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    Cytochrome P450 2D6 Known Drug Interaction Chart: Drugs Metabolized by CYP2D6 Enzyme Drug Inhibitors of CYP2D6 Enzyme

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    This document provides information on drugs that are metabolized by the CYP2D6 enzyme, inhibitors of the CYP2D6 enzyme, and inducers of the CYP2D6 enzyme. It lists various analgesics, antidepressants, antipsychotics, beta-blockers, and other drug classes that are metabolized by or inhibit the CYP2D6 enzyme. It also categorizes inhibitors as strong, moderate, or weak based on the degree to which they inhibit the CYP2D6 enzyme. The sources of the drug interaction data are also cited at the bottom.

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    Cytochrome P450 2D6 Known Drug Interaction Chart: Drugs Metabolized by CYP2D6 Enzyme Drug Inhibitors of CYP2D6 Enzyme

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    Ss
    141 views1 page
    This document provides information on drugs that are metabolized by the CYP2D6 enzyme, inhibitors of the CYP2D6 enzyme, and inducers of the CYP2D6 enzyme. It lists various analgesics, antidepressants, antipsychotics, beta-blockers, and other drug classes that are metabolized by or inhibit the CYP2D6 enzyme. It also categorizes inhibitors as strong, moderate, or weak based on the degree to which they inhibit the CYP2D6 enzyme. The sources of the drug interaction data are also cited at the bottom.

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    This document provides information on drugs that are metabolized by the CYP2D6 enzyme, inhibitors of the CYP2D6 enzyme, and inducers of the CYP2D6 enzyme. It lists various analgesics, antidepressants, antipsychotics, beta-blockers, and other drug classes that are metabolized by or inhibit the CYP2D6 enzyme. It also categorizes inhibitors as strong, moderate, or weak based on the degree to which they inhibit the CYP2D6 enzyme. The sources of the drug interaction data are also cited at the bottom.

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    141 views1 page

    Cytochrome P450 2D6 Known Drug Interaction Chart: Drugs Metabolized by CYP2D6 Enzyme Drug Inhibitors of CYP2D6 Enzyme

    Uploaded by

    Ss
    This document provides information on drugs that are metabolized by the CYP2D6 enzyme, inhibitors of the CYP2D6 enzyme, and inducers of the CYP2D6 enzyme. It lists various analgesics, antidepressants, antipsychotics, beta-blockers, and other drug classes that are metabolized by or inhibit the CYP2D6 enzyme. It also categorizes inhibitors as strong, moderate, or weak based on the degree to which they inhibit the CYP2D6 enzyme. The sources of the drug interaction data are also cited at the bottom.

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    Cytochrome P450 2D6 Known Drug Interaction Chart

    Drugs Metabolized by CYP2D6 Enzyme Drug Inhibitors of CYP2D6 Enzyme


    ANALGESICS CHOLINESTERASE INHIBITORS STRONG INHIBITORS OTHER KNOWN INHIBITORS:*
    codeine donepezil bupropion ANALGESICS
    hydrocodone cinacalcet celecoxib
    oxycodone COUGH SUPPRESSANT fluoxetine methadone
    phenacetin dextromethorphan paroxetine
    tramadol quinidine ANTIEMETIC/PROKINETICS
    PSYCHOTROPICS metoclopramide
    ANESTHETICS amitriptyline MODERATE INHIBITORS
    lidocaine amphetamine duloxetine ANTIHISTAMINES
    aripiprazole sertraline chlorpheniramine
    ANORECTICS atomoxetine terbinafine clemastine
    dexfenfluramine chlorpromazine diphenhydramine
    clomipramine WEAK INHIBITORS hydroxyzine
    ANTIEMETIC/PROKINETICS desipramine amiodarone
    metoclopramide duloxetine cimetidine ANTINEOPLASTICS
    ondansetron fluoxetine doxorubicin
    fluvoxamine
    ANTIHISTAMINES haloperidol ANTIRETROVIRAL, HIV
    chlorpheniramine iloperidone INHIBITORS
    promethazine imipramine ritonavir
    methamphetamine indinavir
    ANTINEOPLASTICS methoxyamphetamine
    tamoxifen minaprine ANTITHROMBOTIC AGENTS
    nortriptyline ticlopidine
    CARDIOVASCULAR paroxetine
    alprenolol perphenazine CARDIOVASCULAR
    carvedilol pimozide midodrine
    clonidine risperidone
    debrisoquine sertraline HISTAMINE H2 ANTAGONIST,
    diltiazem thioridazine ACID SUPPRESSANTS
    disopyramide venlafaxine ranitidine
    flecainide zuclopenthixol
    S-metoprolol PSYCHOTROPICS
    mexiletine chlorpromazine
    nebivolol citalopram
    perhexiline clomipramine
    propafenone cocaine
    propranolol doxepin
    sparteine escitalopram
    timolol haloperidol

    Drug Inducers of CYP2D6 Enzyme perphenazine

    dexamethasone pimozide
    rifampin thioridazine
    *Extent of inhibition not well defined, degree of inhibition may vary.
    This chart is a partial listing of drugs known to affect CYP2D6 activity based on data from:
    1. http://medicine.iupui.edu/clinpharm/ddis/table.aspx
    2. http://www.pharmgkb.org/gene/PA128
    3. FDA-approved drug information
    Reviewed 08/2014

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