Name: Alondra A.

Sagario Course/Year: BSMT 2A

Instructor: Mr. Andre Bencee V. Barimbao, RMT Date: 10/25/2020

NATURAL HISTORY OF DISEASE

I. Diagram

CAUSATIVE AGENT
 Single stranded
RNA virus in the
family arenavirus
 Lassa Virus
PROGNOSIS OF THE DISEASE
 The overall case fatality SUSCEPTIBILITY FACTORS
rate is 1%. Among patients
 Person of all ages
who are hospitalized with
 Multimmamate rat
severe clinical presentation
of Lassa fever, case fatality
is estimated at around
15%. Early supportive care
with rehydration and LASSA FEVER
symptomatic treatment
improves survival. INCUBATION PERIOD
 The incubation period
ranges from 6-21 days.

ONSET OF DISEASE
DIAGNOSIS OF THE DISEASE
 When it is symptomatic, is
 Lassa fever often diagnosed by usually gradual, starting with
using enzyme-linked fever, general weakness, and
immunosorvent serologic assays malaise. After a few days,
(ELISA), which detect lgm and
headache, sore throat, muscle
igG antibodies as well as Lassa
pain, nausea, chest pain,
antigen. Reverse transcription-
cough, and abdominal pain
polymerase chain reaction (RT-
PCR) can be used in the early may follow.
stage of disease.
II. Description

Lassa fever is an acute viral illness characterized by multi-organ failure and hemorrhagic
manifestations. Lassa fever is most frequently diagnosed in Nigeria, Sierra Leone,
Liberia, and Guinea, although sporadic cases have been recorded in other West African
countries, including Mali. The etiological agent of Lassa fever is Lassa virus (LASV),
an Arenavirus which is maintained in nature and frequently transmitted to humans
by Mastomys natalensis.