‫معهد اإلسراء لمعادلة الشهادة‬

71. polypeptide which is produced during the biosynthesis of tetracycline consist of

 C-18
 C- 20
 C - 16
 C- 19

72. Oxytetracycline is

 6 - deoxytetracycline
 3 - deoxytetracycline
 5-hydroxytetracycline

73. all of the following drug are amphoteric except

 quinine
 tetracycline
 theobromine
 morphine

74. all of the following derived from amino acid except

 reserpine
 doxorubicin
 Codeine
 Chloramphenicol

75. all of the following drug derived from acetate except

 mitomycin
 Chlortetracycline
 Nicotine
 Doxorubicin

76. Bergapten is

 furanocumarine
 isocoumarin
 diacumarol

77. The shikimic acid pathway converts simple CHO to

 alphatic amino acid

 aromatic amino acid
 carboxylic acid
 all of them

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‫معهد اإلسراء لمعادلة الشهادة‬

78. digoxin

 bufa_dienolide
 containe acetyl group at c-16 B
 Cardinolide
 contain acetyl group at c 16

79. all of the following drug are steroidal compound except

 diosgenin
 arbutin
 solanum
 veratrmine

80_ Goldenseal plant contain as a major constituents

 quinolone alkaloid
 Isoquinline alkaloid
 Purine alkaloid
 indole alkaloid

1 The final step in the biosynthesis of Penicillin G is

 condensation of amino acid

 oxidative hydrolysis of ACV
 Oxidative conversion
 Transamination

62. Cefoxitins

 3rd - generation cephalosporin A.B

 derived biosynthetically from aa and CHO
 has broad range of G- bacteria
 has dihydrothiazine ring

63. Arcoline is derivative of

 Piperidine
 nicotinic acid
 Pyridine
 Pyrrolidine

63. Esterification of tropic acid + tropine produced

 Hyoscine
 Hyoscyamine

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‫معهد اإلسراء لمعادلة الشهادة‬

 Atropine
 Tropan

65. helicin is direct precursor for

 Arbutin
 coumarine
 Salicine
 vanillin

66. Papaverine

 Benzylisoquinoline
 Phenylalkylamine
 Isoquinoline
 phenylacetylamine

One of the structural requirement for central acting analgesic

 Secondary nitrogen
 Chiral carbon atom
 central carbon atom
 all of above

68. vincristine & vinblastine are

 Monoterpenoide indole alkaloid

 Hemiterpenoide indole alkaloid
 Pyrrolo indole alkaloid
 Simple indole alkaloid

69. Flavonoid type which doesn't have O in the structure

 flavan
 Flavone
 Chalcone
 flaveon


70. Myricetin is

 pyragallol flavonol
 pyragallol flavan
 catechol flavonol
 pyragallol flavone

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1.Fixed oils are:

o ester of fatty acid

o carbaxylic acid
o phenolic compound
o none of them

2. Bergapten is produced by the plant as a protection mechanism against:

o fungal infection
o bacterial infection
o high dose of sunlight
o None of them

3. Scopoletin is:

o alcohle glycoside
o phenol glycoside
o coumarine glycoside
o aldehyde glycoside

4. Black mustard contains

o cardio-active glycoside
o laxative glycoside
o isothiocyanate glycoside
o cyanide glycoside

5. Flavonoid glycoside which is characterized by the absence of carbonyl group at C-4 &double
bond between C-2&3 is:

o Flavone
o Flavanon
o Flavanonol
o Flavan

6. Flavonoids glycoside act as anti-inflammatory drug by interfering with the action of

o nitric oxide synthase enzyme

o cyclooxygenase & lipooxygenase enzymes
o glutathione
o All of them

7.Amygdaline is:

o cardio-active glycoside

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‫معهد اإلسراء لمعادلة الشهادة‬

o b) laxative glycoside
o c) isothiocyanate glycoside
o d) cyanideglycoside

8. Bictracin is derived from

o amino acid metabolism

o b) acetate metabolism
o c) amino acid +CH0 metabolism
o d) CHO metabolism

9.Doxorubicin anti- neoplastic A.B. derived from

o amino acid metabolism

o b) acetate metabolism
o c) amino acid +CHO metabolism
o d) CHO metabolism

10. Chlorotetracycline is derived from

o amino acid metabolism

o b) acetate metabolism
o c) amino acid +CHO metabolism
o d) CHO metabolism

11.Cholinergic alkaloid:

o Thebaine
o b) Pilocarpine
o c) Nicotine
o d) Quinine

12. Quinoline nucleus possess two rings:

o quinolone tquinuclidine
o b) benzene +piperidine
o c) pyridine +piperidine
o d) pyridine +benzene

13. The main alkaloids found in Goldenseal plant:

o berberine
o b) emetine
o c) curarine
o d) cocaine

14.Benzyl-isoquinoline alkaloid:

o heroine

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‫معهد اإلسراء لمعادلة الشهادة‬

o b) morphine
o c) codeine
o d) papaverine

15. An ester alkaloid:

o hyoscymine
o b) caffeine
o c) morphine
o d) quinine

16. Phenanthrene alkaloid:

o Narceine
o b) Morphine
o c) Nicotine
o d) Caffeine

17.A colored alkaloid:

o Atropine
o b) Morphine
o c) Cocaine
o d) Berberine

18. .An anthelmintic alkaloid:

o quinine
o quinidine
o hyoscine
o arecoline

19. Solanine is

o proto-alkaloid
o steroidal alkaloid
o alkaloidal amine
o purine alkaloid

20. Ephedrine is

o anti-cholinergic drug
o stimulate a and  adrenergic receptors
o anti-hypertensive drug
o anti-arrhythmic drug

. 21.A stimulant laxative glycoside:

o Diosfenin

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‫معهد اإلسراء لمعادلة الشهادة‬

o Sennoside A&B
o Silymarine
o Digitoxin

22- A True-alkaloid

o Caffeine
o Theophlline
o Atropine
o Theobromine

23- Khellin is:

o alcohol glycoside
o phenol glycoside
o coumarine glycoside
o sreroidal glycoside

24- Dehydrogenation to form a double bond between C-5a & C-11 a in the tetracycline will:

o increased activity
o decreased activity
o form minocycline
o complete losing in activity

25- Brucine is derived biosynthetically from:

 Tryptophan
 Phenylalanine
 Omithine
 Histidine

26-In the flavonoids, Ring derived from:

 shikimate pathway

 xanthin pathway

 CHO pathway

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‫معهد اإلسراء لمعادلة الشهادة‬

 acetate pathway

27- para-hydroxy aminobenzyl penicillin

o Active against G-ve bacteria

o Stable in acidic PH
o Penicillinase enzyme insensitive
o Act by inhibition of protein synthesis

28- Triterpenes consist of:

o 6 isoprene units
o 3 isoprene units
o 2 isoprene units
o 4 isoprene units

29- The polyketide is involved in the biosynthesis of:

o Tetracycline
o Cefipime
o Ampicillin
o Amikacin

30- Heroin is produced by:

o methylation of morphine
o acetylation of morphine
o decarboxylation of morphine
o oxidation of morphine

31- Palmitate ester salt of chloramphenicol is used to:

o Increase water solubility A.B

o Avoid bitter test of A.B
o Increase bioavailability of A.B
o All of the above

32- Stychinine is:

o From nux-vomica
o It causes convulsion

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o It can treat GI carcinoma

o All of the above

33. Squill plant:

o Contained bufadienolides cardio-active glycoside

o Contauned cardinolides cardio-active glycoside
o Contained oleandrin as major compound
o Contained dianthrone glycoside

34- Carbenicilline is:

o Carboxy benzyl- penicillin

o Aminobenzyl-pencillin
o P-hydnoxy benzyl- penicillin
o Epaxybenzyl-pencicillin

35.All of the following are correct about hyoscyamine, EXCEPT:

o It is tropane alkaloid
o It is cholinergic drug
o It is anticholinergic drug
o It increases heart rate

36.All the following A.B are semisynthetic except:

o Doxycycline
o Demeclocycline
o Minocycline
o Rolitetracycline

C-Glycosides:

o They are hydrolyzed by heating with dilute acid

o They are hydrolyzed by heating with alkalies
o They are hydrolyzed by oxidative hydrolysis
o They are hydrolyzed by direct heat

19-Diosgenein is:

o Steroidal saponin
o Cyanogenetic glycoside
o Anthraquinine
o An anti-oxidant

20- Psoralens are :

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‫معهد اإلسراء لمعادلة الشهادة‬

o Coumarins that possess furan ring

o Coumarins that possess pyron ring
o Coumarins that possess spiro-ketal side chain
o Coumarins that possess steroidal nucleus

21- Narceine is:

o Phenanthrene alkaloid

o Benzylisoquinoline alkaloid
o Phenylethyamine alkaloid
o none of the above

22-In the flavonoids, Ring (A)&(C) derived from:

o Shikimate pathway
o b)Xanthin pathway
o c)CHO pathway
o d)Acetate pathway

23- All of the following about cathinone are correct, EXCEPT: a) It is phenylalkylamine alkaloide

o b) It causes euphoria
o c) It is from khat plant
o d) It is xanthine alkaloid

24- All of the following are correct about cefepime, EXCEPT: a) It is fourth generation
cephalosporin

o b) it has extended spectrum against gram +ve and –ve

o c) it is third generation cephalosporin
o d) none of the above

25- Pilocarpine is:

o Purine alkaloid
o Imidazole alkaloid
o Isoquinoline alkaloid
o Pyridin-piperidine alkaloid

26- It is unsaturated plant sterol found in soybean oils and many herbs:

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‫معهد اإلسراء لمعادلة الشهادة‬

o Bergapten
o Stigmasterol
o Theophylline
o Atropine

27- ____ is a special test for theobromine.

o Tannic acid test

o Murexide test
o Ferrous sulfate test
o Mayers test

28 -Reserpine is:

 An anti-arrhythmatic drug
 A cardio tonic drug
 An anti-hypertensive drug
 An anti-malarial drug

29- It a cardio tonic glycoside:

 Caffeine
 Ergotamine
 Vincristine
 Digoxin

30- Bufadienolides are:

 C-24 containing 6 membered unsaturated lactone ring

 C-23 containing 5 membered unsaturated lactone ring
 C-24 containing 6 membered saturated lactone ring D- C-23 containing 5
membered saturated lactone ring

31- It is a colored alkaloid:

 Atropine
 Morphine
 Cocaine
 Berberine

32- The direct precursor of tyrosine is:

 Phenyl pyruvic acid

 Shikimic acid
 P-hydroxy phenyl pyruvic acid D- Chorismic acid

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‫معهد اإلسراء لمعادلة الشهادة‬

33- Oleandrin is:

 Bufadienolide
 Cardtrienolide
 Contain acetyl group at C-16 B
 Contain acetyl group at C-16 a

34- The main alkaloid found in goldenseal plant is: Berberine

o Emetine
o Curarine
o Cocaine

35- Benzylisoquinoline alkaloid:

 Heroine
 Morphine C- Codeine
 Papaverine

36- It is an ester alkaloid:

 Hyoscymine
 Caffeine
 Morphine
 Quinine

37- All of the following alkaloids are insoluble in water EXCEPT:

 Quinidine
 Nicotine
 Thebiane
 Caffeine

38- It is an anti-cholinergic alkaloid drug:

 Pilocarpine
 Atropine
 Nicotine
 Quinine

39- Natural narcotic analgesic drug:

 Pethidine
 Tramadol
 Morphine D- Heroine

40- Salicin is:

 Alcoholic glycoside

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‫معهد اإلسراء لمعادلة الشهادة‬

 Aldehyde glycoside
 Phenol glycoside
 Anthrancene glycoside

41- Chloroquine is a synthetic:

o Narcotic drug
o Anti-malarial
o Laxative
o CNS stimulant

42- Cocaine is:

 Tropane alkaloid
 Indol alkaloid
 Purine alkaloid D- Quinolone alkaloid

43- Emetine is:

 Quinolone alkaloid
 Isoquinoline alkaloid
 Pyridine alkaloid D- Imidazole alkaloid

44- Vanillin is:

 Aldehyde volatile oil

 Phenolic glycoside
 Keton volatile oil
 Alcoholic glycoside

45- Ergotamine is:

 Serotonin antagonist
 Alpha antagonist vasodilator
 Oxytocic agent D- Alpha agonist vasoconstrictor

46- Racemization of hyoscyamine yield:

 Atropine
 Scopolamine
 Cocaine
 Nicotine

47- One of the negative effect of caffeine is:

 Increasing metabolic rate

 Increasing alertness

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‫معهد اإلسراء لمعادلة الشهادة‬

 Increasing attention
 Anxiety

48- Vicristine biosynthesis is derived from: Tryptophan

o Phenylalanine
o Orthinine
o Histidine

49- Quinine is:

 Anti-malarial
 Anti-hypertensive
 Anti-diabetic
 Anti-arrhythmatic

50- Monoterpenes cosist of:

 6 isoprene units
 3 isoprene units
 2 isoprene units
 4 isoprene units

51- Steroidal saponin glycoside:

 acidic compound
 contain C atom connected to 2 O in the same plane
 consists of 27 C atoms
 contains cyclic ester as a side chain

52- Sinalbin is:

 an aromatic compound
 Obtained from brassica nigra
 Gives upon hydrolysis allythiocynate
 none of the above

53- Cinchona alkaloids possess two rings:

 Quinolone + quinuclidine
 Benzene + pyridine
 Benzene + piperidine
 Quinolone + benzene

54- Flavonoids glycosides consist of:

 23 carbon atom
 19 carbon atom
 15 carbon atom

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‫معهد اإلسراء لمعادلة الشهادة‬

 24 carbon atom

55- Which of the following are incorrect regarding the phases of antibiotics production:

 Growth phase(Tropho phase) in which the number of microorganism per

unit time increase, last (0-24 hrs)
 Idio phase in which there is substantial antibiotic production rapidly (24-
80 hrs)
 During production phase, glc has been used up directly then lactose as a
source of carbon
 The increased availability of carbon source (glc) is thought to be the
triggering mechanism of penicillin production

56- Aminobenzyl penicillin:

 Acid stable (orally)

 Inactivated by penicillinase enzyme
 Active against gram +ve and limited against gram –ve
 all of the above

57- Carboxybenzyl penicillin:

 Extend spectrum against gram –ve such as E.coli

 Acid stable
 Alkaline stable
 Semisynthetic penicillin that are susptible to degredation by B lactmase
enzyme

58- Tetracycline:

 A broad spectrum antibiotic obtained from Streptomyces aureofaciens

 Derived from acetate metabolism
 Used for acne
 All of the above

59- Chloramphenicol:

 Obtained from culture of Streptomyces venezuelae

 Aplastic anemia can occur
 Drug of choice for acute typhoid fever
 All of the above

60- Aminoglycoside are effective against all the following EXCEPT:

 Anaerobic bacteria
 G +ve and G –ve bacteria
 Fungi
 Viruses

61- Which of the following is true about macrolides:

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‫معهد اإلسراء لمعادلة الشهادة‬

 The lactone ring are usually 14-15 or 16-memberd

 Belong to the polyketide class
 Binding to 50s subunit of ribosome and inhibiting protein synthesis D- All
of the above

62.Erythromycin antibiotic:

 It is produced by saccharopolyspora erythraea

 14-memberd ring of macrolides
 Its use has limited due to GI intolerance and short half life
 all of the above

63. the following antibiotics works by inhibiting cell wall synthesis?

 ofloxacin
 rifampin
 chloramphenicol
 tetracycline
 cephalosporin

64.Prolongedadministration of streptomycin may result in damage to which of the

followingnerves?

o Optic
o Facial
o Auditory
o Trigeminal

33.Mayer's reagent consist of

o A Potassium Bismuth Iodide

o B Potassium Mercuric Iodide
o C Saturated solution of picric acid
o D Iodine in KI

32.  Examples of proto alkaloid i

o A Ergot
o B Cinchona
o C Colchicum
o D Kurchi

33  ________________ liquid alkaloid

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‫معهد اإلسراء لمعادلة الشهادة‬

o A Nicotine
o B Caffeine
o C Theophylline
o D kurchicine

36.  Veratrum is __________alkaloid

o A Amino alkaloid
o B Steroidal
o C Purine
o D Quinazoline

35.  Pseudo alkaloid is

o A N present in heterocyclic ring, derived from amino acid

o B N present in side chain, derived from amino acid
o C N present in heterocyclic ring, not derived from aminoacid
o D N present in heterocyclic ring side chain, not derived from amino acid

36 Alkaloids are naturally occurring compounds which contain .............in their molecules.

o one or more N atom(s) 

o   B) two heterocyclic rings  
o C) one C15 side chain on the benzene ring
o D) one or more N atom(s) originated from amino acids
o E) one or more O atoms besides the S atoms

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