9/18/2020 Role of vitamin D on gut microbiota in cystic fibrosis - ScienceDirect

Access through your institution

Get Access Share Export

The Journal of Steroid Biochemistry and Molecular Biology

Volume 175, January 2018, Pages 82-87

Review

Role of vitamin D on gut microbiota in cystic fibrosis

Mansi Kanhere a, Benoit Chassaing b, Andrew T. Gewirtz b, Vin Tangpricha c, d

Show more

https://doi.org/10.1016/j.jsbmb.2016.11.001 Get rights and content

Highlights
• Vitamin D plays a vital role in maintaining the integrity of the gut epithelium.

• The mechanism underlying this association involves the reduction of pro-

inflammatory cytokines such as IL-8 and inhibition of inflammation-induced
apoptosis of intestinal epithelial cells by vitamin D.

• Intestinal dysbiosis is prevalent in CF owing to multiple factors including

malabsorption of nutrients and recurrent antibiotics.

• VDR regulates the composition and functions of the gut microbiota and
decreased expression of intestinal epithelial VDR disrupts microbial
homeostasis.

• Vitamin D could be a potential treatment option for altering dysbiosis in CF, but
additional trials are needed to evaluate this.

https://www.sciencedirect.com/science/article/abs/pii/S0960076016302965 1/3
9/18/2020 Role of vitamin D on gut microbiota in cystic fibrosis - ScienceDirect

Abstract
This review explores the potential for vitamin D to favorably alter the gut microbiota, given
emerging evidence of the role of vitamin D in controlling mucosal inflammation in the gut. It
will focus on cystic fibrosis (CF) patients, a population with both vitamin D deficiency due to
gut malabsorption and an altered gut microbiota composition. Recent evidence shows that
vitamin D acts to maintain the integrity of the gut mucosal barrier by enhancement of
intercellular junctions that control mucosal permeability and reduction of pro-inflammatory
cytokines such as IL-8. In addition, vitamin D receptor-mediated signaling has been shown to
inhibit inflammation-induced apoptosis of intestinal epithelial cells. As a result of these
effects on the intestinal mucosa, maintenance of sufficient vitamin D status may be essential
for the development of a healthy gut microbiota, particularly in conditions defined by chronic
mucosal inflammation such as CF. We hypothesize here that high dose vitamin D may be used
to favorably manipulate the aberrant mucosa seen in patients with CF. This may result in
improved clinical outcomes in association with a low inflammatory environment that allows
beneficial bacteria to outcompete opportunistic pathogens. Current evidence is sparse but
encouraging, and additional evidence is needed to establish vitamin D as a therapeutic
approach for gut microbiota modification.

Previous Next

Keywords
Vitamin D; Intestinal microbiota; Cystic fibrosis; Vitamin D receptor; Inflammation

Special issue articles Recommended articles Citing articles (16)

View full text

© 2016 Elsevier Ltd. All rights reserved.

About ScienceDirect

Remote access

Shopping cart

Advertise

C t t d t
https://www.sciencedirect.com/science/article/abs/pii/S0960076016302965 2/3
9/18/2020 Role of vitamin D on gut microbiota in cystic fibrosis - ScienceDirect
Contact and support

Terms and conditions

Privacy policy

We use cookies to help provide and enhance our service and tailor content and ads. By continuing you agree to the use of cookies.
Copyright © 2020 Elsevier B.V. or its licensors or contributors. ScienceDirect ® is a registered trademark of Elsevier B.V.
ScienceDirect ® is a registered trademark of Elsevier B.V.

https://www.sciencedirect.com/science/article/abs/pii/S0960076016302965 3/3