Professional Documents
Culture Documents
Preventive and Social Medicine: Subject Outline
Preventive and Social Medicine: Subject Outline
MEDICINE
Subject Outline
Concept of Health and Disease............................. 285 Maternal and Child Health.................................... 316
Health Information & Biostatistics..................... 296 Health Care and Planning...................................... 325
Demography................................................................. 314
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History of Medicine
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zz BEINGS model:
B-Biological and behavioural factors
E-Environmental factors
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I-Immunological
N-Nutritional
G-Genetic factors
S-Social, Spiritual and service factors
zz Malarial parasite discovered by – Alphonse Laveran
zz Transmission of Yellow fever by a specific mosquito - Walter Reed
zz Pioneer of evidence based medicine- david sackett
zz Edward JeNNer developed the first vaccine and coined the term ‘vacciNatioN’
zz First country to socialise medicine: Russia
zz First country to introduce compulsory sickness insurance: GERMANY
zz First country to start Family planning programme: INDIA
zz First country to start Blindness control programme: INDIA
zz First country to start bath, sewer and aqueduct for sanitation- ROME
zz First country to start concept of health care and public health – ENGLAND
zz First country to start pasteurisation- FRANCE
zz WHO declared global eradication of small pox on 8th May 1980
zz Concept of social medicine was introduced by JULES GUERIN.
Importance august
Eye donation fortnight 25th August to
Anti leprosy day 30th January 8th september
World disabled day 15th March World Literacy day 8th September
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Standard of Living
zz refers to usual scale of our expenditure, goods we consume and services we enjoy
zz includes level of education, food, dress, house, amusements and comforts of modern living.
Quality of Life
zz A composite measure of physical, mental and social well being as PERCEIVED by each Individual
zz PHYSICAL QUALITY OF LIFE INDEX [PQLI]
Adult literacy rate
Infant mortality rate
Life expectancy at age 1
[Remember it as “ADIL AT AGE 1”]
zz HUMAN DEVELOPMENT INDEX [HDI]
Knowledge (mean years of schooling for adults and expected years of schooling for 0-18 year
olds) [Maximum-100 & Minimum-0 ]
Income (Real GDF in purchasing power parity) [Maximum-40,000 & minimum- 0]
Life expectancy at BIRTH [Maximum-85 & minimum- 0]
[Remember HDI as “KILL AT BIRTH”]
zz HUMAN POVERTY INDEX
Knowledge → adult literacy rate
Long and healthy life (probability at birth of not surviving till age 40)
Standard of living(% of population not using improved water source/% of underweight
children)
[Remember it as “knowledge LOST”]
HPI-1 → for developing countries
HPI-2 → for developed countries
zz GLOBAL HUNGER INDEX
Child mortality rate
Child Malnutrition rate
Calorie deficient population proportion
[Remember it as “Chandu Chandrakar Memorial College-CCMC”]
Measures of Disability
zz Sullivan's index = life expectancy - years of life lived with disability [YLD] = Expectation of Life
free of disability
zz Disability Adjusted Life Years [DALY] = YLD + YLL (years of life lost due to premature death)
zz Health adjusted Life Year [HALY] = life expectancy - years of ill health (disability + disease)
zz Years of potential life lost → Years of potential life lost due to premature death
Y P L L
zz YPLL rate = Population under 65 X 100 285
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Levels of Prevention
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HEALTH PROMOTION SPECIFIC PROTECTION: [Brand New Vodka Daru at Cnnaught Place]
• Environmental sanitation • Bednets for malaria
• Proper Nutrition • Nutritional supplementation
• Health education • Vaccination
• Correction of Lifestyle
• Defluoridation of water
• Minus Desk to prevent backache
• Condoms for HIV, Chemoprophylaxis for contacts
• Pasteurisation
VACCINATION
zz Pioneer in concept of specific protection by vaccine were Chinese.
zz Currently vaccine derived polio outbreaks is due to Type-2.
zz Live attenuated vaccines- [BOMYVJHT]
BCG
OPV
MMR
Yellow fever
Varicella
Japanese encephalitis
Hepatitis-A
Typhoral
zz Post exposure immunisation given in: MoTipuR Medical College Hospital
M — Mealses
T — Tetanus
286 R — Rabies
M — Meningococcal meningitis
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C — Chicken pox
H — Hepatitis
zz Avian influenza vaccine- Intramuscular route
zz Early Chinese Physicians were Pioneer in concept of specific protection by vaccine
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zz Prophylaxis for travellers-
Diarrhoeal diseases- precaution is most important
Hep-A Immunoglobins(0.02-0.05 mg/kg every 4 months)
Hep-B- Vaccine
Hep-E-avoidance of contaminated food.
Malaria- Chemoprophylaxis
YF- vaccine
Tetanus- vaccine
zz Minimum interval between two live vaccines is 4 weeks[2018]
H — Hep-B
O — OPV
T — TB(childhood)
Maal — Measles
D — Diphtheria
P — Pertussis
T — Tetanus
BCG Vaccine MEASLES Vaccine
• Bacilli Calmette Guerin • Zagreb strain
• Danish 1331 strain • Lyophilised freeze dried vaccine
• Lyophilised freeze dried vaccine • 0.5 ml, subcutaneous over Right Fold of triceps at
• 0.1 ml (>1 month) or 0.05 ml(<1 month) 9 months
Intradermal over Left deltoid at birth(maximum • Incubation period for vaccine induced measles→7
till 1 year) days
• Normal Saline is used as a diluents • To be used within 4 hours of reconstitution
• To be used within 4 hours of reconstitution • If used after 4hrs→TSS
• If used after 4hrs→TSS • Efficacy of vaccine→85%
• Efficacy after 2 doses→95%
Rotavirus vaccine Pentavalent vaccine
• Available as RotaTEC and RotaTRIC • DPT + Hep B + Hib vaccine
• 5 drops Given at 6, 10, 14 weeks • 0.5 ml Intramuscular in thigh at 6, 10, 14 weeks
OPV Vaccine
• Bivalent is used in Pulse Polio immunisation
• Trivalent is used in Routine immunisation
• July-september is high transmission season for Polio
Vaccine vial monitor (VVM)
DPT vaccine Rubella vaccine
• D and T are Toxoids whereas P component is killed acellular bacilli • Priority given to
• Side effects are mainly due to P component reproductive age group
• 0.5 ml Intramuscular in Anterolateral Thigh, middle 1/3 females
• Al2(PO4)3 and Al(OH)3 is used as adjunct →↑ immunogenicity 287
• Thiomersal is used as a preservative
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EPIDEMIOLOGY
Tools of Measurement
zz RATE
It measures the occurance of some particular event in a population during a specified time
period.
Expressed per 1000/10,000/1,00,000 (to avoid fractions)
Numerator is a part of denominator
zz RATIO
It expresses relation in size of two random quantities
Result of division of two quantities expressed as X/Y or X:Y
Numerator is not a part of denominator
zz PROPORTION
It is a ratio that tells the relation of a part to the whole.
Usually expressed as percentage
Numerator is always a part of denominator.
Mortality Indicators
zz CRUDE DEATH RATE
number of deaths from all causes per 1000 estimated mid year population
Number of deaths during the year
CDR = X 1000
Mid-Year population
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Good measure of severity of acute disease, i.e Represents Killing Power of Disease
Total no. of deaths due to a particular disease
CFR = X 100
Total no. of cases of the same disease
zz PROPORTIONAL MORTALITY RATE
Number of deaths due to a particular cause per 100 (or 1000) total deaths
zz SURVIVAL RATE
It is number of patients alive after 5 years per 100 patients diagnosed/treated
Yardstick for assessment of standards of therapy
zz ADJUSTED/STANDARDISED RATES
Standardization: for comparing health status of Population
DIRECT STANDARDIZATION INDIRECT STANDARDIZATION
(as does not needs age-specific death rate)
• Age specific death rate of a study population • Death rate of a standard population applied on a
applied on standard population and added study population and added and divided by total
and divided by standard population to number of expected death x 100 to calculate
calculate standardized age adjusted death standardized mortality ratio [SMR]
rate Observed deaths
• SMR = X 100
Expected deaths
Morbidity Indicators
Incidence
Prevalence
zz Types
PREVALENCE Point prevalence
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Epidemiological Methods
Periodic Fluctuation
zz Seasonal trends- Seasonal variations in a disease, occurs specially in many communicable diseases.
Ex; measles in early spring and URTI in winter
zz Cyclic trends- Diseases occurring in cycles spread over short periods of time which may be days,
weeks, months or years. Ex: Influenza pandemics occurring once every 7-10 years.
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[B]-Analytical studies
Ecological Studies
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zz 1st level of hypothesis study
zz Unit of study is population [2018]
zz Less expensive and easy to perform
zz It involves investigation of a
disease or a condition in a whole
population.
Longitudinal Study
ambiguity _ c d
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Epidemiological Biases
Experimental Studies
Randomised control trials
zz Patient is the unit of study
zz Study designs:
Parallel Study design:
ff Comparisons made between two randomly assigned groups with one group exposed to
specific treatment
ff Patient remains in the study group or control group for the entire duration of trial
Cross over Studies:
ff each patient serves as his own control
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ff Patients are assigned study/comtrol group randomly and after a period both groups cross
over
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ff This design assures that each patient receives the new treatment
ff ideally suitable if the changes DOES NOT change during the study
ff Not suitable if therapy of interest cures the disease
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Non-Randomised/Non-Experimental Trials
zz Crude approach
zz Done in cases where:
direct experimentation on humans is not possible due to ethical reasons
preventive measures can be applied only to groups or community(water Defluoridation)
disease frequency is low and natural history is long
zz Examples are:
proving validity of Pap test for CaCx
Before and after comparison study in John Snow's community diagnosis of Cholera
Before and after comparison study in Australia regarding difference in Motor accident deaths
after introduction of compulsory seatbelts
*Metanalysis-Statistical analysis that combines and summarises the results of multiple scientific
studies
Association
zz Association may be defined as the concurrence of two variables more often than would be
expected by chance.
zz SPURIOUS ASSOCIATION
There seems an association between two variables when actually there is not.
Occurs when ‘like’ is not compared with ‘like’
zz INDIRECT ASSOCIATION
It is a statistical association between a characteristic (or variable) of interest and a disease
due to the presence of another factor, known or unknown, that is common to both the
characteristic and the disease.
This third factor (i.e., the common factor) is also known as the "confounding" variable. It is
related both to the disease and to the variable.
zz DIRECT (CAUSAL) ASSOCIATION- it may be one on one or a multifactorial relationship.
zz BRADFORD - HILL’S CRITERIA OF CAUSATION
TEMPORAL ASSOCIATION
ff Cause should precede the effect
ff Most important criteria
ff Best deduced from a Cohort study
STRENGTH OF ASSOCIATION: The stronger the association, the more likely it is that the
relation of A to B is causal
DOSE: RESPONSE RELATIONSHIP → As the amount of exposure increases, so does the risk.
SPECIFICITY OF ASSOCIATION
ff One on one relationship between cause and effect
ff Most difficult criteria to establish
ff Not necessary to prove
CONSISTENCY OF ASSOCIATION → consistent if the results are replicated when studied in
different settings and by different methods.
BIOLOGICAL PLAUSIBILITY → there should be biological credibility to the association 293
COHERENCE OF ASSOCIATION → coherence with known facts that are thought to be relevant
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INDEX CASE First case identified by Investigator, may or may not be the primary case
PRIMARY CASE First person becoming Sick in an epidemic
SECONDARY CASE Those which develop disease from contact with Primary case
SECONDARY ATTACK It is the number of exposed persons developing the disease out of total exposed
RATE [2018] susceptible.
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