General Santos Doctor’s Medical School Foundation, Inc.

National Highway, General Santos City

NARCE, ALMERA ROSE F. PHARMACOLOGY

BSN-2A INSTRUCTOR: MS. KENVYNE QUIDES-CALUGAY, RN, MAN

DRUG STUDY 2 FINALS

DRUG NAME MECHANISM OF ACTION DOSE ROUTE INDICATION CONTRA-INDICATION ADVERSE  NURSING RESPONSIBILITIES
AND EFFECTS
FREQUENCY
Inhibits an enzyme, 3-
GENERIC NAME: hydroxy-3- Dose:40 mg Adjunct to Contraindicated in CNS: Dizziness, -Obtain a dietary history,
Simvastatin methylglutarylcoenzyme dietary therapy in hypersensitivity, cross- headache, insomnia, especially with regard to fat
(HMG-CoA) reductase, Route: PO the management sensitivity among weakness consumption.
BRAND NAME: which is responsible for of primary agents may -Evaluate serum cholesterol and
Azterol catalysing an early step Frequency: hypercholesterol occur. Sepsis, acute EENT: rhinitis triglyceride levels before
in the synthesis OD HS emia and mixed hypotension, major initiating, after 4-6 weeks
CLASSIFICATION of cholesterol. dyslipidemias. surgery, trauma, RESPI: bronchitis therapy, and periodically
: Therapeutic Effects: Reduction severe metabolic thereafter.
Lipid-lowering >Lowering of total and of lipids/choleste disturbances, GI: abdominal cramps, -Monitor liver function tests.
agent LDL cholesterol. rol reduces the endocrine or constipation, diarrhea, -Administer once daily in the
>Increase HDL and risk of MI and electrolyte disorders, flatus, heartburn, altered evening. May be administered
decrease VLDL stroke sequelae uncontrolled seizures, taste, drug-induced without regard to food.
cholesterol and and decreases and active liver hepatitis, dyspepsia, -Instruct patient to take
triglycerides. the need for disease. Use elevated liver enzymes, medication as directed and not
>Slowing of the bypass cautiously in: History of nausea, pancreatitis to skip doses or double up on
progression of coronary procedures/angi liver disease or missed doses.
artery disease with oplasty.  significant alcohol GU: impotence
resultant decrease in use/abuse.
MI/stroke and need for DERM: rashes, pruritus
myocardial
1
revascularization.