Fermentor

Fermentor
Bioreactor I Photo Bioreactor
 Autoclavable Fermentor

Biotron GX
TYPE 1

50RPM~ Vessel : 1.5L ~ 14L

1.5L~14L 1,200RPM Temp : Ambient +3 C ~ 80 C
Speed : 50RPM ~ 1200RPM

Main Control Screen PC Monitoring Software

Features
Intelligent 7" wide touch screen fermentation controller Remote control by PC software Data Logging system
Fermentor

Self data logging system within fermentation controller
High density fermentation : DO-stat, pH-stat, Exponential feeding, etc
Parallel design of vessel and controller : 4 peristaltic pump and pH, DO, foam,
74 temperature sensor port
Easy control of external device by fermentation controller : O2/CO2 analyzer,
glucose analyzer, spectrophotometer, fluorescence, spectrophotometer, NIR,
gas mixer, level, weight, etc
Accurate PID temperature controller system
Hi-res color touch screen is built-in, hence it is easy to learn how to use
controller
Instead of wires, one-chip Micom is applied for minimizing noise and making
set-up process simpler
unified ATMega128 CPU and sensor board into One-board to handle problems
immediately in case of emergency
Easy to calibrate temperature, pH, DO, foam sensors in use of graphic
calibration mode
Reliable operation due to the automatic controllers.
Intelligent self diagnostic system to maintain fermentation process from start to
the end : Diagnostic, Setup, Dead Band, Offset, Warning, Feeding condition
Easy to setup feeding program
Programmable multi stage operation : Setting pH, DO, Foam, temperature for
each stage to the end of the fermentation process
Stainless steel ring-shaped sparger consistently supplies gas for manufacturing
process
Easily disassembling sprager for cleaning inside
Controls agitation speed precisely despite of viscosity changing of culture
media by servo motor which controls agitation speed in real time
Records monitored agitation speed to save extra emission

Specification
Drive Top drive motor(mechanical drive)
Agitation Range 50~1,200 rpm
Impeller 2-Rushton turbine impeller, 1-foam breaker
Temperature Range & Sensor Ambient + 3 C~80 C, RTD(Pt-100), PID control
Sparger & Gas mode Ring sparger(Round Type), 2gas and 4 gas Mixer(Option)
Aeration
Inlet Filter 0.2 air filter cartridge
Exhaust system Filter & Condenser 0.2 air filter, SUS 316 Condenser
Range 2.0~12.0 pH of set point, PID control
pH
Electrode Gel Type
Range 0~200%, PID control
DO
Electrode Polarographic Type
Anti-foam Electrode Conductivity Type
Peristaltic Pumps 4 constant speed pumps each assignable to a wide variety of function fo
Control
control of acid, base, foam and feed
Recording pH, DO, Temp, Foam, Agitation, Peristaltic pump, etc.
Dimension 550(W) x 480(L) x 550(H) (Single Vessel 5L), Controller Size : 220(W) x 478(L) x 445(H))
Voltage 220V, 1 , 50/60Hz, 0.6kW
Weight 35kg (Controller : 20kg, Vessel 5L 1set : 15kg)
Please note that technical specifications subject to change.
Autoclavable Fermentor

Biotron GX
TYPE 2

50RPM~ Vessel : 1.5L ~ 14L

1.5L~14L 1,200RPM Temp : Ambient +3 C ~ 80 C
Speed : 50RPM ~ 1200RPM

Fermentor
Main Control Screen PC Monitoring Software

HANIL SCIENCE INDUSTRIAL

Features
Intelligent 7" wide touch screen fermentation controller
Self data logging system within fermentation controller
High density fermentation : DO-stat, pH-stat, Exponential feeding, etc
Parallel design of vessel and controller : 4 peristaltic pump and pH, DO, foam,
temperature sensor port
Easy control of external device by fermentation controller : O2/CO2 analyzer,
glucose analyzer, spectrophotometer, fluorescence, spectrophotometer, NIR,
gas mixer, level, weight, etc
Accurate PID temperature controller system
Remote control by PC software Data Logging system
Easy to calibrate temperature, pH, DO, foam sensors in use of graphic
calibration mode
Reliable operation due to the automatic controllers.
Intelligent self diagnostic system to maintain fermentation process from start to 75
the end : Diagnostic, Setup, Dead Band, Offset, Warning, Feeding condition
Easy to setup feeding program
Programmable multi stage operation : Setting pH, DO, Foam, temperature for
each stage to the end of the fermentation process

Specification
Drive Top drive motor(mechanical drive)
Agitation Range 50~1,200 rpm
Impeller 2-Rushton turbine impeller, 1-foam breaker
Temperature Range & Sensor Ambient + 3 C~80 C, RTD(Pt-100), PID control
Sparger & Gas mode Ring sparger(Round Type), 2gas and 4 gas Mixer(Option)
Aeration
Inlet Filter 0.2 air filter cartridge
Exhaust system Filter & Condenser 0.2 air filter, SUS 316 Condenser
Range 2.0~12.0 pH of set point, PID control
pH
Electrode Gel Type
Range 0~200%, PID control
DO
Electrode Polarographic Type
Anti-foam Electrode Conductivity Type
Peristaltic Pumps 4 constant speed pumps each assignable to a wide variety of function fo
Control
control of acid, base, foam and feed
Recording pH, DO, Temp, Foam, Agitation, Peristaltic pump, etc.
Dimension 550(W) x 480(L) x 550(H) (Single Vessel 5L), Controller Size : 220(W) x 478(L) x 445(H))
Voltage 220V, 1 , 50/60Hz, 0.6kW
Weight 35kg (Controller : 20kg, Vessel 5L 1set : 15kg)
Please note that technical specifications subject to change.
 Autoclavable Fermentor

Biotron GX
50RPM~ Vessel : 1.5L ~ 14L
1.5L~14L 1,200RPM Temp : Ambient +3 C ~ 80 C
Speed : 50RPM ~ 1200RPM
ORP : Monitoring
Variable Speed Pump

Main Control Screen PC Monitoring Software

Features
Intelligent 7" wide touch screen fermentation controller
Self data logging system within fermentation controller
High density fermentation : DO-stat, pH-stat, Exponential feeding, etc
Fermentor
Stainless steel ring-shaped sparger consistently supplies gas for manufacturing
process
Easily disassembling sprager for cleaning inside

Parallel design of vessel and controller : 4 peristaltic pump and pH, DO, foam,
temperature sensor port
Easy control of external device by fermentation controller : O2 / CO2 analyzer,
glucose analyzer, spectrophotometer, fluorescence, spectrophotometer, NIR,
76
gas mixer, level, weight, etc
Accurate PID temperature controller system
Remote control by PC software Data Logging system
Easy to calibrate temperature, pH, DO, foam sensors in use of graphic
calibration mode
Reliable operation due to the automatic controllers
Intelligent self diagnostic system to maintain fermentation process from start to
the end : Diagnostic, Setup, Dead Band, Offset, Warning, Feeding condition
Easy to setup feeding program
Programmable multi stage operation : Setting pH, DO, Foam, temperature for
each stage to the end of the fermentation process
Variable speed motor control system: available for installing variable speed
peristaltic pump
ORP sensing: diagnostics (inverter selection)
4 gas signals : available to send control signals to directly 4 gas controller from
main control system
Multi-fermentor suitable for various experiments simultaneously
Multi-vessel : 2-6 channels
Individual experiment available by attached controller on each 6 fermentors
Available to perform experiment with different parameters, under the same
condition
Controller that accessible to multiple monitoring by PC and control systems.
Able to lock controller by setting password in order to prevent changing
culture-condition randomly
Saved measured data and control parameters in excel sheets and transmits to
computer

Specification
Drive Top drive motor(mechanical drive)
Agitation Range 50~1,200 rpm
Impeller 2-Rushton turbine impeller, 1-foam breaker
Temperature Range & Sensor Ambient + 3 C~80 C, RTD(Pt-100), PID control
Aeration Sparger & Gas mode Ring sparger(Round Type), 2gas and 4 gas Mixer(Option)
Exhaust system Condenser 0.2 air filter, SUS 316 Condenser
Control Range 2.0~12.0 pH of set point, PID control
pH
Electrode Gel Type
Control Range 0~200%, PID control
DO
Electrode Polarographic Type
Control Range mili volt
ORP
Electrode Gel Type
Anti-foam Electrode Conductivity Type
Peristaltic Pumps Control fixed speed 14.4 rpm
Peristaltic Pumps Control variable speed
Recording pH, DO, Temp, Foam, Agitation, Peristaltic pump, etc.
Dimension 550(W) x 480(L) x 550(H) (Single Vessel 5L), Controller Size : 220(W) x 478(L) x 445(H))
Voltage 220V, 1 , 50/60Hz, 0.6kW
Weight 35kg (Controller : 20kg, Vessel 5L 1set : 15kg)
Please note that technical specifications subject to change.
Autoclavable Fermentor

Biotron
Smart GX

Fermentor
HANIL SCIENCE INDUSTRIAL
Main Control Screen Calibration Menu

Features
Control the Biotron Smart GX from your iPad
You can perform any action from your iPad. Uses WiFi for a local connection to
any cooperating
Self data logging system within fermentation controller
High density fermentation : DO-stat, pH-stat, Exponential feeding, etc
Parallel design of vessel and controller : 4 peristaltic pump and pH, DO, foam,
temperature sensor port
Easy control of external device by fermentation controller : O2 / CO2‚ analyzer,
glucose analyzer, spectrophotometer, fluorescence, spectrophotometer, NIR,
gas mixer, level, weight, etc
Accurate PID temperature controller system
Remote control by PC software Data Logging system
Easy to calibrate temperature, pH, DO, foam sensors in use of graphic
calibration mode
Reliable operation due to the automatic controllers
Intelligent self diagnostic system to maintain fermentation process from start to 77
the end : Diagnostic, Setup, Dead Band, Offset, Warning, Feeding condition
Easy to setup feeding program
Programmable multi stage operation : Setting pH, DO, Foam, temperature for
each stage to the end of the fermentation process
Variable speed motor control system : available for installing variable speed
peristaltic pump
ORP sensing : diagnostics (inverter selection)
4 gas signals : available to send control signals to directly 4 gas controller from
main control system

Specification
RF Operating Frequency 2.4 GHz WiFi
Drive Top drive motor(mechanical drive)
Agitation Range 50~1,200 rpm
Impeller 2-Rushton turbine impeller, 1-foam breaker
Temperature Range & Sensor Ambient + 3 C~80 C, RTD(Pt-100), PID control
Aeration Sparger & Gas mode Ring sparger(Round Type)
Exhaust system Filter & Condenser 0.2 air filter, SUS 316 Condenser
pH Range 2.0~12.0 pH of set point, PID control
DO Range 0~200%, PID control
Anti-foam Electrode Conductivity Type
Peristaltic Pumps Control 4 constant speed pumps for control of acid, base, foam and feed
Recording pH, DO, Temp, Foam, Agitation, Peristaltic pump, etc.
Dimension 550(W) x 480(L) x 550(H) (Single Vessel 5L), Controller Size : 220(W) x 478(L) x 445(H))
Voltage 220V, 1 , 50/60Hz, 0.6kW
Weight 35kg (Controller : 20kg, Vessel 5L 1set : 15kg)
Please note that technical specifications subject to change.
 Biotron Smart GX Network
IPAD Smart Phone
Fermentor
78
Rack for i-pad connecting
(charging in use available)
RF Specification
Modulation Technique
Data Rate
Receive Sensitivity
Transmit power (Average)
WizFi220 : 17dBm ± 1.5dB @ 11Mbps
Frequency Range
Web
Internet
PC(Server)
Data logging serial & USB port
(front side)
DSSS for 1, 2Mbps
CCK for 5.5, 11Mbps
IEEE 802.11b : 1, 2, 5.5 and 11Mbps
-84dBm ±1dB @ 11Mbps
-88dBm ±1dB @ 5.5Mbps
-90dBm ±1dB @ 2Mbps
-94dBm ±1dB @ 1Mbps
WizFi210 : 8dBm ± 1dB @ 11Mbps
USA: 2.400 ~ 2.483GHz
Europe: 2.400 ~ 2.483GHz
Japan: 2.400 ~ 2.497GHz
China: 2.400 ~ 2.483GHz
App
Biotron Smart GX
WiFi
Biotron Smart GX
Resistive Overlay
Touch Screen
USA/Canada: 11 (1~11)
Major Europe Countries: 13 (1~13)
France: 4 (10~13)
Operating Channels Japan: 14 for IEEE 802.11b (1~13 or 14th),
13 for IEEE 802.11g (1~13)
Korea/China: 13 (1~13)
U.FL External Antenna Support
External Antenna Pad Support
Antenna
1dBi Chip Antenna (Optional)
Please note that technical specifications subject to change.
Autoclavable Fermentor

Biotron
Smart GM

Fermentor
Main Control Screen Calibration Menu

HANIL SCIENCE INDUSTRIAL

Features
Control the Biotron Smart GX from your iPad
You can perform any action from your iPad. Uses WiFi for a local connection to
any cooperating
Self data logging system within fermentation controller
High density fermentation : DO-stat, pH-stat, Exponential feeding, etc
Parallel design of vessel and controller : 4 peristaltic pump and pH, DO, foam,
temperature sensor port
Easy control of external device by fermentation controller : O2 / CO2‚ analyzer,
glucose analyzer, spectrophotometer, fluorescence, spectrophotometer, NIR,
gas mixer, level, weight, etc
Accurate PID temperature controller system
Remote control by PC software Data Logging system
Easy to calibrate temperature, pH, DO, foam sensors in use of graphic
calibration mode
Reliable operation due to the automatic controllers.
Intelligent self diagnostic system to maintain fermentation process from start to
the end : Diagnostic, Setup, Dead Band, Offset, Warning, Feeding condition
Easy to setup feeding program
Programmable multi stage operation : Setting pH, DO, Foam, temperature for
each stage to the end of the fermentation process
Variable speed motor control system: available for installing variable speed
peristaltic pump
ORP sensing : diagnostics (inverter selection)
4 gas signals : available to send control signals to directly 4 gas controller from 79
main control system
Use 1 i-pad with controllers up to 8 ea to manage data
One PC or one i-pad can monitor and manage all of data by network even each
controller is scattered.
Rack connecting i-pad to main body
Able to charge during using
Sensor port and communication port on front side for user's convinience
Pressure sensor to store data and control pressure, differentiated from other
existing fermentors
Able to monitor and manage data anywhere
Compatible with android based products such as smart phone, galaxy tab and etc
Save and manage data on PC by connecting controller to PC

Specification
Drive Top drive motor(mechanical drive)
Agitation Range 50~1,200 rpm
Impeller 2-Rushton turbine impeller, 1-foam breaker
Temperature Range & Sensor Ambient + 3 C~80 C, RTD(Pt-100), PID control
Sparger Ring sparger
Aeration
Inlet Filter 0.2 air filter cartridge
Exhaust system Filter & Condenser 0.2 air filter cartridge, SUS 316
pH Range 2.0~12.0 pH of set point, PID control
DO Range 0~200%, PID control
Heating Plate Electric Heater & Control 400 watt, PID control
Recording pH, DO, Temp, Agitation, Peristaltic pump, etc.
Dimension 1750(W) x 1200(Depth) x 700(H)
Voltage 220V, 1 , 50/60Hz, 3.6kW
Weight 192kg (Controller : 102kg, Vessel 5L 1set : 15kg)
Please note that technical specifications subject to change.
 Autoclavable Fermentor

Biotron GM
50RPM~ Vessel : 1.5L ~ 14L
1.5L~14L 1,200RPM
Temp : Ambient +3 C ~ 80 C
Speed : 50RPM ~ 1200RPM
2ch ~ 6ch

Main Control Screen PC Monitoring Software

Fermentor

Features
80 Intelligent 7" wide touch screen fermentation controller
Self data logging system within fermentation controller
High density fermentation : DO-stat, pH-stat, Exponential feeding, etc
Parallel design of vessel and controller : 4 peristaltic pump and pH, DO, foam,
temperature sensor port
Easy control of external device by fermentation
controller : O2/CO2 analyzer, glucose analyzer, spectrophotometer, fluorescence
spectrophotometer, NIR, gas mixer, level, weight, etc
Accurate PID temperature controller system
Remote control by PC software Data Logging system
Easy to calibrate temperature, pH, DO, foam sensors using graphic calibration mode
Reliable operation due to the automatic controllers
Intelligent self diagnostic system to maintain fermentation
process from start to the end : Diagnostic, Setup, Dead Band, Offset, Warning,
Feeding condition
Easy to setup feeding program
Programmable multi stage operation : Setting pH, DO, Foam, temperature for
each stage to the end of the fermentation process
Multi-fermentor is suitable for the various experiments simultaneously
Multi-vessel : 2-6 channels

Specification
Drive Top drive motor(mechanical drive)
Agitation Range 50~1,200 rpm
Impeller 2-Rushton turbine impeller, 1-foam breaker
Temperature Range & Sensor Ambient + 3 C~80 C, RTD(Pt-100), PID control
Sparger Ring sparger
Aeration
Inlet Filter 0.2 air filter cartridge
Exhaust system Filter & Condenser 0.2 air filter cartridge, SUS 316
pH Range 2.0~12.0 pH of set point, PID control
DO Range 0~200%, PID control
Heating Plate Electric Heater & Control 400 watt, PID control
Recording pH, DO, Temp, Agitation, Peristaltic pump, etc.
Dimension 1750(W) x 1200(Depth) x 700(H)
Voltage 220V, 1 , 50/60Hz, 3.6kW
Weight 192kg (Controller : 102kg, Vessel 5L 1set : 15kg)
Please note that technical specifications subject to change.
Autoclavable Fermentor

Biotron GM
50RPM~ Vessel : 1.5L ~ 14L
1.5L~14L 1,200RPM
Temp : Ambient +3 C ~ 80 C
Speed : 50RPM ~ 1200RPM
2ch ~ 6ch

Fermentor
ORP : Monitoring
Variable Speed Pump

HANIL SCIENCE INDUSTRIAL

Main Control Screen PC Monitoring Software

Features
Self data logging system within fermentation controller
High density fermentation : DO-stat, pH-stat, Exponential feeding, etc
Parallel design of vessel and controller : 4 peristaltic pump and pH, DO, foam,
temperature sensor port
Easy control of external device by fermentation controller : O2/CO2 analyzer,
glucose analyzer, spectrophotometer, fluorescence, spectrophotometer, NIR, gas
mixer, level, weight, etc
Accurate PID temperature controller system
Remote control by PC software Data Logging system
Easy to calibrate temperature, pH, DO, foam sensors in use of graphic calibration
mode
Reliable operation due to the automatic controllers.
Intelligent self diagnostic system to maintain fermentation process from start to
the end : Diagnostic, Setup, Dead Band, Offset, Warning, Feeding condition
Easy to setup feeding program
Programmable multi stage operation : Setting pH, DO, Foam, temperature for
each stage to the end of the fermentation process
Intelligent 7" wide touch screen fermentation controller
Multi-fermentor suitable for various experiments simultaneously
Multi-vessel : 2-6 channels
Stainless steel ring-shaped sparger consistently supplies gas for manufacturing
process
81
Easily disassembling sprager for cleaning inside
Variable speed motor control system: available for installing variable speed
peristaltic pump
ORP sensing : diagnostics (inverter selection)
4 gas signals : available to send control signals to directly 4 gas controller from
main control system
Individual experiment available by attached controller on each 6 fermentors
Available to perform experiment with different parameters, under the same
condition.
Controller that accessible to multiple monitoring by PC and control systems.
Able to lock controller by setting password in order to prevent changing culture-
condition randomly.
Saved measured data and control parameters in excel sheets and transmits to
computer.

Specification
Drive Top drive motor(mechanical drive)
Agitation Range 50~1,200 rpm
Impeller 2-Rushton turbine impeller, 1-foam breaker
Temperature Range & Sensor Ambient + 3 C~80 C, RTD(Pt-100), PID control
Sparger Ring sparger
Aeration
Inlet Filter 0.2 air filter cartridge
Exhaust system Filter & Condenser 0.2 air filter cartridge, SUS 316
pH Range 2.0~12.0 pH of set point, PID control
DO Range 0~200%, PID control
Peristaltic Pumps ACID, BASE fixed speed 14.4 rpm
Peristaltic Pumps FEED PUMP variable speed
Recording pH, DO, Temp, Agitation, Peristaltic pump, etc.
Dimension 1750(W) x 1200(Depth) x 700(H)
Voltage 220V, 1 , 50/60Hz, 3.6kW
Weight 192kg (Controller : 102kg, Vessel 5L 1set : 15kg)
Please note that technical specifications subject to change.
 Autoclavable Fermentor

Biotron GR
50RPM~ Vessel : 3L ~ 7L
3L~7L 1,200RPM
Temp : Ambient +3 C ~ 80 C
Speed : 50RPM ~ 1200RPM

Features
IEasy operation
Space saving installation
Various sizes of vessel available
Air pump installed in the body to supply air into vessel.
Microprocessor on digital PID control.
LCD displayer

Specification
Range 50~1,200 rpm(In the condition of no load)
Fermentor

Impellers 2-Rushton turbine impeller, 1-foam breaker

Sensor Magnetic hall sensor
Agitation
Drive Top drive DC motor 60W(Option:150W)
82 Control Microprocessor based PID
Indication Digital display in 10 rpm increments
Temp.( C) From 3 C above the ambient temp. to 80 C
Temperature
Control/Heater/Sensor PID / 200 watt / RTD(Pt-100)
Sparger Ring sparger
Aeration
Inlet Filter 0.2 air filter cartridg
Please note that technical specifications subject to change.

Accessory

Basic vessel for microorganism fermentation 500ml Small vessel for microorganism fermentation
Single Vessel
High-speed agitation by applying durable Tob Single Vessel High-speed agitation by applying durable Tob
Drive Motor Drive Motor
Single glass type : Pyrex / Stainless 316 Single glass type : Pyrex / Stainless 316
Temperature control : Heater plate in underbody, Temperature control: Heater plate in underbody
coldfinger(from 3L) inside Applied pH, DO, Inoculum port on side wall
Volume Order No. Description
Single 1.5L 101 0102 I.D 115mm, V.H 170mm, 1:1.5
Single 3L 101 0103 I.D 133mm, V.H 220mm, 1:1.7
Single 5L 101 0104 I.D 170mm, V.H 220mm, 1:1.3
Single 7L 101 0105 I.D 170mm, V.H 310mm, 1:1.8 Volume Order No. Description
Single 10 101 0106 I.D 190mm, V.H 355mm, 1:1.8 Single 500ml 101 0101 I.D 85mm, V.H 120mm
Accessory

Double Vessel Double glass type vessel Bowl Vessel Stainless Double Jacket in upper body, Single Glass in
Circulating water in double jacket for effective under body
temperature control by large contact surface Circulating water in double jacket for effective
Connected to extra Water Bath for temperature control temperature control by large contact surface

Fermentor
Connected to extra Water Bath for temperature

Volume Order No. Description

Double 1.5L 101 0201 I.D 110mm, V.H 150mm, 1:1.3
Double 3L 101 0202 I.D 130mm, V.H 220mm, 1:1.7 Volume Order No. Description
Double 5L 101 0203 I.D 145mm, V.H 300mm, 1:1.2 Bowl 10L 101 0301 I.D 190mm, V.H 355mm, 1:1.8
Double 7L 101 0204 I.D 160mm, V.H 330mm, 1:1.7 Bowl 14L 101 0302 I.D 190mm, V.H 500mm, 1:2.6

Single Round Single round vessel: round type under body PBR Single Single vessel type, LED Bar inside to make growth by

HANIL SCIENCE INDUSTRIAL

Vessel Temperature control: Glass surrounding heating Vessel exposing light into algae
blanket LED inside / flourscent jacke
Usually applied in animal cell fermentation

Volume Order No. Description

Volume Order No. Description Single 1.5L 101 0102 I.D 115mm, V.H 170mm, 1:1.5
Single Round 2L 101 0405 I.D 115mm Single 3L 101 0103 I.D 133mm, V.H 220mm, 1:1.7
Single Round 3L 101 0402 I.D 133mm Single 5L 101 0104 I.D 170mm, V.H 220mm, 1:1.3 83
Single Round 5L 101 0403 I.D 170mm Single 7L 101 0105 I.D 170mm, V.H 310mm, 1:1.8
Single Round 7L 101 0404 I.D 170mm Single 10 101 0106 I.D 190mm, V.H 355mm, 1:1.8

Rushton turbine Rushton turbine impeller is located from middle to Installed in upper side of inside shaft, used in bursting
Foam Breaker
impeller bottom and basically used to agitate liquid in vessel. fermentation foam.
It makes the flow to the same direction with turning It is not used in the case of animal cell fermentation
radius and has features of paddle and propeller types since there is barely any foam.
to be available for high-speed rotation by minimizing 1 ea / 1 vessel
resistance.
General model to be used due to the highest
ventilation efficiency

Marine Impeller Applied to damageable cell Hollowed Paddle It stirs liquid from up to down rotating in low-speed
It stirs liquid from down to up rotating in low-speed Impeller since it has the large surface of wings.
since it has the large surface of wings Extra additional it
 In situ sterilizable Fermentor

Biotron SP (Pilot)
Fermentor

84

30L~ 50RPM~ Vessel : 30L ~ 100L 200L~ 50RPM~ Vessel : 200L ~ 1,000L
100L 1,200RPM 1,000L 550RPM
Temp : Ambient +3 C ~ 80 C Temp : Ambient +3 C ~ 80 C
Speed : 50RPM ~ 1000RPM Speed : 50RPM ~ 550RPM

Features
Intelligent 17" wide touch screen fermentation controller
One-chip Micom is applied for minimizing size and making simple set-up
process
ATMega128 CPU and sensor board into One-board solve problems
immediately
High density fermentation : DO-stat, pH-stat, Exponential feeding, etc
Remote control by PC software Data Logging system
Automatic head lift system built-in to move Top plate easily
Everything on one skid frame : Easy to install and move additional vessels and
vessel controllers
Accurate temperature control with cooler and heater
Automatic flow control: mass flow controller
Additional vessels for bigger capacities and peristaltic pumps for more accurate
operation
User’s programmable sterilization process program : user password, set up
sterilization time, and temperature
If there is a problem with external steam supply, its own steam can be
generated to change sterilizing process. There is no need to change the
structure of pipes, but just need to change sterilizing valve sequence. User can
manage sterilization program directly when changing of valve sequence is
needed to sterilize in site
Convenient DO management by one point calibration
Getting zero point available without nitrogen

Head Lifting System

Head plate is lifted by air cylinder and guided by the two sets of linear
motion guide
Safety pin is used to hold the lifted head plate
Lifting system is made of stainless steel(SUS 304) that it is rustles
Basic system with the 50L capacity
 In situ sterilizable pilot scale fermentor ; for bio reaction or bio response such as microbial fermentation, conversion and enzyme bioconversion.
Applicable to the special culturing processes such as tissue culture, animal cell culture and insect cell culture with the attachment of additional devices.
The sterilization in place procedure done automatically by using the external steam supply and conveniently changeable of the parameters and
sequences on the basis of user’s experience or designated data.

Fermentor
HANIL SCIENCE INDUSTRIAL
85

Bottom Drive Vessel 50L~ 50RPM~ All-in-one system including seed fermentor and
500L 500RPM main fermentor
Volume of 15L~1500L
4 of Gas Mixers unified in one controller Applied stainless pipe transfer line for perfect
sterilization and user’s convenience
100L~ 30RPM~ Vessel : 50-500 L / 100-1000 L
1000L 300RPM
RPM : 50~500 / 30~300

Specification
30L ~100L : AC motor Top drive(mechanical seal driving) 50~1,000 ±1 RPM(In the condition of no load)
Drive & Range
200L ~1,000L : AC Geared motor Top drive(mechanical seal driving) 50~550 ±1 rpm(In the condition of no load)
Agitation
Impeller Rushton turbine impeller, Foam breaker(SUS 316L)
Sensor & Control Magnetic hall sensor, PID control
Head Lift The head lift system is powered by air cylinder and guided by two sets of linear motion guide
Materials & Finish Vessel/Piping SUS 316L, SUS 304(electrolytic polishing)
Sterilization Heat exchanger or inject steam into jacket.(105 C~130 C)
Temperature Range & Sensor Ambient + 3 C~80 C (0.1 C ), RTD(Pt-100), PID control
Sparger Ring sparger(SUS 316L)
Aeration
Filter Inlet(0.2 ), Outlet filter(0.2 )
pH Range / Electrode 2.0~12.0 pH of set point, PID control / Gel Type
DO Range / Electrode 0~200%, PID control / Polarographic Type
Pressure Control The back pressure is controlled manually and/or automatically
Panel 17” Touch Screen Color LCD
Control
Communications Memory stick, printer, computer, etc with the RS-232C communication protocol
Data Storage pH, DO, Pressure, Temperature and Agitation speed
Please note that technical specifications subject to change.
 In situ sterilizable Fermentor

Biotron SP (Plant)
In situ sterilizable pilot scale fermentor ; for bio reaction or bio response such as microbial fermentation, conversion and enzyme bioconversion.
Applicable to the special culturing processes such as tissue culture, animal cell culture and insect cell culture with the attachment of additional devices.
The sterilization in place procedure done automatically by using the external steam supply and conveniently changeable of the parameters and
sequences on the basis of user’s experience or designated data.
Fermentor

86
1Ton~ 50RPM~ Vessel : 1Ton ~ 35Ton
35Ton 200RPM
Speed : 50RPM ~200RPM

Features
ntelligent 17" wide touch screen fermentation controller Reliable operation due to the automatic controllers
High density fermentation : DO-stat, pH-stat, Exponential feeding, etc Intelligent self diagnostic system to maintain fermentation process from start to
Remote control by PC software Data Logging system the end : Diagnostic, Setup, Dead Band, Offset, Warning, Feeding condition
Automatic flow control : mass flow controller and data logging system IQ/OQ documentation compliant to cGMP level
User’s programmable sterilization process program : user password, valve step,
sterilization time, pressure and temperature

Specification
Total Vol. 1,000L 1,500L 2,000L 3,000L 5,000L 10,000L
Vessel Working Vol. 700L 1,000L 1,500L 2,000L 3,500L 7,000L
Dia:Height 1:2 1:2 1:2 1:2 1:2 1:2
Motor Top mount type AC geared motor
Range 50~300rpm ±1rpm
Agitation Standrad : Rushton turbine impeller and Foam breaker (316L stainess steel)
Impellers
Optional : any kinds of blade type impeller
Control Inverter
Vessel Using 316L stainless steel and polishing
Materials & Finish Piping 316L stainless steel to prevent contamination
O-ring / Gaskets Viton or silicone material is used for the O-ring and the EPDM is used for gasket.
Temperature Sensor RTD(Pt-100)
Power Supply Controller system : 220V 50/60Hz, single phase
Fermentor system : 440V~220V 50/60Hz, single and/or three phase
Data Storage pH, DO, Pressure, Temperature and Agitation speed
Please note that technical specifications subject to change.
Reference

Fermentor
HANIL SCIENCE INDUSTRIAL
Consist of 100L animal cell fermentor, 4 gas mixer, perfusion system by Applied in eco-friendly microbial study for using pesticide microbial
outer spin filter Including steam generator for Biosimilar such as Interferon parasitic on pest Turn-Key process : Systemization from fermentation in
has been producing by using animal cell fermentor in Russia company. 1000L tank, Refinement by industrial centrifuge and stabilization of strain
culture by Spray Dryer
87

Head Lift function: automatic slab lifting Pilot fermentor installed Analyzer
for analyzing ingredients of exhaust emissions

Production line in scale of 35 Ton 50L, 500L, 5ton, 35ton Fermentor

4ton Seed Tank 10ton Feed Tank Fermentor producing
antibiotic(Vancomycin-resistant staphylococcus) in scale of 35 Ton.
 Reference

75L 20L 15L - 150L

Fermentor

88
100L 100L 75L

70L 100L 15L

20L 350L 15L - 50L - 200L

PC Monitoring Software

Sterilization

Fermentor
Graph View

HANIL SCIENCE INDUSTRIAL

Interconnected with Biotron SP to collect data, save and correct chart, on and off valve,
and run and stop controller in PC by excel form. 89

3 6
1 pH Control-Acid & Base
1 2 4 5 2 pH Setting
3 Agitation/RPM Setting & Control
4 DO Setting
5 Foam Setting Control
7
6 Pressure Setting Control
7 Temp Setting Control
8 Fed Batch Control

Interconnected with Biotron SP to collect data, save and correct chart, on and off valve,
and run and stop controller in PC by excel form.
 Autoclavable Fermentor

Biotron
Photo Bioreactor
Volume : 1.5L ~10L
1.5L~10L
Temp : Ambient +3 C~80 C
Illumination : 430nm, 680nm, WHITE LED

WHITE RED BLUE

These days, lots of studies demonstrated that ordinary plants could be grown by
Light Emitting Diodes instead of sun light. LED are very small semiconductor
Fermentor

chips generating light when power supplied.

The elements of diode determine the light spectrum emitting, these solid state
devices have been progressed over the years. And now, it has greatly improved
90
light intensity and specific wavelengths. Light power and spectral coomposition,
temperature and aeration gas composition can be set control.

Features
Intelligent 7" wide touch screen fermentation controller
Self data logging system within fermentation controller
LED illumination with Full spectrum imitates natural sunlight as closely as possible
by emitting light peaks at 430nm and 630nm, without NDIR and ultraviolet
spectrum components
Parallel design of vessel and controller : 4 peristaltic pump and pH, DO, foam,
temperature sensor port
Remote control by PC software Data Logging system
Easy to calibrate temperature, pH, DO, foam sensors using graphic calibration mode
Intelligent self diagnostic system to maintain fermentation process from start to
the end
Programmable multi stage operation : Setting pH, DO, Foam, temperature for
each stage to the end of the fermentation process
Easy control of external device by fermentation controller : O2 / CO2‚ analyzer,
glucose analyzer, spectrophotometer, fluorescence spectrophotometer, NIR, gas
mixer, level, weight, etc
Accurate PID temperature controller system

Specification
Drive Top drive motor(mechanical drive)
Agitation Range 50~1,200 rpm
Impeller 2-Rushton turbine impeller
Temperature Range & Sensor Ambient + 3 C~80 C RTD(Pt-100), PID control
Aeration Sparger & Gas mode Ring sparger, 2gas with CO2
Exhaust system Filter & Condenser 0.2 air filter cartridge, SUS 316
Range 2.0~12.0 pH of set point, PID control
pH
Electrode Gel Type
Range 0~200%, PID control
DO
Electrode Polarographic Type
Anti-foam Electrode Conductivity Type
Peristaltic Pumps Control 4 constant speed pumps each assignable to a wide variety of function for control of acid, base, foam and feed
Recording pH, DO, Temp, Foam, Agitation, Peristaltic pump, etc.
Please note that technical specifications subject to change.
Biotron
Plate Photo
Bioreactor

Fermentor
20L~ Volume ; 20~100L
100L Illumination : 430nm,
680nm, WHITE LED
Temp, pH, DO

Specialized in chlorella, ocean-bio industry

Using for producing clean fuel

HANIL SCIENCE INDUSTRIAL

Photosynthetic microorganism cultivation
Algae are a natural renewable resource of unique products, Microalgae require
only sunlight, carbon dioxide, phosphor and nitrogen to grow rapidly. They produce
a broad variety of basic chemical substances such as vitamins, fatty acids and
carotenoids with high added value potential for the pharmaceutical and food
industries.
Plate photobioreactors have received much attention for cultivation of
91
photosynthetic microorganisms due to their large illumination surface area.Plate
photobioreactors are very suitable for mass cultures of micro algae ,developed by
using thick transparent PC materials.

Features
Able to measure precise growth of biomass
Sensor monitoring in real time
Innovative offering light source for photosynthesis
Controlling system for adequate light source
Easy scale-up
Various type of photo bio reactor (flat, -type, pipe and etc)

Specification
Total volume illuminated 20 L 100 L
Sterilization autoclave possible possible
Photosynthetic module plate plate
Illumination unit 430nm, 680nm, WHITE LED 430nm, 680nm, WHITE LED
Illumination control dimmer dimmer
Illumination control control
Air Flow rate 5 l/min 20 l/min
pH-Value measurement & control measurement & control
pH-Control CO2 Gas CO2 Gas
Temperature measurement & control measurement & control
Optical density turbidity sensor turbidity sensor
Please note that technical specifications subject to change.
 Supercritical Fluid Extraction System

Biotron SFE
Pilot Scale

0~
10 liter 400bar

SFE is a green technology, as this method of extraction does not utilise organic Features
solvents, which have harmful effects.
Material: SS316
Supercritical Fluid Extraction (SFE) technology takes advantage of the unique loading type: easy head open type
properties of a gas Carbon Dioxide, at temperatures and pressures approaching safety: one Relief Valve, one power failure
and exceeding its critical point. At this state, it has a high density, typical of a Material : Stainless Steel 316L
liquid, as well as a high diffusivity, characteristic of a gas. The critical temperature Volume : 10 Liter
Weight : 200kg
of CO2 is 31ºC. This means, an extraction in the supercritical region will be at
Operation Pressure : 300bar
relatively mild temperatures compared to distillation. Temperature control limit : 0~100
Fermentor

Specification
Division Biotron SFE I Biotron SFE II
92
Supercritical fluid CO2 CO2
Capacity : 100ml. Capacity : 10 Liters. 2 ea
Design Pressure : 400 bars Design Pressure : 400 bars
Extractor
Operating Pressure : 350 bars Operating Pressure : 350 bars
Design Temperature : 90 C Design Temperature : 90 C
Capacity : 100 ml Capacity : 2 Liters 2ea
No. In the System : 2 or 3 No. In the System : 2 or 3
Separator Design Pressure : 300 bars Design Pressure : 300 bars
Operating Pressure : 250 bars Operating Pressure : 250 bars
Design Temperature : 100 C Design Temperature : 100 C
Please note that technical specifications subject to change.

Supercritical Fluid Extraction System

Biotron SFE
Lab Scale
Autoclavable Fermentor

Biotron
Mini
Bioreactor

Fermentor
50ml ~ Vessel : 50ml ~ 300ml
300ml 250RPM
Temp : Ambient +3 C ~ 80 C
Speed : 250RPM

HANIL SCIENCE INDUSTRIAL

Mini bioreactor with working volumes from w 40 ml up to w100 ml.
The small volume reduces medium costs and reduces the use expensive
bench space.
mini bioreactor comes with a Control Tower configured for temperature,
heater, pump module and 2-gas mixer , stirrer speed controler, vessel
with 4, temperature sensor, sparger; filters; and storage bottle.

93

Features
Generate more data in less time
Cultivate using less medium
Cultivate using les bench space
Generate scalable results

Specification
Vessel volume 100ml(w50ml), 300ml(w100ml)
Stirring speed 5~120rpm
Temperature Range & Sensor Ambient + 3 C ~80 C, RTD(Pt-100), PID control
Sparger & Gas mode Ring sparger
Aeration
Inlet Filter 0.2 air filter cartridge
Exhaust system Filter 0.2 air filter cartridge, SUS 316
Meida In/out pump 400A Peristaltic pump
Please note that technical specifications subject to change.
 Disposable Bioreactor

Biotron
Wave Tidal
Bioreactor

Wave Tidal Bioreactor is disposable cell culture bioreactor.

This bioreactor consists of a sterile wave bag and a rocker. The single-
use bag can be eliminated any need for cleaning or sterilization. The
rocker can be set and control temperature. Also, It makes regular
rocking motion that induces waves in the culture fluid. The wave action
sweeps up cells and prevents settling. These waves provide mixing and
Fermentor

oxygen transfer, resulting in a perfect environment for cell growth.

It is suggested that their use could improve process efficiency and results
by reducing the time-to-market of new products.
94

Features Application
Easy to scale-up Insect cell culture
Keep sterile environment in the culture using presterile bag Plant cell culture
No cleaning, No sterilization Virus production
Easy to built in and remove disposable bag Inoculums scale-up
High process security High-containment system
Multiple instrument configuration specifically designed for suspension Gene therapy
Simple to operate, Use conveniently GMP Production
Well mixing, High oxygen transfer by the wave motion 9 Cell therapy
Monoclonal antibody Wave Bag
Protein expression
Primary cell line expansion

Specification
Division Rocker Wave Bag
Power 120V,230V 50Hz,60Hz
Bag Volume Bag Volume
Dimensions (W x H x D) 540.5 x 326 x 656 mm Disposable bag
Weight 26Kg Pre Sterile
Housing Stainless steel Air Inlet, Air Outlet
Temperature control range ambient Temp +5~60 C Sample Port, Harvest Port
Rocking angle 10 degree Sensor Port for pH and DO
Speed range 2 ~ 50 rpm Spare Port
Please note that technical specifications subject to change.
Dry Block Heater

Doctor-T(SB) Doctor-T(DB)

Fermentor
HANIL SCIENCE INDUSTRIAL
Features
uniform temperature distribution VDRL Test Blood Chemistries
normal sample culturing Serology procedures Immunohematologic incubating
Coombs test the system supports timer mode and multi step Coagulation studies
Compatibility and antibody testing thermo-cycling mode also Activated clotting times
Colormetric tests RIA-aldosterone culturing Urine and blood cultures
95

Specification
Division Doctor-T(SB) Doctor-T(DB)
Temperature Range ambient +5 C
Temperature Controller PID controller
Temperature Increase 0.1 C
Temperature Accuracy 0.1 C
Temperature Uniformity 0.2 C
Temperature Resolution 0.1 C 
Display 16 x 2 Mono LCD
Operating Mode Temp. Control mode / Timer mode / 3Cycle mode(PCR mode
Dimensions(W x D x H) 150W x 200D x 100H 190W x 220D x 100H
Number of blocks One Two
Block Chamber Fast heating aluminum
Weight (with Block) 2.7kg 4.4kg
Power supply 110/220v 50/60Hz
Various types of aluminum they can accommodate various sizes of tubes, Microplate, and etc.
blocks are supported
Please note that technical specifications subject to change.

Optional Block Accessory

Doctor-T(DB)
Doctor-T(SB)

Combination 96 well
35-6mm 20-10mm 20-13mm 12-16mm 6-20mm 6-25mm 24-1.5ml 24-0.5ml 48-0.2ml, 96 well
(3-25mm, 0.2ml Microplate,
Tubes Tubes Tubes Tubes Tubes Tubes Tubes Tubes PCR strips Microplate
6-13mm, PCR strips
or Tubes
12-6mm) or Tubes