NAME: BAGSICAN, MARILU JANE H.

SCORE:_____________
SECTION: 3EMT DATE: February 9, 2011

BB LECTURE SEATWORK
OTHER BLOOD GROUP SYSTEM

ANTIGEN ANTIBODY
ISB GENE
BLOOD Ig
T ASSIGNME SYMB BIOCHEMISTR PHENOT Clinical
GROUP SYMBOL TY
# NT OL Y YPE Significance
PE

2 genes GYPA and

GYPB code the
glycophorins
carrying the Hemolytic
Anti-M
Chromosom M antigens.Another disese of the
Anti-N
e4 N gene GYPE is M+, N+ IgM Newborn,
MNSs 002 Anti-S
S thought as S+, U+ IgG Hemolytic
Anti-s
(4q) s responsible for the transfusion
Anti-U
gene reaction
arrangements that
result to variant
alleles

Reside on two
closely related
integral protein
Chromosom Immunoblot two Lu(a-b+)
e 19 Lua Anti-Lua IgM
Lutheran 005 protein 78 and Lu(a-b-) Mild HDN
Lub Anti-Lub IgG
(19q) 85kDa
Lu cDNA encodes
a protein of 597
amino acid
Dia,Diab are
located on AE-1
which is involved
Chromosom in the anion Di(a+b+)
Dia Anti-Dia Hereditary
e 17 exchange of Di(a+b-) IgG
Diego 010 Dib Anti-Dib ovalocytosis,
bicarbonate with Di(a-b-) IgM
Wra Anti-Wra Spherocytosis
(17q) chloride in the
RBC membrane.
They are resistant
to DDT
They are located
Chromosom on
Acute Leukemia
e7 acetylcholinesteras Yt(a) Anti-Yta IgG
Cartwright 011 Yta, Ytb Hemolytic
e which is Yt(b) Anti-Ytb IgM
Anemia
(7q) involved in
neurotransmission

Chromosom Antigen is
Heriditary
eX sensitive to most Xg(a+)
Xg 012 Xga Anti- Xga IgG hemoragic
enzymes but Xg(a-)
telangiectasia
(Xp) resistant to DDT
Sc:-1,-2 Anti-Sc1
Chromosom Sc1, Sc:-1,2 Anti-Sc2 Hemolytic
Expressed by
Scianna 013 e1 Sc2, Sc:1,-2,3 Anti-Sc3 IgG disese of the
ERMAP
(1p) Sc3, Rd Sc:1,-2,-3 Anti-Sc4 Newborn,
Rd+ Anti-Rd
Dombrock 014 Chromosom Doa Glycoprotein Do(a+b-) Anti -Doa IgG Severe
e 12 Dob (fixed to cell Do(a-b+) Anti- Dob hemolytic
membrane by transfusion
 GPI, or glycosyl-
(12p) phosphatidyl- reactions
inositol)
Chromosom Acute brain
e7 injury, Co null is
associated with
(7p) monosomy-7 of
Allocated on the bone marrow
integral resulting to
transmembrane myeloid
Coa Co(a+b-) Anti -Doa
Colton 015 protein aquaporin- IgG leukemia and
Cob Co(a-b+) Anti- Dob
1 associated with and preleukemic
osmotic water and
transport dysmieolopoietic
syndromes
Anti-Co3 is
associated with
severe HDN
Antigens are Insulin
located on C4 Dependent
complement Diabetes
component and are Acute hepatitis
adsorbed from
CH1, plasma into the
Chido / Chromosom CH2, CHnull, Anti - Coa
017 RBC membrane. IgG
Rogers e 19 CH3, RGnull Anti- Cob
RG1, They are poorly
RG2 expressed on cord
cells, sensitive to
treatment with
ficin,papain and
resistant to DDT
Antigens are GPD in protein
expressed on RBC 4.1-deficient
Ge2 Ge (-2) Anti- Ge2
Chromosom membrane IgG red cells
Gerbich 020 Ge3 Ge(-3) Anti- Ge3
e2 sialoglycoproteins IgM Hemolytic
Ge4 Ge (-4) Anti- Ge4
glycophorins C or disease of the
glycophorin D new born

Antigens are
sensitive to
chymotrypsin and
pronase treatment Anti-Cra
and resistant to Anti-
other Cr(a)
Cr(a)
enzymes.Reducing Anti- Tca
Tca Intestinal
agents such as Anti- Dra
Chromosom Dra Disorder
Anti- Esa
e1 Esa DDT causes only Paroxysmal
Cromer 021 Cr(a+) Anti- IFC+ IgG
IFC+ slightly weakened nocturnal
Anti-
(1q) WESb expression hemoglobinuria
WESb
UMC+ CROM antigens III
Anti-
GUTI+
are distribute don UMC+
RBC membrane, Anti-
platelets, GUTI+
granulocytes,
lymphocytes and
placental tissues
Knops 022 Chromosom Kna, Antigens reside on Kn(a+b-) Anti- KN Systemic lupus
e1 Knb, complement Kn(a-b+) Ant-McCa IgG erythromatosis,
McCa, receptor 1(CR1 or Anti-SIa AIDS,
(1q) McCb, CD35). Glomeruloneph
SL1,S12 ritis, hemolytic
,S13, anemia,
Yka Depressed
 expression
causes chronic
cold agglutinin
disease

In(a+)
Antigens are In(b+) Hemolytic
Chromosom In(A) Anti-Inb
Indian 023 carried on to the IgG transfusion
e 19 In(B) Anti-Ina
CD44 glcoprotein reaction

JMH antigen
resides on the
John Hemolytic
Chromosom SEMA7 semaphorin
Milton 025 IgG transfusion
e6 A CDw108,a GPI-
Hagen reaction
linked protein the
RBC membrane
Pancreatic
disorder,
Diabetes
Resistant to mellitus,
Bga Anti-Bga
Chromosome Bg(a+b-) Infectious
Bg N/A Bgb enzymes and Anti-Bgb IgG
6 Bg(a-b+) mononucleosis,
Bg c reducing agents Anti-Bg c
Leukemia,
Polycythemia,
Hemolytic
anemia
The determinant
for the antigens\ is
a terminal GalNAc
beta1-4 linked to
Gal alpha Tears, sweat,
2,3NeuAc residing nasal and
Chromosome on glycolipids or Sid(a+) IgM tracheobronchi
SID (Sda) N/A Sda Anti-Sda
17 as components of Sid(a-) IgG al mucus,
O- or N-linked cerebrospinal
glycan chains of fluid
erythrocyte
membrane proteins
or glycoproteins of
a variety of tissues
Jknull RBC resist
lysis in 2 M urea Anti-Jka
Chromosom Jka Jk(a+b+)
Kidd 009 Jk protein is a Anti-Jkb IgG HDN, HTR
e 18 Jkb Jk(a-b+)
single band with a Anti-Jk3
mass of 45kD
Duffy 008 Chromosom Fya Duff antigens Fy(a+b-) Anti- Fya IgG -Individuals
e1 Fyb reside on a Fy(a+b+) lacking Duffy
glycoprotein of Fy(a-b+) Anti- Fyb antigens
336 amino acids Fy(a-b-) altogether are
immune to
having a relative
malaria caused
mass of 36 kD and by Plasmodium
two N- vivax and
glycosylation Plasmodium
sitesThe amino knowlesi
acid at position 42 -HTR
defines the Fya and
Fyab
polymorphismFy3
epitope is on third
loop and Fy6
involves amino
 acid 19 to 25
Anti-
Located on 93-kD K:commo
Kpa Kp
n
Chromosom Kpb glycoprotein Kpb
Kell 006 k, Kpb, IgG HDN, HTR
e7 Jsa consisting of 731 kp(a+b-)
and Jsb
Jsb amino acids. kp(a+b+)
antibodie
s are rare
Exist as
glycosphingolipids
.there are 2
pathways for
synthesis of P
antigen,one Paroxysmal
Chromosom P1 leading to P1 anti-P1 IgM cold
P 003
e 22 P2 formation of P2 anti-P IgG hemoglobinuru
globoside and the a
other with
paragloboside
.Lactosycleramide
is the precursor of
both
I -Associated as a
Defined by a series cause of Cold
of carbohydrate on Agglutinin
the inner portion of Disease (similar
ABh
to PCH)
oligosaccharide
-May be
chains
Chromosom anti-I secondary to
I i-antigen is defined I IgG
027 e anti-i Mycoplasma
i by at least i IgM
6 autoanti-I pneumoniae
tworepeating N-
infections
acetyllactosamine>
-rare and is
I antigen activity is
associated with a sometimes
branch form of i associated with
antigen infectious
mononucleosis