RA is more common in women than men and can be affected by environmental pollutants as women living closer to roads had an increased risk. Genetic factors also contribute to risk such as polymorphisms in the HLA-DRB1 and PTPN22 genes, though over half of genetic risk factors remain unknown.
Explicar Detalladamente Los Efectos Genotóxicos Que Tiene El Componente Seleccionado, Sobre El Material Genético (Tipo de Mutaciones Que Puede Provocar)
RA is more common in women than men and can be affected by environmental pollutants as women living closer to roads had an increased risk. Genetic factors also contribute to risk such as polymorphisms in the HLA-DRB1 and PTPN22 genes, though over half of genetic risk factors remain unknown.
RA is more common in women than men and can be affected by environmental pollutants as women living closer to roads had an increased risk. Genetic factors also contribute to risk such as polymorphisms in the HLA-DRB1 and PTPN22 genes, though over half of genetic risk factors remain unknown.
RA is more common in women than men and can be affected by environmental pollutants as women living closer to roads had an increased risk. Genetic factors also contribute to risk such as polymorphisms in the HLA-DRB1 and PTPN22 genes, though over half of genetic risk factors remain unknown.
RA is far more common in women than in men (3:1). Pollutants may affect the risk of
developing RA. Women living within 50m of a road had an increased risk of RA (hazard ratio: 1.31) compared to 200m (Tobón GJ et al., 2010). Other causes of RA include smoking and vitamin D deficiency (Sokolove, 2017).
1.2.1 Genetic Risk Factors
The main genetic factor is HLA-DRB1*04 and *01 clusters which encode the "shared- epitope" sequences in MHC region. Polymorphisms of PTPN22, TRAF1- C5 and TNFAIP3 have also been described in RA. However, more than half of the genetic risk factors remain to be identified (Stahl et al., 2010)
Explicar Detalladamente Los Efectos Genotóxicos Que Tiene El Componente Seleccionado, Sobre El Material Genético (Tipo de Mutaciones Que Puede Provocar)