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  • IP-Worksheet-2-Endocrine System Mechanism of Hormone Action Second Messenger System

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    Filmae Estomagulang
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    The document discusses the mechanism of hormone action through the second messenger system. It explains that water-soluble hormones like peptides and catecholamines bind to cell surface receptors which activate G proteins, and these G proteins in their active form catalyze the conversion of ATP to the second messenger cAMP via adenylate cyclase. This second messenger cAMP then activates protein kinase which phosphorylates many proteins, amplifying the hormone's effect on the cell until the second messenger is inactivated by phosphodiesterase. Insulin is also noted to bind tyrosine kinase receptors.

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    IP-Worksheet-2-Endocrine System Mechanism of Hormone Action Second Messenger System

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    The document discusses the mechanism of hormone action through the second messenger system. It explains that water-soluble hormones like peptides and catecholamines bind to cell surface receptors which activate G proteins, and these G proteins in their active form catalyze the conversion of ATP to the second messenger cAMP via adenylate cyclase. This second messenger cAMP then activates protein kinase which phosphorylates many proteins, amplifying the hormone's effect on the cell until the second messenger is inactivated by phosphodiesterase. Insulin is also noted to bind tyrosine kinase receptors.

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    © All Rights Reserved
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    275 views1 page

    IP-Worksheet-2-Endocrine System Mechanism of Hormone Action Second Messenger System

    Uploaded by

    Filmae Estomagulang
    The document discusses the mechanism of hormone action through the second messenger system. It explains that water-soluble hormones like peptides and catecholamines bind to cell surface receptors which activate G proteins, and these G proteins in their active form catalyze the conversion of ATP to the second messenger cAMP via adenylate cyclase. This second messenger cAMP then activates protein kinase which phosphorylates many proteins, amplifying the hormone's effect on the cell until the second messenger is inactivated by phosphodiesterase. Insulin is also noted to bind tyrosine kinase receptors.

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    of 1

    Filmae C.

    Estomagulang November 5, 2020


    BIO 50 (Lec)A; 10:00-11:30; WT
    Endocrine System: Mechanism of Hormone Action: Second Messenger System

    1. Water-soluble proteins such as _Peptides_ and _Catecholamine_ bind to receptors located where

    on the cell? _Cell membrane

    2. G proteins:

    a. What is bound to the G protein in the inactive state? GDG

    In the active state? GTP

    b. What catalyzes the conversion of ATP to cAMP? _Adenylate_ _Cyclase_

    c. What is known as the first messenger? _Hormone_ Second messenger? _cAMP_

    d. A molecule of cAMP activates Protein kinase, which can phosphorylate many proteins.

    e. What is the enzyme that inactivates cAMP? Phosphodiesterase

    f. A single molecule of a hormone can have a large effect on the cell due to this process,

    amplification called .

    3. Insulin travels in the blood and binds to what type of receptors on the cell membrane? Tyrosine

    kinase

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