Professional Documents
Culture Documents
Obstetrics PDF
Obstetrics PDF
Obstetrics
notes
My PG
Notes
MEE
M
y
PG
M
EE
N
ot
es
,1
/e
My PG
MEE
Notes
/e
mainly in FT
begins in cervix
,1
es
tract • pH → >7.2
zz main hormone for spermatogenesis— • Total sperm count → >39 million/ejaculate
ot
• Vitality→ >50% live sperms
[FSH+LH+Testosterone] > FSH
• Sperm concentratiion → >15 million/ml
receptor for sperm in Zona Pellucida-
N
zz
• total motility→ > 40%
ZPGP3[zona pellucid glycoprotein 3] • progressive motility→ > 32%
quarantine period for sperm donation is
EE
Implantation
Obstetrics
PG
zz
By day 8 , post fertilization Trophoblast differentiate into outer syncytiotrophoblast and inner
M
zz
cytotrophoblast
zz Cytotrophoblast further gives rise to villous trophoblast which form placental villi and extra
villous trophoblast which invades deeper into decidual Spiral arterioles of mother making it
resistant to vasopressor and maintains uteroplacental circulation
zz Polyspermy prevented by zona pellucida, also by calcium
525
notes
MEE
My PG
Notes
Fetal Membranes
Amnion Chorion
• innermost tough avascular foetal membrane It is of two types :
• Gives tensile strength to foetal membrane 1]chorion frondosum it forms placental villi.
• composed of crosslinking of in collagen 1 and 3 2]chorion laeve
/e
zz Thickness 2 to 3 centimetre 5 placental circulation established
Surface area of placental vili is 12 metre square 7 gross body movement appear first
,1
zz
es
zz
10 fetal swallowing & anterior pituitary
zz Formed from fetal parts mainly called as
hormone secretion
chorionic frondosum and maternal part called is
ot 11 female external genitalia differentiation
decidua basalis
completed
N
zz placental function starts around 10 weeks
11 respiratory movement & thyroxine
zz Placental circulation established post fertilization
secretion
EE
day 12
12 urine production, posterior pituitary
zz Fetal circulation established around Day 21 post
hormone secretion & insulin secretion
fertilization [2018]
M
PG
term is 1:6
20 lung surfactant formed & meconium
zz Nitabuchs layer: appears
Fibrinoid deposition in the syncytiotrophoblast.
24 hearing & sucking movement on USG
It limits further invasion of decidua by the
y
trophoblast absence of this membrane leads 28 light perception
M
to placenta accreta.
zz Placenta lacks 17-α hydroxylase enzyme therefore cannot synthesise oestrogen
zz Spiral arteriole are 120 in number and contains around 140 ml of maternal blood
zz Hofbauer cell are seen in placenta, functions as Macrophages
zz Most common mets to placenta is Melanoma and cancer breast
Placenta Variations
notes
My PG
MEE
Notes
/e
Hormone Secreted by Placenta
,1
Protein hormone Steroid hormones
es
• H CG • human chorionic corticotropin • Estrogens
• HPL (Chorionic growth hormone), • human chorionic thyrotropin
ot • Progesterone
• PAPP-A
N
Human Chorionic Gonadotropin [HCG] Human placental lactogen
Obstetrics
PG
• Half life → 24 hours & doubling time → 48 hours • concentration 5-50 μg/ml
• Post delivery start disappearing from maternal urine in 48 hours. • disappears after first
• Return to normal levels within two weeks after delivery Postpartum day
• After early abortion returns to normal level in 4 to 6 weeks • Maximum production
y
• UPT is based on sandwich ELISA method [sensitivity is 20 Mili IU/ml] throughout pregnancy
M
• HCG can be detected in maternal serum or urine as early as 8 to 9 days • highest concentration among
following ovulation by Radioimmunoassay(RIA) all protein hormones
• Most sensitive test FIA > RIA(5 IU/ml) > ELISA > RRA(20-50 mili IU/ml). • Predictor of placental
• Critical titre of HCG to visualise G sac: function
for transabdominal sonography → 6500 IU • Fetal growth is determined
for transvaginal sonography → 1500 IU by insulin hormone
• HCG levels increases in multiple pregnancy, H.mole, Choriocarcinoma, • Function of HPL
Down syndrome & Rh incompatibility lipolysis
• HCG levels decreases in ectopic pregnancy, abortion & trisomy 18 Angiogenic hormone
Stimulate leydig cells in male foetus to release testosterone → Responsible for Insulin
development of male external genitalia resistance
527
Immunosuppressive action → prevent foetus immune rejection
notes
MEE
My PG
Notes
Alpha Fetoprotein
zz t1/2-→ 5days
zz It is secreted by yolk sac and liver in early fetal life, major source is yolk sac
zz Peak level in fetus or amniotic fluid around 13 weeks
zz Peak level in mother 32 weeks
Fetal DHEA
Umbilical Cord
/e
zz Contains → 2 arteries and 1 vein
,1
zz Wharton's Jelly is the connective tissue of umbilical cord[2018]
zz Normal length → 50 cm
es
zz short cord < 30 cm → associated with malpresentations and Abruptions
zz Long cord > 100 cm → associated with cord entanglement cord prolapse
ot
zz Single umbilical artery
<1% incidence in singleton pregnancy
N
3% incidence in twin pregnancy
It is seen in:
EE
zz
zz Velamentous insertion of cord → umbilical cord inserted two membranes, complication → vasa
M
Fetal Haematopoiesis
notes
My PG
MEE
Notes
Fetal Circulation
zz Fetal Hearts start beating from 21st day fetal heart rate 120 to 160 beats per minute
zz TVS can detect fetal → rate by 5 weeks, TAS and detect around 6 weeks
zz G sac appears on TVS around 4 and half weeks and t a s around 5 and half weeks
zz At birth first closer Umblical vessels → foramen ovale → ductus arteriosus → ductus venosus
zz closure of foramen ovale ductus arteriosus closes
zz ductus venosus obliterates and becomes ligamentum venosum
zz Umbilical vein obliterates and becomes ligamentum teres
zz Umbilical artery obliterates and become hypogastric artery obliterated
zz Surfactant synthesis starts around 20 weeks, detected in amniotic fluid around 28 weeks
/e
zz Full fetal lung maturity:
Test used most common is lecithin - sphingomyelin Ratio
,1
Best test for fetal lung maturity is phosphatidyl glycerol test
Amniotic Fluid
zz Source:
es
ot
upto 12 weeks[1st trimester] → ultrafiltrate of maternal plasma
12 to 16 weeks → transudate of fetal skin
N
zz
zz Increase concentration of uric acid urea creatinine and electrolytes are low sodium and chloride
Obstetrics
compared to maternal plasma
PG
529
notes
MEE
My PG
Notes
Signs
/e
Hartman sign implantation bleeding
,1
Braxton Hicks contractions painless irregular spasmodic contraction without any effect
on dilation of cervix
can also be felt in pedunculated fibroid Submucous type
es
and hematometra
4-8 weeks Palmers sign regular rhythmic contraction during bimanual examination
ot
6 weeks 6oodell's sign [G looks like 6] softening of lower part of cervix
6-10 weeks Hegar's sign and by manual examination abdominal and vaginal fingers
N
opposes each other
6-8 weeks Piskacek sign asymmetric enlargement of uterus
EE
8 weeks Osiander sign [Octa-8] increased pulsation felt through lateral fornix of vagina
8 weeks Chadwick sign/Jacquemier's bluish coloration of vestibule
sign
M
Obstetrics
PG
• Cardiac output ↑ by 40% & oxygen demand ↑ • Iron requirement in second half of pregnancy
by 20% is 6-7 mg/day
• coagulation factors : • Calcium requirement in pregnancy thousand
↓ in factor 11 & 13 and platelet counts milligram per day
↑ in fibrinogen, factor 2,7,8, 9,10 and • In pregnancy calorie requirement increases by
plasminogen 300 kilo calorie for day
• Plasma protein ↓ by 10% • Folic acid requirement : non pregnant female
• Albumin ↓ by 30% 200 μgm & pregnant female 400 μgm
• Total protein ↑ by 20-30%
• BT, CT remains unchanged
530
notes
My PG
MEE
Notes
/e
physiological S3 heard almost double, SGOT & SGPT decreases
• left Axis deviation • Gallbladder → increase chance of stone
,1
• pulse rate ↑ by 10 to 15 beats per minute formation due to progesterone and increase
• On ECG :no hypertrophy or dilatation of risk of cholestasis due to estrogen pruritis due
es
heart to increased bile salt
• Straightening of left heart border MISCELLANEOUS POINTS
ot
• Heart rate↑ by 20% • Krunkenberg spindle seen on posterior surface
• fall in blood pressure of cornea during pregnancy
N
• systemic vascular resistance ↓ can lead to • Anterior pituitary gland size increases→
supine hypotension syndrome growth hormone level increases
EE
• venous pressure increases in lower limb. • Thyroid gland size increases but patient
Oestrogen is vasodilator remain euthyroid total T3 T4 increases TSH
• Uterine blood flow increases to 750 ml/ unchanged
M
Obstetrics
PG
(4%)
y
531
notes
MEE
My PG
Notes
/e
zz Integrated Test :
1st Trimester- PAPPA-A + Nuchal Translucency
,1
2nd trimester- MSAFP + UE3 + HCG + Inhibin-A (Detection rate-94%)
*NIPT- non invasive prenatal testing– Method of detecting fetal chromosomal anomalies; Maternal
es
serum can be used[2018]
PG
fetal loss,
RH isoimmunisation,
hypoplasia
USG FINDINGS
Blighted ovum Ectopic pregnancy
/e
,1
es
ot
N
Intrauterine pregnancy
Presents in early intrauterine pregnancy
EE
Obstetrics
PG
y
M
533
Dichorionic-diamniotic twins
notes
MEE
My PG
Notes
Maternal Pelvis
zz Normal female pelvis: Gynaecoid pelvis
zz Least common type of pelvis: Platypelloid pelvis
zz The only pelvis with AP diameter more than
transverse diameter: AnthroPoid pelvis
zz Face to pubis delivery most common in
Anthropoid pelvis
zz Direct and Persistent occipito posterior is most
common in Anthropoid pelvis
zz Deep transverse arrest/Non rotation is most
common in Android pelvis
zz Super sub parietal diameter instead of
/e
Biparietal diameter engages in Platypelloid
pelvis
,1
zz Naegele’s pelvis: oNe ala of sacrum absent
zz rObert’s pelvis: bOth ala of sacrum absent
es
zz Rachitic pelvis → Rickets
zz triraDiate pelvis → vitamin D deficiency
ot
zz longest diameter of pelvis:transverse diameter of inlet and AP diameter of outlet (13 cm)
N
zz shortest diameter of pelvis: Interspinous diameter
zz Shortest AP diameter of Inlet:Obstetric conjugate SOLD
EE
zz
PG
zz Super sub parietal diameter instead of Biparietal Diameter engages in Platypelloid pelvis
Fetal Head
y
M
notes
My PG
MEE
Notes
zz Brow presentation and persistent Mento-posterior are not suitable for vaginal delivery, hence
caesarean section is mandatory
/e
,1
es
ot
LIE
N
The lie refers to the relationship of the long axis of the fetus to the long axis of the centralized
EE
zz
uterus or maternal spine, the most common lie being longitudinal (99.5%)
zz Types:
M
Obstetrics
PG
y
M
Transverse LIE
zz Shoulder presentation
zz Causes:
Preterm baby [MCC].
Placenta previa [MCC in term pregnancy]
platypelloid pelvis
multiparous women
zz On examination ribcage felt → called as grid iron free 535
zz Management → Elective cesarean section
notes
MEE
My PG
Notes
Presentation
zz The part of the fetus which occupies the lower pole of the uterus (pelvic brim).
zz May be cephalic (96.5%), podalic (3%) or shoulder and other (0.5%).
Cephalic presentation
Vertex presentation Face presentation Brow presentation
(1 in 500 deliveries) (1 in 1000deliveries)
• Causes: • Causes:
anencephaly MCC fetal anomaly
Platypelloid pelvis fetal neck tumor
Multiparous women placenta previa
preterm baby • Partial extension of fetal head
• Complete extension of • Military position
/e
fetal head • Engaging diameter →mento
• Presentation: left vertical (14 cm)
,1
mentoanterior • Management
• Engaging diameter: posterior brow →
es
submentobragmatic (9.5 cesarean section
cm) Anterior brow → face
• X-Ray → Flying foetus to pubis delivery
ot
appearance
• MC presentation
N
• Mentor anterior →
• left occipito transverse: vaginal trial
Most common at the time of labour • Mento posterior → LSCS
EE
Breech Presentation
Obstetrics
PG
prematurity (MCC)
M
oligohydramnios,
short cord,
congenital anomaly,
placenta previa,
multiparity
notes
My PG
MEE
Notes
/e
zz
Elderly primi
,1
Stargazer baby
Placenta previa
Footling breech
es
Cord prolapse
Preterm breach.
Prev CS
ot
N
Presenting part:
EE
The presenting part is defined as the part of the presentation which overlies the internal os and is
felt by the examining finger through the cervical opening
M
Denominator
Obstetrics
PG
Malpositions
y
M
Occipito posterior
zz Causes:
Most commonly seen in Android pelvis
Deflexed head
Placenta previa
Multiparity
zz In labor :
90% occipitoposterior rotates to occipito anterior
Rest 10%:
ff Incomplete rotation → leads to Deep transverse arrest, mostly Seen with Android pelvis
→ needs manual rotation/ Keilland's forceps /cesarean section
ff Non rotation: leads to persistent occipito posterior, management → face to pubis vaginal
537
delivery/ cesarean section.
notes
MEE
My PG
Notes
Miscellaneous
zz Ferguson’s reflex→ vaginal examination and amniotomy increases Oxytocin level in maternal
plasma
zz Constriction ring contraction ring shoulder sling localised Tony contraction it is physiological
because of incoordinated uterine contraction
zz Located at junction of upper segment and lower segment. Mother exertion and fetal anoxia late.
zz Pervaginal examination ring is felt between head and neck. Caput not seen
zz Treatment cesarean section
Pelvic Assessment
zz In nulliparous women done at 37 weeks in multigravida at onset of labour
/e
zz Best for pelvic assessment is MRI followed by manual assessment
,1
Contracted pelvis:
es
zz Suspected in:
Women with height < 140 cm
ot
Abnormal spinal curvature
N
Rickets (triradiate pelvis)
Naegele's pelvis, Robert's pelvis
EE
PG
538
notes
My PG
MEE
Notes
LABOUR
zz Engagement: When biparietal diameter crosses the inlet it rules out CPD [at the level of inlet]
zz Steps of labour: engagement → decent → flexion → internal rotation [at the level of ischial spine]
→ extension → restitution → external rotation
Stages of labour
1st stage of labour: from onset of contraction to
complete dilatation of cervix
• Latent phase < 6 cm
Normal Prolonged
nulliparous 12 hours 20 hour
multiparous 8 hours 14 hours
• Active phase of first stage:
/e
Rate of Rate of Descent of
dilation head
,1
nulliparous 1.2 cm / hour 1 cm/hour
multiparous 1.5 cm / hour 2 cm/hour
es
• Epidural analgesia prolongs active phase by
1 hour
ot
• Arrest of dilatation → 2 hours with no change in
cervix
N
• Arrest of descent → 1 hour with no fetal decent
EE
M
Obstetrics
PG
to expulsion of foetus
epidural epidural
analgesia analgesia
M
539
4th stage – observation Duration 1 hour, risk of PPH
notes
MEE
My PG
Notes
zz UTERINE CONTRACTION:
Pacemaker located in cornu of uterus [right side >left side]
10 mm Hg → uterine contraction can be palpated
15mm Hg → pressure becomes painful and also pressure required for dilation of cervix
40 mm Hg → the uterine wall can’t readily be depressed by the finger. i.e fundus cannot be
indented
Adequate uterine contractions : 3 contractions in 10 minutes and each lasting for 45 seconds
or contraction generating a pressure of >200 Montevideo units
Tachysystole → > 6 contraction in 10 minutes
Hypertonic contraction → single contraction lasting full more than 2 minutes
zz ABNORMAL UTERINE CONTRACTIONS:
BANDL'S RING/RETRACTION RING OF BANDL’S SCHROEDER'S RING/ CONTRACTION RING
AND BARBOUR
• seen in obstructed labor • occurs due to abnormal uterine contraction
/e
• Result of tonic uterine contraction and retraction • Location: usually At junction of upper segment
• Location: Always At junction of upper segment and lower segment, but can occur in any part of
,1
and lower segment and progressive upwards uterus.
• early maternal exhaustion and fetal death • late maternal exhaustion and fetal death
• PA examination →uterus tense & tender, Ring felt • PA examination →uterus normal, FHS (+), Ring
es
as oblique groove not felt
• PV examination →LUS thinned out • PV examination →Ring felt
• Uterine rupture can occur
ot
• uterine rupture does not occur
• caput present • caput absent
N
• Treatment- cesarean section • Treatment- cesarean section
EE
PG
y
M
540
notes
My PG
MEE
Notes
Instrumental Delivery
Forceps Ventouse
zz Prerequisites: zz 0.8 kg/m2 vacuum is used
F-Force(contractions) should be present zz Prerequisites:Engaged head
O-OS fully dilated zz Indications:
R-Ruptured membrane DTA with adequate pelvis
C-Contracted pelvis should not be there Alternative to forceps except in
E- Engaged head cases where forceps is best
P-Presentation- Vertex zz Contraindications:
Surrounding must be empty-bladder and bowel non vertex presentation
zz Indications: Fetal distress
Prolonged 2nd stage of labor prematurity
Conditions threatning the well being of mother
/e
Fetal coagulation disorder ( as
Like Preclampsia, eclampsia, heart disease cephalhematoma is a complication)
Fetal indications like cord prolapse or distress
,1
fetal macrosomia is suspected
Forceps is best for :
ff Fetal distress
es
ff Prematurity
ff Aftercoming head of breech ot
ff Face presentation
N
EE
M
Obstetrics
PG
y
M
Cesarean Section
zz Types:
Lower section Cesarean section (LSCS): Most commonly performed
Classical CS(Sanger operation)
Extraperitoneal- for chorioamnionitis (obsolete) Cervical or Broad ligament fibroid
zz Absolute indications: done even if fetus is dead Advanced Cervical carcinoma
Severe contracted pelvis Repair for VVF or stress 541
Major degree of Placenta previa (IIb, III and IV) incontinence
Vaginal atresia
notes
MEE
My PG
Notes
PPH
zz “any amount of bleeding from or into the genital tract following birth of the baby up to the end
of the puerperium, which adversely affects the general condition of the patient evidenced by rise
in pulse rate and falling blood pressure is called postpartum hemorrhage”.
OR
Blood loss >500 ml in vaginal delivery and >1000 ml in ceasrean delivery
zz Types:[2018]
/e
Primary Third stage haemorrhage Bleeding before placental expulsion
(Within 24 hr) True PPH [MC] Bleeding AFTER placental expulsion
,1
Secondary Endometriosis retained tissue polyp Hemorrhage beyond 24 hours and within puerperium
es
zz
ot
N
EE
M
Obstetrics
PG
y
M
542
notes