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Adenoma: Benign Tumor Epithelial Glandular Organs Adrenal Glands Pituitary Gland Thyroid Prostate
Adenoma: Benign Tumor Epithelial Glandular Organs Adrenal Glands Pituitary Gland Thyroid Prostate
Adenoma
From Wikipedia, the free encyclopedia
Histopathology [ edit ]
Adenoma is a benign tumor of glandular tissue, such as the mucosa of stomach, small intestine,
and colon, in which tumor cells form glands or gland like structures.
In hollow organs (digestive
tract), the adenoma grows into the lumen - adenomatous polyp or polypoid adenoma.
Depending on the type of the insertion base, adenoma may be pedunculated (lobular head with
a long slender stalk) or sessile (broad base).
Locations [ edit ]
Colon [ edit ]
Adenomas of the colon, also called adenomatous polyps, are quite prevalent. They are found
commonly at colonoscopy. They are removed because of their tendency to become malignant
and to lead to colon cancer.
Ashkenazi Jews have a 6% higher risk rate of getting adenomas, and then colon cancer, than do
the general population, so it is important that they have regular actual colonoscopies, and
specifically none of the less invasive diagnostic methods.[1]
Renal [ edit ]
This is a tumor that is most often small and asymptomatic, and is derived from renal tubules. It
may be a precursor lesion to renal carcinoma.
Adrenal [ edit ]
Thyroid [ edit ]
Further information: Thyroid adenoma
About one in 10 people is found to have solitary thyroid nodules. Investigation is required
because a small percentage of these is malignant. Biopsy usually confirms the growth to be an
adenoma, but, sometimes, excision at surgery is required, especially when the cells found at
biopsy are of the follicular type.
Pituitary [ edit ]
Pituitary adenomas are seen in 10% of neurological patients. A lot of them remain undiagnosed.
Treatment is usually surgical, to which patients generally respond well. The most common
subtype, prolactinoma, is seen more often in women, and is frequently diagnosed during
pregnancy as the hormone progesterone increases its growth. Medical therapy with cabergoline
or bromocriptine generally suppresses prolactinomas; progesterone antagonist therapy has not
proven to be successful.
Parathyroid [ edit ]
Liver [ edit ]
Further information: Hepatocellular adenoma
Hepatic adenomas are a rare benign tumour of the liver, which may present with hepatomegaly
or other symptoms.
Breast [ edit ]
Breast adenomas are called fibroadenomas. They are often very small and difficult to detect.
Often there are no symptoms. Treatments can include a needle biopsy, and/or removal.
Appendix [ edit ]
Adenomas can also appear in the appendix. The condition is extremely rare. The most common
version is called cystadenoma. They are usually discovered in the course of examination of the
tissue following an appendectomy. If the appendix has ruptured and a tumor is present, this
presents challenges, especially if malignant cells have formed and thus spread to the abdomen.
Bronchial [ edit ]
Bronchial adenomas are adenomas in the bronchi. They may cause carcinoid syndrome, a
type of paraneoplastic syndrome.[2]
Sebaceous [ edit ]
Most salivary gland tumors are benign – that is, they are not cancer and will not spread to other
parts of the body. These tumors are almost never life-threatening.
There are many types of
benign salivary gland tumors, with names such as adenomas, oncocytomas, Warthin tumors,
and benign mixed tumors (also known as pleomorphic adenomas).
Benign tumors are almost
always cured by surgery. Very rarely, they may become cancer if left untreated for a long time or
if they are not completely removed and grow back. It's not clear exactly how benign tumors
become cancers. There are many types of salivary gland cancers. Normal salivary glands are
made up of several different types of cells, and tumors can start in any of these cell types.
Salivary gland cancers are named according to which of these cell types they most look like
when seen under a microscope. The main types of cancers are described below.
Doctors
usually give salivary cancers a grade (from 1 to 3, or from low to high), based on how abnormal
the cancers look under a microscope. The grade gives a rough idea of how quickly it is likely to
grow and spread.
Grade 1 cancers (also called low grade or well differentiated) look very much like normal
salivary gland cells. They tend to grow slowly and have a good outcome (prognosis).
Grade 2 cancers (also called intermediate grade or moderately differentiated) have an
appearance and outlook that is between grade 1 and grade 3 cancers.
Grade 3 cancers (also called high grade or poorly differentiated) look very different from
normal cells and often grow and/or spread quickly. The outlook for these cancers is usually
not as good as for lower grade cancers.[3]
Prostate [ edit ]
Prostate adenoma develops from the periurethral glands at the site of the median or lateral
lobes.
Treatment [ edit ]
A physician's response to detecting an adenoma in a patient will vary according to the type and
location of the adenoma among other factors.[citation needed] Different adenomas will grow at
different rates, but typically physicians can anticipate the rates of growth because some types of
common adenomas progress similarly in most patients.[citation needed] Two common responses
are removing the adenoma with surgery and then monitoring the patient according to
established guidelines.[citation needed]
References [ edit ]
1. ^ https://www.webmd.com/colorectal-cancer/qa/what-is-the-relationship-between-ashkenazi-
jews-and-colorectal-cancer
2. ^ Table 6-5 in: Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson
(2007). Robbins Basic Pathology. Philadelphia: Saunders. ISBN 978-1-4160-2973-1. 8th edition.
3. ^ "What Is Salivary Gland Cancer?" . www.cancer.org. Retrieved 3 April 2018.
4. ^ American Gastroenterological Association, "Five Things Physicians and Patients Should
Question" (PDF), Choosing Wisely: an initiative of the ABIM Foundation, American
Gastroenterological Association, archived from the original (PDF) on August 9, 2012, retrieved
August 17, 2012
5. ^ Winawer, S.; Fletcher, R.; Rex, D.; Bond, J.; Burt, R.; Ferrucci, J.; Ganiats, T.; Levin, T.; Woolf,
S.; Johnson, D.; Kirk, L.; Litin, S.; Simmang, C.; Gastrointestinal Consortium, P. (2003).
"Colorectal cancer screening and surveillance: Clinical guidelines and rationale—Update based
on new evidence". Gastroenterology. 124 (2): 544–560. doi:10.1053/gast.2003.50044 .
PMID 12557158 .
6. ^ Jarbol, D. E.; Kragstrup, J.; Stovring, H.; Havelund, T.; Schaffalitzky De Muckadell, O. B.; Deal,
S. E.; Hoffman, B.; Jacobson, B. C.; Mergener, K.; Petersen, B. T.; Safdi, M. A.; Faigel, D. O.;
Pike, I. M.; ASGE/ACG Taskforce on Quality in Endoscopy (2006). "Proton Pump Inhibitor or
Testing for Helicobacter pylori as the First Step for Patients Presenting with Dyspepsia? A
Cluster-Randomized Trial". The American Journal of Gastroenterology. 101 (6): 1200–1208.
doi:10.1038/ajg2006227 . PMID 16635231 .
Classification ICD-10: D12 , D35.0 , D34 , D35.2 , and others · ICD-9-CM: 211.3 , D
211.5 ,223.0 , 226 , 227.0 , · ICD-O: M8140/0 · MeSH: D000236 · SNOMED CT:
32048006
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