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  • PATHOPHYSIOLOGY OF OSTEOSARCOMa

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    Osteosarcoma is caused by both modifiable and non-modifiable risk factors. It begins with the activation of an oncogene in malignant osteoblasts, leading to the proliferation of abnormal osteoblasts and formation of uncontrolled osteoid tissue and tumor growth in the metaphysis. This damages surrounding bone and tissues, and can metastasize to other organs like the lungs, liver, and kidneys, impairing their function and potentially causing organ failure.

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    Osteosarcoma is caused by both modifiable and non-modifiable risk factors. It begins with the activation of an oncogene in malignant osteoblasts, leading to the proliferation of abnormal osteoblasts and formation of uncontrolled osteoid tissue and tumor growth in the metaphysis. This damages surrounding bone and tissues, and can metastasize to other organs like the lungs, liver, and kidneys, impairing their function and potentially causing organ failure.

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    1K views1 page

    PATHOPHYSIOLOGY OF OSTEOSARCOMa

    Uploaded by

    kyaw
    Osteosarcoma is caused by both modifiable and non-modifiable risk factors. It begins with the activation of an oncogene in malignant osteoblasts, leading to the proliferation of abnormal osteoblasts and formation of uncontrolled osteoid tissue and tumor growth in the metaphysis. This damages surrounding bone and tissues, and can metastasize to other organs like the lungs, liver, and kidneys, impairing their function and potentially causing organ failure.

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    © All Rights Reserved
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    PATHOPHYSIOLOGY OF OSTEOSARCOMa

    Modifiable NON Modifiable


    Smoker Age 10-25
    injury Male
    Teenage growth spurt
    DNA mutation

    Activate oncogene

    Malignant osteoblast

    Proliferation of abnormal osteoblast

    Formation of osteoid tissue

    Uncontrolled growth of tumor

    Overcrowding to bones

    Increase pressure on affected


    Suppression bon Metastasize cancer cells
    Destroy bone tuberculae To different organs
    Tumor arise in metaphysis and growth
    is More active Decrease production bloo

    Damage periosteum Decrease production RBC


    (anemia ) WBC (decrease
    resitance to infection)
    Extend to medulla and periosteal area

    Destroy bone tuberculae

    Damp medullary canal bec. Formation


    mass

    KIDNEY CNS LIVER/


    lungs spleen
    Disturbances renal
    Impaired circulation Invaded cancer Invaded cancer
    No urine output/ leokocytes cells cells
    less urine
    Flank pain compression Bronchial Inflammation
    leokocytes destruction bleeding
    Renal failure lethargy weakness hypoxia hepatomegaly
    Blussred vision
    Cough, sneeze,
    coma DOB,chest pain

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