1.

R/ Ketamin HCL 10 mg/ml

m.f inj. Da in ampul 1 ml
dtd. No. III
Jawab :
 Ketamin HCl = 10mg/ml = 1g/100ml = 1%
 E 1% Ketamin HCl = 0,21 (FI IV HAL 1246)
 W = 1g/100ml
V = W x E x 111,1
V = 1 x 0,21 x 111,1
= 23,331 ml (Volume Isotonis)
 Pelarut yang belum isotonis = 100 ml – 23,331ml
= 76,669ml
1
Dalam1 ml= x 76,669 ml
100
= 0,77 ml
0,9
 NaCl yang ditambahkan= x 0,77 ml=0,0069 g=6,9 mg/ml
100

2. R/ Morfin HCL 10mg/ml

m.f. injeksi da in ampul 1 ml
dtd no. III
Jawab :
 Morfin HCl = 10mg/ml = 1g/100ml = 1%
 E 1% = 0,086
 W = 1g
V = W x E x 111,1
= 1 x 0,086 x 111,1
= 9,55 ml (Volume Isotonis)

 Pelarut yang belum isotonis = 100ml – 9,55ml

= 90,45 ml
1 ml
Dalam1 ml= x 90,45ml=0,9045 ml
100 ml
0,9 g
 NaCl yang perlu ditambahkan= x 0,9045 ml=0,0081 g /ml = 8,1g/ml
100 ml
3. R/imipramine Hcl 13,5 mg/ml
m.f inj da in vial 5 ml
dtd no. II
Jawab :
 Imipramin HCl = 13,5mg/ml = 1,35mg/100ml = 1,3%
 E 2% Imipramin HCl = 0,20
 W = 1,35g
V = W x E x 111,1
= 1,35 x 0,20 x 111,1
= 29,99ml (Volume Isotonis)
 Pelarut yang isotonis = 100ml – 29,99ml
= 70,01
5
Dalam5 ml= x 70,01=3,5 ml
100
0,9 g
 NaCl yang ditambahkan= x 3,5 ml=0,0315 g=31,5 mg/ml
100 ml

4. R/Methadon Hcl 10 mg/ml

m.f. isotonis cum nacl ad 10 ml
da in vial 5 ml
dtd. No. III
Jawab :
 Methadon HCl = 10mg/ml = 1g/100ml = 1%
 E 1% Methadon HCl = 0,18
1g
 W =Methadon= x 10 ml=0,1 gram
100ml
V = W x E x 111,1
= 0,1 x 0,18 x 111,1
= 1,99ml
 Volume yang belum isotonis = 10ml – 1,99ml
= 8,01ml
 5
dalam 5 ml = x 8,01=4,00 ml
10
0,9 g
 NaCl ditambahkan = x 4,00 ml=0,036 g/ml = 36mg/ml
100 ml