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Antiviral Drugs PDF
Antiviral Drugs PDF
ANTIVIRAL DRUGS
• Viruses are intracellular parasites that take part in metabolism of host cells. They
are formed of protein mass (nucleic acid RNA or DNA) covered with a coat.
Antiviral drugs may inhibit viral replication and may also injure host cells.
Alpha-globulin
(-) Amantidine
Penetration Uncoating (-)
Virus
Zidovidin Zidovidin
Ribavirin (-) DNA RNA (-) Ribavirin
Acyclovir Interferons
Idoxuridine transcriptase
Protein
Assembly
Release
(-)
Rifampicin
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2) Acyclovir:
Indications: - Herpes simplex and Herpes zoster.
Side effects: - Local irritation, GIT upsets, headache, transient renal dysfunction.
3) Ribavirin:
Indications: - Respiratory Syncytial Virus (RSV).
- Acute Hepatitis-B and C.
4) Zidovudin:
Indications: - Treatment of AIDS.
Side effects: - Bone marrow depression, GIT upsets, Acute Cholestatic Hepatitis.
5) Indinavir:
Indications: - Combined with Zidovudin in treatment of AIDS.
Adverse effects:
- GIT upsets, flu-like syndrome, headache, dizziness, confusion, and
hypotension.
- Arrhythmias, alopecia
- Bone marrow depression.