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07 Respi Drugs
07 Respi Drugs
LEUKOTRIENE MODIFIERS
• Leukotriene Modifiers: Action
o Competitively inhibits leukotriene
receptor from interacting to its
receptor resulting to smooth
muscle relaxation, increased
vascular permeability and
increased secretions
o Examples: Montelukast & zafirlukast
• Leukotriene Modifiers: Indication
o Mild to moderate asthma
exacerbations, prophylaxis of
persistent, chronic asthma
• Leukotriene Modifiers: Side Effects or
Adverse Effects
o Headache, N/V, diarrhea, dizziness,
myalgia
• Leukotriene Modifiers: Contraindications:
o Hepatic impairment
• Leukotriene Modifiers: Drug Interaction
o +Warfarin = ↑ Prothrombin time
o +Aspirin, fluoroquinolones, isoniazid:
↑ Effect
o +Erythromycin, rifampin,
amiodarone: ↓ Effect
• Leukotriene Modifiers: Nsx. Action
o Can be taken 1 to 2 hours after
meals o Not used for acute asthma
attacks