GENETIC DISEASES

Monogenic Chromosomal Polygenic

Examples:

Ex. 1. A woman who is a heterozygous for Huntington’s Disease, which is a dominant

disease, marries a man who is also a heterozygous for the disease. What are the genotypes?
What is the probability that their children will have the disease? What is the probability that
their children will not have the disease? Show a Punnett square!

Ex. 2. In order to express sickle-cell anemia, an affected individual must inherit two alleles
(HbsHbs). [Healthy HbAHbA, HbAHbS - codominance, some erythrocytes are normal, some
sickle]
What is the probability that the offspring of two heterozygous parents will also be
heterozygous?

Ex. 3. A woman who is a carrier (heterozygous) for Cystic Fibrosis marries a man who has
Cystic Fibrosis, a recessive disease. What are the genotypes? What is the probability that their
children will have the disease? What is the probability that their children will not have the
disease? Show a Punnett square!