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Khang histamin Wo b. to cheb iy TDP dats by, tid cha. 26/ cc thude sau da kai e inachcaohon: nqors fa fot I uehE cb tic dong chon toe wen 2 nhiéw hon nhumg duge cha 1&6 nguy contin Gen a oxi bi valdercoxis ©: lummiracoxi @rericoxit 27) bién 6 tin inach tien in dén sir dung NSAIDs s4y re abu thé nao? © ‘ana ven Slime tance ius Trong 2 tun dau tin d.Trong 3 thang dau tién f_Trone thang au den Cae ye od cu 7 28YNSAWs gat dhe tinh tean gan, ngoai tr Cae ape ae Sa Ibe edhaig oD ba! ; a. Tudicao Soe be Ganmhigm nd @ilii thio dione 2 Suutine Age ghee 4 29/ tréah si dyug NSAIDs trén cde bénb hia: 4 a Tang iwyet ap c. suy than Soy tm @ ee thao dudng 307 yu td mao 1m yEu id guy co cba bién cbchay mau ten dune teu hod Jonyén ni tub, mapa st ab is Bs dr my abot slic {cle thay dow ats mae - ae ae can ai «Cie wont E-auysn itn dg Ot pa hot bs 1 Ph rg do habe pe 2 Pe Aesth ‘6 Khiamin oxy hoe ane Dey hoa Phan ng Kt to 2a dy Wake yu Athen So i tmibegnesihn. SEOREINTE a, ony coo Leeann che tat i Theda a Men shun cit 6008 Tea te ne fe Law egng ma 90 17 Dut day ache Oc uh vn go a due que de is hs. ea AE : casas Chk eat a Thake Kibo at he The nei a mat it > Oe 450 Coe ye apie ma ho1 > ng tu hoa > i A aad > en rab nol > iuydn nuts boi > Sg Wav hia > ve Sea > de nade tox > dna tu hin > mal > HT Cansei mu Opt > Init? (use mo B61 > Lim Si pte bide nae sau diy kiémg ding wi popaverin= Se Pteb men poehodisteee stan ome AMP vis eee tam ndng d0 Ca trong 16 bho ox rom a eipyng ehons cho tt so trom gay, bi neeytehlin clin nd anes ‘Lam tang men gan Khi-sir dung bo dai < Str dung ong did tr dau that nce, ni and tie Ss vthude ding db gid decd phosphor hee te Atropin + ipratropiam & Pilggerpin + pralidoxins & Atropin + pllcarpin by Atropin ~ necstigmin &: Atropit + pralidexima Atop bu igo ln sing Gb mi x qu fib arin bao gb HO cans ay, goat (rte tau bung, 8n 61 fe Dangtr msrjng eM eine __& Sét ean, da eho mong ‘de Mach bah 37, Thade nto sau dy ding 4@ Giéu ti dir phong com dau vita div: a Exgotatin ‘& Dopamin & Ephedtin b- Propranolol © Terbutalin ‘38, Thude chen thy thé f-adrenergic mio stv Ay eotac dong oudmg giso cin noi tai ‘a Nadotol ‘ce Acebutotol & Esmoiol -Atenotol 4-Timoto} 3. ‘Phd bigu ndo sau day diamg voi adrenalin: ‘a-hi se dyng dria tiem nh mach b- Bj thodi héa trong bao twang: ‘béi men COMT (catechol-O-metiy! transferase) ‘¢ Lam ting nhu ob sit dung oxy ob fim 4 Gay co that eo tron ti cung vdo eubi thai ky tay tt aug huySt nghiém trong Beak nn do dotmg 40. Pri pie mo sn ay Ning ing 1 Cope: ‘unten ay in nach nb eng ae loch a 8s cag bin gy tg so bop eo an v8 tng nh King is dng tren than Ki tug enki ie cn ae & Thi gan Bn th nin ng te ng py 9 nna Rina Dia chi din tong oxe tase sbe do tim, 41. Phi bid ro soe dy King Bug v9i sphedrin, 3-8 die kich tien kn inh pao etm theo coche true tsp vo alin ip 1 Kichthich fide kin Gung wong hen ho phenyiprepanoiamin - Gay sin Kh qui do hich thih receptor 2 adreners F Thaong phi hyp wi theopkyts wong diye fen sy &- Cotte oy ting hiv tp. ogo nhipten 42. Phitbice ndo sau diy dmg vi lebetstol Lie ché chon le receptor BI adtene-yic - tT dng ha hay: sp man de co ktm ie ding ech recep dene © Higa le ng han nan ding Song ingen ink mach 4 Keng st dng ong didn | srg hayek apo beat thn co kuyin Rong stm - Ching chi dinh i vei bans nh extng gdp 49. Inoprenain de dag nfur thé nd ten secant ndergic? 2: Chi vin receptor ol © Ucchf receptor a Eee recepior pt 'b-Chai van receptor 02 & Ch vie receptor f 44, Phitbiés nto sau day khong ating vt ampheantn: 2 Kich thich he giao cian theo coo gién tp Di lan dung st dng nw mgt eit doping wong & Gay quen thud nhanh the theo. Gi ting ein ©- C6 the gy ting hayét apy; loge nh tia 45. Thue m6 the da gy mé tin dK gi doqn do su dy nisin? . A. Giel dean itech Gini dann gii pba , Giai doan phe bi 1B. Giai dogi ich thich D. Gil coan ligt han indo 46, ‘Thube mé thiopental so &Gng thee cr ché no seu ds? © dune cus GABA teen tu thi GABAy 1D: o-ché thy he NMDA cus slucamat katte te teats oonacxionc Us ohd phone Wh chit ann Ih Ki (C. Hogt fn kerb 47. Pht bidu ndo sav d8y ding d6i v6i thude rié halothan? A. Dé bay ho va 48 chay nd D: Khong d6e voi sé bio gan B, Hiu le gay te kém ham ete etyic E Dage si dung bing diéng tinh tach C. Cth gay gian co trom wr eung 48. ‘Thude té ndo sav day lam gidm hod andi téo dung eit sulfamid Ki cong chung? B. Mepivacain naib ruse A. Procain C. Pramoxi B. Bupivacein D. Lidocain A 49. Thude 18 nio sau day gly the dung phy bi tiéu, tidu khéng kiém soat? A. Bupivacaia C.Lidocain E, Tetacain B. Btidocain D.Prilocain 50. Thuée mai nto sau day. e6 uu diém it anh huéng dn gide nigh (REM oy Lidu didn ti, pay tinh ‘trang quen thude: sid yu ed the dong Oe ehé nb ti hip tu serotonioe va norepinephrine? fa opioid yu c the dmg etme 52. Taube no at By ‘ A Mori Methadone B. Meperidine D Codeine 1 re ni su iy th pio agonist? Se ne eaaate Malorne 3, Coxkine D Peniazceine eee ‘Cole au dy tude nhém ching eo itt dae ive chon cho dium dau nguyen abn hen Sh 4, Morgane Amarin Inipramine B, Codeine D.Corbarazepin ae ght tong do loperaeide Ay ra Ki dong ib oa gud Rau tage FDA Hoa KY Gant 6018 vén a8 pao sa ety . A, Xedt yt iu hod 1. Nip ttn whan, 1ogn ip, met ngung tim Bi, Ue cto hip E, Rot logn ete ning sin duc Cleo gat ‘i 56 Pe tinh ado caa aspirin od thé din dén vs vong sau 3-7 ngdy? A.D) ng tbetaa aay ich thich niém moc tiéu hos. B . Keo dA thi gin tha KS, 06 thd gy bang fuySs khi sank D. Ri loan acid base matt p85 co gist E, Hoschung Reye 52, Theo nghién cite, ining 4s thude sau day, thude nto tée dong chon Toe tren COX-2 hon thube dn Val? A. Aspirin ‘€. Ibuprophen E. Biroxicam, DN: B. Dicfofenae “aproxen $6. FDA fea K¢-canh bio dhude gim dau opioid nae saw dey’ cBn Ap nlatntisn thube do thors wily ash cchimg serotonin NHAT khi dng dig tj gigi dau? 1A Festanyl ‘€. Methadone E, Tramadot 'B. Meperidine D. Morphine - ‘59. Thude ndo sau day [A thude chéng dng kinth moi nnd duge chdp thugnr? A. Clobazam C. Bvowabine E. Rufinamide B. Eslicarbazepine 1B. Perampanet GO. Tide mio khong duge sir dung tre em? A Flooetine C, Fluvoxamine ¥, Vilazodone B. Sertraline 1D. Gitaiopram 61, Dau man tinh Khong do ung thu kéo dai omic dO nhe dn trung binh, thode nde sau day dye de agit tun chon? A. Acetaminophen €.Dielofense £. Tramadol B. Codein D. Morphine 2. Trong cép ohit huring dn didu tj dau do nguyén nhén thin Kinh, thud Wao sau My duge Ina chon bang thie A. Amitriptyline €. Gabapentin B. Tramadol B. Duloxetin D. Pregabalin 63. Didn tim mgoh ign quan abn vige sir dung NSAIDs xy ra nhur thé nae? A, Trong tuan diu tien C. Trong thang dau tien E, Trong 06 thang B. Trong hai dau tién ‘ 1D. Trong 03: thang 64. Thude chdng dong kinb thé Idn nao sau day the déng giéng phenobarbital chuyén hoa thanh ‘phenobarbital, phenyletylonamide ‘A. Carbamazepin C. Phenytoin E. Valproate 8: Dianpam ‘D. Primidon «usta sbi ob ps tm wt gy des A Hon eo a SETS ‘Gand Hudng dn 2 clans thube cho opi va co in eit 1k Sse fp te ba, rn a, yb Bi. Sag bo hap ay ey dog thn, sy pi hormone shit CLG creme server, uy HO Bp uy gk Boron gi sib Dit chng ago hd, uy hd bp, a) so Rommone gk is BH ening sero, 23 hp, sy tye cs a Foo tas yt ig en aan Gl ing aia a CSS TS road teal Sng Bt Kh, kang cin dure thay co dine eng ai i oud I thin ts kin A. Carbamazepin © Persson Valproate Diaz B. Primo ‘uo ib ce i vd mg 8 ston a Gk 157 Thee ea su dy habe whi thd ne phi thin Kins, tae deer Kea Cal E. Mi thabe Mie A. Gapabersia ‘Prion B, Lamotrigine D, Vigabutsin (68, Cae habe sau dy eign oe COX? ean tong in view, nasa ‘C, Brorcoxtb Meoccam A Colecencs , Diclofenac 1. indomethacin ooo perrse gaily Seng eda an ch pod ug ttn vi rom Gc ohb tom proto ron situs Ht Her S dL Nén ung trade khi tin TS - 30 phat 6, Repo I an i Ml tn a 8 che aeot fe. Baesneprazo! «feo Niatidin 3 Cinta & Rabepreat : iti aaa dy as NSAIDs ute nae sv 8 9100 ds is nk ot KH tage euevge ca oping NSAIDS hay KONE a. Cinetdin S Nhm hyo Disa sbsaiylae B omenract Sacral PCIe ta v8 abe 8 bom proton ding, gag TP Laie thie wo cn bai it eld man ile 2 Diet bai iva deh jst 5. Chi dénie bio dich o8 kha ning tet HC) i cé gsi dog cubes qu ah tao HC! hen nay fe. Thode o6 thi gian bin hy tod « Thude 73, Sy hai la tie dung King mong muda. Suerallat 4, Colloidal bismuth subcitres b. Misoprostol fe. Colloidal bismuth substi vii bismith ‘subsaiieyit © Bismuth onbsaiylat iy vi ib Jt da diy tng KMig chin xe: npn i ti Ka ee ein G ‘tech bom proton voi antic hege sucrafatgidp rit gin thet gia BG “Thga gan trung Binh trong dieu te} loge da dy la-4 6 win | Teed ecg hyp let de ky Abc pj sot id aS i ‘hing sinh trong dia tr wet art Hp it bi phi hiy trong moi trating ecict 73 The nun tang taco eo oh Tm mem ace tact os tn en tang a S Carbinasamin ce. Mizolotin 76. Toabe Kg hstamin Hi ee 71. Tobe King istooin Hkh tang chu “true he dittng husés (PO) 06 the Bay _gidre tibs cue eon ai ae 2, REE nar ge vpn 5 aN Soe pl en ih te : Sais St ne am toe erty ete [a or saat 5 A an aecm ei Se ivan beta 2 adrenergic «- Conlentbc Glacadruimngcholinersic,, _..0-_ Chic khing escores £5 Chen pat bi den a won ane Pesren6 te dn BGI boot hoa adonyt eyetare, PE opin ~ db khang resent Aden fang leone AMP one meee oh astern tye Theophnyllin.- hog Néa phosphodiesterase Rotation - ae cht tng bop lencotrien at aly Wg, thane vo de mc ung the, ki by Nhay vain v4 apepicsie ‘or Twrigo yu 8 wing HOM « Teomach St Si sit vO Heh Keim ifthe 2 ei dy dae sen ing gs death enon a TiNMe EMD oTiNMs a taNeM ENN ae todd ing who di iy Th a Hy utagumcdn ec hemereue egaytal RY P Mettrext kg a8 fe G54Uskhing ryan ry hube deh fe dona ate us iy 8 ecard oht topcionease | d-Btoposid: de o¥8 Topoisameress I Vinorebir: klig pun Ce Thioganin: King pain ge che sy thanh lap vi quan -6-Thiogusnin: king pUnD &- Doceanel ce thubs dich fr dogo du Oy f Bhuamic: King aseos=® d+ Leta: bhang estrogen te Amunogetiml fe che aroma Leupold: chit tong ty LEAL = khang estrogen inh mao dudi dy 1s KhOng ANE: ‘ Alemtuamat: ung thes pbb Bevscizamab: ung tha ket trae tring Toren a8. Cypthude — cht ‘e Trosturumab ung tev te Rituximab: u fgch khdng Hodekin ‘eeGemuuzumat: Bach che dng ty Clb ssc eur tude co ch te ding no dus dy lh KnOus Sone . A Gefeinib: e ebé chon toc tytosin kinase ‘de Suttinib: ify ehé nhieu loa tyrosin kinase be e Bevaciumab: khéng CD 52 ‘ibe en iin Ae inh ni dh ay biog We 90, Cap tsb Wa a a Co S pemenrenat: 2 pong 4 9, 1 Pacltane! devamethuson, chloe Noxtnid: means 1 "Tmabe nie dt ty pe em lame tit beg how woo mos Se * 2 Trastuesrab 'b Geran Asem & Riera Pumas aa $2, Tv tr ob tyrosine Moan i hth by aye ot dong rong Sb tw he Db he es Serafenb 'b- Geletins ‘ontezoet Imatinib © Senin 193. Thiamin ape hi inh trong te hop xa =e thie metres 4: te it dang Sine fH ching Korat! hid ma ig cu Peleg © Mettmogbbi Sulrynoue depeche brrong ng hh t Palnge Meategbbie Ss pci cine ig A ih mgr bp 2 Ri on pd ge tT ig ht © Metbrogibin %. DE gan ibe hei: sry phy gin mach ki ding niacin du 128* HatLac biim thuémg cé logi nam Aspergillus flavus x4m nhap v20 phan git la mam. Nam nay cé thé san ane ra dc td gay bénh ung the la: i a- alphatoxin @efiatoxin c- hemotoxin : _ @- neurotoxin 1294 Phan khéng xa phong hod cia mot chat béo 12: a- phan con Iai sau khi xa phong hod chat béo. = phan dé tan trong nuréc. - phan dé tan trong cae dung mdi phan cyc, tan duge trong dung moi kém phan cue, & phan doan duge d ding aé tim cdc vitamin. HET PHANI PHAN THAY NGUYEN DUOCLY 1 | V/ thude giam dau ta thude oo tée dung: §. Lam slam hay mit cim pide aan, eden pide ¢ a fp xtic,nhiét. lam gia hay mt B. Lam gidm hay mit ¥-thite @yem du TK, ody ng, mat cam gide day 4/6 bao nhieu yt tiép nbn cém pide dav: 4.2 ed ®3 4.5 31 cb & as co quaninio la noi chinh xan dink cém gide dau: @ pari © ty séng b Virnio Sea quan nko la noi chinh xée din ti va ude tony a Déth ety sing @) Vo nto 6Fe5 bao nhiu nhom thade ding 48 didu tj dau: @ cutie 6 ci side dau: 42 Gs b 3 ) ‘Vopioid va din chit tac dgng chi yeu teen, Fecepier logi nao: é &. Kénh ion receprer €.¢hii din uuyén TK GPC Receper 4. tyrosin kinase iPad > 06:02 .CaK < Quay lai DUOC-LY-1-VB2-2015.pdf PHAN 2: CAU HOI NGAN Néu 3 think phin quan trong dé e6 thé tao nén dip img cia thude tie dng qua receptor: receptor, chat truyén tin, phoi tr ‘Néu 2 kigu tac dong ciia | thude trén kénh ion; chat digu bién, chat chen kénh ion Néu sir dung tri ligu cita papaveim: Co thit co tron duéng tigu hoa, tiet nigu Ké tén 2 thnoc chong co that co trom hung co: drotaverin, Fenoverin Thude gid dde dic higu trong tudng hop qua ligu suceinylcholin: Thude khing cholinesterase ‘Tai sao epinephrin chéng chi dinh 6 bénh nhin dang ding thuée chen receptor B-adrenergic khong chuyén bigt? way ting HA dot ngot do tac dung lén ot > xuit huyét nao. Thude ding dé ngan chin hoai tir da do sy co mach khi tiém noradrenalin: phetolamin 8. Newco’ ché tae dng cua sertralin: tai thu hdi 66 chon Ioe serotonin 9, Neu co ché the dng chinh cua mirtazapin: di Khéng a2-autoreceptor, a2:heteroreceptor, 5-H receptor 10. Néu co ché tae dong cua valproat: chen kénh Na+ IL. Néw co ché tie dong eiia topiramat: d6i King NMDA receptor 12. Néu gia thidt vd co ché sinh beh Jogn thin (tam than phn lig): ting hoot tinh coa dopaminerg D2 receptor 13. Ké tén thude gay mé dudng tinh mach eé tic dung phy lim tang huyét ap? Ketamin 14. Ké tén thude co mach thing dling két hop dé lim ting tae dung cila thude t€ lidocain: adrenalin 15. KE 3 thudc opioid khang nhu dgng nugt: Loperamid, Difenoxin, Diphenoxylate 16. Ké 3 chi dinh cia cia Dioctahedral smectit: Tigu chiy, hdi ching kich thich nudt, trio nguge dy diy- thue quin 17. Hay ké tén cae opioids ndi sinh: Nociceptin, Endomorphines 18. Ngoii opioid va NSAID ra, con nhiing nhém thude nao dye sir dung trong diéu tr} gidm dau: chéng, co giat, tram cam 19. Vitamin nio sau day duge chi dink sir dung bd sung trong tring hop thiéu va dé lim acid héa nude tiéu: acid ascorbic (vitamin C) 20. Vitamin nio gay giin mech da, chimg dé big, kich thich da day, ngita, ton thiong gan, ting acid uric huyét, tang san xudt glucose huyét? vitamin B3 21, Vitamin nio kém bén nhit voi moi trang dinh sing, ¢6 vai rd trong nbigu phin img oxy hoa khit, khi thiéu cé thé din dén tinh trang khé méi, viém min géc migng va vier da? Vitamin B2 22, Tinh trang thiéu vitamin ndo da duge ghi nbd lién quan dén avidin gin két khi str dung ling tring trimg kéo dai? Biotin 23. Vitamin throng duge sit dung dau tién trong di 24. Cac trigu ching hen suyén thudmg xdy ra khi mio? Co that co tron phé quan, ting tiét dich gay tic dung hé hap cua cae chat trung gian hoa hoe (histamin, leucotrien,...) Con dong kinh gay ra bGi Theophyllin nguy hiém vi sao? Khong dip img véi thude chong dong kinh va dé lai di chimg 2,3 hi duege sinh ra? Vitemin K PHAN 2: LY'A CHON DUNGISAL Lieu jz phn nay $8 5 im im “Sink vidn lima bal tre ip trem phibu tr to trde nif vo: a. Ding Sai 1. AUC 4 thé age xem nhu wing lwong thus rong etme 2, G-protein hu luda gay boat hoa phn i higu img 3. Gytoctrom P4506 tin dom hii va o6 thé ty cm mg 1. Thine €6 6 8 en vi protein coo st arin dzgetuong the tube 5.50 Ja hong 35 dng d& uc Iugng de tinh ee chute & Goehé cus phon img hi eng la do ting bidu hi recepice 2) Methysergid diye sr dung de ct con duu aa dia & Drotaverin dang dé aut ing uy 4 3. “Tubocurann con si dang tong chdn dod agin nbicee 60 10, Prazost lai 480 aghich te ddng tang buyét bp tin epinepris 1 Sir ehung stoppin 6 ths gay tang huyst ap do eo. mach 12. Norepinenirm ding trong ep eta sbc do tim 13, i doa 2 ecg hey m6 oe ane 1 gn dan ich teh vi taiube me gy tic Sama menes, 14. Trae me dirong tinh mach etc 60 te dan phv ay ing hurts 8 15 Thude 18 pramocain 26 thé ding gy *@ be mat Sang 11 bo eh gue cy 16. Bb th Ta nek Chin dé sac inh v) tri dau va ue Ivong crs 82 dau? TF Duotenas dng vag 0 nquy oo ey ete gar do gud mu hog ache is ine than ete cfc ‘hayénthéa e& de tink hon cée NSAID Khe, 418, Carbamazepine va Valproate od te dng Ach thich KEnlt Na 75. Ibuprofen avon ubag o6 nguy ov ey Be regan do au nt Hos chuyén ha tgo than eae end tenuyén W6a £6 de inh hon ede NSAID kh ap. Lopetand 28 Kha ling ost hon yu tb, 211 c.g nk Ong lt An Gale polyeatbopil oS kha nag hp ply nace gan 20 an rong vane

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