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1990 03 10-11 Kochi Proceeding Ay Seminar On Cancer
1990 03 10-11 Kochi Proceeding Ay Seminar On Cancer
CANCER
1990
DEPT. OF AYURVEDA,
8.30 am Registration
9.30-11.15am INAGURAL SESSION
Prayer : Students, Amala Nursing School.
11 th MARCH 1990
2. Dr. R. P. Patel,
Hahnemann House,
College Road, Kottayam.
സഹതകെള,
Respected President Dr. P. K. Warrier, Hon ’ble Minister for Health, Kerala Sri A. C.
Shanmugadas, Dr. V. M. Brahmadattan Namboothiri, Director of Indian system of Medicine –Kerala,
Sri K. P. Aravindakshan MLA, Chief whip Kerala Assembly, Rev. Fr. Gabriel, Director of Amala
Hospital, Rev. Fr. Walter, Joint Director, Ladies & Gentlemen,
On behalf of the Ayurvedic unit I am extending a hearty welcome to all of you in this
occasion.
I am before you to present a brief idea about our institution, particularly about the Ayurvedic
unit and also regarding the Ayurvedic Seminar on cancer.
The Ayurveda Hospital and Research Centre is a major unit of Amala Cancer Hospital
Complex. The Ayurveda unit consists of Ayurvedic Research wing. Ayurveda general hospital,
Pharmacy and the Ayurveda Bhavan. The Research wing started to function from 27-3-1982 as a
grant in aid research project of central council for research in Ayurveda and Siddha. The general
hospital started functioning in the newly constructed building from 19-3-1983. Here treatment is given
for all general diseases. Facilities for doing the panchakarma therapy and Kerala special treatments
like Dhara, Pizhichil, Navara Kizhi etc. are also available in this hospital. The Ayurveda hospital has
earned avery good reputation in a short span of time and the increasing number of patients attending
the I. P. and O. P. departments are a proof to the confidence of the public.
The Research wing at present does mainly three types of work:
1. Evaluation of certain Anticancerous drugs supplied by the C.C.R.A.S. under their guidance.
2. Finding of effective and cheap Ayurvedic formulations for general diseases. And
3. Determining the efficacy of certain herbal and mineral preparations in the management of
Cancer.
For all these efforts we are thankful to the whole hearted co-operation extended to us by the
scientists of the Modern medical wing of this institution. A rare feature of this institution which usually
cannot be seen else where, is the presence of experienced scientists in various disciplines of
medicine including Homoeopathy. Modern equipments, dedicated staff,- all made available under one
roof by the management.
Modern medical men from countries like Germany,Italy and England who have interest in
studying Ayurveda visits this institution to get themselves acquainted with the Ayurvedic methods of
therapy and they have even requested us to start a short term course for imparting some knowledge
about Ayurveda, which is under consideration.
Our pharmacy unit is intended only for preparing genuine Ayurvedic medicines for the use of
our patients. This unit is equipped with modern mechanical appliances.
The Ayurveda Bhavan (Health resort) is mainly intended for providing accomadation to
foreigners who are coming for Ayurvedic treatment and the amenities in this section is planned to suit
their requiremints.
The person behind the multifarious development of Amala Cancer Hospital Complex, within a
short span of eleven years to a full fledged Hospital with departments of specialities and super
specialities as well as separate wings for Ayurveda and Homoeopathy is none other than our most
revered Director – Rev. Fr. Gabriel. He is a person with gifted qualities like deep thinking,
farsightedness and proper planning. He has never been a mere executive of plans and projects. His
contribution to the Educatiomal and Health fields of Kerala has few parallels. The prestigious
institutions like the Christ College, Irinjalakuda, Carmal English Medium High School, Chalakudy and
Amala Cancer Hospital and Research Centre are a few notable examples. Even the Chief Architect of
this Seminar is Rev. Fr. Gabriel. Months back he had presented the idea of conducting this Seminar
to the staff members of the Ayurvedic Section and had detailed discussions with them regarding the
same.
As you all know the planning and conduction of a seminar of this type on a subject like
cancer giving emphasis for sharing the experiences with the indigenous drugs in the clinical,
pharmacological and biochemical aspects are not an easy job.
Fundamental to making rational therapeutic decisions is a grasp of the architecture of
clinical trials. Only in the past 30 years has a systematic and scientific approach to clinical research
and its interpretation have developed in modern medicine. Prior to that time, most efforts to assess
the utilityof therapy depended on empiric studies with series of patients. As far as Ayurveda is
concerned the idea of conducting research in its various branches in an organised manner only
fructified in the seventies and some sort of research work, worth mentioning that name started only a
little later. Even now the actual methodology to be accepted in the Ayurvedic field of research is still is
in controversy.
With these difficulties in mind we have decided to accept a few papers also from Ayurvedic
physicians who have some clinical experience in the management of Cancer. Though these may lack
in certain details when viewed through modern standards, definitely the information gatheted from
these papers may be beneficial for future research work. Besides this, top ranking scientists from
Ayurvedic and Modern medical fields who have experience with indigenous drugs are also
participating in this seminar. Scientists from both the Ayurvedic and Modern Medicine wings of Amala
are also actively participating in this effort. An experienced Homoeopath and a Siddha physician are
also expressing their views and experiences in this field.
With all these orations and presentation of papers I am sure that this seminar will be a thought
provoking stimulant to all of us who are present here, especially from the Ayurvedic side.
Finance is an important factor for the conduction of any seminar. Being a Scientific Seminar we
have approached various governmental organizations like D. S. T. for financial help. Unfortunately we
have not received any till date. Scientific minded public at large a few philanthropists and the Director
of Amala came to the rescue in time. Otherwise the organizing committee would have been in great
difficulty. May I conclude by quoting the words of Dr.Hans Holzer former Professor of
Paraspsychology, Institute of Technology, New York, in his famous book “Beond Medicine ”
Published in 1987.
‘Let us all who are healers of one kind of another, therefore work together and not against one
another, and let us not reject notions and experiences we find unusual or in contradiction to what we
were taught in school. Compared to what there is to know, we know preciously little as yet ’:A No
Bhadra: KRATHAVOYANTHU Viswatha”:-Let noble thoughts come to us from everyside.
-(Rigveda)
Thank you.
INAUGURAL ADDRESS
Sri. A. C. SHANMUGADAS,
Hon’ble Minister for Health,
Kerala.
Though it is a privelage but with hesitation and humility, I venture to present before this learned
gathering of experts belonging to different scholls a comprehensive view point regarding the concept
of Oja and effects of Rasayana in the management of Cancer.
As the word Oja is in reference to Ayu, so ler us think about the word Ayu and its relevancy, Ayu
and Nityaga means which is constantly on move or leaking out, never remaining static and it is bound
to exhaust; whereas the other nature of life is opposite to this. It means upholding life. i. e., keeping
the flame and never allows to extinguish, but helps to maintain the flame endlessly. It is denoted by
sord, Jivita and Dhari, meaning continuity of life and preventing or having continuous succession of
continuous flow.
It is the nature of life, to resist death and to pass on the flame of life to successive generation. i.
e., daughter cells. Incidentally the word Dhari is also a synonym of Ojas. Hence in this word Ojas we
find some glimpses.
Now, as told earlier Oja is in reference to Ayu, health; or it can be said in other words, Oja
provides defence to the disease, then how should we take the disease?. The disease is considered to
be forerunner or the agent of ensuing death.
When we come to the disease and its prevention, volition, transgression, inwholesome contacts
and seasonal variations are the causes of the disease. Right knowledge, wholesome sense contacts
and normality of the seasons are the remedies. It is possible through Bala only, as it possesses the
capacity to withstand physical hardship and stress and duressess of hunger, thirst, heat, and capacity
which does not allow to be cowed down against intensity of the disease.
It can be expressed in this way as well as helps freshness and compactness of tissyes and
stability youthfulness inspite of the advancement of chronological age. i. e. delaying the senile
degenerative changes.
Sushruta speaks more elaborately so the strength of the patient should always be maintained
and it reduces the intensity of the disease. Hence Bala as per the above said discussion simply gives
an idea of an abstract condition of inborn power of resistance or of capacity to grow or to undergo and
withstand trying physical and mental stressful conditions without getting perturbed.
But is there any concrete substance or material in the body on which this condition depends?
Yes, it is Ojas, which imparts the body all these different forms of energies; cited above. Therefore, it
is costomary to call Ojas as Bala. Verily speaking the Ojas is the cause and Bala is its effect. Now,
how to ascertain and identify Ojas in reference to Bala is a difficult task.
Synonyms used for Ojas are Bala, Prana, Urja, Shakti, Sara Satwa, Tejas, Rasa and Shleshma.
Whereas the similies quoted for it are;that of ;as nectar in the flowers and fat in the milk, as this
depicts its form and nature of minuteness invisibility and its defusion and uniform distribution.
Further as Bees isolate nector from flowers which is in very subtle form and minute quantity;
similarly our body tissues collect Ojas from nutrient Rasa. Also as ghee is the essence and subtle
product in the various transformations of milk and which gives it, its real value; so does the Ojas
defused uniformly all over the body and gives the person his real value as regards Bala; Abala;
Balavan and Balaheena.
It can further be explained in the manner that there may be lean persons full of vigour and
strength and they withstand stress steadily and there may be corpulent persons looking apparently
robust but devoid of strength and getting easily fatigued.
The difference between the two lies in the natural difference in their constitution and capability
of the tissues and set up.
Regarding the shape and form of the Ojas, it can be said that the Ojas is a watery substance –
Somatmaka, can be measured in Anjali and drops; it is the purest form of Shleshma.
The properties manifested by its presence are compactness unctuousness, durability and
stability against stressful conditions, gives suppleness, freshness and power of repair and growth and
it has the nature of perfusing the tissues with nutrition. It has thus the properties to protect the tissues
from the deleterious effects of roughness, dryness and heat. Further it has the properties of softness
and smoothness and of being fluid and very clear, most minute of sweet taste and of predominately
white colour having slight reddish and yellow tinge.
It is the greatest support to life; it perfuse the wholebody and its minutest fractions i. e. cells.
Moreover the formation of Zygote is only possible if sperm and ovum are animated by Ojas
again zygote can develop into embryo if the nutrient fluid is perfused and saturated with Ojas. And
once heart etc. are evolved then this Ojas takes the possession of heart and remains there to supply
the body strength and to beat the heart ceaselessly throughout the life till death.
As Bala and Ojas are one reference said as synonyms, this has greater roles to play in the
noumal physiology of the body and in the fuctions of Agni., as the transformation of food factor into
Dhatus, Malas, Prasada and Kitta is due to Agni and this finally leads to the formation of Ojas. In
other words, the Bala or Ojas are possible because of the assistance of Agni in the nourishment of
the tissues.
Further let us look this Ojas in different contexts.
IN THE SPEHERE OF DEHA (PHYSIQUE) :
-Shlema: phlegm, protoplasam, fluid matter.
- Rasa: plasma, lymph, tissue fluid.
- Rakta: whole blood.
-Shukra: Seminal fluid.
- Sarva Dhatu Sara: characteristic, minute structure of each specific dhatu.
- Shukra Sara: essence of semen ( spermatozoa).
- Annasara: nutritive element in the food.
- Madhura Swabhava: essence of rasa, vitamins,glucose, glycogen in blood and
tissues
IN THE SPHERE OF PSYCHE:
- Pravara Satwa: moral strength, boldness.
- Prasanna mana: elation, govial mood, high spirit.
- - Tushti: heightened mood.
- - Resistance to disease and depression.
IN THE SPHERE OF AGNI:
- Ushma (capacity to digest and transform energy, heat, opposing coldness and
frigidity and assimilate enzymes intracellular and inertia).
Perhaps in ladies it has to play some more important role in addition to the above
said factors as fair sex body, softness hairlessness etc. now coming to the management of Cancer
it may not be out of place to speak about cancer as per the concept of Ayurveda.
Arbuda, is a clinical entity described in the texts of Ayurveda, which is derived from
the root are, meeting thereby million millions. i.e., Arbuda is a sankhyavachaka word, where
uncontrolled number of cells are formed. It is rightly pointed as a MAMSOPACHAYA SHOPHA by
sushruta who also describe the classification on the basis of Dwirarbuda and Adhyarbuda along
with Doshic varieties like Vataja, Pittaja, Kaphaja, Raktaja, Mamsaja and Medoja. The treatment of
Arbuda needs Lekhana and Rasayana drugs along with the systemic purification by
Panchakarma.however it is said to be a Shastra Sadhya Vyadhi(CHEDANA). The role of
Rasayana drugs is of considerable importance in the effective management of this disease as,
Rasayana is a method of forming the Prashasta Dhatus in the body.
Rasayana, is defined by charaka as a means by which one gets potimem quality
of Dhatus etc. susharuta describes it as a theraphy which arrests aging, increases intelligence and
strength and enables one to prevent the diseases.vagbhata follows charaka whereas
Sharangdhara says that it is a drug which keeps off aging and prevents diseases. Dalhana while
commenting on Sushruta’s views, mians Vayasthapana as enabling a person to live his mornal
span of joyous life. Ayshkara as increasing span of life to 100 years. In this way, Rasayana the
rapy increases the tissue etc., prevents aging and hilps in the formation of such Dhatus which
were not being promptly formed earlier.
CLASSIFICATION OF RASAYANA ON THE BASIS OF ITS APPLICABILITY:
1. Rasayana with or without exposure to sun or wind.
2. Rasayana according to the requirement of persons.
3. Samshodhana and Samshamana Rasayanas.
4. Achara Rasayana.
5. Miscellaneous Rasayana.
Rasayana is classified on the basis of therapeutics as :
KAMYA: (health promoter) -- Prana kama (promoter of physical health )
-- Medhah kama ( mental health promoter )
--Shridama (Social status promoter )
by promoting the lustre-Prabha, complexion, body glow which ultimately
leads one to earn general respect in society and thus reverence of the people.
NAIMITTIKA (Immunity promoter ) __ When used in reference to relieve a particular disease and
may be used independently or as an adjuvant with the other treatments of that disease.
AJASRIK __ Continuous use of milk and ghee.
RASAYANA Vs Cancer :
The beneficial effects of Rasayana are the clear indication of the wastihg diseases
including Cancer, where Agni, Dhatu and all other important factors of the body are disturbed
producing a wrong variety of Dhatus, which can be arrested by the proper utilization of Agni and
Ojas with the help of concept of Rasayana. It engances the life span, makes Doshas in
normalcy,ignites the Agni, clears the Srotamsi and thereby promotes the excellent tissue
formation, which is the strategy in cancer therapy.
Summary
The paper is intended to chart out the possible fields of research and give guidelines as
to the areas that need special attention, in the present context, Oja and Rasayana, when Arbuda is
deliberated upon.
The magnitude of the task ahead should not put off an ardent scholer and an enterprising
research student, but should rather project upon to strive ahead and the author ’s purpose is
served if the paper has given a few points to ponder upon or created new querries in the inquisitive
minds of the fellow physicians and scientists assembled here.
ACKNOWLEDGEMENT :
The author is thankful to the Hon ’ble Vice Chancellor Shri V. R. Mehta and respected
Dean Prof. Harishankar Sharma for permitting to participate in this session. Author is also grateful
to the Amala Cancer Hospital, for providing an opportunity to share the ideas with you all.
ROLE OF PANCHAKARMA IN THE MANAGEMENT OF ARBUDA (CANCER )
Dr. P. K. MOHANLAL,
Professor and Medical Sudpt.
Govt. Ayurveda College Hospital, Trivandrum.
(ച. സ. )
PATHOLOGICAL REPORT
( Signed )
For Professor of Pathology.
DEPARTMENT PF PAEDIATRIC SURGERY
From
I. C. H. Kottayam.
To The Director,
Medical College,
Trivandrum-11.
Sir.
This child Jimmey 6/12(Female) was brought to this hospital with complaints of enlargement of
abdomen. She has a tumour in the abdomen occupying the whole of abdomen. Blood urea-16 mgm%
IVP. the Rt. Kidney, ureter and bladder normal.
The left kidney is pushed up and laterally with crowding of the calyxes and compression of
pelvis from below.
Exploration : The tumour was found to occupy the whole of the retroperitoneum. The aorta and the
major branches were engulfed in the tumour. The tumour was found to infiltrate the mesentery and
the superior mesenteric vessels. The left kidney was found to be infiltrated and pushed up and
laterally.
The pancreas was invaded at the body and tail. The liver had multiple secondaries on the right
lobe.
Hence a biopsy was done and is reported as round cell sarcoma probably neuro blastoma.
Biopsy report (No. 8127/87) is hereby attached.
Sd/-
Tannippally house
Perumbadappu.
Aspirate smear
Cytology Report --RC 1683 /89 Cervical smear – The endocervical cells show
Date -- 16 /8/89
Sd/-
Cytopathologist
ADVANCES IN CANCER RESEARCH
Abstract :
Failure of the universally accepted line of treatment in advanced cancer cases, radiation,
surgery and chemotherapy and organization of societies for further research is the current trend.
There are heretics who challenge the possibility of a cause for cancer, a pre-cancer stage is
preventability and early diagnosis. Cancer according to them is ever there as a part of self and insist
on minimal treatment. Any-how mechanical approach to cancer as simply due to a somatic
derangement as a malady strting locally and spreading or attacking other parts is not correct is
recognized. experiences prove its psychosomatic root and the necessity of a holistic approach to yield
better results. The A.C.P. (Attiva Come Prema ),society in Milan organized and working for
rehabilitation of cancer affected patients, conclude from their investigations that psychic factors
influence relapse. Dr. Lakshmipathy reports how he could relieve many inoperable cancers, by
administering Bhallataka (semicarpus anacardium ) as medicine insisting on purification of toxins by
providing a grape diet and by bucking up the courage and will power of the patient by persuading him
to stick up to faith and devotion. The role of the mental crisis in the onset of cancer and how this
mental situation affects the tissues later are studied and techniques for successfully treating cancer
by reversing the changes, with due importance given to mental consolation along with all current
treatments with a holistic approach by Simontons. These studies engance the importance of a restudy
of Ayurveda approach which always insist on vital strength, psychosomatic approach-a description of
which as given in classical texts followed.
Most of the modern designations for cancer and malignant conditions can be understood in
Ayurveda as with the term Arbuda and many malignant conditions due to provocations of the three
doshas together, although exact equation of terms of the systems may not agree.
Experience of treatment personally conducted and from other ’s experience prove that there is
an effective and reliable approach in Ayurveda which can be improved by modern knowledge and
purposeful researches, cases of cure gained by Naturopathic, Ayurvedic approach and personal
experience are reported.
But for AIDS, Cancer is the most dreaded of all diseases and much controversy is centered on
it. We have a bulky literature on the study of Cancer. Everyday we get reports of trials, versions,
discoveries of possibly effective medicines etc. While official medicine still clings to radiation, surgery
and Chemotherapy and go on organizing cancer scientists for research and treatment and collecting
funds there are heretics who challenge and negate the basis of all these understandings and
proceedings. “ Myths and realities of cause and cure of Cancer ” by Dr. M. L.Kothari and Dr. L.A.
Mehta raises such a challenge. They challenge the very idea that cancer is caused, preventable,
diagnosable and that there is a pre-cancer stage. According to them, cancer is always there. It is not
curable but understandable and often palliable. Cancer has been with mankind since ages and its
occurance is not a punishment. It is a part of your own self. Neither love nor hate it. Decide to live with
cancer is their message. They say must you should be treated, seek surgery. Should you be
irradiated or given Chemo-therapy insist on the minimal and be prepared for the cellular levy from
head to foot that your body must pay”.
Cancer is a species, class or ordinary character. You can neither inherit it or pass it to your
progeny. But inspite of the challenge official medicines goes on as before. We are here to discover
the possibilities and limitations and how we can improve our techniques, approach and medicines in
the Ayurvedic way. But we have today other medical systems, sapecially modern, comparatively with
more command in the field. It is accepted by all that present day medical problem can be tackled only
with a combine effort of all.
Arbuda is seen studied in classical texts and latter ones on Susruta, Charaka, Vagbhata.
Madhava Nidhana, Anjana Nidhana, Rasa Ratna Samucchaya and other works. They are studied in
relation to and in the context of the studies jof Grandhis. It is also a Nija Vrana. Vagbhata says it is
bigger than grandhis. Charaka saya “because there is no difference between the cause, creation,
shape, the doshas involved and affected between that of Grandhi (tumour) and Arbudas (Cancerous
tumours) , the physician has to treat Arbuda as per the instructions or steps as per the instructions or
steps as per grandhis. Susruta gives a clear picture “ the doshas having got vitiated in any part of the
body and affecting the Mamsa (flesh) produce swelling in the later ”. This is circular, fixed, slightly
painful, big in size,broad based, slowly growing and it does not supprate. The same is called
“Arbuda” buy the experts. This is produced by vitiated vata, pitta,Kapha, Raktha, Mamsa and by
Medas. While the grandhis are nine in vumber by each of the three doshas, Blood, flesh, fat, bone
veins and from ulcers (Vrana ) according to Susruta.
Regarding the prognosis, Susruta points out this ( Raktarbuda) which continuously
discharges vitiated blood is incurable and Mamsarbuda also is said to be incurable. Even out of
which are curable those which discharge. Those situated over the vital parts or over the srotases and
those which become fixed should be discarded from treatment. When another tumours grow over the
pre-exsisting ones, this is known as Adhyarbuda by the Oncologists. When two tumours grow
simultaneously or one after the other that is called Dviarbuda and both these are incurable. Here
Dviarbuda is commented as secondaries. The term used “Samprasruta ” denotes ulcerated Arbuda.
The mention of srotases speaks of the knowledge then they had on the spread of Cancer cells by
lymph and blood. The term “Achala”denotes fixity. According to Ayurveda, metabolism is due to
Chalanam ( movement) , Paka( transformation and maturation) and Upachaya ( accumulation) and
these are controlled by Vata, Pitta and Kapha respectively. When the doshas are upset metabolism is
impaired and degeneration sets in the unrestrained and unregulated increase of cells cause
malignancy and manifestation of Cancer. Although malignancy of Arbuda is presented as a special
topic in this context, there are hints of developing Cancer from other grandhis or tumour like
abnormalities. For instance, Kapha gulma in structure is much like a grandhis. There is possibility of
such tumours turning Cancer. Apachi also can take such a course. So Cancers of intestinal organs
also can be inferred. Apache, Galagandha Alaji and Valmika are described as grandhis. The
treatment also for these conditions are similar. Dr. Prabhakar Chatterjee in his book, Ayurvedic
treatment of Cancer says that “ Cancer has an exact resemblance to the disease designated as
Rohini in Ayurveda and Rohini may be regarded as identical to Cancer ”. But some suggest Rohini as
Diphteria. The term Valmika means molehill. some suggest it as actinomycosis madhura foot (Ancient
Indian Surgery Page 191). But in Susruta, it is said to be treated like that of Arbuda. Valmika with
multiple openings and inflammation in the hands and feet is incurable. It is a disease in which all the
three doshas join together. Usually in any tumour in which all the three doshas are in a provoked
stage, malignancy can be suspected, Dr. Lakshmipathy included Valmika, Indraviddha, Gardhabhika
and Paashana Gardhabha among malignant tissues. Sarkaraarbuda is refered to sarcoma of the
fibrous type or to a scirrhous Cancer. In Vata Raktha such a possibility is clearly defined. That which
is originated by the three doshas with discharges which is stuck up prone to turn cancerous is advised
to be discarded.
Since there is no such tissue vice difference in Ayurveda it is very difficult to equalate
these term with Ayurvedic designations. Some may be equated. Rakta Arbuda and Mamsa Arbuda
may be represented as Sarcomas. Raktarbuda as Haemomangio Sarcoma and Mamsa Arbuda as
Myo sarcoma. Dr. Lakshmipathy says it is difficult to say whether Rakta Arbuda is a carcinoma or
sarcoma. The description may apply to a carcinoma or a soft variety of sarcoma. Kapolarbuda is
carcinoma cheek. Medarbuda has Lipo sarcoma. The Ayurvedic designations of Vata, pitta and
Kapha Arbudas are not liable for exact equations taking the relationship of doshas to tissues. Vata
Arbuda can be those related to nervous tissues and skin. Pitta with blood and Kapha with structural
tissues mucous, phlegm etc.,as Kapolarbuda. Cancers associated with white corpuscles according to
modern designations are lympho-sarcoma and lymphatic leukaemia. There is Myeloid Leukaemia
also . these may be represented to cancers due to Pitta and Kapha. There is no mention of
multiplication of white corpuscles in Ayurveda. But when describing Pleehodara in Udara Nidana
there is mention of enlargement of spleen. When blood is increased unevenly i. e. without the uniform
increase of Rasa and other tissues, increase spleen. The symptoms of troubles described are
enlargement of stomach, cough, thirst, fever, distension of stomach, torpor pain and anaemia. Of
these, apart from enlargement of stomach all agree with the symptoms of Leukaemia. Again in Pandu
(anaemia ) also we come across similar symptom. So investigations can be done following these
symptoms. When comparing the modern tissue vice studies and studies in classical texts we have to
bear-in –mind the difference in approach and the time. Susruta ’s description is exquisite and
absolutely conforming to the needs then, because as we can presume cancer may not have been so
prevalent then as today. It is an admitted fact that diseases spring up and disappear as per the
changes in our way of life and circumstances. The same disease may take different form.
Today, since we have more facilities and equipments to examine and study internal
organs. We could note and describe varieties of cancers, sarcomas and others affecting each and
every tissue. At the time of the classics there was no possibility for such detailed investigations of
internal organs and detections. More over our attitude was for more functional studies. So we have
basically Dosha depending descriptions, although Dhatu dependence is not excluded. Basically
Ayurvedic approach is functional, field-oriented, holistic and multi-factoral. Modern approach is
structural, analytic (reductionistic), liner and uni factoral. Both approaches are useful and mutually
contributing. But since Ayurvedic approach is with arrested growth, it is the up-to-date approach that
dominates us. So our first duty is to develop our functional approach, embracing all modern studies
but true to the spirit and as a continuation of the Dosha-Dhatu-Mala conception.
The conceptual frame work and therapy that Carel Simonton a radiation oncologist and
Stephanie Mathews- Simonton, psychotherapist have developed agree basically with the idea that
the imbalance and fragmentation that pervade our culture today play an important role in the
development of Cancer and prevent medical researchers and clinicians from understanking the
disease. At present their work is only a pilot study but so far the average survival time of their patient
is twice that of the best institution of cancer theraphy and three times of the national average in the
United States and the quality of life and levels of activity of these patients are absolutely
extraordinary.
The popular image of cancer is that it is a strong and powerful invader that strikes the body
from outside. Patients see it as a localized problem. Simonton want to reverse this image. According
to modern cellular biology cancer cells are weak and confused. They do not attack but simply over-
produce. They are with incorrect genetic information and so do not function normally. Their
communications with the environment to determine their optimal size and rate of production and self-
organisation are impaired and so normal cohesion weakens, malignant get loose travel and create
meta-stasis. The immune system is weak. So Cancer is a break-down within. The cause of the
formation of cancerous cells and the weakening of the immune system are to be enquired too.
Simonton fully recognize the role of carcinogenic substances and environmental influences and
genetic disposition but these factors alone do not provide an adequate answer. What inhibits a
person’s immune system is the crucial problem, there are the mental and emotional aspects.
Laurence Leshan’s studies of more than five hundred cancer patients approve their
observations. So Simonton approach holds that the development of cancer involves a number of
inter-dependant psychological and biological processes and that these can be recognized and the
sequence of events which lead to illness can be reversed to lead organism back into a healthy state.
Make the patient aware of the wider contexts of their illness. Ask patient questions to identify the
major stresses occurring in their lives six to eighteen months prior. Get the patient ’s participation and
create the basic for reversing the cycle of psychosomatic processes that led to the state of ill- health.
Strengthen belief in the effectiveness of the treatment and create a positive attitude. The response to
treatment depends on their attitude than on the severity of the disease. Once feelings of hope
anticipation are generated the organism translate them into biological processes that begin to restore
balance revitalize the immune system using the same pathways that were used for development of
disease. Physical therapy is also used. So cancer is a problem of the “whole person ” and so a multi-
dimentional approach with various treatment strategies required. Simontons employ a method of
relaxation with visual images and symbolic language. The cancer and the action of the immune
system are pictured in the patients own symbolic imagery. This is extremely good to strengthen the
immune system. The visualization method is excellent for patient to communicate with their
unconscious. Along with the psychological and social problems also are to be reckoned. So
psychological councelling and psychotherapy also to be employed. Often group sessions are held for
therapy. Most patients need a change in the belief system because hopelessness is due to wrong
inter-pretation. Confrontation with death is also a problem. The therapist has to play a supportive role
here also to succeed in improving the quality of ones living and ones dying. the cancer patients are
thus naturally led to consider their goals in life, their reasons for living and their relation to the cosmos
as a whole. Observing these developments, we get more conviction as to how improving upon it in the
light of these modern studies can be a valuable contribution to cancer treatment.
Cancer is basically due to alienation of man from nature and society. It is a psycho-
somatic disease. It cannot stop simply by eradicating the cancerous tissue by radiation or surgery.
Along with such steps the “Bala” factor i.e. preservation and fortification of vitality has to be planned
both during such treatments and afterwards to prevent relapse. In this respect purification steps and
Rasayana are always to be insisted.
In selecting herbs and preparations with mineral and animal products Ayurveda insists on
Dhatusamya or adaptogenic property. In Europe Misletoe is considered as a medicine for Cancer.
There is no wonder that search for cancer medicines has now turned towards the herbal lore. Since
the discovery from Vinca rosea. So many plants are now collected at random and tried. But Barbara
grigs in green pharmacy suggests to turn to traditionally used herbs instead of selecting at random.
This has another suggestion. Traditional medicines are used withaan eye for purity. So this implies
the necessity of purification also. She also points to the scope of new techniques advancing in the
west. Edward Batch (1886-1936),a Welsh born bacteriologist got convinced that Sun warmed dew
absorbed the vital healing powers of the plant in which it rested and that this power could be
transmitted to pure spring water standing in a glass bowl in full sunlight in which were placed specific
herbs. His cure was not to attack the disease. But to flow the body with beautiful vibration from herbs
and flowers in the presence of which disease would melt away as snow in the Sun shine. According to
Ayurveda also we cannot do without surgery, cauterization or alkalies in advanced cases. So the
place of surgery and radiation is still there in such advanced cases. But even here internal use of mild
purifying and strength giving medicines will be helpful. In my persomal experiences, I have found
Chandraprabha gutika with Panchathiktam kashayam and Punarnavadi kwatha are very effective in
Pancreatic Cancer. Gomuthra Hareetaki to heal a throat cancer. Such instances can be reported both
from by experiences and from my colleagues. But since we are not working at clinical research
institution, we have not data to claim for our results.
In cancer the basic problem is the protection of the healthy cell from toxicity or other
unfavourable conditions. So along with eradication of the morbid tissues, promotion of regenerative
tissues taking cancer as a systemic disease involving even mental factors have to be attended to
leeches applied to cells do both together. Purification itself is regenerative. In Charaka Dasemani is
Ballyani, Prajasthapanani are combination of herbs which are purificatory and regenerative. That is
the vision of the preceptors. Our medicines work in that way. So we have to improve our research
taking all these factors.
CLINICAL EXPERIENCE IN ARBUDA TREATMENT
ദവിതീയഭാഗം
തതീയ ഭാഗം
എെന ചികിതാനഭവങൾ
Abstract :
1 ‘നലപ’ :-- അതിെന നിറം മഞൾ േപാെലയിരികം. ഒരപെക നാടിലള അപേയാട സദശമായി
കാടിൽ ഈ െചടിയണാകാം. ഈ മരന് കണവരെണന് പറയെപടന.
Assistant Professor,
Abstract :
“ Jaundice” is one of the common problems in cases of ‘Leukaemia ’ treated with drugs of
western system of medicine. Attempts are being made all over the globe to overcome this
problem/complication. Different traditional and alternative medical systems are found to be effective in
the management of this problem. Ayurveda, the Indian health care system have better prospectus in
this direction.
Here an attempt has been made to manage ‘Jaundice ’ in a case of ‘Leukaemia ’ with Ayurvedic
formulations based on the principles of Ayurveda.
Six years back a 30 years male patient working as a typist at HMT Factory, Bangalore
presented with the signs and symptoms of Jaundice. He was referred by an Ayurvedic physician
working at Kidwai Institute of Oncology (KIMIO) with less hopes of survival (hardly 3-4 months). He
was a known case of chronic myeloid leukaemia since 2 ½ years. i.e.middle of 1980. He was put on
mainly with ‘Myleran’ tablets an anti-Leukaemic drug. Since 2 ½ years with varied dosage, depending
upon WBC, HB% and platelets counts. His WBC count was 1,50,000, HB% 8gms, ESR
40mm/hr..Platelets 50,000 per cmm. And when he was referred the following were his complaints:
Netra-Mootra_Talu Peetata, Dourbalya,Kandu, Yakrut and Pleeha vrudhi and sparsha asahatwa,
aruchi, Annadwesha, Bhrama, Nidralpata Deenata,Alpamalapravrutti, and Hrullasa since one week.
Roganidana (Diagnosis)
After knowing the history, and examining case it was tentatively diagnosed as ‘Pandujanya
Kamala’ based on the concept: Charaka: Chikitsa:Cha/16.
Here his ‘Leukaemia’ was considered tentatively as a type of ‘Pandu roga ’ and the
Jaundice as secondary to that. The reason for this was suspected as (Myleran and other)anti-
leukaemic drugs. They have been considered as Kshara,Amla,Lavana and Athyushna dravyas.
According to Davidsons principles and practice of medicine, “the drug Myleran is an alkylating agent
having Busulphan in it. It is given orally in a commencing dose of 4mg.daily and can bring about a
temporary but satisfactory clinical and haematological remission in a high proportion of cases.
Subsequent maintenance of dosage, e.g. 2mg. daily , is continued and regulated according to the
results of frequent blood examinations and the general state of the patient. It must be emphasized
that all such drugs are capable of producing severe haemopoietic depression and their administration
requires haematological supervision. The too rapid destruction of abnormal white cells may cause a
rise in blood uric acid and even uric acid nephropathy ”.
Chikitsa (Management) :
Looking into the condition of the patient the line of treatment adopted was as follows :
c) Shamanoushadhas.
TABLE
Table showing the No. of complaints and the extent of relief after treatment.
3. Talu Peetata ++ ++ + ±
4. Annadwesha ++ + ± _
5. Aruchi ++ + _ _
6. Hrullasa ++ + _ _
7. Dourbalya +++ ++ + +
8. Bhrama + _ _ _
9. Kandu ++ +± + _
10 Twak Roukshyata ++ ++ + _
11. Nidralpata ++ ± _ _
Treatment given :
First 3 days :
M AN N
15 —20 minute
2. Suvarna sootashekharapills
50 mg 50mg 50mg
3. Paithyantika rasa(impcops)
5. Trivrut leha (Aryavaidyasala, Kottakkal) ½ Tsp at bed time with warm water.
Ahara vihara :
Complete bed rest. Avoided bath, day sleep, exposure to heat or sun.
Rice kanji (Rice gruel) with cream free milk added with little cardamomum, sugar, dry
grapes. 2—3 times a day. 150—200 ml. at a time approximately.
2. Livomyn syrup
M AN N after food
Ahara vihara :
a. Double boiled rice (old rice) with sourless fat free fresh butter milk in semisolid form in
the morning and thick rice in the night.
b. Fruits as usual.
2. Livomyn syrup
M AN N
3. Suvarna sootashekhara
25 mg 25 mg 25 mg
M AN N
a) Allowed to take lukewarm water bath, allowed to walk a little and others as earlier.
b) Allowed to take double boiled rice with mudga yoosha with little of jeeraka,saindhava and
maricha choorna twice a day. Fruits as usual.
After 15 days he was instructed to stop all the drugs and was adviced to take ‘Dhatriloha ’
(Bhai. Ra) ½ gm (prepared of home) twice a day with warm milk after food for one month.
He was allowed to have moderately normal food and also permitted to attend strainless work
at his office for a months time.
He was asked to go back to KIMIO Bangalore and report for further investigation and
treatment. According to the report of Ayurvedic Physician of KIMIO at that time, all the investigations
had shown normal range. No much change was noticed in HB%. Later it was heard that he was not
on any drugs for 2 yrs. After that his leukaemic condition went to the worst status. blood was
transfused for number of times and expired at KIMIO Bangalore on 15-5-1988. Totally he survived for
almost 8 years from the date of detection of Leukaemia.
Remarks :
However the researcher felt the necessity of indepth study of the course of manifestation of
the disease and the treatment based on Ayurvedic lines.
A PRELIMINARY STUDY ON THE PRINCIPLES OF
UDAYASHANKAR,
Gujarat.
Details of the methods adopted and the full results are presented in the paper.
Roga Bhaya,the fear of the disease, says Charaka (Sutra Sthana 11), can be
overcome by Bhaishajya, which is of mainly three types —Yuktivyapashraya,Daiva vyapashraya and
Satwavajaya. The former aims at Chemotherapy, surgery and other measures whereas the latter two
act at the level of mind. In Daiva vyapashraya, it is believed that cure is possible by Bali, Mangala,
Homa etc. satwavajaya is the best method to abstain from Ahita Arthas as it controls mind against
these thoughts.
--20 Cancer patients who had already undergone available modern and traditional
remedies in vain, were selected for the present study from the in patients ward of Shalya Salakya
Department.
--All the routine anticancer drugs were continued through out the present study.
Phase 1 : The spontaneous meditation was for 30 minutes by reciting the following Mantra along
with audio cassette HARI OM TAT SAT JAYA GURU DATTA.
Phase 11: Hypnotic suggestions for the next 30 minutes regarding the improvement in their general
well being and the protection of Almighty.
Observations :
B.T A. T.
Depression 100 20 80
Dejection 100 30 70
Insomnia 100 20 80
Anorexia 100 20 80
Suicidal tendency 80 20 75
Discussions :
The depression and dejection were assessed by looking into the activities of the patients;
inferiority complex and suicidal tendency were inferred by their talks whereas insomnia and anorexia
were evaluated by the quantity of food intake and hours of sleep.
All these six major symptoms of mental breakdown recorded significant improvements as
evidenced by the table above, it can be, therefore, postulated that the selected method of
Satwavajaya therapy helps for the bio feed back mechanism in the body leading to rejuvenate the
confidence and self esteem of the patients.
Conclusions :
It can be concluded from the present study that the adopted method of Satwavajaya can help
the terminal care cancer patients as it adds life to years, though it may not exactly add years to life by
reducing the psychological breakdown symptoms.
Acknowledgements :
Authors acknowledge the co-operation extended from Mr. V. R. Mehta, the vice chancellor of
Gujarat Ayurved University and Dean, Prof, H.S. Sharma is carrying out this research.authors are
grateful to the patients who underwent this course of therapy and the hospital staff.
CLINICAL RESEARCH ON CANCER
Ayurveda is the most sacred knowledge, it increases the life-span, energy and vitality
and it is alleviator of old age and diseases; and this knowledge came from Lord Brahma to Indra to
sage Bharadwaj.
Cancer is a disease caused by our own body; not by infection from outside and it is not
infective to others.
A disease called CANCER is notorious for the development of local recurrence or distant
metastasis even after a lapse of several years, therefore it is obviously rash to speak of cure in the
sense of a cure for all time.
The object of cancer therapy is to cure the patient or atleast to prolong his life and make his
life a tolerable one.
The human body is compromised of millions of cells with varied life span, while the brain
cells are life-long entities. A number of cells in other parts of the body have life-span ranging from 36
hours to a few weeks. We do not know yet the life span of a malignant cell.
As we know there are various known and unknown causes for cancer but I have developed
my own hypothesis – about “Disturbed metabolism” as a cause of cancer from my own experience in
the treatment of cancer.
The disturbed metabolism of a cell or group of cells, tissue or organ is due to faulty diet,
environment, hormones, minerals, vitamins and some changes in physiological functions of an organ
or tissue as per example in Breast-Cyst or adenoma of thyroid where their own secretion remains for
a long time, causing stasis—it leads to auto-infection, then to chronic irritation, all these produce
some metabolites, as call it original metabolities—these metabolites leads to irreversible intracellular
changes in the same place or in other organ or organs which are called malignant tumours.
This story or mine also explains why multiple primaries occur in the same patient.
1. Pancoast tumour of right lung and carcinoma of prostate with secondaries in right
humerus.
Original metabolite and tumour metabolities when they are modified in forms and given
they attack only the malignant cells wherever they are in the body without producing any side-toxic
Allergic or cumulative effect.
I have developed indigenous anticancer drugs which are non-toxic and equally anticancer
compared with available cytotoxic drugs. This is the presentation of my fifteen tears experience.
Since 1975,I have treated over 422 patients. Male 65%, Female 35%, Children 5%
,youngest was four years old and oldest was 85 year old. Over sixty percentage of patients belong to
age group 40 to 60 years,all these patients previously treated with Surgery, Radiation,Chemo-therapy
or combination and given up as terminal cases.
4. Breast Cancer—38
5. Gynecological Cancer—29
6. Testicular Cancer—3
8. Neurological Tumour—42
9. Endocrine—9
11. Sarcoma—8
8 Metastasis
The above factors were considered before giving the treatment, in all eight plants were used
for the treatment. The plant extracts was utilized in form of ;
1. External application
2. Internal Administration
3. In Enemata
These administration is done at regular intervals. Blood count and other investigation
were done during the course of treatment.
Drugs
No patient had any toxic or side effects,there was no mortality due to drugs used, even in a
single case.
Discussion
Present day Chemotherapy is very costly and toxic and recovery is not certain. Due to
improved life standard, the incidence of cancer is increasing in India. Therefore the only satisfactory
solution lies in developing successful indigenous drug treatment. I have made this effort, using plants
which are totally indigenous and these results are comparable to available cytotoxic drugs.
CLINICAL STUDY ON CANCER WITH SELECTED
AYURVEDIC DRUGS
Sr. DONATA
M.KESAVAN
KURIAN. P.CHACKO
R.SREEKUMAR
Kerala (India)
Introduction
Cancer is a disease which has got a long term process of development. Modern research
reveals that it may take about 8 years to develop a neoplasm or malignancy in the body. This period
of developmental changes of cancer is silent. So the patient gets awareness of this, life consuming
disease, only after complete invasion of the body. The advanced modern treatment like surgery,
chemotherapy and radiation could control the progress of the disease to some extend . Even after
long years joined effort with all scientific methods available under the sun, to control cancer, it still
remains as a dreadful disease with its death warrant in the depths of human minds. In Kerala 13% of
death is due to cancer. In India, Kerala is the top most in cancer incidence.
Ayurveda the science of life presents a disease viz.Arbuda which can be co-related with
cancer. Literally the word Arbuda is used to denote a mountain, shape of a hemisphere or a round
shaped mass or a lump in the body. In Rugveda this word is used to describe a serpant. According to
the teaching of vedic physicians Surutha and Charaka, Arbuda is an enormously growing mass which
has got similarities of normal body tissue. this disease manifests are an immovable hard mass fixed
with deep roots in the tissues, having little pain. They are of opinion that it seldom suppurates.
On the Basis of Vitiation of dominating Doshas and Dhatus, Ayurveda describes 6 types of
Arbuda viz. Vata, Pitta, Kapha, Mamsa, Meda and Raktarbuda. The literature gives detailed
descriptions of these types. Apart from these the authors describe various types of Arbuda as
organvise especially in head and neck and genital organs. The nomenclature is given on the basis of
affected organ and nature of appearance.
The Ayurvedic authors are of opinion that before developing a case into Arbuda it may pass
through 2 initial stages. Viz. Sopha and Grandhi. Charaka describes Arbuda along with sopha and
grandhi. Sopha is a distant precursor where as granghi which has got some similarities with Arbuda,
is the immediate precursor of Arbuda.
1. Sopha
2. Grandi
3. Arbuda
4. Adhyarbuda
5. Dwirarbuda
Usually Arbuda gets into abscess formation whether it is internal or external. Once paka is formed it
is classified under the group of vruna or vidradhi instead of Arbuda. The ancient Acharyas Susrutha
and Bhoja are of opinion that Arbuda may not get suppurated due to the dominating Doshas kapha
and medodhatu. But in Anjana Nidana, the author describes, Arbuda in its last stage develops to form
abscess and the disease in this stage is incurable.
The ancient Acharyas have seen through their experience that Arbuda in general is an
incurable (Asadhya) disease. But they have expressed hope. If the disease is in its early stage and
those which developed by vitiation of single Dosha, But this is a very rare incidence. The prognosis
also depends on the site and nature of Arbuda.
1. Vital points
2. Internal organs
3. Viscera
4. Body channels
6. Distent metastasis.
c) The age group and stage of affected person is also a valuable point in the prognosis of
disease.
1. child
2. Diabelitated person
Treatment
Arbuda is enlistend under the group of the disease which needs surgery. Susruthacharya the
famous surgeon of vedic period gives a detailed therapeutic process for pre surgical, surgical and
post operative treatment.
As stated before Arbuda is considered as a systemic disease due to the vitiation of three
Doshas, so the treatment principle is also of systemic nature. Before surgery the body is prepared
according to the dominating Dosha. For Vataja Arbuda external fomentation is advised to prepare the
body. Simultaneously the medicines and diet which regulate vata are to be given internally. For pitta
dominating Arbuda, purgatives, medicated Ghee and decoction of pitta hara dravyas are indicated.
For local treatment, cold poultice is recommended. In the case of Kaphaja type blood letting after the
preparation of body is advised. Poultice with erosive and alkaline natured drugs for local application is
recommended.
After the surgical procedure the wound has to be cauterized with alkali or specific cauterization
fire so that any particle or un removed tumour cells can be destroyed. Any tumour particle left
undestroyed or un removed would lead to fresh growth of tumour which may destroy the life like an
un extinguished fire. Hence it should be destroyed in its entity. After surgery the patient has to
undergo curative and regenerative therapy which will help to heal the wound and ulcer and regain his
health.
The object of the present study is to identify and evaluate the drugs and the therapeutic process
traditionally followed for the management of various types of Arbuda (Cancer).
1. Cancer patients
1. To evaluate the therapeutic process traditionally followed for the treatment Arbuda
( Cancer)
d) Duration of treatment __ The course of treatment was minimum for three months.
a) Medicine
b) Supportive Therapy
4. Nutritive and rejuvenative therapy —to improve the general health and immunity.
Vegetarian diet, fruits, green vegetables. Avoid non –vegetarian meals, hot spices, preserved
and tinned foods etc.
Table No. 1
1—10 2 3.64
11—20 1 1.82
21—30 3 5.45
31—40 5 9.09
41—50 12 21.82
51—60 15 27.27
61—70 9 16.36
71—80 6 10.91
81--90 2 3.64
Table No. 2
Incidence observed according to sex
Male 27 49.09
Female 28 50.91
Table No. 3
Hindu 29 52.73
Christian 15 27.27
Muslim 11 20.00
Table No. 4
Oral --20
Breast --5
Rectum --3
Cervix --4
Vagina --2
Liver --2
Intestine --5
Pharynx --4
Prostate --1
Pancreas --1
Bone --1
Thyroid --1
Ovary --1
Kidney --1
Lymphoma --1
Total : 55
Observations
Cancer Breast -- 3
Cancer Cervix -- 2
Cancer Pharynx -- 2
Cancer Thyroid -- 1
Embryonal Sarcoma -- 1
Olfactory Neuroblastoma -- 1
All these patients had undergone treatment in Oncology department previous to Ayurvedic
treatment. At present the disease is under control. Since 8 years there is no evidence of secondaries
or metastasis. At present they are taking Varanadi quathum.
1. Oral Cancer
Habits
prakruthi
Vatakapha 50%
Kaphavata 35%
Others 15%
previous treatments
Surgery 6
Radiation 17
Untreated 3
Nature of lesion
Pain reduced
11 pharynx
No. of cases 4
Prakruthi
Kaphavata 2
Vatakapha 1
Kaphapitta 1
Habits
Alcoholics 0
Smoking 4
Chewing 0
Previous treatment
Surgery 2
Tracheostomy 2
Response
Expiry –2 ( One case expired after 6 years due to heart attack. Second case was on Stage IV and
expired after one year. )
111. Breast
No. of cases 5
Multipara 4
Nullypara 1
Pradruthi
Vatakapha 3
Kaphavata 2
Stage at trial
Stage 1 1
Stage 11 2
Stage 111 2
Ulcerated lesion 2
Response
1V Intestines
No. of cases -- 4
Previous treatment
Byepass surgery -- 3
Laparotomy -- 1
Response
Regular bowels -- 5
No. of cases -- 3
Prakruthi
Vatakapha -- 2
Vatapitta -- 1
Response
Age 1 ½ years
Sex -- Female
Previous treatments –Chemotherapy –6 months back. There was no response. So advised for
surgery.
Condition on admission
-- paraplegia
--Incontinence of urine
-- Bowels-severely constipated. Hard stony faecal matter was palpable on large bowels.
-- Scoliokyphosis in the size of 4×2 inches towards the left at lumbar level.
Response of treatment
After two weeks treatment voluntary movements started on big toes . By three months
treatment free movements of obtained on the legs. The size of the tumour reduced. The child could sit
with support. The tumour regressed completely after one year and the child started to walk with
support. At present the child goes to school regularly without support.
Selection of cases
Patients were selected after diagnosis confirmed by histopathological study. All types of
leukaemias and blood diseases were selected.
Medicine
4. Light diet -- till regaining appetite and proper digestion (Agni deepti)
After this process of eliminative therapy, the following regime of threatment was given. Those
who are weak no elimination treatment was given. They also will be given the treatment given below.
Supportive therapy
3. Leukaemias having acute nature. It was found difficult to manage emergency conditions with
Ayurvedic medicine. So they are allowed to follow modern medical facilities. After solving the
immediate problems they used to continue Ayurvedic treatment.
Diet
Vegetarian diet, fruits, Avoid hot spices, acidic dietary items tinned and preserved food materials.
Table No. 1
M F H M C
4. Idiophathic Thrombocytopenic
Purpura 2 1 2 1 0 03
5. Aplastic Anaemia 2 0 2 0 0 02
24 6 20 5 5 30
Table No 2.
1—5 5 1 0 0 0
6—10 3 2 0 1 0
11—15 2 2 2 1 2
16—20 1 1 0 0 0
21—30 0 0 0 0 0
31—40 0 3 00 0
41—50 0 0 2 0 0
51—60 0 0 0 0 0
61--70 0 0 0 1 0
Total 12 9 4 3 2
Observation
|. The following patients are still continuing medicine to preserve their healthy condition.
Three cases of Chronic myeloid leukaemia,one case of Idiopathic Thrombocytopinec purpura and one
case of Apalastic anaemia.
These patients are moderately healthy and engaged in professional or student life.
||. one case of Idiopathic Thrombocytopenic Purpura expired after 5 years and one case of
Aplastic anaemia expired after 7 years of treatment. They were regular students till two days before
their death. The I.T. P. and Aplastic anaemia cases were referred from paediatric department of
Amala. Before starting Ayurvedic treatment these patients were getting blood transfusion 1 —2 times
in every month. Their general condition was so poor and weak that they could not walk a short
distance of about 25 meters.
After giving hospitalized treatment in the Ayurvedic unit their general condition improved.
Duration of interval for blood transfusion increased by 3 months. After this no blood transfusion was
needed till now. They started regular school life. Their body weight and height increased according to
their age. They could walk 1—2 Kms.to their school at a stretch and play with boys. But their blood
picture showed no improvement.
e) One of the Aplastic anaemia patient stopped education due to financial problem and
joined in a diamond cutting institute to earn for his lively hood.
f) The three cases of chronic myeloid leukaemia are in moderate health with their
professional life.
6) Extertional dyspnoea and palpitation reduced. So the patients exhibited more interest to
walk
around.
GROUP -- ||
Aim -- The aim of this clinical study was to evaluate the therapeutic action of the selected medicine
on cancer patients.
Selections of patients
The clinical study on the second group of cancer patients were started on 1.4.1985. as in
the previous group study all types of cancer cases confirmed yy histopathology were selected
irrespective of their site and stage.
Medicine
All these three combinations are highly recommended for the treatment of Arbuda.
Dose
( Decotion of 60 gm. Of chopped medicine, was given daily in two divided doses)
Clinical observation
3. Gastrouble reduced __ distension of the abdomen in the evenings was relieved (28/34—
82.35%)
7. Tumour reduction was not observed more than 25%. But there was an initial response with a
reduction of pain and swelling in all cases who had external session in oral cancer patients. (3/5).
10. E.S.R. reduced by 10—30mm in the 1st hour, after 3 months in (10/39—25.64%)
Conclusion
1. This disease has mainly affected the persons while he was on vatakaea or elderly person who
were in the declining period. But the dominating sites were on kapha stanas.
2. The leukaemia patients were on their tender periods, ie kaphakala. Where they have not yet in
full grown stage. This budding is prone to kapha dominating diseases.
3. In pittakala between the age of 20 —30 this disease was comparatively in a lower rate. Pitta
stanas have only a few incidence of cancer. This age groups are more resistant to all types of
diseases.
5. Any disparity between the residential area viz jangala, anoopa and sadharana desa were also
could not be detected among the patients.
Table No. 1
0--10 3 7.69
11—20 2 5.12
21—30 1 2.56
31—40 4 10.25
41—50 10 25.64
51—60 7 17.84
61 above 12 30.76
Table No. 2
Male 19 48.72
Female 20 51.28
Table No. 3
Hindu 19 48.72
Christian 10 25.64
Muslim 10 25.64
Table No. 4
Oral 9 23.08
Cervix 2 5.13
Breast 5 12.82
Intestine 2 5.13
Larynx 3 7.69
Vulva 1 2.56
Lymphoma 1 2.56
Hepatoma 1 2.56
Myxipappillaray Ependymoma of
Astrocytoma 2 5.13
Pancreas 1 2.56
Oesophagus 1 2.56
Total 39
Laboratory investigations
1.5 gm%
2. Leucocyte counts —Total and differential counts recorded were within the normal
limits before and after the treatment in Cancer cases.
4. Blood urea – There was no specific change before and after treatment. The
marginal change was ± .5—1.5mg.
30—39 9.5%
20—29 4.25%
01—19 8.5%
Kaphavata 34.08
Others 15.90
General Response
--Tumour regression was only below 25% at an average. Only two cases got 100%
Tuomur regression
Properties of medicine
guru 15.3%
Veerya Ushna 86.6% Seetha 15.4%
Dosha samanatwa
Kaphavata 92.3%
Vatapitta 7.6%
Pittavardhana 7.6%
Classification of drugs—The ingredients of medicines used for the clinical study was classified as
follows:
Out of these drugs the following are found as anticancerous on experimentas study :
1. Curcuma longa
2. Zingiber officinale
3. Sesamum indicum
4. Allium sativum
5. Moringa oleifera
6. Asaphetida
7. Embilica officinalis
8. Tinosphora cordifolia
9. Terminalia chebula
10 Hemidesmus indicus
The following drugs were supplied in the form of capsules from Captin Sreenivasamoorthi Drug
Research Institute Madras.
These drugs were tried on head and neck Cancers stage ||| and |V.
Dose
Initially the dose was fixed as one capsule twice daily. On getting the response of the first
group, it was decided to increase the dose.
Method of study
The diagnosed cases were selected from OP and IP sections of Oncology and Ayurveda
departments.
Minimum 10 cases were studied in each group. The period of study was 3 months for each
drug.
Dose –1 cap. Thrice daily—in each group. Later on this dose increased to 2 Tds and 3 Tds.
The patients were admitted in Oncology department of Ayurveda Unit according to availability
for one week to start the initial dose. After this, according to the condition of patients they may or may
not discharged. In OP cases weekly check up was insisted. Laboratory investigations were done at
monthly intervels.
Observation
Within three months of treatment there could not record any reduction or arrest in the size
of the tumour in these three groups. The measurements indicated a gradual increase in the tumour
size.
2. Slough formation
In two cases slough was dried after the administration of B-Solamarin but the size of the
lesion increase gradually. In other cases there was no change in the condition of external lesion.
3. Pus discharge
Reduced for two weeks in 10% cases. But gradually this was increased and there was no
response on further medication.
Pain—dose of analgesics reduced in 15%patients for 10—15 days. Since the disease was
on progress they had to increase the dose.
Swelling – There was 25—50% reduction of swelling in 31% cases. This was a temporary
response for 2—3 weeks.
The clinical changes presented were more or less symptomatic and temporary.
Dose of medicine
The dose of medicine was one capsule thrice daily. Seeing the result on first group study the
dose was increased to 2 cap. thrice daily. Since the result of second trial was not satisfactory the
dose increased to 3 cap. thrice daily. This study was conducted with all the three drugs. There was
no marked change after increasing the dose of medicine. No toxic effect was noted in the patients
subjectively or objectively.
TREATMENT
Dr. SYAMALA
Lecturer,
V. A. C. Ollur, Trichur.
Abstract :
Descriptions about the aetiopathogenesis of cancer and allied conditions are available in
Ayurvedic classics. Very much explanatory descriptions about conditions as angiomas (Siragranthi),
leukemia (Raktapitta) etc. and their prognosis and secondary lesions or metastasic (Dwirarbuda) etc.
are available in looks like Sushruta ,Samhita. There are several Ayurvedic drugs (Single & compound
drugs ) used for the treatment of cancer which will be dealt with while presenting the paper in the
seminar.
The cancerous growths which can occur in female genitalia are that of
Bahyayoni(Vulva,Vagina etc.), Antharayoni i.e. ,Garbhashayagreeva (endometrial)
Andashaya(ovaries) etc. Ayurvedic classics are written in ancient time i.e., in an era in which science
and technology were not much developed. As newer scientific techniques are available nowadays to
diagnose and identify the progress of the diseased conditions, the knowledge about the same will
help us in its correct diagnosis and management.
As cancer of cervix is observed to be the most common cancer of female genitalia, I shall
first deal with the general concept about its aetiopathogenesis ,diagnostic measures and treatment
etc. to be undertaken.
3. Invasive carcinoma
Amoung these the first two can be included under Mamsarbuda with predominance of
Kaphadosha and the third one that of the same first, then changing to Pittarakta and then to Vatika.
Aetiopathogenesis
Clinical observations done on cancer cervix cases have shown that the following causes are
specifically responsible for the same. Coitus is said to be having the prime importance in its
causation. Spermatozoa is considered to act as a carcinogen in cancer of cervix.
b) Early marriage i.e. women who had their first coitus and pregnancy before 20 years.
pathogenesis ( Samprapti)
The Mamsarbuda ( cervical tissues) getting vitiated due to the above mentioned factors or
other factors for vitiation of Kaphade doshas gets inflamed (shopham)with the colour that of the same
type of tissue, painless, smooth, unsuppurative fixed like a stone (Su. Ni. 1.22)
According to modern science, in cervical dysplasia, squamous like metaplastic columnar cells
or atypical intraepithelial cells grow from basal part of the cervix i.e., from portio vaginalis to vaginal
part of cervix to 2/3rd of the thickness of cervical tissue. In pre-invasive carcinoma 75 —90% of
atypical cell growth takes places, where as in invasive carcinoma, the atypical cells penetrate beyond
the basement membrane to parametrium, ligaments, bladder, rectum etc. and to distant organs as
ovaries etc., by metastasis (Dwirarbuda or Athyarabuda).
1. Cervical dysplasia :
Clinically no signs or symptoms will be assailable but rarely the patient may complain of
a) Coital bleeding
b) Bleeding on defaecation or urination
d) Persistant white discharge or non- healing cervical erosion after cauterization may also
be detected in some cases.
Invasive carcinoma
menopausal Intermenstrual.
smelling.
Per vaginal examinations will show vascular papillary growth which bleeds on touch (Su. Ni. 11/15)
In advanced cases : Vascular growth appears as cauliflower arising from cervix which spread
to vagina, which are friable, bleeds on touch & may have foul smelling discharge.
(Mamsankurairachitamasu Urdhim Karotyajasram Rudhirapravarthim)
Mobility of uterus will be present in early stages but absent or restricted in advanced stages.
On per rectal examination : Parametrium and rectal wall will be felt hard.
Diagnostic measures
The following are the diagnostic measures useful for diagnosing various types of cancer of
cervix.
1. Cytological
( papinicanl’s stain)
b) Haemorrhage
d) Fever
h) Pyometra etc.
MANAGEMENT (Chikitsa)
1. Prevention (Nidanaparivarjan)
The exact cause of cervical cancer is still unknown. Nevertheless, complete chasity is
associated with almost total freedom from malignancy. The incidence of cervical cancer cancer can
be reduced by the following health measures.
a) improved personal hygiene : Use of candous, Pre-coital washing of penis, prevention &
b) avoidance of intercourse
in an early age : Avoiding early marriage and pregnancy, frequent coital practice
c) frequent cancer outscreening of all women specially women in deprived social circumstances and
those who had many several partners.
Vyadhi vipareetachikitsa
The following are the measures adopted by both the systems of medicine.
Ayurvedic allopathic
a) Cervical dysplasia
(Purifying measures) or
Cryocautery
Agnikarma Surgery
Shastrakarma
surgery is contraindicated.
Invasive carcinoma
Clinical experience
While working in S.S. Hospital B.H.U, I was able to observe about 200 cases of
Garbhashaya greevarbudas (Carcinoma Cervix). Among them 3 cases were of cervical dysplasia, two
of pre-invasive and rest carcinoma. As we were not much interested in treating cancer cases with
Ayurvedic drugs,abdominal hysterectomy was done as a preventive measure in such cases.
Ksharakarma with Snuheekshara (Euphorabia niruri Linn) was done thinking that of cervical erosion
(Kamala) after sending smear for cytological studies.
After Ksharakarma, pichu (tampon) with udumbaradi taila was given to be kept in vagina for
6 hours and then Utharavasti with Thriphala kwatha for 5 days.to our utter surprise, the case was
reported to be that of cervical dysplasia and papsmear tests were done at 6 weeks intervals but no
any dysplasia was detected during the fellow up period.
All other cases were of invasive type that too advanced cases of stage ||| &|V in which the
patients were lean and thin above age group 45, with unhygienic character with foul smell.
Multiparity, early marriage, deliveries happening in frequent succession, malnutrition,
unhygienic character etc. were observed to be the causes of cancer of cervix. All the cases were of
lower socio economic class.
Per speculam examinations showed the cervix to be irregular unhealthy friable which bleded
on touch and, cervix was adhered to the fornics.
Cervical punch biopsy was taken for histopathological studies and the cases, were referred for
radio theraphy. Along with that Rasayana therapies as Chyavanaprasha, Narasimha rasayana,
Kooshmanda rasayana erc were given.
Along with that Lohasava and Draksharishta to combat anaemia and to relieve the conditions as
cachexia etc. were given helping to withstand radiotherapy. Saraswatharishta was also advised in
cases having anxiety, insomnia etc.
So in my opinion the available modern techniques must be accepted and adopted by Ayurvedic
Practisioners also for correct diagnosis and proper management of the disease. Carcinoma of cervix
can be cured by drug therapy (by Ayurvedic drugs) if it is in early stage i.e., in cervical dysplasia and
in advanced cases, if both the systems are applied in union can increase the lifespan of the patients.
AYURVEDIC MANAGEMENT OF AN INOPERABLE CASE
Bangalore .
Abstract :
A male aged 31 years with a history of fever, Diabetes mellitus, hypochromic anaemia and a
mass in the left iliac fossa in an inoperable stage sought Ayurvedic treatment. Fever, which was
teriodic, was treated first followed by the treatment of hypochromic anaemia. Simultaneously
treatment for diabetes mellitus was also begun. The patient was dependent on insulin and after the
introduction of Ayurvedic medicines insulin was withdrawn gradually. The growth of the mass was
also checked and the patient was brought to an operable state. Subsequently he was operated upon
for the mass in the abdomen.
Ayurvedic diagnosis, treatments given and the effect of Ayurvedic medicines are discussed
in the paper.
CASE HISTORY
Mr.S. aged 30 years, moderately built, vegetarian with no habits of smoking or drinking
alcohol, working as a Junior Engineer supervising the job of machinery erection, unemployed since
one year due to ill-health presented the following history in May 1987.
1. Fever on and off since 1.5 years of moderate degree not associated with rigors, subsides
with treatment and reappears.
On examination :
Abdomen –spleen enlarged (2 cm). Hard fixed mass in the left iliac fossa, irregular in shape, non –
tender, dull on percussion. No ascitis.
HISTORY OF PREVEOUS TREATMENT
The patient was undergoing the following treatment when he came for Ayurvedic
treatment.
3. Vitamins.
It was also reported that the patient was treated with antimalarial drugs, sullphonamids,
chloromphenical, antidiarrhoeal and antitubercular drugs.
PRE-THERAPY EVALUATION
1. Chest X-Ray
NAD
Spleen appears enlarged pushing left kidney downwards kidneys, Ureters and bladder normal.
Impression : Splenomegaly.
A spherical hypoechoic mass with central cystic area in left iliac fossa measuring about 5.8 cm.
The retroperitoneal mass was variously diagnosed by different pathologists and Oncologists as
neurilemmoma, liposarcoma, lymphoma, neurofibroma and liomyoma.
5. Marrow Examination __
No evidence of malignancy.
6. Other Tests—
Haemoglobin 7.5G/dl.
ESR 80 mm
AYURVEDIC DIAGNOSIS
Based on the history and clinical examination the patient was diagnosed according to Ayurveda as a
case of :
1. Madhumeha
2. Visamajavara
3. Gulma
4. Pandu
5. Plihodara
AYURVEDIC TREATMENT
All the other medicines were stopped except insulin. Ayurvedic treatment was started for Jvara
first. There was no recurrence of fever after 3 weeks of treatment. Following this, treatment for pandu,
plihodara, and madhumeha were started simultaneously. Insulin dose was gradually tapered from 52
units per day to 24 units per day and later blood sugar level was kept within normal limits with only
Ayurvedic medicines. At this stage treatment for gulma was also started.
The quantities of medicines used, for different disease conditions are shown in Table —1. Each
medicine was administered until the specified quantity exhausted.
Table -- 1
DISEASE CONDITIONS
Disease Total Dose per
Kaisora Guggulu 50 gm 1 gm
Both kidneys normal. Mass in the left iliac fossa, solid in nature with central transonic
cavity,measures 5.9cm. centrally.
2. on Examination –
Performance Status 1.
3. Other Tests _
Haemoglobin 14/dl.
ESR 5mm.
DISCUSSION
It is clear from the post-therapy evaluation report that Ayurvedic treatment had brought about
the following changes.
6. Blood sugar level was controlled and maintained within normal limits.
The patient was operated for the mass in the left iliac fossa in a private nursing home after a
couple of months. Post- operatively the patient is reported to be free from all the ailments since 1½
years.
The positive changes observed in this case are in conformity with the scriptural descriptions of
the effects of Ayurvedic medicines used. The effect may be attributed to a concerted action of the
medicinal preparations.
CONCLUSIONS
2. Tumour growth can be arrested by the use of proper combination of Ayurvedic medicines.
Further clinical evidence is needed to establish the role of Ayurvedic medicines in the
management of tumours.
ACKNOWLEDGEMENT
The author is indebted to Dr. (Mrs.) Bapsy and Dr. B. V. Kumaraswamy of Kidwai Memorial
Institute of Oncology, Bangalore, for their kind guidance and assistance in evaluating the case.
References
1. The Ayurvedic Formulary of India,Part —1, 1st Edition, Ministry of Health and Family
Welfare, Govt. of India, 1978.
Abstract :
After the industrial revolution of the west, the health pattern of the whole world has been
gradually changing. This new civilization has advanced very rapidly. Therefore many diseases
appeared ,Cancer is the biggest challenge of this century.
Ayurveda is the ancient science of life. Some Aurvedic text written more than five thousand
years ago have mentioned details of cancer (Arbuda) its causative factors and remadies. Vagbhata
mentions about cancer of mouth, tongue, eyes, nose, breast and uterus. Charak mentions it as
protrusion of flesh into flesh. Susrut samhita deals with finer details of cancer. According to Tridosh
Theory in Ayurveda all the disorders of body are due to the disturbances of any one of the following
i.e. vayu, pitta and kapha. The doshas are affected to blood and Skin known as Raktaj doshas, the
basic fundamental units for developing tumour growths.
The U.P. Himalaya finds mention in ancient religious books of India. In this context authors
mentions certain traditional medicines locally used for the cure of Arbud and Chronic ulcers from this
region like Beriberis aristata, Berberis asiatica, B.lyciun, urtica dioica Linn etc.
Deep study and critical analysis of various diseases mentioned in ancient and medieval Indian
medical texts clearly indicate that cancers are the kinds which fall under the group ‘Arbud ’ which
means malignant formation of cells forming tumours or deterioting and destructing matural, cells of
animal system (though all the arbud’s are not fatal). Ayurveda also describes the types like
‘Karkatarbud’, ‘Raktarbud’, ‘Mamsarbud’, ‘Jalarbud’, ‘Talwarbud’, ‘Galarbud ’, ‘Sirarbud ’,
‘Sisnarbud’, ‘Yoniarbud’ and so on. The ancient Ayurvedic Surgeon ‘Susruta ’ has prescribed the
operation of ‘Nasarbud’, cancer or nose 1,2,3.
Carak, Susruta, Vagbhata etc,have described this disease at many places in their Granthas’
and ‘Samhitas’ 4-15.
The father of the modern medical science Hippocrates have described the cancer and its
treatment 1400years B.C. Cancer of the breast was treated through operation followed by
cauterization by Greek surgeon Leonides 180 years BC. Roman physician Gallen 200 A.D. also
mentioned the symptoms and identifications. It is very interesting fact for the present medical
research that the Mummies and papyris 1500-3000 years BC. When gone through the process of
research,it was discovered that the cells and tissues of bone were found effected by cancer.
After the cardiad 2, 16 17,diseases, cancer is the second biggest biller in the world. At the present
rate of its extensive attack, if not controlled, by 2000A.D, the world shall see 90 lakhs of cancer
patients out of which 30 lakhs shall come from developing countries. 43 lakhs shall die each year out
of which 25 lakhs will be from the third world still more than 90% cancer patient come from
economically and educationally backward classes. In big industrial towns where the air, water, soil
and other types of pollutions are the common features 17, out of one lakh, 85 people suffer from
cancer with a increase of 5 lakhs every year.
Besides the human beings, animals and birds also suffer from the cancer. 200 body parts
are attacked by cancer in different intensity.
At present the science which studies cancer is called Oncology which indicates that the
main cause of the cancer is disturbed bio-chemical reactions in the body are through careful standard
living effective control can be achieved. Cancer is the result of conspiracy of first time immunological
forces of the body against its own cells. In the normal conditions these forces fight against canser
gene or ossogene which are also made from DNA. In the case of conspiracy this nucleic element
changes its properties and helps in forming cancer cells spread fast and grip the attacked tissue of
system. Susruta says as the remains of fire further spreads the flames similarly the poison left by
‘arbud’ cells multiplies to spread it to fatal limits.
The prime factors responsible for growth and development of cancer are
Cancer is found more after the age of 40 years and maximum intensity of attack between 50-
60 years of age. Anaerobio conditions because of improper exhilation and outlet of CO 2 and other
gases in the body also helps the development of cancerous cells and tissues. Occupations where
workers are exposed to radio-active rays and little carelessness can mulate the genes and cancer
cells can grow and develop easily. It is now more or less established and realized that excessive use
of alcohol, tobacco, synthetic cosmetics, perfumes, synthetic medicines are directly responsible for
increased incidence of cancer. Excessive use of chemicals,fertilixers, insecticides, fungicides and
man’s tendency to keep him self at a distance from the nature are very injurious to health and these
probably by weakening immunity mechanism and inducing toxicity are helping the dreaded disease to
tighten its grip on human and animal life. Whereas for over coming the cancer and defeating it, a
foresaid factors shall have to be carefully looned at, it will also be timely to record some folk and tribal
medicines which should be experimented for finding cure and control of this disease.
4) Detailed research work 19 has been conducted with ‘Bankarkat ’ or ‘Bankakri ’(Podophyllum
hexadrum Royle) and ‘Sadabahar’ (Vinca rosea L.) for their curative properties against the different
types of cancer many positive results has been achieved.
While concluding, it will also be timely to give a list of some medical plants which has been
mentioned to conta in controlling and curing properties against the cancer in various indigenous
systems of medicine20.
Authors, who have ruveyed different regions of India for ethno medico botanical purpose, feel
that there are many pockets like Assam and Garo hills in N.E. region of India. Tribal pockets of south
Mirzapur, higher reaches of Western Himalayas with essence of Buddist —Tibetan culture which can
give further more information on folk tribal medicines and treatments for cancer. Many samts and
‘Yogis’ in Himalayas and elsewhere know effective medicines against ‘Asadhya rogas ’ (diseases
normally considered incurable) who if approached in proper way can give valuable informations for
cure and control of the dreadful disease cancer.
Authors are higher thankful to Dr. V. N. Pandey, The Director, C.C.R.A.S., New Delhi for his
keen guidance and encouragement on collection of folk and tribal medicines regarding disease and
ailments on scientific lines from farflung and remote areas of the nation.
References :
5. -- Srsrut Nidan —
6. – Sushrut chikitsa —
18/29-39; 18/41-42
8. -- Carak Chikitsa—
Misra A.K.
19. Tiwari K.C., Pandey V.N., Cancer ki etihasik prastabhum evem lok prachilit
Nov.1989.pp. 275-277
20. Uniyal M.R., Pandey V.N. (Karkatarbuda) Cancer ka sapeksya midan evam
PHYLLOCIDOS
Pattambi.
Abstract
The aim behind this article is to share my experience on a rare disease and also seek various
expert opinions of the managements from the scholars and practitioners, with our medicine and
treatment, if has any.
Cystosarcoma phyllocidos is rare disease seen in females only. Most of its features like rapid
growth tendency to Ulcerate and bleed, fungation of the ulcer, etc, are so identical with carcinoma of
breast—Though it is purely benign in origin —But unless effective treatment is made 1/4th of the
cases may show malignant changes and even metastasis. This disease usually seen between the
age of 40 and 50. The existing effective treatment in modern medicine is simple or Radical
Mastectomy.
Hope the scholars and eminent physicians will exchange their views on this rare disease.
Here I am presenting a case history of a rare disease, which I came to met within
the short period of my practice. The main aim behind this article is to share my experience with my
friends, whom didn’t get a chance to come across this disease and also to seek the various opinions
and aspects of management with our medicines from the Scholars and Practitioners, those who had
got an opportunity to treat this type of disease with a positive result.
This is a case of young lady of 28 years old, having Poliomyelits of both legs from her
childhood onwards. Beside this she is congenittaly mentally retarded also. Though she is having
above difficulties, she can sit up and do her needs by herself, and also communicate with her family
members for her needs. Her nutritional status and general built is satisfactory except the atrophy of
leg muscles due to the polio. Her menstrual period are regular and normal.
Nearly 11 months back her sister came to my clinic and complaint that this patient has
suffering from fever and rigor, and requested for a house visit. I went there and examined the patient.
The patient was shivering and the temperature was 102 o F. All other systems were within the
normal limit. Though I suspect filarial fever. , I gave some medicine for fever only. After two days her
sister informed me that the fever has subsided and the rigor was settled, but now she complains of
pain in the left breast. I went and examined her both breasts and found that the left one was hot and
tender. There was an area of reddish discolouration in the lateral lower quadrant. Diagnosing as acute
mastitis I advised some external application also. After two days the temperature and pain has come
down. But I can feel the fluctuation of pus in the left breast. I incised the abces and drained out about
150ml of pus and bloody discharge and examined the cavity , which is about 4 ×4cm in depth and
diameter respectively. There was no septa and I plucked the cavity and gave medicine. Dressing was
changed daily. After 5 days I examined the breast and found that the cavity remain as such and
ulcer was not showing any tendency towards healing. In addition to this, the size of the left breast has
slightly increased and its base become mildly hard with irregular surface. 55 more days have gone
like this. On 6th day I noticed that the whole breast has lost its softness and become moderately hard.
The ulcer also increased by 1 cm in diameter, though the cavity remain as such. Thinking a 10%
chance for malignancy I once again examined all the systems thoroughly. The whole breast feels hard
with irregular surface. Small protuberance can feel beneath the skin. The mass was not infiltrated to
deeper structure and can easily slide over the pectoral muscle. The veins on and around the breast,
are clearly visible and palpable. The cervical supra clavicular and axillary lymph nodes are not either
enlarged or tender. The liver and speen are not palpable. There was no oedema on her left arm. All
other systems were found to be normal. Ulcer was clean and there was no pus and only slight serous
discharge was present. Suspecting the prognosis in treating as a O.P. Case and also to rule out any
possibility of malignancy I advised and referred to the local hospital. But they not only refused the
hospitalization, because of their poor economically and family backgrounds, but also begged to
continue the treatment. I explained my risks and difficulties in treating as a O.P. case and suggested
to seek a second opinion of any Experts. On their request I gave a referral letter to Dr. Viswanathan, a
First Grade Civil Surgeon in the local hospital. Next day he came to my clinic and enquired the
details. After that both of us together made a visit. He examined the patient and ruled out the
possibility of carcinoma. Even then, he cannot diagonise it exactly. Suspecting two chances of either
cystadenoma or filarial breast with secondary infection, he also advised to shift to the hospital. But
again they expressed their extreme inability to do so. Then he also explained all the possible risks
and sequelsof the case. He prescribed some antibiotics and anti-inflammatory drugs for 20 days and
advised daily dressing. He himself made arrangement for dressing by a qualified nurse. After 15 days
we again examined her. But , the ulcer has again increased by 1cm in diameter and there was some
areas of black recrossed tissues in the ulcer. The ulcer bleeds ontouch. There was no pus and
copious serous discharge was present. The cavity is already filled up. The size of the breast has
almost doubled. We advise to examine the urine and blood. But the result didn ’t show any
abnormality except slight reduction in Hb% (10.5grams %) and mild albuminurea. The E.S.R.was 25
MM/hr. Once again we forced them for hospitalization. But all are in vain. Explaining the poor
prognosis we decide to continue the treatment. One more month later we examined her and found
that the size of the breast is increased by 2 fold and the ulcer also considerably enlarged (about 7cm
in diameter)with an everted margin. The left breast weighs about 1.5kg. and part of the nipple is
eroded by the ulcer.the ulcer began to fungate. Due to my clinical interest and curiosity I suggested
for a biopsy. Dr. Viswanathan took the specimen and sent for biopsy. The biopsy result is as follows:
“ Sections show breast tissue with few lobules of acini and dilated ducts, all are lined by
uniform cuboidal cells. Stroma shows interlasing bundles of markedly poleferated spindle shaped
uniform sized cells. One area shows abcess walled by inflammatory granulation tissue. No evidence
of malignancy”.
Before entering to the details of the disease a brief description of the anatomy and physiology of
the breast may help better understanding.
BRIEF ANATOMY AND PHYSIOLOGY OF BREAST :
The breast lie in the superficial fascia on the pectoral region between the sternum and axilla and
extend from 2nd to 6th ribs. They enlarge at puberty and atrophy in old age. The breasts are convex
anteriology with a nipple n the middle encircled by a tinted areola. The nipple is perforated by 15to 20
orifices which are the milk ducts of the gland.
The breast consists of alveolar substance arranged in lobes separated by fibrous, connective
and fatty tissue. Each lobes further divided into lobules which consists of a cluster of alveoli opening
into tubules or lactiferous ducts. This ducts unite each other and form a larger ducts when this larger
ducts approach the nipple they expand to form reservoirs for the milk, called lactiferous sinus which
then narrow and open on the nipple.
According to “Baiely and love ” this tumour is classified under massive tumours of breast.
Others are diffuse hypertrophy and sarcoma of breast. The Greek Word phyllocidos means leaf like,
because there are branching of projections of the tumour into the systic cavity. The origin of the
tumour is not a specific entity. But the outcome of systic degeneration of fibroadenoma into cyst
adenoma may proceeds in some cases and a cysto sarcomaphyllocidos results. This disease can
appear at any age above sixteen year and frequently seen between 40 and 50th year.the striking
feature of this neoplasm is its tendency to grow rapidly and attain a great size(see the figure 1).
Nevertheless it is surroundered by a capsule. The surface of the tumour is unevently bosselated with
areas of softening and even fluctuations in the larger convexities. The overlying skin is thin and tense
and large veins can be seen coursing beneath the integument. Occasionally, in very large tumour,
due to rubbing or pressure up on it, the skin ulcerates. When the tension is greatest and if the capsule
become eroded, the tumour protrude as a fungating mass (which is happened in this case see figure
2). As a rule the tumour is adherent neither to the skinnor to the deeper structures.
On occasions there is serous discharge from the nipple. Axillary lymph nodes are not
enlarged except secondary infection occurs. Through the tumour is benign in nature about a quarter
of cases, the tumour may undergo sacromatus changes and give rise to distant metastasis. The
malignant change take place in the stroma not in the glandular tissue. The treatement is simple or
radical mastectomy with post operative radio therapy through its value is doubtful. This tumour is also
known as Serocystic disease of Bordie.
Aftyer one more month the breast weighs about 1.75kg. and the ulcer has achieved the
size of 10 x 10 cm. the whole breast is hanging as a separate component ( See the figure 1). After 8
month of continues treatement to check and control the secondary infection (the only medical
treatement available in modern medicine for this) the tumour has continued its growth and it weighs
about 2.75Kg. (the normal right breast weighs only about 600gm and the ulcer is 14 x 12cm in size
and medically speaking the ulcer is “clean ”. The patient can hardly sit up due to the heavy mass. In
spite of good food, oral protein and iron suppliments her nutritional status has come down. Nutritional
oedema dewvelops all over the body especially on depended parts like buttock, sides of the chest and
legs. The skin on the remaining parts of left breast become pitted in appearance (Peau d ’ orange like
appearance). The whole mass feels remarkably hard with irregular surface. After two months, the
patient died on account of pulmonary odema and cardiac failure.
Due to lack of adequate knowledge and the controversy of the term “Arbuda ”, I didn ’t like to
attempt to compare this disease without terminology. Though some of the symptoms of arbuda and
Grandhi are seems to be identical with this, of course most of the symptoms differs from it. I request
the scholars to consider this matter also. I kindly request once again to my friends, teachers and
scholars to share their experience about this disease, if had any.
Before concluding the article I use this occasion to thank to Dr. Viswanathan who has taken a
keen interest in this case and also helped me extensively
CASE REPORT
SREEKUMAR.T.,
M.D.(Ay).
Dept. Of Shalakya,
Ollur – Thaikkattussery,
Abstract
Cases of squamous Cell Carcinoma following Fistula-in-Ano not been seen reported (though
fistulae following carcinoma of rectum are common). Such a case is being reported here. The non-
healing, hard ulceration with everted edges and induration, found associated with multiple fistulae-in-
ano of prolonged chronicity was clinically labeled as neoplastic and subsequent biopsy proved it to be
a squamous cell carcinoma of Stage – 1.
The effect of BHALLATHAKA KSHEERA was found worth trial and was given. But, though the
drug brought out some symptomatic relief by 14 days treatment, due to constitutional problems, it had
to be discontinued and the patient was discharged. The drug appears to be effective in such cases
besides it being cheap. Further prospective studies in this field are welcome.
Interventions : The patient was given Bhallathaka ksheera and the therapy was expected to be
Parameters : Reduction in the exudates through the multiple fistulous openings, reduction in the
Results : Though the drug brought out some symptomatic improvement, it had to be
withdrawn
Conclusion : Although the efficacy of Bhallathaka ksheera in squamous cell carcinoma is not
Proved by this case alone, it appears to be effective in such cases. It is cheap also.
Introduction
Multiple fistulae in ano results from a host of infections ans inflammatory conditions, besides it
heralding the presence of carcinoma of the rectum. But fistulae itself is not mentioned to precipitate
malignancy.
Various preparations of Bhallathaka, especially Bhallathaka Ksheera is known to have been
tried at many centres for carcinoma and it seems the early results are encouraging. So, the drug was
found worth trail.
Mr. A, 78 years, retired school teacher presented himself with a history of multiple
fistulae in ano of 19 years chronicity. His main complaints were discharge through the openings, an
ulceration on the left buttock and occasional constipation. He was not complaining about pain. He
gave the history of two surgical interventions tried for cure. He was anaemic and debilitated.
On local examination, the patient was found to have left sided multiple fistulae in ano, totaling
four in number with cavities filled with pus. Evidence of previous operations were there and these
scars extended to the anal verge. The discharge was mucopurulent. Occasionally, the discharge was
clear or bloody and was jelly like. A solitary round ulceration on the left buttock of two centimeters
diameter was there which was hard with everted edges and fixed to the underlying tissues. The floor
of the ulcer showed pale granulation tissue. It was not tender.
On rectal examination, the anal verge was found to be distorted with the previous operated
scar on the left lateral side. There was no evidence of my prolapsed piles, prolapsed rectum, or
fistulae in ano. Digital examination gave no clue of any pathology with the mucous membrance being
smooth, soft and non adherent. Proctoscopy was also performed and no masses were visualized.
Sigmoidoscopy and other investigations were not done.
As the clinical data of the ulceration gave clues of malignancy, tissue taken from the same
was sent for histopathological examination to the pathology department of the College of
Veterinary&Animal Sciences. The report proved conclusively that the ulcer in question was a
squamous cell carcinoma of stage-1. As the patient was aged, anaemic and debilitated and even
though of the first stage, the ulcer was complicated by surrounding areas of pus filled cavities and
multiple fistulae in ano and above all, as the patient was reluctant to surgery or radiotherapeutic
management, it was found worthwhile to try conservative management and administer an indigenous
drug.
Besides Bhallathaka Ksheera, the patient was also given iron preparations for his anaemia.
Before the therapy was started, routine laboratory investigations were done. No other
abnormality was seen other than a raised ESR of 40 mm at the end of 1st hour and slight
leucocytosis. His blood sugar was within normal limits and BP was 140/90.
Results
It is notable feature that by the end of 5th day of management itself, the discharge from his
fistulous openings reduced considerably. The hard edges of the ulceration turned soft and red and by
the seventh day, healthy granulation tissue was found to take the place of the paler one. The
elevation of the edge of the ulcer was decreasing slowly day by day and the indurated fistulous tracts
were becoming softer to feel. But the patient ’s overall condition was becoming bleak. By the 7th day
of management, the patient was very weak and by the 14th day of management, the patient began to
have moderate to high rise in temperature. These changes were thought to be due to constitutional
idiosyncrasy of the patient towards Bhallathaka Ksheera and so, the drug had to be withdrawn.
Discussion
But it may not be susceptible to be used in all the patients and all the conditions. That might be
why, even at the beginning of the therapy itself, the patient developed fever and other constitutional
problems.
Summary
Squamous cell carcinoma, to the best of knowledge of the author is a rare complication of
chronic fistula-in-ano. Even though Bhallathaka Ksheera failed to bring about significant effect in the
case projected here the satisfactory symptomatic effect in itself gives scope for is further study in a
wide spectrum of cases of squamous cell carcinoma.
IMMUNOLOGY OF CANCER
Department of Biochemistry,
Medical College,
Trichur.
Immune Mechanisms
Some of the important immunological mechanisms by which the body is able to destroy the
cancer cells are :
1. Direct cytolysis by sensitized T cells, ( classical cell mediated immunity ). The precursor
cells, originating from bone marrow, pass through the thymus, thereby acquiring certain thymus
specific antigens. These are called the T cells. When a ‘sensitized ’ T cell comes into contact with the
target cell, (to which the T cell has already been sensitized), then the T cell become enlarged in size
(blast-transformation ), and this ‘activated’ T cell can directly hit and cause cytolysis of the target cell.
This mechanism is independent of the presence of antibodies.
a) Macrophage activation factor (MAF), When released by the T cells will ‘arm ’ or ‘activate ’ the
macrophages so that the latter can attack and lyses the target cells.
b) Macrophage migration Inhibition Factor (MIF), When released will cause inhibition of the
movements of the macrophages, leading to local accumulation of these cells. Thus the new members
of the effector cells are recruited to the side of activity.
3. Opsonized target cells are phagocytosed by normal macrophages : This reaction is antibody
dependent, but complement components may or may not take part. The target cells carry negative
surface charges which will repel the attacker cells. But when the target cells are coated by the
antibodies (opsonization), the surface charges are neutralized and hence the macrophages can make
a contact and later engulf the cancer cells.
4. Cytotoxicity by K cells : When the antibodies attach over the antigens of the target cells, the
normal (non-immune) lymphocytes to K series can lyse the target cells. Therefore, this mechanism is
described as the antibody-mediated, non-complement dependent cell-mediated cytotoxicity. The K
cells are 5% of the lymphocyte population, and they belong to neither the T cell nor the B cell series.
T cells are the Thymus-derived lymphocytes, which are mediators of classical cell-mediated
immunity against transplantation and neoplastic antigens B cells are the Bursa-processed
lymphocytes , or Bone-marrow derived cells, i.e., lymphocytes which are not passing thymus, but are
processed by the gut-associated lymphoid follicles (bursa-equivaient in mammals), and they are the
mediators of humoral immunity.
Expressions of immunity
There are many circumstantial evidences to conclude that immune mechanisms are operating
in cancer patients as well as in tumour-bearing animals :
3. Post-mortem prevalence of cancer is more than that is seen in the normal population.
This is because, minute pockets of cancer are checked from spreading by the immune mechanisms
of the body.
4. There are more than one thousand reports of well documented cases of ‘spontaneous
regression’ of cancer, where the histologically proved cancers were miraculously cured by inadequate
treatment or with no treatment at all. Most of these cases belong to the retinoblastoma,
nephroblastoma, renal carcinoma, malignant melanoma and choriocarcinoma. Incidentally these are
the group of tumours which elicit powerful immunological response.
5. Generally speaking, there is a good correlation between the lymphoid infiltration of the
malignant area, with that of the survival time of patients. Thus the histological finding of a good
lymphocyte infiltration indicates better prognosis.
6. In tumour-bearing animals if a few number of cells from the same tumour are taken and
injected into another site of the same animal, the cells at the new site (auto-transplant) will be rapidly
eliminated, while the tumour at the original site will go no proliferating. This ‘concomitant immunity ’ is
explained by the fact that the fewer cells at the second inoculation site are killed by the immune
rejection mechanism, while the large number of tumour cells at the original site are beyond the
competency of immune attack.
7. Antibodies against cancer cells could be detected in the circulation of normal healthy
persons. Ordinarily, antibodies are produced only when the body comes into contact with the
corresponding antigens. So the natural line of argument is that cancer cells are being frequently
produced in all individuals; but most of them are eliminated by the body by immune mechanisms.
8. Mutation is a statistical probability during cell division. As the number of cell divisions (and
the total number of cells) in the body is increased along with the advancement of age, the chances of
mutations are also increasing. Among such somatic mutations some will be of neoplastic in nature.
Hence cancer is essentially a disease of old age. Burnet has postulated that the cell nediated
immunity had developed in the multicellular organisms, mainly to detect and eliminate the cancer
cells. This is called ‘Immune survailance’
The following methods are widely used for the detection of tumour-specific
immunological reactions in patients.
2. Mixed lymphocyte-tumour cell cultures : Tumour cells and autologous (from same
person) lymphocytes were cultured together for 3 or 4 days. Due to the recognition of the specific
antigens, the sensitized lymphocytes will become lympho-blasts. This blastogenesis is aseayed by
the amount of radio-active thymidine incorporated into the newly syethesised DNA of lymphoblasts.
This test will detect the antigens, but may not quantitate the state of immunity adequately.
4. Colony inhibition assay : Colony forming ability, of the tumour cells in agar gel could be
inhibited by patient’s lymphocytes. This is a tedious and time consuming test. Quantitation is difficult.
6. 51-Cr releases assay (Brunner assay) : Target cells are tagged with radio-active
chromium, and then incubated with lymphocytes from patients. Lymphocytes will lyse the cancer cells
and chromium is released from the lysed cells. So, the radio activity measured in the supernatant
medium will be proportional to the cytolysis of cancer cells. This cytotoxic reaction is mediated by T
cells. ‘Blocking’ factors could not be easily demonstrated by this method. Even though this is the best
method forquantitation purpose, due to certain technical difficulties, this test could not be applied
universally to all types of cancer cells.
8. Complement dependent cytotoxicity of serum : this detect the antibody levels. The test
will be positive in early disease, and after remission, especially in melanoma, neuroblastoma and
sarcoma. But the test will usually be negative in most patients. This is an insensitive assay system.
9. PHA (Phyto-haemaglutinin) stimulation : T cells are stimulated and so they are
transferred into blasts when they are cultured along with a non-specific mitogen, called
phytohaemagglutinin. With limitations, this could be used to assess the non-specific immunity.
As a generalization, in most cases, the specific and non specific immunity of the patients are
going on decreasing as the tumour size is increasing.
Introduction
I am extremely happy to attend this seminar which is conducted by the Amala Cancer
Institute, Trichur ; a well known Institution of its ’s kind. Probably this Institution is unique even in India;
because of the fact that the patient is benefited by a combined system of therapy; both allopathy and
Ayurveda.
It is said that “Rishis” assembled in Himalaya and discussed about the methods to treat
disease of the human beings. They knew that Indra knows Ayurveda. So they deputed “Rishi
Bharadwaja”, to “Devalokam”(േദവേലാകം) to study the Ayurveda. After returning from Devalokam he
delivered the Science of Ayurveda in the Seminar of Rishis.
In the seminar; Athreya and Actual God “Dhanwanthari ” were present; Later on “Athreya ”
taught Ayurvedic medicine to his six desciples like Agnivesan(അഗിേവശൻ); and dhanwanthari
taught “Ayurvedic surgery” to this desciples like Susrutha. Along with this system, another branch of
medicine, “രസപേയാഗപധാനചികിത” originated from Maheswara, Nithyanath(നിതയനാഥൻ) and
Nagarjunan.
ൈദവം -- രസപേയാഗം
മാനഷം -- ഔഷധചികിത
ആസരം -- ശസപേയാഗചികിത
Whereas allopathy is the fruit of intelligence and research based observations of our fore-
fathers.
Both systems are fundamentally based on specific way of thinking and principles of action.
Thus Ayurveda is based on “Tridosha” whereas allopathy is based materialistic foundation. Ayurveda
gives more emphasis on prevention of disease, but allopathy gives more importance on eradication.
To some extent, allopathy is more materialistic in nature, and Ayurveda is more of a spiritual
mature.
So, if the materialization and spirituality can be combined in a healthy way for the treatment of
disease, the outcome will be miraculous.
As you know, the disease is a state of affairs affecting both the mind and the body, and the
treatment should be aimed at treating the body as well as the mind.
Another important point I wish to emphasise, is that the physician should treat the patient as a
whole with a full spectacle of observation. Specialization and super specialization heads one to think
only in his own angle; and other systems are rather ignored.
Coming to our subject of discussion, cancer is a disease, having world wide distribution. It is
seen in man and other animal kingdom. The crude form of the disease was described in ancient
literature.
The real aetiology of the disease is not known. Several factors may be causative like smoking,
chewing, Alcohol and spices. Similarly the nature of the present food articles, the way of life in stress
and strain, and the atmospheric pollution everything will contribute to either the beginning or to boost
up the disease.
At the same time a man without any such wishes also gets the attack. In this situation, we are
inclined to think of genetic or mutation abnormality.
A detailed description of the aetiology, pathology and signs and symptoms are not relevant for
the occasion. But I would like to emphasise certain important points only regarding the above subject.
As I have already mentioned; mental stress and strain is a major cause of the
disease(മാനസികാഘാതം& പിരിമറകം)
Of course in many cases, we are totally helpless in finding out the cause.3.7% of Indias
population is at the risk of cancer.
Age incidence
I have seen patients from 5 years to 85 years; but more prevalence is between 30-60 years.
Sex
Male population is having slightly higher incidence; and aerodigestive tract ( Tongue, soft palate,
oral cavity, uvala) cancers are more common among males. One interesting fact to mention is that,
nearly 70-85% of these cancers are regionally spread, at first diagnosis itself.
Pharynx 19%
Leukaemia 6%
Larynx 5%
Brain
Lymphoma
In female population
Carcinoma cervix 25%
Brest 17%
Stomach 4%
Pharynx
Ovary 3% each
Leukaemia
Thyroid 2% each
Lymphoma
In female population, Carcinoma cervix stands first and Breast cancer is the second in order.
Both of them are seen in married women; having more than two children.
Signs and symptoms vary according to the nature of the disease and the body resistance.
Some type of disease is more Virulent and painful in some Individuals, where as it may not be so
painful in others. So much so, the symptoms also will vary.
Diagnosis
Almost all the cases can be diagnosed by the modern method of investigation. But a small
percentage is still there, which is resistant for investigation as a result of which; the primary cannot be
spotted out in many cases.
Treatment
Regarding the treatment, all the systems has got their own line of treatment. But the result is
unsatisfactory; though some improvement is claimed by all. So I feel it is time to think of a “Combined
treatment—method”(സംേയാജിത ചികിതാ പദതി)which is binding to all the systems. A combined
therapy is proved to be very effective in many cases of cancer. This is being tried by myself and the
famous Ayurvedic Physician the Ashtavaidyan Cheria Narayanan Namboodiri. Our silent dedicated
work started 15 years back. Now, it is proved to be very effective in many cases.
My own medicine is an alkaloid obtained mainly from three Indian Medical Plants namely
Calotropis gigantia-Proceva, Acorus calamus and Plumbago.
It is being processed and combined in such a way that the potency is maintained without any
untoward reaction and loosing the individuality. The name “NAVAYOGE ” is given to the final product.
This was prepared in an injectable form by Navaratna Pharmaceuticals and intra-resion injection was
given in some cases with some beneficial effect. But some patients reported that even in the small
doze hypersensitivity reaction do occur. So I have stopped the injection for the time being
Now it is given orally in the Powder form and as drops. Attempt is being made to prepare and “
Intra-resion” injection.
The treatment patterns of the patients, is based on the extend of spread of their cancers.
Here one important finding is the invariable increase of Serum alkaline Phoshatase in advanced
cases. This is important for the calculation of the dosage.
2. Carcinoma Tongue
Total 65 Nos.
3. Pharynx—Male more:
4. Carcinoma Thyroid, male only; one case was operated 12 years back,
Following which he developed the disease.
5. Carcinoma Breast – Female only; 30—50 yrs, married having children; in good socio-economic
position.
25 years—65 years, married having more than two children only one is nulliparous
2) All the cases attended in my OP have undergone some form of treatment either surgery,
Irradiation, Chemotherapy of treatment from other systems.
5) Peripheral oedema, Ascitis and Lymphnode enlargement were seen in some regionally spread or
advanced cancers.
Treatment started only after routine investigation Hb; T.C., D.C., E.S.R.and specially serum
alkaline and acid phosphatase; urine, Blood, urea. Liver function Tests and weight of the patient in
Kgms. The medicine is given in the powder form or drops; the dosage being calculated according to
the weight of the patient in Kgms and the level of Phosphatase.
It is given in three equally divided doses at 8 hrs. interval (6 A.M. —2 P.M. 10 P.M) Patient is
restricted from taking any form of food one hour before and after medication. Honey and water can be
combined with the medicine if necessary.
Routine investigation will be done every three months; and special investigation like X-ray and
Scanning will be done at 12th and 18th months.
Duration of Treatment
Usually the treatment will have to be continued for 18 months; in exceptional cases it may
go upto 24 months. In responsive cases; by this period the patient will be cured of the disease. I say
responsive cases, because the alkaloid will have individual response and selective action. It may be
highly responsive in some individuals and totally resistant in some others. The cause of this
interesting observation is not known.
Result
The overall response is satisfactory. Patients used to get relief from pain and subjective as well
as objective improvement will be noticed within a couple of weeks. Radiological improvement can be
noticed at the minimum of three months.
I am presenting herewith a case report of one Carcinoma Thymus. A middle aged lady came to
me with H/O Dyspnoea of sudden on set and pain left Inframamary region. No H/O Fever.
B.P. 130/80(CVS)NAD
The only positive finding I could make out is the dullness at the left inframammary region with
comparatively low air entry.
She was referred to the Medical College Hospital, Trivandrum. Where she has undergone
“Thoracotomy”. On examination; there was a huge mass. The mass was inoperable, so they did a
biopsy only; and report came as carcinoma Thymus. She has undergone this treatment for 18 months
with remarkable improvement.
Discussion
As mentioned earlier, the anti-cancer activity is noticed in the alkaloids of certain plants.
Probably som” labile alkaloid” may be the active principle, which cannot be isolated in our present set
up. So the whole extract is given to the patient. Mainly the root and the bark is the medicinal part
used.
Hypersensitivity to the drug is seen in exceptional cases. It will be of the allergic nature. As a
rule the medicine can be continued to be administered by desensitization by lower doses along with
antiallergic drugs.
Restrictions (പഥയം)
The medicine should not be mixed with food at least one hr.before and after
administration. If necessary Honey and boiled water can be given. Smoking, spices and alcohol
should be totally avoided. Day time sleeping is contra indicated and 8 hrs. sleep at night should be
ensured. Vegetarian food is to be preferred; though controlled non-vegetarian food is not contra
indicated.
CONCLUSION
The incidence of cancer can be controlled by modified way of life and thinking. Strict personal
Hygien is to be observed. A well balanced mental condition, without any undue fear or favour is
necessary for the well being of the individual. Attitude towards the relatives, friends and the society
should be calm& sobri. I do believe that a philosophical attitude towards life, is the part and parcel of a
healthy body and mind. When the body and the mind is in harmony, health and life expectancy will be
ensured.
MINERAL PREPARATIONS USEFUL IN CANCER THERAPY
Coimbatore.
In the ancient sidha book Agatyar karma kandam 600 , the following medicines are described
for cancer treatment.
2. Gandhaka, Kattuli mixed together made into thaila. Thailam &rasa added together is
made into cakes after which is undergone putapaka.
Uses
Uses in kustha, Granthi, Sula, poisonous bites, putru(cancer) Bhagandara Kapala Sula etc.
“ The word ‘putru’ mentioned by ‘Siddha’s of ancient times, is now called as cancer.
Those cases of cancer given up by the allopathists have been successfully cured by me using
the sidha medicines alone. They are absolutely healthier now.
The Rasapashnas, Loha bhasmas, Sindhuras, etc. mentioned by ancient sidda ’s and also
diamond (pravalam, Mukthi) etc. along with some anupanas of herbal origins, churnas, and also
gritha’s made of bhallataka, chitramula etc. They help in curing the disease at their begining stage.
The severity of the chronic cases can also be cured by using the same medicines.
For treatment
BLOOD CANCER
In nasal cancer :
Sutam senduram :
Talaka senduram :
Kanta senduram
Loha senduram
Swarna senduram
Muthu chunnam
Veera chunnam
Bronze senduram
Sapta senduram
Turusu senduram
M.S.,D.M.R.
I have been using 4 types of Sidha drugs in the management of Cancer since the last 6
years. The schedule is a combination treatment using Allopathic and Sidha drugs. The provocation to
switch on to this modality of treatment was from an accidental observation. One patient diagnosed as
advanced lung cancer and discharged from the medical college hospital without any treatment was
struck by the marvelous result of this treatment, and started an intensive search to get some insight in
to this system. After a detailed study of the various drugs commonly used for cancer I settled down to
the following four drugs which I am using rather extensively in the management of Cancer.
1. Nandhi Mezhugu
2. Rasagandhi Mezhugu
3. Chandamarutha Chendooram
4. Rasa chendooram
I have treated over 300pts on this schedule in the course of last 6 years. It is indeed
surprising that in some advanced cases I could achieve total arrest of the growth and in some even
cure.
Illustrateve cases
1. – A case of cancer of the urinary bladder with extensive metastasis after total cystectomy. Pt
was treated in Nov. 85. Pt is disease free and is healthy todate.
2. – A case of cancer of the prostate advanced with secondaries in the inguinal region —under
treatment from 1987 keeping good health.
3. – Carcinoma stomach, ovary, breast , colon, urinary bladder are some of the cases treated on
this schedule.
Some observations
1. – There is remarkable improvement in general health of the pts when put on these drugs.
Their appetite improves and there is a feeling of well being.
2. – They stand the chemotherapy well. The usual adverse reactions of chemotherapy are
much less when this drug is given.
It is interesting to note that Arsenic has been in use in allopathy as a tonic in olden days
and it is being used as such in vetinary practice even today. So the effectiveness of Arsenic as a
general stimulant is well known. It may be noted that most of the Sidha drugs contain Arsenic as the
main ingredient. The drug that was given to the advanced lung cancer pt by the Ladaguru, the first
case I saw which cured the pt. I discovered later to be NAVAPASHANA. This combination consists
of the following 9 pashanas.
1. Sulpher
2. Mercury
This according to the Sidha Vaidyas is a very potent drug. Only well experienced Vaidyas are
permitted to handle this drug. The drug contains 4 compounds of Arsenic and 4 of Mercury. Most of
the compounds are deadly poisonous and hence restriction in its use.
There is a legened connected with this drug. The idol of Lord Muruga of Palani Temple is
made of these Navapashanas—9 compounds. This is said to have been fabricated by Bogormaharshi
about 700 AD. The abhishekams of this idol is found to have medicinal properties. It is obvious that
abhishekom will have traces of the compounds dissolved in it and hence its medicinal property. It is
also interesting to note that the Madras Gove. Has now restricted the number of abhishekams to six a
day because the large number of abhishekoms has resulted in gross deformity of the idol. Formerly
600 to 700 abhishekoms were done in a day.
The Navapashanam is not available in the market. Expert vaidyas make it on their own
following the detailed instructions given in ancient books on Sidha system.
NANDHI MEZHUGU
1. Rasachedooram
2. Copper Sulphate
3. Zinc Carbonate
4. Mercury
5. Sulpher
RASAGHANDHA MEZHUGU
1. Sulpher
2. Mercury
5. Copper Sulphate
6. 28 Medicinal Herbs
CHANDAMARUTHA CHENDOORAM
1. Sulpher
2. Rasa Chendooram
GIRIJA KUTTEN,
D.M.VASUDEVAN,
RAMADASAN KUTTAN.
Summary
An extract from Viscum album has been found to reduce ascites and solid tumour induced
with Dalton’s lymjphoma ascites tumour cells (DLA-cells) in mice. Tumour reducing activity could be
demonstrated when the extract was given simultaneously with the cells, prophylactically and after
tumour development. The cytotoxic component in the extract was isolated using column an paper
chromatographic procedures. The isolated component had a molecular weight of 5000 and liberated
amino acids upon acid hydrolysis indicative of its peptidyl nature. It was cytotoxic to DLA-cells and LB
cells but showed only very little cytotoxicity to human lymphocytes. Isolated component reduced solid
tumour in mice induced by DLA cells. The peptide did not show any hemagglutinating properties
indicating that it is not a lectin. Activity is reduced by pre-incubating with a DLA cell sonicate indicative
of a possible receptor to this peptide in tumour cells. Possible mechanism of action and identity of the
component will be discussed.
Introduction
An extract of Mistletoe (Viscum album) known by the proprietory name Iscador had been
found to be useful in cancer therapy (10,8). However due to its inconsistent response its efficacy is
still being questioned (11). This extract had been found to be cytotoxic to various cell lines (5).
Reduction in some of the animal tumours including Sarcoma 180 and Ehrlich ascites tumour was
observed during the administration of Iscador while some other tumours such as L1210 and p388
leukemia were non-responsive. Since L—1200 and P388 are used for the primary screening of
antitumour agents non-responsiveness to these tumours made its action controversial (1).
Recently we had reported that Iscador administration reduced ascites tumours and solid
tumours induced in mice by Dalton’s lymphoma ascites tumour cells(7). The latter originated from a
spontaneously grown tumour of mouse thymus. In the present manuscript we have isolated the
cytotoxic and tumour reducing component from Iscador and studied its properties.
In vitro cytotoxicity assay was conducted using Dalton ’s lymphoma ascites tumour cells(6).
Briefly a small aliquot of the extract or isolated fraction was incubated at 370 C with 1 million cells in
one ml phosphate buffered saline (PBd) for 3 hr. After incubation percentage of dead cells was
determined using Trypan Blue exclusion method.
Female Swiss albino mice weighting 16 —20gms were used for animal tumour
experiments. They were fed with standard mouse chow (Lipton,India )and were housed in ventilated
cages in airconditioned rooms. Dalton’s lymphoma ascites tumour cells were propagated in the
peritoneal cavity of the mice by injecting 106 cells. The cells were aspirated from developed tumours
and washed in PBS. Solid tumours were produced in mice by injecting 1 million cells subcutaneously
on bind limbs. Isolated component (equivalent to approximately 50ul of original extract) was injected
from next day subcutaneously at the same site and continued on alternate days. Totally five injections
were given. Solid tumours were measured from day six andvolume was calculated from the formula
V=4/3πr12r22 where r1 and r2 are radial of tumour.
We have used in vitro cytotoxicity assay during the whole isolation procedure. 50ml of
Iscador M(5%) was lyophilized to 5ml and was loaded on Sephadex G-50 (40cm ×2cms )column and
was eluted with isotonic saline. 2ml fractions were collected and assayed for cytotoxicity. Active
fraction(eluted at 23-28)were pooled and concentrated to 2ml and passed through DE-52 cellulose
column (15cm×1cm) and eluted with saline. Fraction (2ml) containing active material eluted at (5-8)
were pooled and concentrated to 2ml and passed through a Senphadex G.10 (44cm+1cm) and eluted
with water. Fractions (2ml) containing cytotoxic component were pooled,concentrated and streaked
on whatman No.1 paper and the developed with butanol ascetic acid-water (4:1:1). The position of
cytotoxic component as determined from quide strip was eluted with water and concentrated to
dryness by lyophilizer.
RESULTS
Initial column chromatography of Iscador on Sephadex G-50 indicated that molecular weight
of the cytotoxic component was lower than that of a protein molecule, but larger than that of very
small molecular weight components. Fractionation on Sephadex G-50 also separated the active
fraction from a hemagglutinating component eluted at the end of inner volume of Sephadex Column.
The active component was found to react with Folin ’s reagent indicative of a peptidyl nature but
contained very little sugar.
The active material did not bind on DE-52 cellulose column indicative of its basic nature.
Further sephadex G-10 column chromatography and paper chromatographic separation isolated the
material into a pure component free from large molecular weight protein, free from lectin activity and
free from iron small molecular weight amino acids and no detectable sugar. SDS-gel;electrophoresis
of the isolated component and further staining with coomassie Blue indicated that this component is a
low molecular weight peptide (molecular weight apprex 5000).
Cytotoxicity :
There was a dose dependent cytotoxicity to Dalton ’s lymphoma tumour cells in vitro. The
cytotoxicity was also time dependent and needed hardly 3hrs for its maximum effect. Cytotoxicity was
reduced at 40 C by 50%. It was found that treatment with isolated component produced a complete
disintegration of Dalton’s lymphoma ascites cells.
The isolated component did not produce any cycotoxicity to lymphomytes (isolated from
human volunteers by Fiacol-Hypaque method). It was found that concentrations with is 10 times more
than needed for tumour cells cytotoxicity did not produce any effect on lymphocytes in vitro.
Tumour reduction :
Injection of isolated component reduced solid tumour volume in mice considerably. For
example, tumour volume of untreated mice was 0.5cc on 10th day,1.5cc on 15th day,3cc on 20th
day,3.75cc on 25th day,and 6.5cc on 27th day, while for the treated mice the tumour volume where nil
on 10th day, nil on 15th day, 0.5cc on 20th day,1cc on 25th day and 1.25cc on 27th day. This data
indicates a considerable reduction in tumour volume during the treatment with isolated component
from Iscador.
DISCUSSION
Viscum album as well as the proprietory extract prepared from Viscum album; Iscador
has been shown to produce a regression of several kinds of tumours in experimental animals as well
as clinically (2,8, 10). However the tumour reducing component in Iscador has not been
characterized. Several types of compounds has been isolated. This include Lectins which has been
classified as ML 1, ML 11,and ML111(3). Viscotoxins (9), Vester protein complex(10), Alkaloids(5),
Polysaccharides (4) and Polyphenolic substances (13), Vester found that non-protein and protein
components in Viscum album was found to have anticancer activity. But the exact nature of the
component has not been determined. Other components such as Viscotoxins and Lecting were found
to be cytotowic to tumour cells but their anti cancer activity has not been reported. In fact some of the
immunomodulatory activity that is produced by Viscum album has been suggested to be mediated by
the lectins or its component side chain (3).
In the present manuscript we have identified a tumour reducing component from Iscador as a
peptide of molecular weight 5000. Identification of the tumour reducing component as a low molecular
weight peptide is not unexpected as many peptides of known antitumour properties, have been
reported recently. This list include interferon, interleukins and several lymphokines. The molecular
weight profiles, resistance to trypsin, pronase and heat inactivation indicate that isolated peptide is
similar to Viscotoxin (9) in its properties. However at present we do not know whether this is the only
tumour reducing component present in Iscador. Its role in tumour prophylaxis is also not known at
present.
ACKNOWLEDGEMENT
Authors are thankful to Dr. Rita Leroi for kindly supplying Iscador used in this study.
REFERENCES
2. Evams M.R. and Preece, A.W.(1973) : Viscum album —a possible treatment for Cancer Bristol.
Med. Chir. J. 88, 17-20.
3. Franz,N (1986) : M Stletoe lectinsand their A &B chains. Oncol. 43 Suppl.1, 23-34.
4. Jordan, E and Wagner, H (1986) : Structure and properties of polysacchades from Viscum album
L : Oncol. 43 Suppl. 1, 8—15.
5. Khwaja, T. A. ; Dias,C.B. and Pentecost, 5(1986) : Recent studies on the Anticancer activities of
Mistletoe (Viscum album) and its alkaloids, Oncol.43.suppl. 1,42 —50.
6. Kuttan R. Bhanumathy P; Nirmala K and George M.C. (1985) : Potential anticancer activity of
turmeric ( Our uma longa): Cancer Letters, 29, 197-202.
7. Kuttan G., Vasudevan D.M. and Kuttan, R. (1986) : Anticancer activity of extract from Viscum
album :Soc. Biol. Chom. 55th Annual Meeting 4, 105.
8. Leroi R. (1975) : In clinical experience with Misletoe preparation, Iscador. Vittorio Klostermann,
Frankfurt.
9. Samuelson G. and Petterson B. M. (1971). The amino acid sequence of Viscotoxin B. from
European mistletoe. Eur. J. Biochem. 2, 86-89.
10. Steiner R. (1920) in spiritual sciences and Medicine, Rudolf Stainer Publishing Co., London.
11. Unproven methods of cancer management Iscador (1983) Can. J. clinicians 33, 186-189.
12. Vester F. and Neinhaus, J. (1965) Cancerostatuche protein Komponenten and Viscum album.
Experientia 21, 197-199.
13. Wagner H. Jordan P. and Fcel B (1986) studies on the standardization of Mistletoe preparation :
Oncol. 43, suppl. 1, 16-22.
Modulatory effects of extracts of Natural products like
SATISH C. NAIR,
SALOMI M.J. ,
PANIKKAR K.R.
Kerala, India.
Cisplatin is the most effective and widely used cytotoxic drug. Although renal toxicity is the
dose limiting factor, others toxicities include emesis, nausea, diarrhea, anorexia and
myelosuppression. The tumoricidal activity of cisplatin results in part from the reaction with DNA.
Reactions with proteins may also be responsible for the observed toxicity to the kidneys and the
gastro- intestinal tract.
Considerable interest has been focused on the isolation of compounds that might be
administered with cisplatin to reduce dose limiting toxicity. On the above basis, we investigated the
extracts of Natural Products like Crocus Sativus and Nigella Sativa. As potential agents against
cisplatin induced toxicities.
Crocus Sativis and Nigella Sativa (Seeds) were extracted using 100% alchohol. The extracts
were further concentrated under reduced pressure and puridied by Sillica gel column
Chromatography technique. The purified extracts was used for the present study. Each of the mice
receiveg 50mg /kg body weight equivalent of the extract I.P. for five alternate day ’s either alone or in
combination with cisplatin at a dose of 2 mg/kg body weight.
An increase in the life span (ILS= 194%) of mice treated with the purified extracts along with
cisplatin was observed when compared to the groups of mice that received cisplatin alone. The mice
that received combined treatment did not show loss of body weight, anorexia, and lethargy indicating
the protective effects of these extracts at the gastro-intestinal level. Hematopoietic and bone marrow
toxicities which included leuckopenia, thrombocytopenia, fall in Heamoglobin levels were also
prevented by the use of co- dministration of these extracts.
The exact nature of the active compound present in the extracts is not known to us
known. However co-administration of these extracts along with cisplatin helps to prevent drug induced
toxicities of cisplacin. Thus these extracts can be effectively used as rescue agents in clinical trials to
increase its therapeutic index.
ANTI-TUMOUR AND ANTI CACINOGENICITY OF SPICES
M. C. UNNIKRISHNAN,
RAMADASAN KUTTAN,
K. K. SOUDAMINI.
Summary
Tumour reducing activity of extracts of eight commonly used spice in India were studied in
mice transplanted intraperitoneally with Ehrlich ascites tumour. Oral administration of extracts of black
pepper, asafetida, pippali and garlic could increase the percentage of life span in these mice by
64.7%, 52.9%,47% and 41.1% respectively. However intraperitoneal administration of spice extracts
did not produce any significant reduction in tumour growth except for sesame (38.8%). Garlic extract
and asafetida extracts also inhibited two stage chemical carcinogenesis induced by 7,12 dimethyl
benzanthracene and croton oil on mice skin with significant reduction in papiloma formation. These
results indicate the potential use of spices as anti-cancer agents as well as anti-tumour promoters.
INTRODUCTION
Extracts of some spices were found to inhibit the growth of tissue cultured cells as well
as cytotoxic in vitro to tumour cells. (1,2). Ginger, turmeric and pippali were found to be most
cytotoxic. Curcumin isolated from turmeric was found to inhibit the cell growth at concentrations of 4—
8ug/ml and had a tumour reducing activity when given to animals (3). Some of the spices such as
garlic andasafoetida were also found to have antimutagenic activity in Salmonella assay systems (4).
Moreover recently the anti-promoting activity of curcumin has been demonstrated in TPA and croton
oil as promoters (5,6) as well as in benzo (a) pyrene induced stomach cancer in mice (7).
The anti-tumour and anticarcinogenic action of other spices are largely unknown. In the
present manuscript we have studied the antitumour activity of eight spice extracts using transplanted
tumours as well as in two stage chemical carcinogenesis models induced by 7,12 dimethyl
benzanthracene (DMBA) was bought from Sigma Chemicals (USA) and croton oil was prepared from
the seeds of Croton tiglium by light petroleum extraction.
Extraction :
10gms of dried powder of each spice was stirred with 200ml 70% ethanol overnight at room
temperature. The extract was evaporated in vaccum and made upto 10ml in 70% ethanol. This was
diluted to 100ml with isotonic saline. Asafoetida extract was prepared by boiling 10gm of asafetida in
water and finally making up the volume to 100ml in water.
Inbred strains of Swiss albino mice (6 in each group)were used for tumour reduction
experiments. They were housed in ventilated cages and were fed with pellotted mouse chow
(lipton,India) and water ad libitum. Transplantable tumours Dalton ’s lymphoma ascites tumour cells
(106 cells) and Ehrlich ascites tumour (106 )were injected (i.p.) into the animals (6 animals in each
group) and after 24hrs. 500 ul of extract of spices (containing 50mg of spice) was injected either
intraperitoneally or given orally from day 1 to day5. Mortality of animals dying of tumour were noted
and average increase in life span was calculated.
Antipromoting studies :
Two stage carcinogenesis produced by painting of DMBA (200 in mole )and croton
oil(100ul) was used to study antipromoting activity of garlic and asafetida extracts in mice. Fresh
garlic (50gm) was extracted with 400ml 70% ethanol and concentrated and made upto 10ml in water
and asafetida extract (10%)was made in hot water. Dorsal hair was topically treated with 200n mols of
DMBA in acetone (200ul). After 1 week croton oil (100ul) was applied at the same site twice weekly
for 4 weeks. The effedt of the extracts of spices on tumour promotion was determined by topically
applying 200ul of either garlic extract or 200ul of asafetida extract 15 minutes prior to croton oil
application for 4 weeks. Number of animals with pappiloma, their onset, size and number were
determined during the next several weeks.
RESULTS
Table 1 shows the effect of administration of spice extract by intraperitoneal route 24 hrs after
transplantation of tumours. The untreated control animals survived 25 to 27 days in the case of
tumours induced by Dalton’s lymphoma ascites cells and 17 to 19 days in the case of Ehrlich ascites
cells. These values were not significantly changed after administration of extracts of spice by
intraperitoneal route, although moderate increase were noted in the case of sesame (Table 1).
Oral administration of extract of spices were found to yield berrer results (Table11). Extracts of
black pepper (64.7%)Pippali(47%), Asafoetida(52.9%)and garlic(41.1%)were found to increase the
life span of Ehrlich ascites tumour bearing animals significantly. Other spices did not increase the life
span as compared with controls.
Table |V indicates the number of pappiloma formation in mice after two stage
carcinogenesis in presence and absence of extracts of asafetida and garlic. As seen in the table
topical application of asafetida and garlic extract reduced number of animals with pappilloma (from
100% to 16.85%and 29.85%) as well as their onset. Moreover there were also a substantial inhibition
in the number of pappillomas produced per animal (8.5% and 15%). These values were highly
significant (P <0.001. No pappilloma were produced either by croton oil or DMBA alone as well as by
the vehicle used. These tumours were not malignant and no deaths were seen due to the tumour
proliferation.
DISCUSSION
Spices are parts of the world. Harmful effects of spices such as mucosalf irrigation and
possible mutagenicity are known. The antioxidant property of some spices make them not only useful
preservative but also possible antitumour promoters. However the usefulness of spice in inhibiting
cancer promotion has not been studied, excepting for turmeric. The active ingredient from turmeric,
curcumin has been shown to inhibit the promotion brought about by CPA and croton oil (5,6).
Extracts of spices have also been known to be cytotoxic in tissue culture and to in vitro
tumour cells indicating the possible presence of growth inhibiting substances. In the present
manuscript we have shown the tumour reducing activity of spices in experimentally implanted tumours
and there was a significant increase in life span of animals treated with extracts of black pepper,
pippali, garlic and asafetida. The effect could be demonstrated only when the drug was given orally
but not w hen given intraperitoneally, indicating a prior metabolism of the ingredients in spices may be
needed for their activity. Moreover it was of interest to note that black pepper and pippali were highly
cytotoxic in cultures (1) and hence there was a correlation between cytotoxicity and tumour reduction.
In the case of asafetida extract the increase in life span seen was concentration dependent and
maximum increase was seen at 50mg.
Asafetida and garlic were not only found to increase the life span of tumour bearing animals
but also was shown to inhibit chemical carcinogenesis. Possible ingredients responsible for the
activity are ferulic acid and sulfydryl compounds present in the extracts which can scavenge free
radicals and superoxides which are generated during promotion. More work is needed to evaluate the
usefulness of spices as anti-promoters in human neoplasms.
ACKNOWLEDGEMENT
Authors are thankful to Dept. of Science &Technology, Govt. of India for final assistance.
TABLE 1
In tumour reduction
Ginger
Pippalia
Asafetida
Black peppera
Garlic
Mustard
Horsegram
Sesame
Tumour cells (1x106 cells ) were injected (i.p) and after 24 hrs each spice as aqueous extract (50
mg/animal) injected (i. p) for five days. Value are average of six animals/each set of experiment.
In tumour reduction
Control 17 ± 0.85 --
Ehrlich ascites cells (106) were injected (i.p). after 24hrs. an extract prepared from 50mg. of spice
were given to each animal. Orally for 5 days.
TABLE -- |||
Effect of oral administration of asafetida extract in
Tumer reduction
Nil 20 ± 0.75 --
10mg 21 ± 0.63 5%
Ehrlich ascitas cells (106)were injected intraperitoneally and after 24 hrs. various concentration of the
asafetida extract (10—100mg/animal ) was given for 6 days.
TABLE -- IV
Promotion
Treatment Percentage of mice Mean number of tumours
Dorsal hair of the mice (10 in each group) were removed and after 48hrs. mice were treated topically
with 200n moles of DMBA in 0.2ml acetone. After one week Croton oil (0.1ml ) was applied topically
as a promoter twice weekly for 4 weeks. The experimental animals also were applied with 200ul of
asafetida or garlic extract prior to croton oil application. Values are average of two independent
experiments consisting of 10 animalsper group. Values were highly sibnificant. **P<0.001
REFERENCES
1. Unnikrishnan M.C. and Kuttan R. (1988) Cytotoxicity of extracts of spices to cultured cells,
Nutrition and Cancer, 11,4,251.
2. Goodpasture C.E. and Arrighi, F.E. (1976) : Effects of food seasoning on the cycle and
chromosome morphology of mammalian cells invitro with special reference to turmeric. Food Cosmet
Toxicol, 14,2.
3. Kuttan R. Bhanumathy P., Nirmala K. and George M.C. (1985) Potential anticancer activity of
turmeric. Cancer Lett. 29, 197.
5. Huan M.T., Smart C. R., Wong C.O., and Conney A.H. (1988) inhibitory effect of curcumin,
chlorogenic acid and ferulic acid on tumour promotion in mouse skin by 12-0-Tetradecanoyl phorbol-
13-acetate.
Dr. RAMANAND,
Dr.ASWANI KUMAR.
The Arbuda (Cancer)which are produced Med &Kaf are having no pain or a little pain,
take a long time to grow and there is no suppuration. The Arbud (Cancer)can grow any where in the
body by making the base of mucos membrance. Specially this type of Arbud (Cancer) is found in lips,
palaie, pharynx etc.
We used Glycyrrhiza Glabra in the form of different preparations in Kafaj Arbud. We tried
in such types of arbud (Cancers ). Powder, extract and Decoction of Glycyrrhiza Glabra on two
patients. One of the patients was declared Ca of Pharynx and other Ca of Larynx. After the biopsy
done by P.G.I. Chandigarh and then they had given radiation therapy to these patients. By that time
patients got temporary relief. But after some time the disease revived. We give to these patients
Powder of Gyucyrrhiza Glabre 1gm. Three times a day for chewing and extract of Glycyrrhiza Glabra,
Piper Cubeba, Pure campher and Sugar Candy after mixing of all these in a dose of 1gm. Three times
a day with water. We pasted Dasang Lape on both sides of throat. Both the patients got the complete
relief. Uptill 1yr. the patients had not got any problem.
In this way we tried Glycyrrhiza Glabra at the initial stages of Arbud(Cancer) and
experimental study is going on.
How long will it take for medical science to cure cancer? At this stage the cure seems to
be a for off cry. Despite all the efforts of men and mechines and millions of dollars spent on the
research to find a cure for cancer, there seems to be no hope yet, and the disease remains an enigma
for all the medical scientists. No body seems to have any clue to its cure. Millions of people
throughout the world are suffering from this disease and they lead a very miserable life in the grip of
pain and the fear of death. They know fully well that death is inevitable and there is no hope for them
to survive for long.
A question is often put to Ayurvedic physicians whether there is any remady for this
dreadful disease. But before giving any satisfactory reply the physician must know the meaning of the
term cancer.
According to the modern views the main cause of cancer is abnormality of tissues. The
enzymes are full of burning effects. The D.N.A. break down because of this burning effect of
enzymes. The break down of D.N.A. triggers the collapse of Lysosomes and they also break down.
The Lysosomes mix with the base causing abnormality in the base. The abnormal base causes
SROTOAVRODH and they gather there. Then they start decaying. Tissues are known as Dhatuen or
cells.
D.N.A : It is a cellular fibre which is a mixed and a changed form of sugar & phosphates.
Lisosome: These are fine cellular granules,from these numerous granules cell body is made.
Acharya Sushruta in about 4th century AD described the varieties of cancer as malignant
and non-malignant.
All these classification and by classification derived their names according their locations
and the treatment of these abnormalities was done during the days of Sushuruta.
The following medicinal plants are used in the treatment of cancer.
2. Erythrina Indica : It purifies blood due to Tidat Ras. It is also Kaf & Vat kiseases.
In various books.
3. Cassia fistula : It curesVat due to Madhur & Sanigdh properties. Pit due to shit property.
Due to its Rechak property it causes Sanshodhan of Kosthagat pit & kaf.
4. Ficus Racemosa : Kaf Pit Shamak &Rakat Pit Shamak. Dah Parshamak, Varn Ropak.
Swelling in the form of PAN & LEP. It is used in Grandhi. Apache &
Gandmala.
7. moringa oleifera :
8. piper cubeba : it is shothhar &Vrunaropan Dah Parshamak
The first patient of Ca Larnx was declared by P.G. I. Chandigarh Cr. No. A15 1986. After that
patient came to us with the complaint that he was unable to drink even liquid. He was given the
treatment. After six month he started taking normal diet. And upto one year patient did not give any
complaint.
The second patient of Ca Pharynx was declared by P.G. I. Chandigarh Biopsy No.S-8399/88.
The patient was suffering with the complaint of dysphagia. The treatment was given for three months.
Then he started taking normal diet. Upto one year patient did not give any complaint.
We give to these patients powder of Glycyrrhiza Glabra 1gm. Three times a day for chewing
and extract of Glycyryhiza Glabra, Piter Cubeba,Pure camphor and Sugar candy after mixing of all
these in a dose 1gm. Three times a day with water. We pasted dasang Lape on both sides of throat.
In this way we triedGlycyrrhiza Glabra at the initial stages of Arbud(cancer) and experimental
study is going on.
SANKARANARAYANAN A.S.
Abstract :
Medicinal herbs or combination of medicinal plants are employed in treating all diseases
including Arbuda from time inmemorial. Here author evaluates the medicinal plants used by the
primitive tribals viz Cholanaikans, Irulars, Kurumbars, Mudugas, Malayar and Kadars distributed in
various settlements of Tamilnadu and Kerala. Auther wishes to compare the methods of utilization of
herbs among the tribals with the Ancient Ayuvedic classics.
Introduction
The medicinal plants used against cancer among the above origins are supported by the
Ayurvedic texts. A vety few plants screened for anticancer by the central drug research Institute can
be referred in the Ayurvedic Classics. Of the 2818 plants screened till 1987, only 42 single drugs are
active as antiviral and 131 as anticancer. Though most of the antiviral plants have got reference in
Ayurveda a very few are supported for anticancer effect in Ayurveda.
Evaluation
Medicinal herbs or combination of medicinal plants are employed in treating all the diseases
from time immemorial. As disease cancer if found to its seriousness only 3 decades back, we
presume that this disease is a manifestation of micro organisms developed due to the so called
civilization and sophisticated way of life deviating from natural life.
A very few drugs are mentioned in Ayurvedic literatures like charakasamhita, susrutha
samhita and Ashtangahridaya.
The occurrence of Cancer among the primitive tribals is comparatively megre. Among
Cholanayikkans of Nilambur there is no report of cancer. Irulars of Anaikatty reported 2/5670,
Kurumbars of Attappady reported 1/3100, Mudugars of Attappady has no report Malair of
Malampuzha treat cancer by chanting Mantra. Here it is notable that the Folk-lore practices their
medicine by a random diagnosis.
The medicinal plants Boerhbavia diffusa, Melia azadirachta, Strychnos Nux-vomica and
Trichosanthus cucumerina used an anticancer plants by the Tribals have references in Ayurved and
these plants when screened are found to be either anti cancer or antiviral herbs. The Kadars of
parampikulam reported the plant barks of Cassia fistula and ficus glomerulata are ground and taken
internally unlike the enternal application as mentioned by susrutha.
The screening of 2812 plants by C.D. R. I. Lucknow revealed 42 single drugs active as
antiviral and 131 drugs as anticancer. Of these plants Calotropis gigantea, Cocculus, Zingiber,
Cyperus sp. Indigofera tincteria, Semecarpus anacardium and Inula racemosa have reference in
Ayurved where as the other 124 plants ack reference in Ayurved for Arbuda chikitsa. Of the 42
Antiviral herbs a majority have got references in Ayurved. The 5 plants mentioned in Ayurvedic
literature found to be active after screening as antiviral and anticancer are Cassia fistula, Indigofera
sp. Terminalia chebula and zingiber sp. These plants have got enough reference in Arbuda and
Grandi chikitsa in Ancient Ayurvedic classics.
Taking this into account the combination of antiviral herbs mentioned in Ayurved will have
greater efficacy as anticancer drug.
Nilambu 0%
2. Irulars
Anaikatty 2/5670 --Boerhoaria diffusa and Malia azadirachta-
Pulp-external application
Attappady internal
5. Malayar
Malampuzha --Manthra
6. Kadars
1. Cassia Fistula
2. Cassia Tora
3. Indigotera sp.
4. Terminalia Chebula
5. Zingiber officinale.
External
1. Seeds of cucumber and seeds of Recimus Communis boiled in milk or urine and apply with
coconut oil (Susrutha)
2. Leaves of ficus and leaves of tinotoria uranums ? these leaves in cancerous growths.
3. Glyzeriza glabra stembark with olea racemosa bark ground in honey and apply.
6. Common treatment for ghandhi and Arbuda. Seeds of Indigotera tinctoria and seeds of Dolichos
--kwatha --internally.
Auurveda supported
Coscinium tenestratum
7. Inula racemosa.
EPIDEMIOLOGY OF CANCER
P.R. VARGHESE,
Lecturer,
St.Aloysius College
Elthuruth,
In 1982, ICMR launched a National Cancer Registry Project (NCRP) which includes
population based cancer Registeries at Bombay, Bangalore, Madras and later at Delhi and Bhopal.
The data available from these registries describes the incidence rates in that particular cities. This
data is not sufficient to compute the incidence of Cancer in the country. Hence for the purpose of
public health administration and also for the research, prevalence data available from various hospital
besed Cancer registries throughout the country from the precious data base.
It has been estimated that there are about one and half million cases of Cancer in the country
at any given time with about half a million new cancer cases being added every year. More than 60%
of these affected patients are in the prime of their life betweenthe ages of 35 and 65 years. When this
situation is projected to the year 2000AD the problem of cancer is likely to become far more acute
than it is today with the increasing life expectancy and changing life styles concomitant with
development, the number of cancer cases will be almost three times the current number. Cancer
incidence among males are 48.7 (Bangalore) 64.4 (Bombay) and 62.3 (Madras) per one lakh
population. In females the rates are 57.3, 68.6 and 88.9 respectively.
TABLE –1
MALES % FEMALES %
TABLE II
TABLE –III
POPULATION
Breast 15.8 17
Christian Breast 25 17
Breast 11.9 17
The most frequent age group among the patients are 60-49. A significant change in
this regard is observed in the case of female breast cancer which are frequently diagnosed in the age
group of 49- 49.
All the centers in India as well as in abroad have reported an increase in the year wise
incidence of cancer. This may be due to improving diagnostic and reporting facilities. However, the
most frequent sites remain unchanged during successive years. Another important observation to be
reported from Kerala are the consistently increased percentage of oral cancer at all centers and a true
reduction in cervix cancer at Trivandrum in successive years. The increased oral cancer is correlated
with the Pan-chewing and oral hygiene practices and decrease in cervix cancer to the improving
family planning drive in the state.
ACKNOWLEDGEMENTS
Professor,
Trivandrum -23.
Being a true Homoeopath, I naturally feel myself obliged to tapping at the resources
available in Homoeopathy to offer as a remedy to this gruesome disease. As regards other systems of
medicine like Ayurveda and Allopathy, they have been in the midst of the human race from time
immemorial when compared to the origin and existence of Homoeopathy in this world. Homoeopathy
has just completed only a period of say two hundred years or so. In the history of a medical system,
this period comes only within its infancy ie. Homoeopathy system of medicine has entered only its
infancy and it is yet to grow beyond that stage to stand in comparison with other medical systems. It is
against this view that I propose to initiate a paper fully conscious of the limitations of Homoeopathy in
this field. What I means to say is that Homoeopathic system has no so far been able to conduct
serious and deep research works in this field mainly owing to the depth of facilities which feature this
system of medicine because of its infancy. Yet this system is not utterly ignorant of certain means of
remedies which are of its own. There is also another factor which hampers any successful move
initiated towards treating this disease in Homoeopathy. Because of its relatively low publicity and
popularity among the masses, and because of lack of sophisticated diagnostic equipments and well
established institution, a new case of cancer does not at all come before a homoeopath for his
medical attention this case naturally goes for treatment after treatment to other physicians in Allopathy
and Ayurveda until it is decreed by them ‘incurable ’. it is now that as a last resort the patient is
brought before a homoeopath for his treatment in a mood of ‘let come what may come ’. By this time
the patient would have been over drugged and exposed to various therapies like, radiation, X-ray,
Chemotherapy etc. With all these the patient would have come to a stage of past-cure even by God
Almighty. It is then the unfortunate Homoeopath has to do his treatment on the patient. Even in such
past-cure cases certain Homoeopathic medicines have been proved highly efficacious at least to
palliate the sufferings. It is a silver lining in the all too confused and confounded horizon of treatment
of this dreadful disease.
Before going deep into the present subject, I wish to enlighten on the salient features of
Homoeopathic system of medicine, because I find it necessary on this occasion to do so in the midst
of a gathering almost allient to this relatively new system of medicine.
Homoeopathy is based on a system insisting on treating the patient rather than the
disease. It is a very highly systematic method of powerfully stimulating the body ’s vital force to cure
illness. It is based on a simple but profoundly insightful principles of nature which are contrary to
commonly held beliefs. The principles are simple in concept. But they require years of intensive
training and experience to apply.
It was Dr. Hahnemann, that founded this system of medicine and propounded its
salient principles. He found that a drug which was known to be curative in Malaria-Cinchona actually
produces the very symptoms of Malaria when given to a healthy person. He conducted keen
observation and got convinced himself by repetitive experiments and observations. Thus he proved
that curative power of a drug is nothing but its pathogenetic power. It is from this principle he deduced
the low of similar ie. ‘ let likes be treated by likes ’. It is closely analogous to the Indian concept
‘Ushnam Ushnena Santhi’ or ‘Vishasia Visha Maushadham’.
As regards medication too Homoeopathy has its own unique principle. It deosnot
believe in giving more than one medicine at a time as it is difficult to distinguish the effect of each
medicine produced in human body when it is given as misturse so it categorically insists on
administering only one medicine at a time –the low of single medicine.
Hahnemann also stressed the necessity of giving the minimum dose of the medicine.
He proved that the least possible dose is very convenient and more effective to produce a reaction in
the human system especially when the human body is over sensitive due to disease. And this has
completely ruled out any possibility of adverse sipe effects due to drugging in Homoeopathy.
Homoeopathy has to concerned itself with the concept of causation of disease. There
are mainly two factors of causation viz. the extrinsic and intrinsic. They combined together to
contribute to the causation of the disease. Under the extrinsic factors come bacteria, virus, fungus,
protozoa, Heat and cold, radiation and all other environmental stimuli. These factors no doubt are
capable of producing the incidence of many diseases in human beings. But, if the above factors are to
make their impact on an organism, the latter must be having a tendency or say a susceptibility or
predisposition to invite or welcome the influence of the above factors to result in disease. It is here
that the intrinsic aspects of a patient are also considered along with the extrinsic ones. The intrinsic
factors consist in the consideration of the patient ’s hereditary tendencies or susceptibilities to certain
diseases and his past stigmas acquiredhisom his very intra uterine life to till date. These are the twin
factors that render the patients susceptible to a particular disease capable of being contributed to by
the extrinsic influences. For example things like Tobacco, Arsenic, asbestoes, Benzene Benzedine
are believed to be carcinogenic agents. Let us take the instance of tobacco. The use of tobacco does
not produce equal response in its consumers. Certain consumers begin to develop the malignant
effect whereas others do not develop any such effect. It is here that we have to apply the principle of
the combined action of both the extrinsic and intrinsic factors. The tobacco being an extrinsic factor
finds in some person condusive atmosphere to exert its impact in a thriving manner because by the
intrinsic factors, the persons are susceptible to the incidence of the tobacco malignant disease.
Psora develops from the nonvenerial itch or similar to skin disease. It produces mainly
functional disturbances in the system and the system is rendered hyper sensitive. This hyper
sensitivity may pave way for many infections. Hence it is considered to be the mother of all the
diseases.
Sycosis and syphilis are venereal in origin. These stigmas are cast on account of
suppression of gonorrheal and syphilitic Infections respectively by the crude form of drugging. Sycosic
produces proliferation of tissues while syphilis produces destruction and disintegration of tissues. And
these two features are clearly visible as malignant ones in cancer. If there is only proliferation of
tissues it is benign for which sycosis is alone responsible. Though there are only three basic miasms
as detailed above, when these miasms are blended together, the situation gives rise to the origin of
yet another miams known as ‘tubercular miasm’. This miasm is characterized by both proliferation
and destruction which are nothing but characteristic features of cancer.
Although Hahnemann has classified cancer under psora in a precancerous state, usually the
incidence of cancer is discernible in the blending or mixing of all the three miasms in an organism.
This fact has been established beyond doubt iu the findings of Dr. H.A. Robert, Dr. A.H. Grimmer, Dr.
Bernovelli, Dr. Kasad and others.
What is evident from the above revelation is that it is the predisposition of a patient to the
incidence of a disease that has to be set right or corrected by a physician. This is what a Homoeopath
believes. It has convincingly been attributed this tendency to the combined and cumulative effect of
above miasms in an organisms resulting into cancer.
It is under this awareness that Homoeopathy approaches a cancer patient for treatment. As
the treatment has to be directed towards constitutional changes, deep acting drugs capable of
correcting the constitutional dyscresia have to be administered. Homoeopathy has got such
medicines in plenty, some of them are as follows.
This method is effective in a precancerous as well as in the curative phase of a cancer. But
such cases are rarely brought to a Homoeopath on account of reasons mentioned in the earlier part of
my speech. What a homeopath gets, is a rejected case of cancer as a last resort to attend on.
Because of the hazards of over drugging and many other experiments already done on the patients,
he would have well passed the stage of recovery at this time. So what is left to be done by a
Homoeopath is palliation and not cure. In a devilish and diabolic disease like cancer palliation is as
important as cure. So it can also be rightly aimed at with a view to giving relief to the patient. For this
purpose also there are certain effective remedies in homoeopathy. A few of them are as follows.
Again, there are a few very precious medicines in Homoeopathy which are capable of
mitigating and agonizing pain associated with a cancer patient at the final stage. This pain, intolerable
in nature as it is, will not even permit the patient to die peacefully. So giving relief to such a patient at
such a stage is not a small thing, which I am proud to say. Homoeopathy is capable of. The following
are some of medicines which can be used effectively for the purpose.
Arsenic Album, Nitric Acid, Apis Mellifica, Arnica, Calcarea aceticum, Euphorbium,
Magnesium phos, Rutta, Colocynth, Ecoinacea, Cali Cyanatum, etc.
Let me be permitted to draw your attention to a popular saying that prevention is better
than cure. This is highly relevant to ponder over. Homoeopathy has to its credit very effective
methods to help prevent the incidence of this disease in a scientific way. This is because it is only
Homoeopathy which has discovered the fact that a patient ’s predisposition is more tantamount to the
incidence of this disease, than any other factor or factors after which other systems of medicine are
heatically waging a shadow war. It is here that Homoeopathy can achieve wonderful result in adopting
constitutional therapy with medicines mentioned earlier.
It is thus clear that Homoeopathy can effectively interfere in preventing curing and
palliating even the diabolic disease cancer. This position has been proved here and there by certain
isolated individuals who are vereran Homoeopath through their experiments and observations. They
have to their credit certain miraculous achievements in this field also. Had there been a concerted and
combined attempt scientifically designed towards getting such achievements in Homoeopathy, as is
done in other systems of medicine in the world, Homoeopathy, which has only a few years of
existence would definitely have proved unambiguously that it is capable of delivering the goods to the
envy and jealousy of other systems of medicine. Let this seminar make a start to direct the attention
of all concerned to usher this branch of medical science in all diverse directions to achieve the
cherished result. I hope the Amala Cancer Hospital and Research Centre which has been successful
in establishing two research units each in Allopathy and Ayurveda, will definitely pioneer the cause of
Homoeopathy to this direction. In such an event, we will be in a position to benefit more by
comparison and contrast of the results produced by these three systems in one subject —Cancer.
Thank you.
CONCLUDING SESSION