Colegio de San Gabriel Arcangel

City of San Jose del Monte, Bulacan, Philippines

LEARNING ACTIVITY SHEET (LAS)

College College of Medical Allied Courses (CMAC)
Program: BS Pharmacy
Course Title Pharmaceutical Dosage Forms, Drug Delivery Systems and Medical Devices
Course Code Pharma 2
Unit No. and Title Unit 12 Solutions
LAS Code
References Aultonl, M.E. Pharmaceutics: The Science of Dosage Form Design
Loyd Allen,Nicholas Popovich,Howard Ansel,. Ansel’s Pharmaceutical Dosage Forms and
Drug Delivery Systems 9th Edition and 10th edition

Michael Aulton and Kevin Taylor, Aulton’s Pharmaceutics: The design and manufacturing of
medicines 4th edition

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City of San Jose del Monte, Bulacan, Philippines

FULL NAME SCORE

YEAR LEVEL DATE

LEARNING ACTIVITY for UNIT No. 12

Simple syrup

Formula Quantity Computed quantity

sucrose 850g

Purified water 1000ml

To make 60ml

Computation:
Sucrose

Purified water

Make a label for simple syrup

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City of San Jose del Monte, Bulacan, Philippines

Sample label

QUESTIONS
1. What are syrups?
 thick sticky liquid consisting of a concentrated solution of sugar and water with or without the
addition of a flavoring agent or medicinal substance syrup of codeine

2. Give the % w/v of simple syrup.

Syrup USP, having a specific gravity of 1.313 and a concentration of 85% w/v is a 65% w/w solution.

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3. Identify and describe the method in preparing syrups.

Solution with the aid of heat;

•The usual method for preparing syrup, used for

•Volatile substance (flavored substances).

•Substance injured by heat.
•Rapid preparation of syrup.
•Sucrose is added to the purified water and heat is applied until the solution is

Solution by agitation without the aid of heat;

•To avoid heat-induced inversion of sucrose.
•This process is used in those cases where heat would cause loss of valuable volatile constituents.
•The syrup is prepared by adding sucrose to the aqueous solution in a vessel of greater capacity than of syrup to
be prepared. This permits active agitation and rapid solution.
•This process is time consuming than that using heat but result in a product has maximum stability.

Addition of sucrose to a medicated liquid or to a flavored liquid

•Occasionally, a medicate liquid (tincture or fluid extract) is the source of medication in the preparation of the
syrup.
•Tinctures and fluid extracts contain alcohols soluble ingredients.
•Addition of tincture or extracts to syrup may cause precipitation of the alcohol soluble components.

Percolation
•In this procedure, purified water or an aqueous solution is permitted to pass slowly through a bed of crystalline
sucrose packed in a percolator, thus dissolving it and forming syrup.
•A piece of cotton is placed in the neck of the percolator to prevent the passage of un-dissolved sucrose.
•To be successful in this process:
nThe percolator should be cylindrical with a short conical base.
nCoarse crystalline sucrose must be used to avoid formation of compact mass through which the liquid can not
pass.

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