Patriarca, Janna Mae H.

BSN-4

ACTIVITY TA BAI!
ROUTE OF TUMOR
Instruction: Make a diagram of the spread of the tumour through the body.

DNA Failure to DNA damage DNA MUTATION

damag

Normal healthy DNA mutation success

DNA repair success
cell

Oncogene activation Tumour suppression genes in activate

Acquired
DNA
damaging
agents:
-chemicals
-radiation Unregulated cell proliferation
-viruses

Primary
tumour

Grows rapidly

TO SPREAD OF THE TUMOUR:

Breakaway from primary
-Breakaway from the primary Cancer cells travelling by
tumour. Cancer cells travelling by the blood stream
the lymph system
-Eat through the basement
membrane
(Type IV collengenase)
-eat through the extracurricular
matrix
(Metallo proteinase)
-enter the lymphatic’s/blood
-survive travel in the fluid
-exit blood Apoptosis
-survive in new sites

Metastatic tumor