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    Natural Course: of Treponema Pallidum Infeciton

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    Jeas Montera
    1. Natural infection with Treponema pallidum begins with a primary chancre which disseminates through the bloodstream within 2-6 weeks, resulting in secondary syphilis symptoms like rashes and lymphadenopathy 4-6 weeks later. 2. Without treatment, secondary syphilis can transition to latent syphilis which is asymptomatic but still detectable by serology. Approximately 25% of latent cases will relapse into late symptomatic tertiary syphilis affecting organs like the heart, brain and skin. 3. Clinical manifestations of syphilis include a painless chancre, rashes, alopecia, mucosal lesions, and constitutional symptoms in secondary sy

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    Natural Course: of Treponema Pallidum Infeciton

    Uploaded by

    Jeas Montera
    31 views4 pages
    1. Natural infection with Treponema pallidum begins with a primary chancre which disseminates through the bloodstream within 2-6 weeks, resulting in secondary syphilis symptoms like rashes and lymphadenopathy 4-6 weeks later. 2. Without treatment, secondary syphilis can transition to latent syphilis which is asymptomatic but still detectable by serology. Approximately 25% of latent cases will relapse into late symptomatic tertiary syphilis affecting organs like the heart, brain and skin. 3. Clinical manifestations of syphilis include a painless chancre, rashes, alopecia, mucosal lesions, and constitutional symptoms in secondary sy

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    1. Natural infection with Treponema pallidum begins with a primary chancre which disseminates through the bloodstream within 2-6 weeks, resulting in secondary syphilis symptoms like rashes and lymphadenopathy 4-6 weeks later. 2. Without treatment, secondary syphilis can transition to latent syphilis which is asymptomatic but still detectable by serology. Approximately 25% of latent cases will relapse into late symptomatic tertiary syphilis affecting organs like the heart, brain and skin. 3. Clinical manifestations of syphilis include a painless chancre, rashes, alopecia, mucosal lesions, and constitutional symptoms in secondary sy

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    31 views4 pages

    Natural Course: of Treponema Pallidum Infeciton

    Uploaded by

    Jeas Montera
    1. Natural infection with Treponema pallidum begins with a primary chancre which disseminates through the bloodstream within 2-6 weeks, resulting in secondary syphilis symptoms like rashes and lymphadenopathy 4-6 weeks later. 2. Without treatment, secondary syphilis can transition to latent syphilis which is asymptomatic but still detectable by serology. Approximately 25% of latent cases will relapse into late symptomatic tertiary syphilis affecting organs like the heart, brain and skin. 3. Clinical manifestations of syphilis include a painless chancre, rashes, alopecia, mucosal lesions, and constitutional symptoms in secondary sy

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    of 4

    NATURAL COURSE

    OF TREPONEMA PALLIDUM INFECITON


    6-12 weeks

    4-6 weeks results from immune


    evasion due to
    2-6 weeks Histopathology: detectable only by most
    antigenic variation of
    perivascular serologic testing common types:
    surface antigens
    infiltration, capillary - gumma
    Penetration and
    25% relapse - cardiovascular
    dissemination endothelial Histopathology:
    - late symptomatic
    proliferation and hyperkeratosis,
    identification & Neurosyphilis
    Blood is infections subsequent capillary proliferation
    examination of
    obliteration with endothelial
    sexual contacts (<1 nearly eliminated
    swelling, dermal
    year) thanks to antibiotics
    TH1-type cytokine papillae with
    profile transmigration of
    PMN, perivascular
    infiltration

    Incubation Primary Secondary Latent Tertiary


    Period Syphilis Syphilis Stage Syphilis
    CLINICAL MANIFESTATIONS
    OF TREPONEMA PALLIDUM INFECITON
     Chancre -  Polymorphic rash on trunk,  Positive serologic tests
    extremities, palms, and soles
    ➢ single painless papule  Normal CSF examination
     Lues maligna
    ➢ cartilaginous consistency on  Absence of clinical
    palpation of the edge and  Patchy alopecia manifestations
    base of the ulcer
     Condylomata lata
    ➢ Atypical
     Superficial mucosal erosions  On patients with:
     Regional (usually inguinal) (mucous patches)
    ➢ history of primary or
    lymphadenopathy
     Constitutional signs and secondary lesions
    symptoms
    ➢ history of exposure to
    ➢ sore throat, fever, weight loss, syphilis,
    malaise, anorexia, headache,
    meningismus ➢ the delivery of an infant

    Primary Syphilis Secondary Syphilis Latent Syphilis

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