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  • Fase de Disposición Lenta/eliminación: BETA: T (H) CP Real (Ug/ml) LN CP Real

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    The document analyzes the pharmacokinetics of a drug following administration of a 500,000 ug dose. It finds the drug exhibits a two compartment model with an initial alpha phase of rapid disposition over 0.45 hours followed by a beta phase of slower elimination over 2.78 hours. Key parameters estimated include the alpha half-life of 0.45 hours, beta half-life of 2.78 hours, and CL of 146.57 mL/min.

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    Ejercicio LBF.xlsx

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    The document analyzes the pharmacokinetics of a drug following administration of a 500,000 ug dose. It finds the drug exhibits a two compartment model with an initial alpha phase of rapid disposition over 0.45 hours followed by a beta phase of slower elimination over 2.78 hours. Key parameters estimated include the alpha half-life of 0.45 hours, beta half-life of 2.78 hours, and CL of 146.57 mL/min.

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    2 views8 pages

    Fase de Disposición Lenta/eliminación: BETA: T (H) CP Real (Ug/ml) LN CP Real

    Uploaded by

    dana
    The document analyzes the pharmacokinetics of a drug following administration of a 500,000 ug dose. It finds the drug exhibits a two compartment model with an initial alpha phase of rapid disposition over 0.45 hours followed by a beta phase of slower elimination over 2.78 hours. Key parameters estimated include the alpha half-life of 0.45 hours, beta half-life of 2.78 hours, and CL of 146.57 mL/min.

    Copyright:

    © All Rights Reserved
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    of 8

    t (h) Cp real (ug/mL) Ln Cp real

    M
    0 0 Err:502 C
    0.5 20.6 3.02529107579554
    1 13.4 2.59525470695687 20
    2 7.3 1.98787434815435
    3 5 1.6094379124341
    4 3.7 1.30833281965018 15
    6 2.2 0.78845736036427

    Cp real (mg/L)
    8 1.4 0.33647223662121
    10 0.82 -0.1984509387238 10
    12 0.5 -0.6931471805599

    5
    Fase de eliminación beta
    r -0.9997541338681
    r2 0.9995083281863
    0
    0 1 2 3 4
    b 2.304280179274
    B0 10.01696523751 ug/mL
    m (beta) -0.24949341498 h -1
    t 1/2 2.778218337459 h

    t (h) Cp real (mg/L) ln Cp real Ln Cp extrapol Cp extr (mg/L)


    0 0 0 2.30428017927372 10.016965237505
    0.5 20.6 3.02529107579554 2.17953347178601 8.8421801698049
    1 13.4 2.59525470695687 2.0547867642983 7.8051733535578
    2 7.3 1.98787434815435 1.80529334932288 6.0817552656559
    3 5 1.6094379124341 1.55579993434746 4.7388757988922

    Fase alfa
    r -0.999981424412
    r2 0.9999628491691
    b 3.237303823599
    A0 25.464971053 ug/mL
    m (alfa) -1.52433883664 h -1
    t 1/2 0.454719885039 h

    Ecuación general: C=Ao*e^(-alfa*t)+ B0*e^(-beta*t)


    t(h) C (ug/mL)
    5 2.889657556455
    7 1.7474625221682
    9 1.060632984831
    16 0.1849602287376
    20 0.0681810835292
    24 0.0251332959475

    PARÁMETROS FARMACOCINÉTICOS
    Dosis 500000 ug
    alfa 1.5243388366444 1/horas
    beta 0.2494934149754 1/horas
    A0 25.464971053001 ug/mL
    B0 10.016965237505 ug/mL
    t1/2 alfa 0.4547198850394 horas
    t1/2 beta 2.7782183374589 horas
    Cp0 35.481936290507 ug/mL
    ABC 56.854801294064 ug/mL*h
    CL 146.57220047665 mL/min
    VD 14.09167740752 L
    K21 0.6240798575126 1/horas t 1/2 k21 1.110670649302
    K10 0.5403552194413 1/horas t 1/2 k10 1.282762071359
    K12 0.6093971746659 1/horas t 1/2 k12 1.137430906108

    alfa + beta 1.7738322516198


    k12+k21+k10 1.7738322516198
    Fase de disposición lenta/eliminación: BETA

    Modelo Bicompartimental
    Cp real (ug/mL) vs t(h)
    3.5

    2.5

    Ln Cp real
    1.5

    0.5

    0
    0
    -0.5

    1 2 3 4 5 6 7 8 9 10 11 12 13 -1
    t (h)

    ln Cp extrap

    Fase de disposición rápida: ALFA


    Cp Res (mg/L) Ln Cp Res
    Modelo Bicompartimental
    10.01696523751 2.304280179274 Cpres (ug/mL) vs t(h)
    11.7578198302 2.464518536695
    14
    5.594826646442 1.721842357627
    1.218244734344 0.197411080421 12
    0.261124201108 -1.342759118534
    10
    Cp resid (ug/mL)

    0
    0 0.5 1 1.5 2

    t (h)
    h
    h
    h
    BETA

    Modelo Bicompartimental
    Ln Cp real vs t (h)
    3.5

    2.5

    2
    Ln Cp real

    1.5

    1
    y=−0.2494x+2.3042
    R2=0 .9995
    0.5

    0
    0 2 4 6 8 10 12 14
    -0.5

    -1

    t (h)

    LFA

    ompartimental Modelo Bicompartimental


    mL) vs t(h) Ln Cp extrapol vs t (h)
    3

    2.5
    f(x) = − 1.52433883664435 x + 3.23730382359928
    2 R² = 0.999962849169103

    1.5
    Ln Cp extrapol

    0.5

    0
    0 0.5 1 1.5 2 2.5
    -0.5

    -1
    1.5 2 2.5
    -1.5
    t (h)
    t (h)
    -1

    -1.5

    t (h)

    El proceso de absorción es de primer orden


    14

    partimental
    l vs t (h)

    + 3.23730382359928

    2 2.5 3 3.5

    (h)
    (h)

    s de primer orden

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