PDE Example: Nerve Cable |GSBmE
+ Consider the following! D distributed parameter
model of a nerve cable:
Re intracellular resistance (cm)
transmembrane capacitance (Fim?)
log: Membrane lon currant (Am?)
———
+ To derive the underlying PDE of this system, we
represent it first as a lumped parameter model
voy —W nTR Ne A — tracer domain
le = .
extracellular domain
axNerve Cable (continued) IGSBmE
+ For any given node k, we can write a current
conservation relationship
Using R=pL/A
length (2)
A: cross sectional area (a)Nerve Cable (continued)
+ The LHS of this equation is simply the finite
difference approximation to the 2" spatial derivative
of V.
+ In the limit as Ax + 0, the equation may be written as
the PDE:
P, :Mosolic resistivity
(om
1 axon rads (m)
For the Hodgkin-Huxley formulation of ign, we have
(recall from last lecture)+ This cable equation can be solved using the method
of lines.
+ Re-arranging, we have
» [z ex
and discretising in x
ave 1 ve
aC,Hodgkin-Huxley Cable Equations [eyiiis
HO Tg) Ben Te) eel 1),
ah
Fah
Be lth)
in
Bea l-nh ar
20000,8en?
36000 cu 0006MOem
10 Seat? 0.0025 euxMatlab Implementation |GSBmEMatlab Implementation
HH. cable_prime.m:Matlab Implementation (esti
HHL cable_prime.m (continuedMatlab Implementation Pg