GENRIC NAME DOSAGE/ROUTE CLASSIFICATION INDICATION ADVERSE REACTION NURSING RESPONSIBILITY

Cisplatin Dosage: Antineoplastic - Kill cancer cells by - Nausea and vomiting BEFORE
1 mg/mL in 50 (Alkylating agent) binding to DNA and - Diarrhea - Perform sensitivity test
mg and 100 mg interfering with its - Temporary hair loss - Instruct not to eat before the
vials repair mechanism, - Loss inability to taste treatment it may help relieve
eventually leading to food vomiting
Route: cell death - Hiccups - Instruct changes in diet such
Intravenous - Inhibits DNA - Dry mouth as eating several small meals or
- Dark urine limiting activity may help lessen
synthesis by causing - Decreased sweating some of these effects
- Dry skin - Tell the client that hair loss
intrastrand and may occur and normal hair
growth should return after
interstand cross- treatment has ended
- Advice client that he/she wil
linking of DNA. be unable to taste food.
DURING
- Dilute Cisplatin in 2L D5W 5%
dextrose in ½ or 1/3 normal
saline containing 37.5 g
mannitol
- Instruct client to hold his/her
breath for a short time to
prevent hiccups
- Apply lip balm/petroleum jelly
on the client’s mouth to
minimize dryness
- Apply water or cool cloths to
the skin of the client to make
him/her like sweating
- Make sure that the drugs was
taken, by checking the client’s
mouth
AFTER
- Instruct client to drink 8 oz of
water every hour while awake
- Advice client on BRAT
(bananas, rice, applesauce, and
toast) diet to prevent diarrhea
- Advice promptly report
bleeding, bruising, hearing loss,
yellowing of skin or eyes,