Индекс: Фо 04.01.

01-02
ФОРМУЛЯР
Издание: II-01
Дата: 09.01.2013 г.
УЧЕБEН ПЛАН
Страница 1 от 9

SYNOPSIS BIOLOGY
GENERAL AND MOLECULAR BIOLOGY
1. General biology: definition, subject, position in the system of sciences.
2. Biological macromolecules. Proteins – structure and function.
3. Nucleic acids – structure and function of DNA and RNA.
4. DNA synthesis (replication). Mechanisms and types of replication in prokaryotes and
eukaryotes.
5. DNA repair in prokaryotes and eukaryotes.
6. RNA – synthesis (transcription) in pro- and eukaryotes.
7. Transcription control in prokaryotes. Lactose and tryptophan operons.
8. Transcription control in eukaryotes.
9. Posttranscriptional modifications (maturation) of RNA in pro- and eukaryotes.
10. Genetic code. The role of tRNA.
11. Protein synthesis (translation) – mechanism and control in pro- and eukaryotes.
12. Posttranslational modifications and protein transport.
13. Aging and degradation of proteins – proteasomеs.
14. Prokaryotic genes: general structures and organization. Extranuclear genome in
prokaryotes.
15. Eukaryotic genes: general structures and organization. DNA packaging in chromatin fibers.
16. Structure of eukaryotic chromosomes. Karyotype. Methods of cytogenetic analysis.
17. Cytoplasmic inheritance. Mitochondrial genome in eukaryotes.
18. DNA recombination. Molecular mechanisms of crossing over. Homologous and site specific
recombination.
19. Heredity. Mendel’s lows and deviations from predicted ratio. Gene interactions and patterns
of inheritance.
20. Genetic linkage and crossing over. Recombinant variation.
21. Inheritance and environment. Phenocopy and genocopy.
22. Allele, genotype and phenotype frequencies. Hardy-Weinberg equilibrium theory.
23. Factors affecting allele frequency. Migration. Isolation. Gene drifts.
24. Gene mutations. Molecular diseases.
25. Structural and numerical chromosomal mutations. Human pathology examples.
26. Mutagenic factors and mechanism of DNA changing.
27. Denaturation, renaturation and hybridization of DNA.
28. Genetic and gene engineering. Experimental DNA recombination. Gene therapy.

CELL AND REPRODUCTIVE BIOLOGY

29. Cell cycle. Individual development of cells.
30. Cell reproduction. Mitosis.
31. Control of cell cycle. Mitosis-promoting factor.
32. Cell aging. Apoptosis.
Разработил: Одобрил: Утвърдена:
Доц. М. Атанасова, д. р-л Проф. д-р Аспарух На Секторен съвет, Екземпляр № 3
с-р «Биология» Аспарухов, д.м.н. Декан Протокол № 21/
ф-т «Медицина» 14.01.2018 г.
Валиден от:
14.01.2018 г.………… ………..…………
/дата, подпис/ /дата, подпис/ /дата, подпис/ 14.01.2018 г.
33. Meiosis. Origin of gametes.
34. Ovogenesis. Characteristics and types of mature eggs.
35. Spermatogenesis. Characteristics of male gametes.
36. Sexual reproduction. Sex determination and differentiation.
37. Fertilization. External fertilization – mechanism and blockage of polyspermy.
38. Internal fertilization in mammals. In vitro fertilization.
39. Animal development. Mechanisms in mammals and humans.

IMMUNOLOGY
40. Immunological homeostasis. Organs and cells of immune system.
41. Innate and acquired immunity.
42. Immunogens and antigens – characteristics.
43. Alloantigens in man – ABO/H systems.
44. Alloantigens in man - Rhesus, Lewis, Secretors.
45. Antibodies – structure and functions. Biological properties of immunoglobulin classes.
46. Antigen-antibody interactions. Immunological methods.
47. The genetic basis of antibody structure. Ontogeny of B-lymphocytes.
48. The genetic basis of T-cell receptor. Ontogeny of T-lymphocytes.
49. Complement. Pathways of complement activation.
50. Types of immune response. Primary and secondary immune response.
51. Major histocompatibility complex in the immune response.
52. Antigen-presenting cells. Immune response against endogenous and exogenous antigens.
53. Cellular immunity. Cell-cell interactions in immune response. T- and B-cell receptors and
their activation.
54. Transplantation immunology. Immune response in Graft rejection. Adoptive immunity. Graft
versus host reactions.
55. Control of the immune processes. Immune tolerance. Types of immune tolerance.
56. AIDS.

PARASYTOLOGY
57. Parasites and parasitism. Parasite-host interactions. Classification of parasites and
diseases.
58. Characteristics of Protozoa. Trypanosoma gambiense, T. rhodesiense, T. cruzi.
59. Leishmania donovani, L. tropica, L. infantum, L. mexicana.
60. Giardia lamblia.
61. Trichomonas vaginalis, T. hominis, T. tenax.
62. Subphylum Sarcodina. Entamoeba histolytica, E. coli, Balantidium coli.
63. Phylum Apicomplexa. Toxoplasma gondii. Opportunistic infections.
64. Plasmodium vivax, P. malariae, P. falciparum.
65. Class Trematoda. Fasciola hepatica, Dicrocelium dendriticum, Opistorchis felineus, Genus
Schistosoma
66. Class Cestoda. Taenia solium, T. saginata, Taenia echicoccus, Hymenolepis nana,
Diphyllobothrium latum
67. Phylum Nemathelminthes. Ascaris lumbricoides, Enterobius vermicularis, Trichinella spiralis,
Trichiuris trichiura.
68. Phylum Arthropoda. Spiders and scorpions.
69. Ticks and mites – their role in vector-borne diseases.
70. Insects – their role in vector-borne diseases.
71. Pediculus humanus, Phthirus pubis.
72. Cimex lectularis, Pulex irritans.
73. Mosquitoes - Genus Culex and genus Anopheles.
74. Phlebotomus papatasii, Musca domestica.
 Recommended books

MOLECULAR BIOLOGY

1. Molecular cell biology J. Darnell, H. Lodish, D. Baltimore. Scientific American Books,

6th edition 2010 www.whfreeman.com/lodish
2. Molecular biology / Alexander McLennan et al. - 4th ed. - New York : Garland Science,
2013. - ix, 382 p. : ill. ; 25 cm. - (BIOS instant notes)
3. Biological science. N.P.O. Green, G.W. Stout, D. J. Taylor. Cambridge edition, 1996
4. Molecular biology of the cell / Bruce Alberts et al.; with problems by John Wilson, Tim
Hunt. - 5th ed. - New York: Garland Science, 2008. - 1 vol. v.p. (xxxiii, 1268, G1-G40, I1-
I49, T1)

IMMUNOLOGY
5. Immunobiology Ch. Janeway et al., Garland Science, 7th edition
6. Immunology: A Short Course. Benjamini E., S. Leskowitz, Wiley-Liss Inc., New York,
1991, 2003, 2009 (sixth edition)
7. IMMUNOLOGY Roitt I., J. Brostoff, D. Male, , Mosby-Year Book Europe Ltd., London,
1993.; 6-th edition 2011and newer
8. Kuby immunology / Thomas J. Kindt, Richard A. Goldsby, Barbara A. Osborne. - 6 ed.
- New York : W. H. Freeman, 2007. - xxii, 574, A-31, G-12, AN-27, I-27 p. : ill. (some col.)
; 28 cm. + online access
9. Immunology : a short course / Richard Coico, Geoffrey Sunshine, Eliezer Benjamini. -
5. ed. - Hoboken, N.J. : Wiley-Liss, 2003. - xxv, 361 p. : col. ill. ; 28 cm.
10. Basic human immunology / Eds. Daniel P. Stites, Abba I Terr. - Norwalk : Appleton
[and] Lange, 1991. - vii, 253 p. : ill. ; 25 см. - (A LANGE Medical Book)
11. Medical immunology : a Lange Medical Book / Eds. Daniel P. Sites and al. - Stamford :
Appleton&Lange, 1997. - 900 с. : ill. ; 25 см. - (A LANGE Medical Book)
12. Immunology / Richard M. Hyde. - 3. ed. - Philadelphia : Williams & Wilkins, 1995. - 316
с. : ill. ; 25 см
13. Cellular and molecular immunology / Abul K. Abbas, Andrew H. Lichtman, Shiv Pillai ;
illustrations by David L. Baker, Alexandra Baker. - 7th ed. - Philadelphia :
Elsevier/Saunders, 2012. - x, 545 p. : col. ill. ; 28 cm.

PARASITOLOGY
14. Medical parasitology (Markell and Voge’s) David T. John, William A. Petri,Jr ninth
edition, 2006
15. Medical parasitology / Rattan Lai Ichhpujani, Rajesh Bhatia. - 3 ed. - New Delhi, India :
Jaypee Brothers Med. Pbl, 2002. - 309 p. : ill. ; 24 cm
16. Basic clinical parasitology / Franklin A. Neva, Harold W. Brown. - 6 ed. - Norwalk,
Conn. : Appleton & Lange, 1994. - xi, 356 p. : ill. (some col.) ; 26 cm.
17. Medical parasitology : [ Textbook ] / D.R. Arora, Brij Bala Arora. - 3th ed. - New Delhi :
CBS Pbl, 2010. - xvi, 271 p. : ill., tabl. ; 28 cm
18. Encyclopedia of parasitology / Ed. Heinz Mehlhorn. - 3th ed. - New York : Springer,
2008 - . - 2 v. ; 1573 p. : ill., 1000 fig. 205 tabl. ; 28 cm

RECOMMENDED WEBPAGES
http://ilib.mu-pleven.bg/ iLibrary Medical University of Pleven
www.amazon.ca - find recommended books
http://www.bio.davidson.edu/immunology/ Flash Animations to help students learn immunology.
www.medicine.mcgill.ca/tropmed/txt/ - find some parasitological lectures and images
Head of Biology dept.:
Assoc. Prof. M. Atanasova