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Delayed Tooth Emergence
Delayed Tooth Emergence
1. Recognize abnormalities in tooth emergence timing and order based on oral inspection.
Author Disclosure 2. Discuss local and systemic causes of delayed tooth emergence.
Dr Karp has disclosed 3. List treatment modalities available for management of delayed tooth emergence.
no financial 4. Determine when timely referral to a dentist is necessary.
relationships relevant
to this article. This
Introduction
commentary does not
Delayed tooth emergence (DTE) is a clinical term used when exposure of a tooth or
contain a discussion multiple teeth through the oral mucosa is overdue, according to population norms based
of an unapproved/ on chronologic age. DTE is common in childhood and adolescence, yet it is often
investigative use of a overlooked or dismissed in pediatric primary care. Timely screening and recognition of
commercial product/ DTE by clinicians can minimize medical, developmental, functional, and esthetic prob-
device. lems resulting from untreated underlying local and systemic causes. This article provides
clinicians with an overview of conditions responsible for DTE in children. Multidisci-
plinary care for patients who experience DTE in medical, dental, and surgical settings also
is discussed.
Odontogenesis
Human teeth develop through a series of complex, reciprocal interactions between the oral
epithelium and migrating cranial neural crest ectomesenchymal cells of the first branchial
arch. This process is tightly regulated by more than 300 genes expressed temporospatially
within the jaws. Dental patterning of the primary and permanent dentition is expressed
in three dimensions, exerting morphogenetic controls over tooth number, position, size,
and shape. In the end, the normal primary dentition consists of three tooth classes (four
incisors, two canines, four molars) in each jaw, for a total of 20 teeth. Thirty-two teeth
distributed among four tooth classes (8 incisors, 4 canines, 8 premolars, 12 molars)
comprise the permanent dentition.
*Assistant Professor, Division of Pediatric Dentistry, Departments of Dentistry and Pediatrics, University of Rochester Medical
Center, Rochester, NY.
the past 100 years report marked variation in dental chro- Tooth eruption through alveolar bone causes expansion
nology based on race, ethnicity, and sex as well as environ- and fullness of the alveolar ridge. On average, 2 months are
mental factors. Tooth development, eruption, and emer- required for a tooth to progress from causing palpable
gence in healthy mouths are genetically controlled, with enlargement of the gingival tissues to overt clinical emer-
high heritability scores reported in monozygotic twin stud- gence. Palpation of the oral mucosa in the area of erupting
ies. As seen in Table 1, tooth emergence and exfoliation teeth should cause localized tissue blanching if tooth emer-
times are usually presented as ranges of chronologic age to gence is imminent. In addition, redness of the mucosa or an
account for the previously mentioned factors. Clinicians eruption hematoma has been noted to precede tooth emer-
should recognize that teeth that fail to emerge within 12 gence in more than 30% of cases. Thin, knife-edge alveolar
months of the normal range are considered delayed. In ridges suggest the absence of teeth in the area.
these cases, referral to a dentist is warranted for further The dentition should be inspected systematically for
clinical and radiographic assessment. Some cases require age-appropriate tooth counts (Figs. 1 and 2). Proper
surgical treatment to permit tooth emergence. inspection requires a working knowledge of the differ-
ences in tooth morphology among tooth classes and
Detection of DTE between the two dentitions. Tooth counts should be
DTE is a nonspecific clinical finding that can occur in a assessed for appropriateness in timing and order. For the
localized or generalized distribution. Oral inspection most part, the primary dentition adheres to the follow-
coupled with history can provide clinicians with substan- ing emergence order in each jaw: central incisors, lateral
tial information to define further the natural history and incisors, first molars, canines, and second molars. Al-
clinical manifestations of the underlying condition. Oral though published emergence orders are available for the
examination should consist of evaluation of the alveolar permanent dentition, clinicians observe countless varia-
ridges as well as the alignment and morphology of the tions in order as a result of numerous genetic, anatomic,
teeth that are present. The size and shape of the alveolar and environmental influences.
ridges can help determine whether DTE is due to abnor- Generalized timing delays in tooth emergence caused by
malities in tooth development, eruption, or emergence. systemic disease do not usually result in changes in the order
Causes of DTE
of tooth emergence or exfoliation. In contrast, localized Anomalies in Tooth Number
disease should be investigated when the order of tooth Tooth agenesis, one of the most common developmental
emergence is altered. Three general rules exist for normal anomalies in humans, alters the order of tooth emer-
tooth development and emergence: 1) anterior teeth within gence. Although missing teeth are noted in only 1% of
a specific tooth class (eg, first premolars) always precede children in the primary dentition, approximately 30% of
posterior teeth within the same class (eg, second premo- the general population fails to develop a full complement
lars), 2) mandibular teeth emerge earlier than their maxil- of primary and permanent teeth. Agenesis of one or more
lary counterparts, and 3) symmetric emergence of tooth permanent third molars (wisdom teeth) affects about
Figure 3. An 8-year-old white boy who has bilateral agenesis Figure 4. A 9-year-old white girl who has ectodermal dys-
of the maxillary lateral incisors (3) causing a wide diastema plasia. Agenesis of the permanent maxillary lateral incisors
between the maxillary central incisors. Photograph courtesy of and all mandibular incisors is seen, and a conical permanent
Ryan Walker, DDS. maxillary central incisor (*) is present. Photograph courtesy of
David Levy, DMD MS.
oligodontia AXIN2 Permanent tooth agenesis across tooth types Colon polyps and cancer, cleft lip and palate
MSX1 Agenesis of second premolars and third molars Cleft lip and palate
Witkop syndrome MSX1 AD Agenesis of permanent mandibular incisors and Nail hypoplasia (especially toenails)
second molars, maxillary permanent canines
Van der Woude IRF6 AD Permanent tooth agenesis, second premolars, Cleft lip and palate, mandibular lip pits
maxillary lateral incisors
Down syndrome Numerous Trisomy 21 Agenesis of incisors and second premolars, peg- Dysmorphic facies, congenital heart disease,
Ellis-van Creveld EVC AD Tooth agenesis, enamel hypoplasia, multiple oral Chondrodysplasia, polydactyly, congenital heart
frenula, premature exfoliation of primary defects
teeth
Apert syndrome FGFR2 AD Permanent tooth agenesis Craniosynostosis, maxillary hypoplasia, hand
anomalies
Osteogenesis imperfecta COL1A1/2 AD Hypodontia, dentinogenesis imperfecta Blue sclera, multiple fractures
Incisor-premolar Unknown AD Agenesis of lateral incisors and second None documented
hypodontia premolars, taurodontism, ectopic maxillary
canines
Hutchinson-Guilford LMNA Sporadic Permanent tooth agenesis, ectopic eruption of Precocious senility, early death, coronary artery
progeria syndromes permanent incisors disease, beaked nose, baldness, lipodystrophy,
short stature
Hypohidrotic ectodermal EDA Xd Primary and permanent tooth agenesis, conical Defective hair, nails, skin; hypohidrosis; poor
dysplasia EDAR AD, AR incisors, anodontia hearing; respiratory infections
EDARR AD, AR
Incontinentia pigmenti IKK␥ Xd Permanent tooth agenesis, conical teeth, delayed Defective hair, nails, eyes; intellectual disability;
exfoliation of primary dentition autochthonous tattooing
NEMO Agenesis, conical teeth, delayed tooth Hypohidrosis, immunodeficiency
emergence
Axenfeld-Rieger syndrome PITX2 AD Agenesis of incisors and canines, enamel Glaucoma, redundant periumbilical skin
hypoplasia, conical teeth
Orofacial-digital syndrome CXORF5 Xd Agenesis of incisors and canines Cleft palate, hand anomalies, intellectual disability
type 1
Holoprosencephaly Numerous AD Solitary maxillary central incisor Seizures, syndromic facies, premaxillary agenesis,
cleft lip and palate, hypotelorism
Cleidocranial dysplasia RUNX2 AD Multiple supernumerary teeth, retained primary Hypoplastic calvaria, absent clavicles, midface
teeth, impacted permanent teeth hypoplasia, delayed fontanelle closure, short
stature, scoliosis, sinus/respiratory infections,
Figure 5. A 14-year-old African American boy who has Figure 7. A 15-year-old Hispanic boy who has delayed exfo-
hypodontia. The mandibular right second premolar (**) did not liation of the mandibular right primary molars (3) as well as
develop. Clinically, the mandibular right second primary molar delayed emergence of the mandibular left premolars (*). An
(3) shows delayed exfoliation. The permanent third molars age-appropriate set of permanent teeth is present in the
continue to develop in the jaws (*). Photograph courtesy of maxillary arch. Four supernumerary mandibular premolars,
Aliakbar Bahreman, DDS, MS. two on each side, are the cause for the delayed emergence of
the mandibular premolars. Photograph courtesy of Aliakbar
Bahreman, DDS, MS.
develops SPs. Moreover, SPs, unlike other supernumer-
ary teeth, recur in 8% of patients. Of note, natal and are best determined using radiographic stages of tooth
neonatal teeth should be maintained when possible be- formation.
cause they not supernumerary in more than 90% of cases. Few studies have focused on the primary dentition
Clinicians who suspect the presence of a supernumerary because radiography is limited by patient cooperation.
tooth should refer the child to a dentist for radiographic However, numerous methods have been proposed to
examination. score dental age using a variety of statistical methods
based on scores of crown and root formation for the
Delayed Dental Age permanent teeth. The Demirjian method, originally
Biologic delays in dental development generally retard studied in a French Canadian pediatric population, is
emergence of the primary and permanent dentitions. used most commonly. (2) This method scores the man-
Delayed dental age has been studied using tooth counts dibular left permanent teeth, excluding the third molars,
from clinical inspection as well as the stage of tooth according to eight developmental stages. More than
formation on panoramic radiography. As mentioned, 100 studies have used the Demirjian method and modi-
DTE using clinical tooth counts is an inexact measure of fications of it to compare dental age to the chronologic
dental age due to a host of local factors. Dental age scores age of a population. This method, although validated
through epidemiologic studies, gives varied results by
sex, race, and ethnicity of the population of study. Dental
age scoring using these methods is used commonly in
forensics and immigration proceedings for unaccompa-
nied minors as a means of age estimation when additional
information is not available.
Dental age does not consistently correlate with skele-
tal age and the timing of puberty. However, the mandib-
ular canine has been shown to be the best indicator of
pubertal onset using tooth formation stages. In general,
skeletal age delayed by systemic disease or malnutrition is
often two to six times more severe than the delay noted in
Figure 6. A conical mesiodens (3) has emerged into the
dental age.
anterior maxilla, causing the permanent maxillary right cen- Using the Demirjian method and others in conjunc-
tral incisor (*) to emerge late and out of position. Surgical tion with clinical tooth counts, patients who have a host
removal of the mesiodens is recommended. Photograph cour- of systemic diseases have been found to have delayed
tesy of Aliakbar Bahreman, DDS, MS. dental age. Most studies, however, involve a limited
number of affected individuals, lending poor statistical source of DTE in children. A tooth-to-jaw size discrep-
power. In addition, numerous genetic syndromes have ancy is often responsible for dental crowding. This dis-
DTE (also described as delayed tooth eruption) listed as harmony occurs as a result of: 1) normal-size teeth in
a clinical finding. Case reports and studies involving these small jaws, 2) larger-size teeth in normal-size jaws, or 3) a
patients do not usually assess dental age based on radio- combination of both. Children who have constricted,
graphic parameters. V-shaped alignment of the teeth are more likely have
Nonetheless, oral inspection of children who have tooth crowding than those in whom the dental arch is
Down syndrome, hypothyroidism, growth hormone de- U-shaped. Dental crowding among primary incisors pre-
ficiency, hypopituitarism, and chronic malnutrition often dicts moderate-to-severe crowding in the permanent
results in a finding of DTE. In small case-control studies, dentition.
patients who have hypodontia and those who have pala- Early tooth loss due to dental caries raises a child’s risk
tally displaced canines (PDCs) are also noted to have for dental crowding and delayed emergence of perma-
delayed dental age. DTE resulting from delayed dental nent teeth. Primary teeth serve as placeholders for their
age in children who have Down syndrome remains un- successors. Premature extraction of primary canines or
treatable. In contrast, growth hormone therapy has been molars results in migration of adjacent teeth (Fig. 8), loss
shown in preliminary studies to accelerate dental matu- of dental arch length and circumference, and shift of
ration and improve the timing of tooth emergence. (3) dental midlines toward the side of early tooth loss. Pedi-
Although preterm birth has been associated with de- atric dentists and orthodontists attach appliances to teeth
layed dental age according to chronologic age, dental age adjacent to tooth extraction sites to maintain space for
normalizes when the child’s term age is used. (4) Simi- later permanent tooth emergence.
larly, children who have enamel and dentin anomalies The presence of supernumerary teeth as well as fused
due to X-linked hypophosphatemic rickets do not teeth (Fig. 9) can exacerbate dental crowding. Later
present initially with delayed dental age. They do, how- developing teeth can remain unerupted in the jaws or be
ever, develop spontaneous dental abscesses due to micro- forced to emerge ectopically when adjacent teeth are
scopic abnormalities in the mineralized dental tissues impediments to the normal eruption path. Odontogenic
that allow ingress of microorganisms and pulpal necrosis. pathology and jaw bone disorders also worsen dental
Early primary tooth loss due to infection can slow the crowding through displacement of unerupted and
dental development of the permanent successors and emerged teeth into compact areas of the jaws.
lead to DTE. Dental crowding can be alleviated by transverse ex-
pansion of the jaws. Posterior retraction of medially
Dental Crowding positioned molars also increases the amount of space for
Insufficient space in the jaws for eruption and emergence future tooth emergence. In some cases, dental crowding
of teeth constitutes the most benign, yet common, necessitates the removal (serial extraction) of healthy
primary canines and molars as well as permanent first
premolars sequentially to allow proper alignment of the
permanent dentition in adolescence and adulthood.
Dentists, orthodontists, and oral maxillofacial surgeons
Figure 12. Maxillary permanent left canine with left first Figure 13. The maxillary primary central incisors are delayed
premolar transposition. In this case, reshaping of the teeth in exfoliation. They are forcing the maxillary permanent
with dental composite restorations can permit normal func- central incisors to erupt in the anterior palate. When the child
tion and satisfactory esthetics. Photograph courtesy of Aliak- occludes his teeth, the maxillary permanent central incisors
bar Bahreman, DDS, MS. are behind (crossbite) the mandibular incisors (3). Orthodon-
tic correction of this condition becomes necessary. Photo-
graph courtesy of Aliakbar Bahreman, DDS, MS.
Early permanent tooth loss due to dental caries or
trauma as well as traumatic displacement of developing, feel that pain is likely. Timely extraction of over-retained
unerupted teeth within the jaws accounts for most other primary teeth is indicated if maxillary permanent incisors
cases of transposition in the maxilla, including canine/ will be deflected palatally and malocclusion such as ante-
lateral incisor, canine/first molar, lateral incisor/central rior crossbite (Fig. 13) is likely to occur.
incisor, and canine/central incisor patterns. Mandib- Soft-tissue infection is another indication for tooth ex-
ular canine/lateral incisor transposition, identified in traction when food becomes impacted under the exfoliat-
0.03% of dental patients, often is seen in conjunction ing primary tooth. Lingual emergence of mandibular per-
with permanent third molar agenesis, suggestive of ge- manent incisors is common but rarely a cause for concern.
netic influences. Transposition cases, if recognized early In these cases, further emergence of the permanent teeth
enough, usually can be managed effectively with inter- ultimately causes exfoliation of their predecessors, followed
ceptive orthodontics without surgery. by anterior repositioning of the permanent incisors within
the dental arch by tongue pressure. Extraction of over-
Delayed Exfoliation of Primary Teeth retained mandibular primary incisors is needed more fre-
Delayed exfoliation of primary teeth is intimately associ- quently in cases of severe dental crowding.
ated with delayed root development and eruption of Infraoccluded primary molars (teeth that fail to reach
their permanent successors. As a result, permanent tooth the normal occlusal plane) are reported to occur in 5% of
agenesis or delayed dental maturity typically results in the general population. These teeth often appear to be
delayed exfoliation of primary teeth according to chro- ankylosed on clinical examination because they are im-
nologic age. In these cases, the timing of primary tooth mobile to palpation and tend to be submerged in the
root resorption is appropriate from a biologic standpoint. gingival tissues compared with continually erupting ad-
In contrast, primary tooth exfoliation is considered bio- jacent teeth (Fig. 14). Nonetheless, infraoccluded pri-
logically delayed when the primary tooth remains in place mary molars usually exfoliate within 1 year of the normal
despite permanent tooth root length greater than 75% of range as long as the permanent tooth successor is present
its expected final length. with adequate root formation.
Primary teeth that appear biologically ready for exfo- Infraoccluded primary molars can become surgical
liation are common in primary care. These teeth are problems if the crowns of the adjacent teeth are allowed
usually retained in soft tissue or interlocked between to migrate over top of them. In addition, alveolar bone
adjacent teeth, limiting their ability to be removed at levels surrounding the adjacent teeth can approximate
home. Children also tend to delay tooth removal if they the crown of the infraoccluded molar, leading to im-
Figure 14. The mandibular left primary first molar is infra- Figure 16. A 6-year-old boy born in Uganda presents with
occluded. The adjacent teeth continue to erupt while it malformed mandibular primary canines (*) and missing max-
remains stationary, creating the clinical appearance of a tooth illary primary canines (ⴙ). His history corroborates that canine
submerging into the gingiva. Photograph courtesy of Aliakbar extirpation was completed before emigration from Uganda.
Bahreman, DDS, MS. Photograph courtesy of Terry Farquhar, RN, DDS.
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Suggested Reading
American Academy of Pediatric Dentistry. Guideline on manage-
Summary ment of the developing dentition and occlusion in pediatric
dentistry. Reference Manual. 2009;32(6). Accessed August
• The presence of DTE, a commonly overlooked finding 2009 at: http://www.aapd.org/media/Policies_Guidelines/
in primary care, signals abnormalities in tooth G_DevelopDentition.pdf
formation, eruption, or emergence. Bailleul-Forestier I, Berdal A, Vinckier F, et al. The genetic basis
• DTE often occurs through benign acquired processes of inherited anomalies of the teeth. Part 2: syndromes with
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• Children awaiting emergence of teeth for more than
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