tiempo (h) Conc (mg/L) conc extra Cresi ln(Cresi) AUC AUC acc AUC *kel

0 0
0.5 3 9.9592324 6.9592324 1.94006918 0.75 0.75 0.05775
1 5.2 9.58308917 4.38308917 1.47775377 2.05 2.8 0.2156
1.5 6.5 9.22115223 2.72115223 1.0010554 2.925 5.725 0.440825
2 7.3 8.87288503 1.57288503 0.45291153 3.45 9.175 0.706475
2.5 7.6 3.725 12.9 0.9933
3 7.75 3.8375 16.7375 1.2887875
3.5 7.7 3.8625 20.6 1.5862
4 7.6 3.825 24.425 1.880725
5 7.1 7.35 31.775 2.446675
6 6.6 6.85 38.625 2.974125
7 6 6.3 44.925 3.459225
9 5.1 11.1 56.025 4.313925
11 4.4 9.5 65.525 5.045425
15 3.3 15.4 80.925 6.231225

kel 0.077 h-1 AUC o-t 80.925

ka 0.971 h-1 AUCt-inf 42.8571429
Finf AUC total 123.782143
Finf 9.531225
Abs t Abs/Ainf 1-abs/abs inf ln(1-Abs/Absinf)
1 ln(cresi) versus tiempoChart Title Chart Title
3.058 0.32 0.68
2.5 -0.39 2.50 9
5.416 0.57 0.43 -0.84
8
6.941 0.73 0.27
2 -1.30
2.00
8.006 0.84 0.16 = − 0.987634263223677 x +7 2.45249029838319
f(x) -1.83 f(x) = − 0.076949666183736 x + 2.33685295302855
R² = 0.998358741759887 R² = 0.998708048609193
8.593 0.90 0.10
1.5 -2.32 6
9.039 0.95 0.05 -2.96 1.50 5
9.286 0.97 1
0.03 -3.66 4
9.481 0.99 0.01 2.03 1.00
0.5 3
9.547 1.00 0.00 1.96
9.574 1.00 0.00 1.89 0.50 2

9.459 0.99 0
0.01
0.4 0.6 1.79 0.8 1 1
1.2
0.00 1.4 1.6 1.8 2 2.2
9.414 0.99 0.01 1.63 0.00 0 0 0.5 1 1.5 2
9.445 0.99 0.01 ln(cresi)
1.48 versus
2 tiempo
4 0 6 1Linear (ln(cresi)
8 2 versus 10tiempo)
3 12 4 14 5
-0.50 f(x) = − 0.971412034260957 x + 0.12086789785
9.531 1.00 0.00 1.19 R² = 0.999168737284719

-1.00
12.61
-1.50

-2.00

-2.50

Column L Linear (Column

Title Chart Title

x + 2.33685295302855

.8 2 2.2
1 1.5 2 2.5 3
versus
10tiempo)
3 12 4 14 5 16 6 7
971412034260957 x + 0.120867897857508
9168737284719

Column L Linear (Column L)

0-1 24.7 0.35 8.645 8.645 2.16 1
1-2 14.48 0.53 7.6744 7.6744 2.04 1.5
2-4 8.97 1.25 11.2125 5.60625 1.72 3
4-6 12.17 0.78 9.4926 4.7463 1.56 5
6-8 8.7 0.85 7.395 3.6975 1.31 7
8-12 5.95 1.75 10.4125 2.603125 0.96 10
12-24 5.31 2.25 11.9475 0.995625 0.00 18
24-36 0 2.25 0

Chart Title
2.50

2.00 f(x) = − 0.128734507747202 x + 2.21344786210779

R² = 0.982931537558832
1.50

1.00

0.50

0.00
0 2 4 6 8 10 12

Column F Linear (Column F)

9.14676258 0.03658705 0.28428167

0.0927 0.72027972
 Periodo de Conc. de fármaco en Volumen de orina (L) Xu Xu acc. (Xuinf-Xu) Ln(Xuinf-Xu) tiempo
recolección (h) orina (mg/L)
0-1 24,7 0,35 8,645 8,65 58,13 4,06 1
01-feb 14,48 0,53 7,6744 16,32 50,46 3,92 2
02-abr 8,97 1,25 11,2125 27,53 39,25 3,67 4
04-jun 12,17 0,78 9,4926 37,02 29,76 3,39 6
06-ago 8,7 0,85 7,395 44,42 22,36 3,11 8
08-dic 5,95 1,75 10,4125 54,83 11,95 2,48 12
dic-24 5,31 2,25 11,9475 66,78 0,00 24
24-36 0 2,25 0 66,78 36

10 12

F)
u) tiempo

4,06 1
3,92 2
3,67 4
3,39 6
3,11 8
2,48 12
24
36
BD
dosis (mg) AUC (mg/L)*h DS
comprimido 200 89.5 19.7
solución oral 200 86.1 18.1
bolo iv 50 37.8 5.7

BD relativa 1.03948897 103.90%

BD absoluta AUC*D iv/AUC*dosis oral 0.59193122 59.20%
Vd 10 L
kel 0,234 h-1
tiempo (h) dosis (mg) Cp (mg/L)
0 200 10

4 150
6 ??? 11.84992832

12 250

14 17.47904338