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  • VC Obstruction, Heart Failure (Post-Hepatic) Portal Vein Thrombosis (Pre-Hepatic) Excessive Vomiting/retching

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    Nenita Gayo Fronda
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    1. This document discusses potential causes of gastrointestinal bleeding, including H. Pylori infection, NSAID use, and stress-induced bleeding in intensive care settings. 2. It outlines how portal hypertension from liver cirrhosis can lead to esophageal varices and bleeding. 3. Obstruction of the portal or hepatic veins is described as pre-hepatic or post-hepatic causes that increase portal pressure and risk of variceal bleeding.

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    Original Title

    GIBLEEDING-pathophysio

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    1. This document discusses potential causes of gastrointestinal bleeding, including H. Pylori infection, NSAID use, and stress-induced bleeding in intensive care settings. 2. It outlines how portal hypertension from liver cirrhosis can lead to esophageal varices and bleeding. 3. Obstruction of the portal or hepatic veins is described as pre-hepatic or post-hepatic causes that increase portal pressure and risk of variceal bleeding.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    14 views1 page

    VC Obstruction, Heart Failure (Post-Hepatic) Portal Vein Thrombosis (Pre-Hepatic) Excessive Vomiting/retching

    Uploaded by

    Nenita Gayo Fronda
    1. This document discusses potential causes of gastrointestinal bleeding, including H. Pylori infection, NSAID use, and stress-induced bleeding in intensive care settings. 2. It outlines how portal hypertension from liver cirrhosis can lead to esophageal varices and bleeding. 3. Obstruction of the portal or hepatic veins is described as pre-hepatic or post-hepatic causes that increase portal pressure and risk of variceal bleeding.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as docx, pdf, or txt
    of 1

    1. H.

    Pylori (gram-negative bacteria)


    Portal vein Cirrhosis VC obstruction, heart Excessive
    2. NSAIDs
    thrombosis failure
    (hepatic) 3. Stress induced (ischemic\ICU vomiting\retching
    (pre-hepatic) (post-hepatic)
    setting)

    Hepatic portal venous pressure Imbalance Physically strains


    esophageal mucosa
    (portal HPN, HTN)

    Less Gastroprotective factors: More injurious substances:

     Mucous -HCI
    Backing up of blood into  Bllod flow
    - Toxins (NSAIDS) Tear in esophageal
    esophageal veins Dilated, tortuous  Epithelial cells mucosa, near GE function
    veins  Prostaglandins

    Erosion of Mucosa

    Esophageal Varices
    Mallory-Weiss Tear
    - Can rupture and bleed Peptic Ulcer

    - May erode into blood vessels

    GI BLEEDING

    Bleeding into
    Bleeding into stomach
    esophagus\stomach (often
    larger volume)
    Blood passes through GI tract,
    Blood gets oxidized by HCI but
    becomes oxidized by HCI & is
    moves back up esophagus
    digested

    Hematemesis
    Melena
    “Coffee ground” Emesis
    (Vomiting blood)
    (dark, tarry, foul smelling stool

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