Adverse Reaction Contraindication Nursing

Name of Drug Classification Indication Action

Consideration

Dopamine o Symptomatic o Headache/migraine 1 Hypersensitivity to Avoid use in

Generic Antagonist management of upper Chemical Effect: o Xerostomia (Dry mouth). domperidone or any patients with
Name: Domperidone GI motility disorders component of the diagnosed or
 Altered cardiac conduction:
suspected
associated with QT c prolongation, life- formulation.
congenital long
chronic and subacute threatening tachyarrhythmias 2 patients with GI QT syndrome.
Brand Name: Dompy, gastritis and diabetic (eg, torsade de pointes), and hemorrhage,
Motilium cardiac arrest have been mechanical
gastroparesis. Domperidone
reported after use; these adverse
o prevention of GI obstruction, or may enhance the
effects may be precipitated in
symptoms associated hypokalemic patients or in perforation. QTc-prolonging
Doase, Route & 3 concomitant use
with use of Therapeutic Effect: patients receiving other QT c - effect of
Frequency : prolonging agents with ketoconazole.
dopamine-agonist o Domperidone Ketoconazole
Available as Tablets & o
anti-Parkinson has peripheral (Systemic).
Syrup agents. dopamine (D2) Ketoconazole
o Usual dose :
receptor (Systemic) may
ORALLY (P.O)
10 mg 3-4 blocking increase the
times/day, 15- properties and serum
30 minutes does not readily concentration of
before meals cross the blood- Domperidone.
and at bedtime brain barrier so , Risk X: Avoid
if needed. less likely to combination
o 20 mg 3-4
cause
times/day
extrapyramidal Monitor patient
(higher doses
side effects. It
may be
increases
necessary
esophageal
during titration
peristalsis and
of anti-
increases lower
Parkinson
esophageal
therapy).
sphincter
pressure,
 increases gastric
motility and
peristalsis, and
enhances
gastroduodenal
coordination,
therefore,
facilitating
gastric
emptying and
decreasing
small bowel
transit time.
o The antiemetic
properties of
dopamine are
related to its
dopamine
receptor
blocking
activity at both
the
chemoreceptor
trigger zone and
at the gastric
level.