MD (Pharmacology) - Final Year Examinations MAY-2018: Roll No

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Roll No.
MD (PHARMACOLOGY)-FINAL YEAR EXAMINATIONS; MAY- 2018

rSUB.:- RECENT ADVANCES IN PHARMACOLOGY; PAPER CODE: 01230104]
Time: 03:00 H rs. Max. Mar'ks: 100

Instructions:-
I. Write your 1{0H No. on the Question paper.
2. Candidate should ensure that they have been provided correct question paper. Complaints in this regard, if
any, should be made within 15 minutes of the commencement of the exam. No complaint(s) will be
entertained thereafter.
3. Attempt all questions. Parts of a question should be attempted in sequential order. Marks are indicated
against each question.
4. Illustrate your answer with diagram wherever required.
It Discuss brief1y:-
Q. 1 Biosimilars, (10)
Q. 2 Novel clinical trial designs. (10)
Q. 3 Novel antimicrobial agents. (10)
Q. 4 Drug repurposing. (10)
Q.5 How to critically evaluate a paper describing a pharmacogenetic study? (10)
Q. 6 Current treatment options for drug-resistant tuberculosis. (10)
Q.7 Novel drugs for depression. (10)
Q.8 Novel oral anticoagulants (NOACs). (10)
Q. 9 Evidence Based Medicine. (10)
Q. 10 Targeted therapy. (10)
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Roll No.
MD (MICROBIOLOGY)-FINAL YEAR EXAMINATIONS; MAY- 2018

[SUB.:- GENERAL MICROBIOLOGY AND IMMUNOLOGY; PAPER CODE: 01220101]
Time: 03:00 Hrs. Max. Marks: 100

Instructions:-
I. Write your Roll No. on the Question paper.
3. Attempt all questions. PaJ1sof a question should be attempted in sequential order. Marks are indicated
-- --- .. ------~---~~~~~~~~~~--~~~~~~~~~~~-
Q. 1 Define and classify carbapenemases, their clinical importance and methods of

detection. (10)
Q. 2 Discuss role of probiotics in health and disease. (10)
Q.3 Discuss recent advances in sterilization. (10)
Q. 4 Write in brief about various methods of gene sequencing; their merits and
demerits. (10)
Q. 5 Write short notes on:- (5+5=10)

a) Pathogenicity islands
b) DNA vaccines
Q.6 Write short notes on:- (5+5=10)

a) Lyophilisation
h) Bacterial Growth Curve
Q. 7 Write in detail about Toll like receptors and innate immunity. (10)
Q. 8 Describe role of immunomodulators and adjuvants in health and disease. (10)
Q. 9 Classify Hypersensitivity reactions. Describe Type IV hypersensitivity reaction. (10)
Q. 10 Describe major histocompatibility complex. Write in brief about various classes

of MHC molecules. (10)
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,.
I
Roll No. ----------------

ISlJB.:- VIROLOGY AND PARASITOLOGY; PAPER CODE: 01220103]

Tnstructions:-
• Q. 1
Q. 2
Describe the viral agents causing encephalitis. Discuss the laboratory diagnosis of
anyone arboviral infection.
Enumerate the parasitic agents of diarrhea in imrnunocompromised host, Discuss

(10)
the life cycle, pathogenicity and laboratory diagnosis of anyone. (10)
Q.3 Write briefly on Tropical Eosinophilia. (10)
Q.4 Enumerate the parasitic infections caused by trematodes in India. Discuss briefly
the laboratory diagnosis. (10)
Q.5 Describe the transmission and the laboratory diagnosis of toxoplasmosis. (10)
Q. 6 Discuss the current epidemiology, laboratory diagnosis and treatment of swine flu. (10)
Q. 7 Discuss the recent advances in Rotavirus vaccine. (10)
• Q. 8
Q. 9
Write briefly on congenital viral infections.
Describe the antemortem diagnosis and post exposure prophylaxis in Rabies.

(10)
(10)
Q.I0 Discuss the laboratory diagnosis and Quality assurance program in HIV. (10)
*****************************
Roll No. _

[SUB.:- APPLIED MICROBIOLOGY AND RECENT ADVANCES; PAPER CODE: 01220104]

Instructions:-
Q. 1 Write briefly on isothermal amplification methods. (10)
Q.2 Discuss Biosafety cabinets. (10)
Q. 3 Discuss the interventions to be taken to minimize occupational hazards in health care

workers. (10)
Q. 4 Write briefly on present status of drug resistance in Neisseria gonorrhoea and its
implications. (10)
Q.5 Scope ofmicrohial testing for organ transplantation. (10)
Q. 6 What are the CLSI guidelines for detection of ESBLs. (10)
Q. 7 List the key features for selecting a bioterror agent. Give two examples ofbioterror
attacks which have occurred in the past. (10)
Q. 8 Write briefly on Probiotics and their uses. (10)
Q. 9 Discuss the principles of next generation sequencing and its future prospects in
Microbiology. (10)
Q. 10 Role of immunomodulators in Microbiology. (10)
*****************************
I
. t,
Roll No .
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MD (PHYSIOLOGY)-FINAL YEAR EXAMINATIONS; MAY- 2018

[SUB.:- SYSTEMIC PHYSIOLOGY (INCLUDING BIOPHYSICS, BIOCHEMISTRY &
HISTOLOGY; PAPER CODE: 01190102)

Instructions:-
4. llIustrate your answer with diagram wherever required.
Q. 1 Discuss the changes in cardio-respiratory system associated with first breath of new
born. (10)
Q.2 Discuss the functions of capillary endothelium. (10)
Q. 3 Discuss the application of laws of physics to hemodynamics. (10)
Q.4 What is respiratory quotient. Describe the factors affecting respiratory quotient. (10)
Q.5 Describe the digestion and absorption of fats. Write a note on steatorrhoer. (10)
Q.6 Discuss the ventilatory responses to changes in acid-base balance. (10)
Q. 7 Discuss the recent advances in the field of immunity. (10)
Q. 8 Write short notes on:- (2x5=10)

a) Balanced diet in pregnancy.
b) Regulation of feeding.

c) Fibrinolytic system
d) Blood storage and transfusion
Q.I0 Write short notes on:- (2xS=10)

a) Physiology of deglutition
b) Migrating motor complexes
*****************************
,
I
Roll No. ----------------

[SUB.:- GENERAL PHYSIOLOGY (COMPARATIVE, WORK, ENVIRONMENTAL &
SPORTS PHYSIOLOGY; PAPER CODE: 01190101]

Instructionse-
Q.1 Describe the measurement of body fluid volumes. (10)
Q.2 Describe endocrine responses to exercise. (10)
Q.3 Describe in detail the structure of cell membrane. (10)
Q.4 Describe mountain sickness and its treatment. (10)
Q.5 Write briefly about- (2x5=10)

a) Von Helmhotz
b) ANOVA
Q. 6 Describe the chemical and electrical events of Action Potential. (10)

a) peR
b) Positive feedback
Q. 8 Describe primary active transport process in detail. (10)

a) Recombinant DNA Technology
b) Blotting Technique
Q. 10 Describe body responses to cold environment. (10)
*****************************
"
Roll No.
----------------
MD (PHYSJ()LOGY)-FINAL YEAR EXAMINATIONS; MAY- 2018

[SUB.:- SYSTEMIC PHYSIOLOGY-II (INCLUDING RECENT ADVANCESJ
[PAPER CODE: 01190103J

Instructions:-
2. Candidate should ensure that they have been provided correct question paper. Complaints in this regard,
if any, should be made within 15 minutes of the commencement of the exam. No complaint(s) will be
4t Q. 1 How is the secretion of thyroid hormones regulated? Describe the functions of

thyroid hormones. Add a note on hypothyroidism. (10)
Q. 2 What is the basis of generation of Resting Membrane potential and how it IS

maintained? (10)
Q. 3 Describe hormonal changes occurnng during menstrual cycle. Discuss

physiological mechanism of oral contraceptive pills. (10)
Q. 4 Define renal clearance. How the GFR is measured by renal clearance tests. (10)
Q. 5 Describe the tunning fork tests for different hearing defects. (10)
Q.6 What are the types of speech? Write briefly on different types of aphasia. (10)
Q. 7 Discuss the physiological basis of EEG. Add a note on its clinical uses (10)
Q. 8 Describe the receptors and pathways involved in pain sensation. How the inhibition
of pain can be achieved. (10)
Q. 9 What are stem cells? Write about their types and use. (10)
Q. 10 Discuss the regulation of food intake. Define obesity and its criteria. (10)
*****************************
,,
Roll No
--

rSUB.:- CLINICAL APPLIED PATHO-PHYSIOLOGY & BASIS OF THERAPY]
(PAPER CODE: 01190104]

Instructions:-
1. Write your Roll No. on the Question paper.
2. Candidate should ensure that they have been provided correct question paper. Complaints in this regard,
if any, should be made within 15 minutes of the commencement of the exam. No complaint(s) will be
entertained thereatter.
3. Attempt all questions, Parts of a question should be attempted in sequential order. Marks arc indicated
Q. 1 Describe the patho- physiology and management of hypovolemic shock. (10)
Q.2 Compare and contrast the functioning of Meissner's and Myenteric plexus. (10)
Q.3 Give a brief account of the commonly used sampling techniques (10)
Q. 4 Describe the composition and functions of feto-placental unit. (10)
Q. 5 What is the patho-physiological basis of symptoms of Diabetes mellitus?

Add a note on hypoglycaemia. (10)
Q.6 Describe the role of endothelium as an endocrine organ. (10)
Q.7 Describe the mechanisms underlying onset of puberty. (10)
Q. 8 Discuss the role of Yoga in the maintenance of health. (10)
Q. 9 Describe the theories of aging and recent advances in anti-aging therapies. (10)
Q.I0 Discuss the features of Metabolic syndrome in detail. (10)
*****************************
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Roll No.
MD (BIOCHEMISTRY)-FINAL YEAR EXAMINATIONS; MAY- 2018

[SUB.:- BIOMOLECULES, CELL BIOLOGY, PRINCIPLES OF BIOPHYSICS AND PHYSICAL
CHEMISTRY, BIOSTA TICS/ RESEARCH METHODOLOGY AND BIOCHEMICAL
TECHNIQUES QUALITY CONTROL IN LABS; PAPER CODE: 01200101]

Instructions:-
2. Candidate should ensure that they have been provided correct question paper. Complaints ill this regard, if
Q. 1 Enumerate hetropolysacharides. Describe their structures and functions and disorders

associated with them. (4+3+3=10)
Q. 2 Describe the movement of substances across cell membrane. (10)
Q. 3 Explain the following: (5x2=10)

a) Chi Square Test
b) Multivariate analysis
Q.4 Describe Mass Spectrometry. (10)

a) PAGE
b) Nanotechnology
Q. 6 Define p I I. Describe the body buffers. (3+7=10)
Q. 7 Describe how internal quality control IS maintained 111 the clinical biochemistry
Laboratory. (10)
Q. 8 Describe intracellular traffic. (10)
Q. 9 Describe cytoskeleton and cell motility. (5x2=10)

a) pH meter
b) DNA isolation
*****************************
,r
Roll No. ----------------

rSUB.:- ENZYMES, BIOLOGICAL OXIDATION, INTERMEDIARY METABOLISM AND
REGULATION, INBORN ERRORS OF METABOLISM, NUTRITION (VITAMINS & MINERALS)
ENDOCRINOLOGY; PAPER CODE: 01200102]

Instructions:-
any, should be made within 15 minutes of the commencement of the' exam. No complaint(s) will be
against eaeh question.
Q. 1 Regulation of Enzyme Activity. (10)
Q.2 Oxidative phosphorylation and its inhibitors. (10)
Q.3 Glycolytic pathway in RBCs. (10)
Q.4 Transport of ammonia from various tissues to the liver. (10)
Q.5 What is Basal Metabolic Rate? How it is measured? Explain factors affecting Basal
Metabolic Rate. (10)
Q. 6 Obstructivejaundice. (10)
Q. 7 Mechanism of action of steroid hormones. (10)
Q.8 Hemolysis in Pyruvate Kinase deficiency and G6 PD deficiency. (10)
Q.9 Complication of diabetes mellitus. (10)
Q. 10 Exogenous transport of lipoproteins. (10)
*****************************
,
I
Roll No.

[SUB.:- MOLECULAR BIOLOGY, IMMUNOLOGY, CANCER-MOLECULAR AND GENETIC
ASPECTS, ENVIRONMENTAL BIOCHEMISTRY; PAPER CODE: 01200103]
Time: 03:00Hrs. Max. Marks: 100

Instructions:-
any, should be made within 15 minutes of the commencement of the exam. No complainus) will be
,.
.
Q. 1 Write molecular mechanism of development of resistance against (a) methotrexate in
cancer cells and (b) rifampicin in mycobacterium tuberculosis. (10)
Q.2 Describe different methods of assessing gene expression from eukaryotic cells. (10)
Q. 3 Describe diseases associated with defects in different DNA repair mechanisms. (10)
Q. 4 Mention post-translational modifications of histones that occur in eukaryotic cells.

Write the role of histones in DNA folding. (10)
Q.5 What is pyrosequencing? How does it differ from DNA sequencing by Sangar's
method? (10)
Q. 6 Describe the structure and functions of HLA molecules. (10)
Q. 7 Define Warburg's effect? Explain its biochemical basis and functional significance. (10)
Q.8 Define epigenetics. Discuss the role of epigenetic mechanism in carcinogenesis. (10)
Q.9 How do cancer cells evade immune surveillance mechanism? (10)
Q.10 Justify the statement that Cyt P450 is a monooxygenase. Write the significance of
studying 'single nucleotide polymorphism' of cyp genes in clinical practice. (10)
*****************************
·, Roll No. ---
MD (BIOCHEMISTRY)-FINAL YEAR EXAMINATIONS; MAY- 20t8

[SUB.:- BIOCHEMISTRY OF DIFFERENT BODY SYSTEMS. ORGANS IN HEALTH AND
DISEASE (MOLECULAR MEDICINE), CLINICAL BIOCHEMISTRY, RECENT ADVANCES]
[PAPER CODE: 01200104]

Instructions:-
3. Attempt all questions. Parts of a question should he attempted in sequential order. Marks are indicated
against eaeh question.
Q. 1 Discuss various hiochemical changes in blood and urine of a patient suffering from
hemolyticjaundice. (10)
Q.2 Receiver operating characteristic (ROC) curve of laboratory assay. (to)
Q.3 Effect of insulin or carbohydrate, protein and lipid metabolism. (10)
Q.4 Enzyme inhibition. (10)
Q.5 Diet and coronary artery disease. (10)
Q.6 Onco-fetal proteins. (10)
Q.7 Biochemical changes in pregnancy. (10)
Q.8 Describe the various renal function test. Explain their significance. (10)
Q.9 Metabolic function, regulation, associated disorders and laboratory assessment of

adrenal medullary hormone. (10)
Q. 10 Ion-exchange chromatography. (10)
*****************************

MD (Pharmacology) - Final Year Examinations MAY-2018: Roll No

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MD (PHARMACOLOGY)-FINAL YEAR EXAMINATIONS; MAY- 2018

Time: 03:00 H rs. Max. Mar'ks: 100

Q. 2 Novel clinical trial designs. (10)

Q. 3 Novel antimicrobial agents. (10)

Q. 4 Drug repurposing. (10)

Q.5 How to critically evaluate a paper describing a pharmacogenetic study? (10)

Q. 6 Current treatment options for drug-resistant tuberculosis. (10)

Q.7 Novel drugs for depression. (10)

Q.8 Novel oral anticoagulants (NOACs). (10)

Q. 9 Evidence Based Medicine. (10)

Q. 10 Targeted therapy. (10)

MD (MICROBIOLOGY)-FINAL YEAR EXAMINATIONS; MAY- 2018

Time: 03:00 Hrs. Max. Marks: 100

Q. 1 Define and classify carbapenemases, their clinical importance and methods of

Q. 2 Discuss role of probiotics in health and disease. (10)

Q.3 Discuss recent advances in sterilization. (10)

Q. 5 Write short notes on:- (5+5=10)

Q.6 Write short notes on:- (5+5=10)

Q. 8 Describe role of immunomodulators and adjuvants in health and disease. (10)

Q. 9 Classify Hypersensitivity reactions. Describe Type IV hypersensitivity reaction. (10)

Q. 10 Describe major histocompatibility complex. Write in brief about various classes

Roll No. ----------------

MD (MICROBIOLOGY)-FINAL YEAR EXAMINATIONS; MAY- 2018

Time: 03:00 Hrs. Max. Marks: 100

Enumerate the parasitic agents of diarrhea in imrnunocompromised host, Discuss

the life cycle, pathogenicity and laboratory diagnosis of anyone. (10)

Q.3 Write briefly on Tropical Eosinophilia. (10)

Q. 7 Discuss the recent advances in Rotavirus vaccine. (10)

Describe the antemortem diagnosis and post exposure prophylaxis in Rabies.

MD (MICROBIOLOGY)-FINAL YEAR EXAMINATIONS; MAY- 2018

Time: 03:00 Hrs. Max. Marks: 100

Q. 1 Write briefly on isothermal amplification methods. (10)

Q.2 Discuss Biosafety cabinets. (10)

Q. 3 Discuss the interventions to be taken to minimize occupational hazards in health care

Q.5 Scope ofmicrohial testing for organ transplantation. (10)

Q. 6 What are the CLSI guidelines for detection of ESBLs. (10)

Q. 8 Write briefly on Probiotics and their uses. (10)

Q. 10 Role of immunomodulators in Microbiology. (10)

MD (PHYSIOLOGY)-FINAL YEAR EXAMINATIONS; MAY- 2018

Time: 03:00 Hrs. Max. Marks: 100

Q.2 Discuss the functions of capillary endothelium. (10)

Q. 3 Discuss the application of laws of physics to hemodynamics. (10)

Q.6 Discuss the ventilatory responses to changes in acid-base balance. (10)

Q. 7 Discuss the recent advances in the field of immunity. (10)

Q. 8 Write short notes on:- (2x5=10)

Q. 9 Write short notes on:- (2x5=10)

Q.I0 Write short notes on:- (2xS=10)

Roll No. ----------------

MD (PHYSIOLOGY)-FINAL YEAR EXAMINATIONS; MAY- 2018

Time: 03:00 Hrs. Max. Marks: 100

Q.1 Describe the measurement of body fluid volumes. (10)

Q.2 Describe endocrine responses to exercise. (10)

Q.3 Describe in detail the structure of cell membrane. (10)

Q.4 Describe mountain sickness and its treatment. (10)

Q.5 Write briefly about- (2x5=10)

Q. 6 Describe the chemical and electrical events of Action Potential. (10)

Q. 7 Write short notes on:- (2x5=10)

Q. 8 Describe primary active transport process in detail. (10)

Q. 9 Write short notes on:- (2x5=10)

Q. 10 Describe body responses to cold environment. (10)

MD (PHYSJ()LOGY)-FINAL YEAR EXAMINATIONS; MAY- 2018