Commercialization of New Proteins:

Feedkind Protein

BIO World Congress Montreal

July 2017
 Food Security Is the Issue of the Future
By 2050, 9.6B people will demand 75% more protein than currently available

2006 Protein Demand 2050 Protein Demand

63.9
110.8 million
million
tonnes
tonnes

“ Our research shows people will spend one-third of any

increase in incomes on a more varied high-protein diet
Greg Page – Former Chairman of Cargill
”
Source: UN World Population Prospects: The 2012 Revision. World agriculture: towards 2030/2050. Food and Agriculture Organization of the United Nations, 2012.
Creating a Sustainable Food Future, World Resources Institute Report 2013-2014: Interim Findings

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 Feedkind Protein is a
Premium, non-GMO Ingredient
• Bacteria (methanotrophs) metabolize methane as their sole
source of carbon and energy, producing a nutritious, high-
protein biomass
• Approved for use in the EU, Australia,
Ecuador
– >10 years of safety data in salmon farming
– Safety studies completed in pigs, chickens,
calves, rats, mink, and fox
• Analogous to yeast extract
• Supplied dry as powder or pellets; shelf-
life >12 months at ambient temperature

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 Calysta Production Process

Methane Drying
Product
Fermentation Separation

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 Commercialization Under Way:
European Fermentation Center Opens in the UK
• Operational since Feb, 2017
• Over 5 tonnes produced, up to 50-100 per year
• Demonstrated achievement of yield and
productivity metrics in first campaign
• Samples currently available for customers and
regulatory agencies
European Fermentation Center in Teesside, England.
• Partnered with Center for Process Innovation
(“CPI”) to facilitate quick build – 9 months from
start to finish
• Critical fermentation and analytical staff in place
• Received grant for up to ~£3 million from the UK
eRGF
• Access to contract staffing provided by CPI and
anaerobic digestion facilities for biogas work
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 Memphis, TN –
Corn Sweetener Terminal & Corn Oil Refinery
OVERVIEW

• Original construction in 1974

as corn sweetener operation.
• Corn sweetener production
operations idled in 2014
• Corn sweetener terminal and
corn oil refinery operations
continue
• 24/7/365 Days a year

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Memphis Site View
Planned Memphis Atlantis Build Layout
 Superior High Protein Ingredient
Major Sources of Aquaculture Protein and New Alternatives
100%

80%

72%
70%
60% 67% 66% 66%
62%
56%

40% 47% 42%

Herring FeedKind Anchovy Soy PC Activated Spirulina Corn Gluten Chlorella Soldier Fly
Fishmeal Fishmeal Brewery Meal Larva
Waste
Crude Protein Lipid Crude Fiber Ash

• High protein, low ash/fiber are major price drivers

• However! Composition is not the whole story

Source: FAO Feed Ingredients and Fertilizers for Farmed Aquatic Animals, 2009.
ADM Arcon SPC composition.
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Feed Conversion Ratio – Rainbow Trout

* * *
* * *

Digestability and nutritional value of Feedkind Protein is higher than super

prime fishmeal in this study

Feed Conversion Ratio is the primary driver of profit on the farm; same output
of fish for less feed eaten.
Improved performance – Vannamei

10 PL shrimp per tank, 5-6 tanks per group, 8 weeks growth, fixed feeding schedule
Control diet: 15% fishmeal compared to 100% replacement by Feedkind protein

Significant increase in survival relative to fishmeal diet

No significant difference in total biomass even completely eliminating fishmeal
 Calysta Feedkind protein
compared to alternatives
Bacterial Insect Fishmeal Feedkind
meal meal
Protein Digestability 69% 82% 75%-85% 97%
(multiple species)
Shrimp Survival 85% 91% 85-91% 97%
(@100% inclusion)
Shrimp Growth (@100% 85% 51% 100% 100%+
inclusion relative to
fishmeal)

Feedkind represents a premium ingredient that

performs better than competitors, including fishmeal!

Source: Tlusty et al., 2017. Peer J.

Cummins et al., 2017 Aquaculture
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Superior performance on multiple metrics
Aquaculture Growth Product Quality Survival / Disease
Atlantic Salmon + = + Feedkind protein has been
Yellowtail = + ND tested extensively across a
Shrimp (Vannamei) + ND + wide range of species and
Livestock Growth Product Quality Survival / Disease markets.
Weaning piglets + ND +
Adult Pigs = + = Performance is generally
Cattle = + = significantly improved on
Chicken - + = key price metrics
Pets Growth Palatability Health
Cats = = +
Dogs = = +
Human Nutrition Palatability Health
(PDCAAS)
Comparison to performance of
+ + ND equivalent ingredient in a control diet

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 Barriers to Entry - SCP
• IP: How to protect a natural strain? GMO strains can be protected, but how
to overcome consumer acceptance?

• Production technology: How to scale up feedstocks? Mass transfer, surface

area, toxicity, safety? Proprietary reactor vs off-the-shelf?

• Product performance: All SCPs are not equivalent! Target species, product
profile, inclusion level, digestability, nutritional value, palatability.

• Regulatory approval: Approvals are not generic. Approval bodies will assess
potential pathogenicity (species name). New products require extensive
safety testing.

• Commercial scale-up: How to cross the valley of death?

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Sustainable source of protein with superior impacts on
both health and product quality

THANK YOU!

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