UMA VISÃO DAS FIBRAS

MUSCULARES
E
PROTEÍNAS DO
CITOESQUELETO
MUSCLES = FIBERS
CELLS
sliding-filament theory

Andrew Fielding Huxley

1917-2012
HISTOLOGY
 LISO

ESQUELÉTICO

CARDÍACO
SKELETAL FIBERS
Diidropiridina Rianodina
 Tipos de fibras
esqueléticas
 Vermelha: mioglobina e
metabolismo oxidativo,
resistente a fadiga. Contração
lenta (I) e contração rápida
(IIa);

 Branca: ausência de
mioglobina, predomina
metabolismo anaeróbico,
contração rápida e pouco
resistente a fadiga (IIb).
1, Type 1 fibers; 2, Type 2A fibers; 3, Type 2X
fibers; 4, Type 2B fibers.
Skeletal muscle fibre types
 Type I
 Red fibers. Slow oxidative
(also called slow twitch or
fatigue resistant fibers).
 Contain:
 Large amounts of myoglobin.
 Many mitochondria.
 Many blood capillaries.
 Generate ATP by the aerobic
system, hence the term
oxidative fibers.
 Split ATP at a slow rate.
 Slow contraction velocity (80-
200 ms).
 Resistant to fatigue.
 Found in large numbers in
postural muscles.
 Needed for aerobic activities
like long distance running.
 These cells are thin (high
surface to volume ratio) with
a good capillary supply for
efficient gas exchange.
 Skeletal muscle fibre types
 Type IIa
 Red fibers. Fast oxidative
(also called fast twitch A or
fatigue resistant fibers).
Contain:
 Large amounts of myoglobin.
 Many mitochondria.
 Many blood capillaries.
 High capacity for generating
ATP by oxidation. Split ATP
at a very rapid rate and,
hence, high contraction
velocity (7-8 ms).
 Resistant to fatigue but not
as much as slow oxidative
fibers.
 Needed for sports such as
middle distance running and
swimming.
 These cells are thin (high
surface to volume ratio) with
a good capillary supply for
efficient gas exchange.
 Skeletal muscle fibre types
 Type IIb White
 Fast glycolytic (also called
fast twitch B or fatigable
fibers). Contain:
 Low myoglobin content.
 Few mitochondria.
 Few blood capillaries.
 Large amount of glycogen.
 Split ATP very quickly.
 Fatigue easily.
 Needed for sports like
sprinting.
 These are large cells with a
poor surface to volume ratio
and their limited capillary
supply slows the delivery of
oxygen and removal of waste
products.
 They generate ATP by the
anaerobic fermentation of
glucose to lactic acid.
SMOOTH FIBERS
MÚSCULO LISO UNITÁRIO - VISCERAL
Smooth muscle
CARDIAC FIBERS
MÚC. CARDÍACO