Hubungan Reaksi Hipersensitifitas Tipe 1 Dengan Fenomena Anafilaksis Dan Atopi - Cover

You might also like

Download as docx, pdf, or txt
Download as docx, pdf, or txt
You are on page 1of 6

IMUNOLOGI

MAKALAH :

HUBUNGAN REAKSI HIPERSENSITIFITAS TIPE 1 DENGAN


FENOMENA ANAFILAKSIS DAN ATOPI

DISUSUN OLEH :

JUEN CARLA WARELLA

NIM : 011814153012

PROGRAM MAGISTER

FAKULTAS KEDOKTERAN

UNIVERSITAS AIRLANGGA

SURABAYA

2018
DAFTAR PUSTAKA

Abboud, G., Staumont-Salle, D., Kanda, A., Roumier, T., Deruytter, N., Lavogiez,
C., ... Dombrowicz, D. (2009). Fc(epsilon)RI and FcgammaRIII/CD16
differentially regulate atopic dermatitis in mice. Journal of Immunology
182(10), 6517–6526.

Banerjee, S., Weber, M., Blatt, K., Swoboda, I., Focke-Tejkl, M., Valent, P.,
Valenta, R., Vrtala, S., (2014). Conversion of Der p 23, a new major
house dust mite allergen, into a hypoallergenic vaccine. J. Immunol. 192,
4867–4875.

Barata, W. (2010). Imunologi Dasar. Jakarta: Fakultas Kedokteran UI.

Bartnikas,L.M; Gurish,M.F; Burton,O.T; Leisten,S; Janssen,E; Oettgen,H.C,


Beaupre,J; Lewis,C.N; Austen,K.F; Schulte,S; et al.(2013): Epicutaneous
sensitization results in IgE-dependent intestinal mast cell expansion and
food-induced anaphylaxis. J Allergy Clin Immunol 131:451-460 e451–
e456.

Bieber, T. (2008). Atopic dermatitis. The New England Journal of Medicine


358(14), 1483–1494.

Blank, U., Ra, C., Miller, L., White, K., Metzger, H., & Kinet, J. P. (1989).
Complete structure and expression in transfected cells of high affinity IgE
receptor. Nature 337 (6203), 187–189

Burton, O. T., & Oettgen, H. C. (2011). Beyond immediate hypersensitivity:


Evolving roles for IgE antibodies in immune homeostasis and allergic
diseases. Immunological Reviews 242(1), 128–143.

Burton,O.T; Noval,Rivas.M; Zhou,J.S; Logsdon,S.L; Darling,A.R;


Koleoglou,K.J; Roers,A; Houshyar,H; Crackower,M.A; Chatila,T.A et al.
(2014). Immunoglobulin E signal inhibition during allergen ingestion
leads to reversal of established food allergy and induction of regulatory T
cells. Immunity, 41:141-151.

Chu,H.M; Wright,J; Chan,Y.H; Lin,C.J; Chang,T.W; Lim,C. (2014). Two


potential therapeutic antibodies bind to a peptide segment of membrane-
bound IgE in different conformations. Nat. Commun. 5:3139.
http://dx.doi.org/10.1038/ncomms4139.

Conti, A., Burastero, G.J., Suli, C., Banerjee, S., Vrtala, S., Alessio, M.,
Burastero, S.E., (2017). Identification by serological proteome analysis of
paramyosin as prominent allergen in dust mite allergy. J. Proteom. 166,
19–26.

Coombs R R A, Gell P G H. (1968). Classification of allergic reactions


responsible for clinical hypersensitivity. Clinical Aspects of Immunology,
2 nd ed, edits. GELL P G H, and COOMBS. R R A Blackwell Scientific
Publications. p.575.

D.K. Shah, J.C.,(2014). An overview of the intrathymic intricacies of T cell


development, J. Immunol. 192 4017- 4023 .

Dharmage, S. C., Lowe, A. J., Matheson, M. C., Burgess, J. A., Allen, K. J., &
Abramson, M. J. (2014). Atopic dermatitis and the atopic march revisited.
Allergy 69(1), 17–27

Dombrowicz, D., Flamand, V., Brigman, K. K., Koller, B. H., & Kinet, J. P.
(1993). Abolition of anaphylaxis by targeted disruption of the high affinity
immunoglobulin E receptor alpha chain gene. Cell 75(5), 969–976.

Dombrowicz, D., Flamand, V., Miyajima, I., Ravetch, J. V., Galli, S. J., & Kinet,
J. P. (1997). Absence of Fc epsilonRI alpha chain results in upregulation
of Fc gammaRIII-dependent mast cell degranulation and anaphylaxis.
Evidence of competition between Fc epsilonRI and Fc gammaRIII for
limiting amounts of FcR beta and gamma chains. The Journal of Clinical
Investigation 99(5), 915–925.

Dudeck A, Dudeck J, Scholten J, Petzold A, Surianarayanan S, Ko¨hler A, et al.


Mast cells are key promoters of contact allergy that mediate the adjuvant
effects of haptens. Immunity 2011;34:973e84

Dullaers, M., De Bruyne, R., Ramadani, F., Gould, H. J., Gevaert, P., &
Lambrecht, B. N. (2012). The who, where, and when of IgE in allergic
airway disease. The Journal of Allergy and Clinical Immunology 129(3),
635–645.

E. Maier, A. Duschl, J. Horejs-Hoeck.,(2012). STAT6-dependent and


-independent mechanisms in Th2 polarization, Eur. J. Immunol. 42: 2827
and 2833 .

Feyerabend, T. B., Weiser, A., Tietz, A., Stassen, M., Harris, N., Kopf, M., ...
Rodewald, H. R. (2011). Cre-mediated cell ablation contests mast cell
contribution in models of antibody- and T cell-mediated autoimmunity.
Immunity 35(5), 832–844.
Hamilton, R. G., MacGlashan, D. W., Jr., & Saini, S. S. (2010). IgE antibody-
specific activity in human allergic disease. Immunologic Research 47(1-
3), 273–284.

Holgate, S.T. (2014). New strategies with anti IgE in allergic diseases.World
Allergy Organ. J. 7:17. http://dx.doi.org/10.1186/1939-4551-7-17.

Ishizaka, K; Ishizaka, T and Hornbrook, M. (1967) ldentification of γ-E


antibodies as a carrier of reaginic activities. J. lmmunol 99. p.1187

J Alergi Clin 156 Immunology 2016; 137: 1449-1456. doi: 10,1016 /


j.jaci.2015.12.1324

Kim CH, Hashimoto-Hill S, Kim M. (2016). Migration and tissue tropism of


innate lymphoid cells. Trends Immunol ;37:68e79.

Korosec, P., Turner, P. J., Silar, M., Kopac, P., Kosnik, M., Gibbs, B. F., Rijavec,
M. (2017). Basophils, high-affinity IgE receptors, and CCL2 in human
anaphylaxis. The Journal of Allergy and Clinical Immunology 140(3),
750–758 e715.

Lakin, J.D : Classification of hypersensitivity reactions. ln: Allergic Diseases,


edit. Pattcrson R, J B Lippincott Company, 1972, p.L

Laske, N., & Niggemann, B. (2004). Does the severity of atopic dermatitis
correlate with serum IgE levels?.Pediatric Allergy and Immunology 15(1),
86–88.

Leung, D. Y., & Bieber, T. (2003). Atopic dermatitis. Lancet 361(9352), 151–160

Lilla, J. N., Chen, C. C., Mukai, K., BenBarak, M. J., Franco, C. B., Kalesnikoff,
J., Galli, S. J. (2011). Reduced mast cell and basophil numbers and
function in Cpa3-Cre; Mcl1fl/fl mice. Blood 118(26), 6930–6938.

N. Schmitt, H. Ueno., (2015). Regulation of human helper T cell subset


differentiation by cytokines, Curr. Opin. Immunol. 34; 130 e 136 .

Normansell,R; Walker,S; Milan,S.J; Walters,E.H; Nair,P. (2014). Omalizumab


for asthma in adults and children. Cochrane Database Syst. Rev.,
CD003559, http://dx.doi.org/10.1002/14651858.CD003559.pub4. Peng,
C.,Davis, F.M.,Sun, L.K., Liou, R.

Oka, T., Kalesnikoff, J., Starkl, P., Tsai, M., & Galli, S. J. (2012). Evidence
questioning cromolyn's effectiveness and selectivity as a ‘mast cell
stabilizer’ in mice. Laboratory Investigation 92(10), 1472–1482.
Oyoshi, M. K., He, R., Kumar, L., Yoon, J., & Geha, R. S. (2009). Cellular and
molecular mechanisms in atopic dermatitis. Advances in Immunology
102, 135–226.

Roediger, B., Weninger, W.,(2015). Group 2 innate lymphoid cells in the


regulation of immune responses. Adv. Immunol. 125, 111–154.

Roitt I ,M. (1971) Essensial Immunology. Blackwell Scientific Publications. p.105

S.L. Swain, K.K. McKinstry, T.M. Strutt. (2012) Expanding roles for CD4(+) T
cells in immunity to viruses, Nat. Rev. Immunol. 12 (2) 136–148.

Sawaguchi, M., Tanaka, S., Nakatani, Y., Harada, Y., Mukai, K., Matsunaga, Y.,
Kubo, M. (2012). Role of mast cells and basophils in IgE responses and in
allergic airway hyperresponsiveness. Journal of Immunology 188(4),
1809–1818

Schwartz, L. B. (2006). Diagnostic value of tryptase in anaphylaxis and


mastocytosis. Immunology and Allergy Clinics of North America 26(3),
451–463.

Schuch, A., & Brockow, K. (2017). Mastocytosis and anaphylaxis. Immunology


and Allergy Clinics of North America 37(1), 153–164.

Sibilano,R; Frossi,B; Pucillo,C.E. (2014) Mast cell activation: a complex


interplay of positive and negative signaling pathways. Eur J Immunol,
44:2558-2566.

Sudiono, J. (2014). Sistem kekebalan tubuh. Jakarta: Penerbit buku kedokteran


ECG. p.2-5

Tan, C., Gery, I., (2012). The unique features of Th9 cells and their products.
Curr. Rev. Immunol. 32, 1–10.

Tomassen P, Vandeplas G, Van Zele T, Cardell LO, Arebro J, Olze H, et al.


Inflamasi 155 endotypes rinosinusitis kronis didasarkan pada analisis
cluster biomarker.

Wynn, T.A.,(2015). Type 2 cytokines: mechanisms and therapeutic strategies.


Nat. Rev. Immunol. (15), 271–282.

Yin, X.Y. Pei, H. Shen, Y.N. Gao, X.Y. Sun, W. Wang, Q. Ge, Y. Zhang., (2017)
Thymic homing of activated CD4( þ) T cells induces degeneration of the
thymic epithelium through excessive RANK signaling, Sci. Rep. 7; 2421 .
DAFTAR ISI

Halaman
HALAMAN JUDUL ................................................................................... i
DAFTAR ISI ................................................................................................ ii

BAB I. PENDAHULUAN
A. Latar belakang................................................................................. 1
B. Rumusan masalah............................................................................ 2
C. Tujuan penelitian............................................................................. 2
D. Manfaat penelitian........................................................................... 2

BAB II. TINJAUAN PUSTAKA


A. Hipersensitivitas.............................................................................. 3
B. Klasifikasi Hipersensitivitas............................................................ 4
C. Penyebab Hipersensitivitas.............................................................. 7
D. Anafilaksis....................................................................................... 8
E. Atopi................................................................................................ 8

BAB III. PEMBEHASAN


A. Reaksi Hipersensitivitas Type-1...................................................... 9
B. Kerja antibodi IgE sebagai respons terhadap antigen...................... 10
C. Mekanisme Th2 dan sel T-Helper pensekresi IL-4......................... 12
D. Reseptor FC spesifik pada sel mast................................................. 13
E. Mekanisme reaksi anafilaksis.......................................................... 15
F. Mekanisme reaksi atopik................................................................. 16

BAB V. KESIMPULAN DAN SARAN


A. Kesimpulan ..................................................................................... 18

DAFTAR PUSTAKA .................................................................................. iii

You might also like