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  • NutraHacker COVID19 Novel Coronavirus Report Customer

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    Gabriel Guimarães
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    This report analyzes genetic polymorphisms related to COVID-19 susceptibility and severity. It finds that the ACE2 receptor, used by COVID-19, SARS, and H1N1, increases susceptibility when cleaved by the TMPRSS2 enzyme. Polymorphisms in TMPRSS2 affecting its expression level correlated with increased H1N1 severity. The customer's genotype for the risk-associated rs2070788 polymorphism was AA, conferring no increased risk. Nicotine may impact COVID-19 negatively while chloroquine shows promise as a treatment.

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    NutraHacker_COVID19_Novel_Coronavirus_Report_Customer_0a2e8cde-9751-4692-9d59-3148648069d5 (1)

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    This report analyzes genetic polymorphisms related to COVID-19 susceptibility and severity. It finds that the ACE2 receptor, used by COVID-19, SARS, and H1N1, increases susceptibility when cleaved by the TMPRSS2 enzyme. Polymorphisms in TMPRSS2 affecting its expression level correlated with increased H1N1 severity. The customer's genotype for the risk-associated rs2070788 polymorphism was AA, conferring no increased risk. Nicotine may impact COVID-19 negatively while chloroquine shows promise as a treatment.

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    © All Rights Reserved
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    43 views1 page

    NutraHacker COVID19 Novel Coronavirus Report Customer

    Uploaded by

    Gabriel Guimarães
    This report analyzes genetic polymorphisms related to COVID-19 susceptibility and severity. It finds that the ACE2 receptor, used by COVID-19, SARS, and H1N1, increases susceptibility when cleaved by the TMPRSS2 enzyme. Polymorphisms in TMPRSS2 affecting its expression level correlated with increased H1N1 severity. The customer's genotype for the risk-associated rs2070788 polymorphism was AA, conferring no increased risk. Nicotine may impact COVID-19 negatively while chloroquine shows promise as a treatment.

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    © All Rights Reserved
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    NutraHacker

    COVID-19 Novel Coronavirus Free Genetics Report for Customer: 0a2e8cde-9751-4692-9d59-3148648069d5

    Disclaimer: This report is offered for free by Nutrahacker, LLC. It is not intended to diagnose, treat, or prevent any
    disease. It is for informative and educational purposes only. Please follow the advice of your healthcare provider.

    ACE2 has been shown to be the receptor for COVID-19 (1). This is the same receptor identified and used by the closely related viruses SARS and H1N1
    (2,3). It follows that higher levels of ACE2 would be implicated in poorer disease outcomes, however no SNPs in the ACE2 have been shown to have an
    effect in the severity of SARS (4).

    ACE2 is cleaved (cut) by two different enzymes. Cleavage by one enzyme in particular, TMPRSS2, appears to make the protein susceptible to viral attack
    (5). TMPRSS2 and ACE2 colocalize (6). Blocking TMPRSS2 appears to be a treatment modality (7).

    Polymorphisms in TMPRSS2 affect severity of H1N1 (8) by increasing infectivity of the virus. Hence, it is likely that related viruses using the same entry
    path will have a similar response to these polymorphisms. Rs2070788 (G overrepresented in high severity cases, GG 2-fold risk of high severity disease),
    this polymorphism is probably tagging to rs383510. Higher expression of gene is higher severity of H1N1. rs38310 T allele enhances activity of the gene.
    These polymorphisms are not independent, so just one is needed to assess the activity of TMPRSS2.

    Gender of customer: Male

    RSID Risk Allele Your Genotype

    rs2070788 G AA: 0/2

    Nicotine seems to affect this disease process negatively (9) while Chloroquine is a valid therapeutic modality (10).

    Citations:

    (1) https://www.ncbi.nlm.nih.gov/pubmed/32169119
    (2) https://www.ncbi.nlm.nih.gov/pubmed/15549175
    (3) https://www.ncbi.nlm.nih.gov/pubmed/25391767
    (4) https://academic.oup.com/clinchem/article/50/9/1683/5640134
    (5) https://www.ncbi.nlm.nih.gov/pubmed/24227843
    (6) https://jvi.asm.org/content/85/2/873
    (7) https://www.ncbi.nlm.nih.gov/pubmed/22496216
    (8) https://www.ncbi.nlm.nih.gov/pubmed/25904605
    (9) https://www.ncbi.nlm.nih.gov/pubmed/32189428
    (10) https://www.ncbi.nlm.nih.gov/pubmed/16115318
    (11) https://www.ncbi.nlm.nih.gov/pubmed/32226946

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