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Ansiedade e Treino Combinado PDF
Ansiedade e Treino Combinado PDF
CI 2 to 56) for RET and 10 (95% CI –7 to 3) for AET. A significant patients tend to be physically inactive [3]; (2) exercise
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of equal size. No patient refused randomization. of the tendency to worry excessively. Patients responded on a
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5-point Likert scale for which higher scores indicated greater lev- increase for any condition across the investigation. No
els of worry. Completion of the scale required approximately patient discontinued the intervention, and all patient
5 min. Favorable psychometric data support the PSWQ [16]. In the
present investigation PSWQ scores (using all trials) demonstrated data were used in analyses.
appropriate internal consistency (Chronbach’s ␣ = 0.92) and sta-
bility [ICC (2, 4) = 0.73; 95% CI 0.59 to 0.85]. Baseline Patient Characteristics
Using the 9th item of the Beck Depression Inventory-II (Sui- Table 1 presents baseline demographic, medical, phys-
cidal Thoughts or Wishes) [17], suicidal ideation was examined ical activity, and psychiatric characteristics of the sample.
for safety monitoring, as a potential adverse event, and for inter-
vention tolerability. Each patient completed a 24-hour prescrip- Corrected 2 tests showed a significantly larger number
tion and nonprescription medication and supplement recall. of comorbid psychiatric diagnoses for WL compared to
Nonintervention physical activity also was estimated [12]. RET.
Preliminary Analyses Intervention Fidelity
Descriptive statistics are presented in the text and tables as
means [standard deviation (SD)] and in the figures as means (SE). WL patients completed 100% of the outcome assess-
2 tests, Bonferroni-corrected for multiple comparisons, were ments. Patients in the RET condition attended 100%
used to evaluate baseline differences in the number of comorbid (120/120) of sessions and complied with 99.1% of the RET
psychiatric diagnoses and psychoactive medication use. Baseline protocol, completing 28,550 of 28,800 repetitions at the
comparisons of other patient characteristics were performed us- prescribed intensity. One RET session was not completed
ing univariate ANOVA. Intervention intensity variables were av-
eraged across 12 sessions and compared using independent sam- due to illness. Patients in the AET condition attended
ples t-tests. 100% (120/120) of sessions and complied with 100% of the
AET protocol, each completing 12 bouts of 16 min of cy-
Outcome Analyses cling exercise at the required power output. Thus, the av-
Clinician diagnoses of GAD were analyzed using the number erage total minutes of exercise for the AET and RET pa-
needed to treat (NNT) [18]. The NNT and associated 95% CI were
calculated as the inverse of the absolute risk reduction for each tients was 192 and 190, respectively, out of a total of 192
exercise condition compared with the WL condition. possible minutes. Five total exercise bouts, i.e. 4 RET
Worry symptom scores were analyzed using a mixed-model 3 bouts and 1 AET bout, were completed away from the
(condition: RET, AET, and WL) ! 3 (time: weeks 2, 4, and 6) testing facility but were documented via phone calls in
ANCOVA adjusted for baseline scores. Bonferroni-corrected which exercise session duration and RPE were provided.
pairwise comparisons were conducted to assess group differenc-
es. Because only 30% (n = 9) of patients were tested during the first During the exercise sessions, RET was characterized
4 months (August to December), a 1-way intraclass correlation by an overall mean (SD) RPE and heart rate (beats per
coefficient [ICC(1)] was calculated to examine the percentage of minute) of 14 (1) and 125 (12). The overall means for AET
variance accounted for by the testing period (August to December were 8 (1) and 122 (8). There was not a significant differ-
and January to April). The testing period accounted for 5% of the ence in heart rate between exercise conditions [t(18) = 0.81,
variance, so a follow-up mixed-model 3 ! 3 ANCOVA adjusted
for baseline and the testing period was conducted. Because no dif- p = 0.429]. The mean RPE during exercise was signifi-
ferences between exercise conditions were hypothesized, a follow- cantly higher for RET compared with AET [t(18) = 9.52,
up contrast (adjusted for the testing period) comparing WL with p ! 0.0001]. The session RPE was significantly higher for
the combined exercise conditions on week 6 scores was computed. RET compared to AET [t(18) = 8.74, p ! 0.001]. As planned,
At each time point, Hedges’ d effect sizes and associated 95% RET resulted in larger strength increases across 6 weeks
CIs were calculated for each exercise condition [19]. Effect sizes
were adjusted for small sample bias and calculated so that symp- than did AET and WL (all Hedges’ d 6 0.64).
tom improvement resulted in a positive effect size [19]. Patients were asked to refrain from participating in
other therapy programs during the intervention. How-
ever, after the trial 4 patients (1 RET, 2 AET, and 1 WL)
Results reported that during the intervention they had minimal
engagement (2 sessions) in an additional form of psycho-
Patient Flow therapy. A sensitivity analysis with these 4 patients re-
Patients were recruited from August 2009 through moved did not change the statistical significance of the
March 2010. Figure 1 illustrates the flow of patients outcomes.
through the trial. There were no musculoskeletal injuries
or adverse events reported by the patients. The mean Outcomes
baseline BDI-II suicidal ideation item scores were 0.10, 0, Remission rates were 60%, 40%, and 30% for RET,
Claude Moore Health Sciences Lib - Univ of Virginia
and 0.50 for RET, AET, and WL, respectively, and did not AET, and WL, respectively. The absolute risk reduction
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for RET was 0.30 (95% CI 0.02 to 0.58) and the NNT was up model adjusted for baseline scores and the testing pe-
3 (95% CI 2 to 56). The absolute risk reduction for AET riod showed a significant condition-by-time interaction
was 0.10 (95% CI –0.15 to 0.35) and the NNT was 10 (95% [F(3.962, 49.529) = 2.815, p = 0.035, = 0.991]. A follow-up
CI –7 to 3). Psychoactive medication use did not moderate contrast of week 6 scores (fig. 2) showed larger reductions
remission. for the combined exercise conditions compared to WL
Table 2 presents the descriptive data for PSWQ scores. [t(25.943) = 2.168, p = 0.039]. Worry symptoms were not
There was a significant condition-by-time interaction moderated by psychoactive medication use.
[F(3.72, 48.4) = 2.74, p = 0.042, = 0.931]. Bonferroni-cor- Weekly extra-intervention energy expenditure at
rected pairwise comparisons of week 6 scores for RET weeks 2, 4, and 6 did not change significantly from base-
[t(18) = 1.106, p = 0.28] and AET [t(18) = 1.845, p = 0.081] line for RET, AET, or WL groups [F(2, 52) = 0.056, p =
compared with WL were not significant; however, mod- 0.946]. These data suggest that symptom improvements
erately large reductions in worry symptoms were found were not confounded by nonintervention physical activ-
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Table 1. Baseline demographic, physical activity, medical, and psychiatric characteristics
Age, years
Mean 8 SD 23.585.9 25.687.1 20.783.0 24.286.3
Range 18437 19437 18426 18436
College graduate 8 26.7 3 30.0 1 10.0 4 40.0
Married 3 10.0 1 10.0 0 0 2 20.0
Race/ethnicity
Caucasian 19 63.3 5 50.0 8 80.0 6 60.0
African-American 3 10.0 0 0 1 10.0 2 20.0
Hispanic 3 10.0 2 20.0 1 10.0 0 0
Middle Eastern 2 6.7 2 20.0 0 0 0 0
Asian 2 6.7 1 10.0 0 0 1 10.0
Indian 1 3.3 0 0 0 0 1 10.0
Weight, kg
Mean 8 SD 65.7812.2 60.689.1 70.0815.5 66.488.1
Height, cm
Mean 8 SD 164.786.6 162.686.2 165.087.6 166.584.6
BMI, kg/m2
Mean 8 SD 24.285.8 22.882.8 25.785.2 24.083.0
7PAR, kcal/kg/week
Mean 8 SD 253.5827.7 263.3836.6 249.2821.5 248.0822.6
Medication
Contraceptive 15 50.0 5 50.0 5 50.0 5 50.0
Psychoactive
SSRI 7 23.3 2 20.0 2 20.0 3 30.0
SNRI 2 6.7 1 10.0 1 10.0 0 0
NDRI 2 6.7 0 0 1 10.0 1 10.0
Muscle relaxant 2 6.7 1 10.0 1 10.0 0 0
Psychostimulant 1 3.3 0 0 0 0 1 10.0
Psychiatric comorbidity (casesb) 21 (50) 70.0 5 (9) 50.0 6 (14) 60.0 10 (27)a 100.0
Social phobia 12 24.0 2 22.2 5 35.7 5 18.5
Specific phobia 19 38.0 2 22.2 5 35.7 12 44.4
OCD 5 10.0 1 11.1 1 7.1 3 11.1
PTSD 2 4.0 0 0 0 0 2 7.4
MDD 7 14.0 1 11.1 3 21.4 3 11.1
Dysthymia 4 8.0 2 22.2 0 0 2 7.4
Substance abuse 1 2.0 1 11.1 0 0 0 0
BMI = Body mass index; SSRI = selective serotonin reuptake inhibitor; SNRI = serotonin-norepinephrine reuptake inhibitor;
NDRI = norepinephrine-dopamine reuptake inhibitor; OCD = obsessive compulsive disorder; PTSD = posttraumatic stress disorder;
MDD = major depressive disorder.
a WL vs. RET [2 = 6.107, p = 0.01]. b Actual number of cases, not percentage.
(1)
verse events, suggest that exercise training is a feasible, than pharmacotherapy [21]. Widespread access to CBT is
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Although the research design was sufficiently pow- morbid psychiatric diagnoses. Notwithstanding the need
ered to detect a statistically significant effect for the pri- for more and better clinical trials of exercise training
mary outcome, the small sample size, short treatment du- among anxiety patients, these initial findings encourage
ration, and predominantly young-adult sample limit the continued investigation of plausible cognitive or biologi-
generalizability of the present findings. Another poten- cal mechanisms that might explain antianxiety effects of
tial limitation is that, because of initial strength differ- exercise [28], including a reduction in the allostatic load
ences, the exercise training conditions were not ideally and neurotrophic or neuroprotective effects [29].
equated on positive work; consequently, differences be- Preliminary findings suggest that exercise training,
tween AET and RET cannot be completely ruled out. including RET, is a feasible, well-tolerated intervention
Nonetheless, favorable effects on remission and worry that can reduce worry symptoms among GAD patients
symptoms were found regardless of the exercise condi- and may be an effective adjuvant, short-term treatment,
tion. or augmentation [30] for GAD. Further investigation of
A better understanding of the efficacy of exercise as a exercise training effects on patients is warranted.
potential treatment for GAD could be realized through
well-designed investigations that: (1) use large samples
sizes to compare exercise effects to empirically-supported Acknowledgments
treatments for GAD, (2) compare the effects of different
types of exercise that use different intensities and dura- This research was supported by a grant from The University
tions matched for perceptual responses during the time of Georgia’s College of Education. The authors would like to
thank Olivia Barkett, Kristin Espiau, Darren Gillman, Sean Hes-
actively engaged in exercise to better understand the son, Robert Leibman, Allyce Naeger, Akil Piggot, Brad Schwartz,
minimal and optimal dose necessary to improve symp- Kristel Thomassin, Matthew Weintraub, and Lina Vayner for
toms, and (3) block randomize patients to conditions their assistance with data collection.
based on potential confounding variables including co-
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