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Wpa040142 PDF
Wpa040142 PDF
Anorexia nervosa (AN) usually onsets in mid-adolescence and presents with serious psychiatric and medical morbidities. Yet, few psy-
chological treatments for this debilitating disorder have been studied. One intervention which involves the parents of the adolescent has
proved to be promising, especially in patients with a short duration of illness, i.e., less than three years. The benefits of this family-based
treatment have also been shown to be enduring at five-year follow-up. All available studies of psychological treatments for adolescent
AN, both controlled trials and case series, are reviewed here. Almost all of them involve parents in treatment. These studies show that the
majority of patients, even those who are severely ill, can be treated quite successfully as outpatients provided that the parents participate
in treatment. In this family-based treatment, parents are viewed as a resource rather than a hindrance. Optimism regarding these encour-
aging findings should be tempered until larger scale randomized trials have been conducted.
Anorexia nervosa (AN) is a serious illness and has a EARLY ACCOUNTS OF FAMILY THERAPY
profound impact on the lives of many individuals and their FOR ADOLESCENT ANOREXIA NERVOSA
families. It usually onsets in adolescence and affects about The first effort to include families in the treatment of AN
2% of young women and 1% of males (1,2). AN is charac- in adolescents was conducted by Minuchin and his col-
terized by persistent efforts to achieve a low weight, often leagues at the Child Guidance Clinic in Philadelphia
to the point of severe malnutrition, and is accompanied by (17,18). These clinicians treated a series of 53 patients and
a specific psychopathology that includes a morbid fear of provided outcome data for family therapy in a follow-up of
fatness. Unrelenting dieting usually leads to weight loss as this cohort. Most patients were adolescents with a relative-
well as amenorrhea (3). ly brief illness history (less than 3 years). Treatment was
If weight loss is not reversed, major medical complica- quite mixed, with most patients initially receiving inpatient
tions, such as bradycardia, peripheral edema and osteo- treatment and some individual therapy. However, the pri-
porosis, may develop (4-6). Numerous other complica- mary intervention was family therapy and the authors
tions can also result from AN: interference with physical reported successful outcome in about 86% of patients. It is
development, growth and fertility (7), generalized and due to this success rate, as well as the theoretical model of
occasional regional atrophy of the brain (8), poor social the “psychosomatic family” upon which much of Min-
functioning (9,10), low self-esteem (11), and high rates of uchin’s work was based, that he and his colleagues ulti-
comorbid substance abuse, mood disorders, anxiety disor- mately exerted considerable influence on ensuing treat-
ders, and personality disorders (12,13). ment efforts for adolescents with AN (17,18).
Outcomes for AN are generally not optimistic. Only A primary distraction from the optimism that Min-
44% of patients followed at least 4 years after the onset of uchin’s findings created is the methodological weaknesses
illness are considered recovered, i.e., being within 15% of that underlie this study. Members of the treatment team
ideal body weight, one-quarter of patients remain serious- conducted patient evaluations, there were no comparison
ly ill, and another 5% have succumbed to the illness and treatment groups, and follow-up varied greatly (range 18
died (14). Other studies (15,16) have reported mortality months-7 years). However, this study did not purport to be
rates as high as 20% in chronically ill adults with AN. a clinical trial and ought to be recognized for its signifi-
Although there is general consensus regarding the cance in the treatment of AN. Consequently, the underlying
severe morbidity and mortality of AN, only modest efforts theoretical principles and clinical application of Min-
have been devoted to the exploration of psychosocial uchin’s approach have served as the foundation for a num-
treatments for these patients. While findings from the few ber of controlled family-based treatment studies which
published studies for adults with AN are inconclusive, a were pioneered at the Maudsley Hospital in London.
more optimistic picture has emerged for adolescent AN.
The handful of treatment studies that have been conduct- CONTROLLED STUDIES OF FAMILY TREATMENT
ed for adolescent AN all include the patient’s parents in FOR ADOLESCENT ANOREXIA NERVOSA
treatment, and most of these reports point to positive out-
The Maudsley studies
comes. The aim of this paper is to examine these adoles-
cent studies more closely and put family-based treatment The first controlled study to build on Minuchin’s work
forward as a promising approach for this patient popula- was conducted at the Maudsley Hospital in London
tion. (19,20). It was a comparison of outpatient family-based
143
ond case series, Le Grange et al (32) report pre- and post- ment focus discussions on adolescent issues such as indi-
treatment data for 45 adolescents with AN who have viduation, sexuality and career.
received a course of manualized FBT. Overall, their findings
are favourable, in that 89% of cases were recovered or made
Family treatment in an inpatient setting
significant improvements in outpatient treatment over a rel-
atively short period of time (mean = 10 months; mean num- Only one study employed family therapy in an inpatient
ber of treatment sessions = 17). They conclude that their setting. Geist et al (36) compared two modes of treatment:
series provides preliminary support for the feasibility of out- family therapy versus family group psychoeducation. The
patient FBT which underscores the beneficial impact of effects of these interventions are difficult to evaluate, as
active parental involvement in the treatment of adolescents nearly half of the family treatment occurred in the context
with AN. In the most recent of these series utilizing manu- of an inpatient setting. Most of the recorded weight gain
alized FBT, an open trial of 20 adolescents with AN, Loeb et (76%) was achieved prior to discharge from hospital, with
al (33) demonstrate high retention rates and significant equivalent treatment effects observed with both family
improvement in the specific and associated psychopatholo- interventions. The authors argued that family group psy-
gy of their patients. choeducation is an equally effective but more economical
method of involving the family in treatment (36).
Work based on the Maudsley approach
UNCONTROLLED FAMILY TREATMENT STUDIES
Behavioral systems family therapy (BSFT), based on the
Maudsley treatment, has been compared to ego-oriented Since the seminal works of Minuchin (17,18) and Russell
individual treatment (EOIT) (34,35). These researchers (19,20), and in addition to the case series already reported
reported significant improvement in AN symptomatology at above, several smaller case series using family therapy have
the end of treatment. More than two thirds (67%) of been published (37-45). Although modest in sample size, all
patients reached target weight and 80% regained menstrua- these studies have demonstrated the value of employing
tion. Patients continued to improve and, at one-year follow- parents in the recovery of their adolescent with AN. Taken
up, approximately 75% had reached their target weight and together, results are supportive of family treatments for ado-
85% had started or resumed menses. However, there were lescent AN, although only provisional conclusions can be
noticeable differences between the two treatments. Patients drawn from uncontrolled studies that describe a relatively
in BSFT achieved significantly greater weight gain than small series of cases. However, in conjunction with Min-
those in EOIT, both at the end of treatment and at follow- uchin’s work, as well as the controlled studies, these prelim-
up. Similarly, patients who received BSFT were significant- inary investigations further emphasize the value of the fam-
ly more likely to have returned to normal menstrual func- ily’s involvement in the treatment of adolescents with AN.
tioning at the end of treatment compared to those in EOIT.
Both treatments were similar in terms of improvements in
DISCUSSION
eating attitudes, depression, and self-reported eating-related
family conflict. Neither group reported much family-related Most of the studies involving adolescents with AN sug-
conflict regarding eating, either before or after treatment. gest that family therapy is helpful in younger patients with
While both treatments produced comparable improvements a short duration of illness and that most patients do not
in eating attitudes and depression, BSFT produced a more require hospitalization for recovery to occur. For the most,
rapid treatment response. 70% of patients will have reached a healthy weight by the
While BSFT was modelled after the Maudsley approach, end of treatment, while a majority will have started or
it differed in some important albeit subtle ways. First, Robin resumed menstruation. At five years post treatment, 75-
et al (35) defined the adolescents in their study as ”out of 90% of patients are fully recovered and no more than 10-
control” and not able to take care of themselves, while the 15% will remain seriously ill (23,25).
parents were coached to implement a behavioral weight The involvement of parents in the treatment of their AN
gain program. This differs somewhat from the Maudsley offspring appears beneficial, but conclusions can only be
approach, in that parents were to explore and, with the help made provisionally. FBT encourages parents to take an
of the therapist, find the optimal way to restore healthy active role in restoring their adolescent’s weight and, for
weight in their adolescent with AN. Second, Robin et al (35) now, seems to have some advantages over the more “rou-
broadened the focus of treatment to include cognitions and tine” advice to parents, which is to involve them in a way
problems in “family structure” while the parents were still in that is supportive and understanding of their child, but
charge of the re-feeding process. The Maudsley approach encourages them to step back from the eating problem.
typically would refrain from ”distractions” until weight has However, many aspects regarding the effectiveness of FBT
been restored. Both BFST and the Maudsley approach remain unanswered. For instance, it is unclear how best to
would return control over eating to the adolescent when involve parents in treatment or how essential their active
target weight was achieved, and in the final stage of treat- involvement might be, given the limited data. Both Eisler et
145
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