complications: Retinal Detachment
Vs.
An OKAP moment...
An OKAP moment...
If you get this picture on you OKAP…
• Ophthalmological Exam
– Toxocara Canis, Toxoplasma gondi, Birdshot, AZOOR,
Intraocular Lymphoma, Retinitis Pigmentosa.
• History and Physical Exam:
– MS, Sarcoidosis, Becet’s, HTLV-1
• Laboratories:
– FTA-Abs, RPR, CXR (Always)
– Consider: MRI, Lyme Ab, Bartonella Ab.
Clinical Course