Asthma and GERD frequently coexist

Asthma and GERD may exacerbate each other. GERD may induce bronchospasm, and
asthma may induce GERD. Breaking the cycle by aggressively treating both conditions is
the key to mitigating patients’ symptoms. 

No of patients: 770
Drugs: Esomeprazole 40 mg, placebo
Dose: bid
Study Type: double-blind study
Patient Type: GERD, Asthma
Duration:  16 weeks

Improvement in morning peak Improvement in morning Improvement in evening

expiratory flow (PEF) over peak expiratory flow (PEF) peak expiratory flow (PEF)
Placebo (L/minute) over Esomeprazole over Esomeprazole
(L/minute) (L/minute)
6.3 8.7 10.2

Exilok 40 recommended for a minimum of 2 to 3 months in the management of GERD-

related Asthma

Ref
https://www.atsjournals.org/doi/pdf/10.1164/rccm.200507-1167OC
https://pubmed.ncbi.nlm.nih.gov/12928078/

For continuous care from hospital to home a purest form PPI is Esomeprazole

Approved for more patients than any other I.V. PPI

https://www.nexiumtouchpoints.com/nexium-information/gerd-treatment.html

Improved PEF in subjects with asthma who presented with both GERD and NOC
moderate to severe asthma who present with GERD symptoms and NOC

Over the whole treatment period, in GERD/ NOC subjects (n 350),

esomeprazole provided an 8.7-L/min improvement (p 0.03) in morning PEF, and
10.2-L/min improvement (p 0.012) in evening PEF over placebo.

Among 307 subjects taking long-acting 2-agonists, improvements over placebo were observed in
morning PEF (12.2 L/min, p 0.017) and in evening PEF (11.1 L/min, p 0.024); these improvements were
more pronounced in GERD/NOC subjects. Esomeprazole 40 mg twice daily was well tolerated and no
safety concerns were noted. Conclusions: Esomeprazole improved PEF in subjects with asth

Figure 4. Randomization of patients with poorly controlled asthma to proton pump inhibitor therapy
or placebo showed no benefit of acid-suppressive therapy. The primary outcome was a decrease of
30% or more in peak expiratory flow for 2 days.

https://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-
59322009000800010&lng=en&nrm=iso
https://medcraveonline.com/GHOA/gastroesophageal-reflux-disease-related-sleep-dysfunction-and-
driving-simulator-impairment-response-to-treatment-with-esomeprazole.html

 Clinically proven to relieve night-time heartburn for a good night’s sleep, Just 1 pill a day for
24-hour protection and zero heartburn
https://www.amazon.co.uk/Nexium-Control-Heartburn-Gastro-Resistant-
Esomeprazole/dp/B00MA5RMIQ

GERD is an important cause of uncontrolled asthma and its management

significantly improves the uncontrolled asthma and significantly reduces the
inhaled oral corticosteroid.

https://www.uspharmacist.com/article/the-relationship-between-gerd-and-asthma