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Pathopysiology of Colorectal CA
Pathopysiology of Colorectal CA
Pathopysiology of Colorectal CA
Predisposing Fx Precipitating Fx
• 90% in age >50 (pt-68) • Adenomatous polyps
• Race: Asian
• Alcohol Intake
• Fat/Low fiber intake
Alteration in fecal-floral
Maybe carcinogenic
Concentration of potential
Carcinogens into smaller Presence of Carcinogen in the
volume descending colon
Metabolism
(metabolic actiation)
Electrophilic reaction
Preneoplastic clone
Colorectal Polyps
Enlargement of polyps
Malignant neoplasm
Colon cancer