DESMODUR Ultra N 3390 BA

Safety Data Sheet according to Regulation (EU) No.
1907/2006
DESMODUR ultra N 3390 BA

Version 2.0 Revision Date 19.06.2019 Print Date 20.06.2019
SECTION 1: Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
DESMODUR ULTRA N 3390 BA

Material number: 86223279
1.2 Relevant identified uses of the substance or mixture and uses advised against
Use:
Hardener for coating materials or adhesives for industrial and trade applications
For details of the identified uses according to REACH-Regulation (EU) No. 1907/2006 refer to the annex of this
safety data sheet.
Uses advised against:

Not suitable for use in homeworker (DIY) applications.
1.3 Details of the supplier of the safety data sheet

Covestro Deutschland AG
COV-CTO-HSEQ-PSRA-PSI
51365 Leverkusen
Tel.: +49 214 6009 4068

Email: ProductSafetyEMLA@covestro.com
1.4 Emergency telephone number

+49 214 30 99300 (Sicherheitszentrale Currenta)
SECTION 2: Hazards identification
2.1 Classification of the substance or mixture

Flammable liquids, Category 3 (H226)
Acute toxicity, Inhalative, Category 4 (H332)
Sensitization of the skin, Category 1 (H317)
Specific target organ toxicity (single exposure), Category 3 (H335)
2.2 Label elements
Warning
Hazardous components which must be listed on the label

Hexamethylene-1,6-diisocyanate Homopolymer
Hazard statements:
H226 Flammable liquid and vapour.
H317 May cause an allergic skin reaction.
H332 Harmful if inhaled.
H335 May cause respiratory irritation.
Precautionary statements:
1/74 BMS_SDS_DE / DE
Safety Data Sheet according to Regulation (EU) No. 1907/2006
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.
P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with
water.
P304 + P340 + P312 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a
POISON CENTER/doctor if you feel unwell.
P403 + P235 Store in a well-ventilated place. Keep cool.
Supplementary hazardous characteristics and labeling elements:

EUH204 Contains isocyanates. May produce an allergic reaction.
2.3 Other hazards

In case of hypersensitivity of the respiratory tract (e.g. asthmatics and those who suffer from chronic
bronchitis) it is inadvisable to work with the product.
Symptoms affecting the respiratory tract can also occur several hours after overexposure.
Dust, vapors and aerosols are the primary risk to the respiratory tract.
This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic
(PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
SECTION 3: Composition/information on ingredients
Type of product: Mixture
3.2 Mixtures
aliphatic polyisocyanate
ca. 90 % in n-butyl acetate
Hazardous components
Concentration [wt.-%]: ca. 90
EC-No.: 500-060-2
REACH Registration Number: 01-2119485796-17-0000, 01-2119485796-17-0001, 01-2119485796-17-0012
CAS-No.: 28182-81-2
Classification (1272/2008/CE): Acute Tox. 4 Inhalative H332 Skin Sens. 1 H317 STOT SE 3 H335
n-Butyl acetate
Concentration [wt.-%]: ca. 10
EC-No.: 204-658-1
REACH Registration Number: 01-2119485493-29, 01-2119485493-29-0059
CAS-No.: 123-86-4
Classification (1272/2008/CE): Flam. Liq. 3 H226 STOT SE 3 H336
This contains:
Hexamethylene-1,6-diisocyanate
Concentration [wt.-%]: < 0,1
Index-No.: 615-011-00-1
REACH Registration Number: 01-2119457571-37-0000, 01-2119457571-37-0005, 01-2119457571-37-0006
CAS-No.: 822-06-0
Classification (1272/2008/CE): Acute Tox. 4 Oral H302 Acute Tox. 1 Inhalative H330 Skin Irrit. 2 H315 Eye
Irrit. 2 H319 Resp. Sens. 1 H334 Skin Sens. 1 H317 STOT SE 3 H335
Specific threshold concentration:
Resp. Sens. 1 H334 >= 0,5 %
Skin Sens. 1 H317 >= 0,5 %
No annex is required for the impurities of the substance according to article 3(1) of Regulation (EC) No 1907/2006
mentioned above.
Candidate List of Substances of Very High Concern for Authorisation
This product contains no substances of very high concern in concentrations where an information obligation
applies (REACH Regulation (EC) No. 1907/2006, Article 59).
SECTION 4: First aid measures
4.1 Description of first aid measures

General advice: Take off all contaminated clothing immediately.
If inhaled: Take the person into the fresh air and keep him warm, let him rest; if there is difficulty in breathing,
medical advice is required.
In case of skin contact: In case of skin contact wash affected areas thoroughly with soap and plenty of
water. Consult a doctor in the event of a skin reaction.
In case of eye contact: Hold the eyes open and rinse with preferably lukewarm water for a sufficiently long
period of time (at least 10 minutes). Contact an ophthalmologist.
If swallowed: DO NOT induce vomiting. Wash/clean mouth with water. Medical advice is required.
4.2 Most important symptoms and effects, both acute and delayed
Notes to physician: Basic first aid, decontamination, symptomatic treatment.
4.3 Indication of any immediate medical attention and special treatment needed
Therapeutic measures: No information available.
SECTION 5: Firefighting measures
5.1 Extinguishing media

Suitable extinguishing media: Carbon dioxide (CO2), Foam, extinguishing powder, in cases of larger fires,
water spray should be used.
Unsuitable extinguishing media: High volume water jet
5.2 Special hazards arising from the substance or mixture

Burning releases carbon monoxide, carbon dioxide, oxides of nitrogen, isocyanate vapors and traces of
hydrogen cyanide. In the event of fire and/or explosion do not breathe fumes.
Fire in vicinity poses risk of pressure build-up and rupture. Containers at risk from fire should be cooled with
water and, if possible, removed from the danger area.
5.3 Advice for fire-fighters

For firefighting, self-contained breathing apparatus is required, plus a gas-tight chemical hazmat suit.
Do not allow contaminated extinguishing water to enter the soil, ground-water or surface waters.
SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures

Put on protective equipment (see section 8). Keep away from sources of ignition. Ensure adequate
ventilation/exhaust extraction. Keep unauthorized persons away.
6.2 Environment related measures

Do not allow to escape into waterways, wastewater or soil.
6.3 Methods and material for containment and cleaning up

Remove mechanically; cover the remainder with wet, absorbent material (e.g. sawdust, chemical binder
based on calcium silicate hydrate, sand). After approx. one hour transfer to waste container and do not seal
(evolution of CO2!). Keep damp in a safe ventilated area for several days.
Spill area can be decontaminated with the following recommended decontamination solution:
Decontamination solution 1: 8-10% sodium carbonate and 2% of liquid soap in water
Decontamination solution 2: Liquid/yellow soap (potassium soap with ~15% anionic tenside): 20ml;
Water:700ml; Polyethylenglycol (PEG 400): 350ml
Decontamination solution 3: 30 % commercial laundry detergent containing monoethanolamine, 70 % water
6.4 Reference to other sections

For further disposal measures see section 13.
SECTION 7: Handling and storage
7.1 Precautions for safe handling

General conditions of use are further specified in the annex according to REACH-Regulation (EU) No. 1907/2006.
Provide sufficient air exchange and/or exhaust in work rooms. Exhaust ventilation necessary if product is
sprayed.
The threshold limit values noted in section 8 must be monitored. In all areas where isocyanate aerosols
and/or vapor concentrations are produced in elevated concentrations, exhaust ventilation must be provided in
such a way that the workplace exposure limits (WEL) is not exceeded. The air should be drawn away from the
personnel handling the product
Products containing solvent: Explosion protection required.
The personal protective measures described in section 8 must be observed. The precautions required in the
handling of solvents and isocyanates must be taken. Avoid contact with skin and eyes and the inhalation of
vapor.
Keep away from foodstuffs, drinks and tobacco. Wash hands before breaks and at end of work and use
skin-protecting ointment. Keep working clothes separately. Take off all contaminated clothing immediately.
7.2 Conditions for safe storage, including any incompatibilities

Keep container dry and tightly closed in a cool and well ventilated place. Further information on the storage
conditions which must be observed to preserve quality can be found in our product information sheet.
Storage class (TRGS 510) : 3: Flammable liquids

7.3 Specific end use(s)
For details of the identified uses according to REACH-Regulation (EU) No. 1907/2006 refer to the annex of this
safety data sheet.
SECTION 8: Exposure controls/personal protection
Risk management measures are further specified in the annex according to REACH-Regulation (EU) No.
1907/2006.
8.1 Control parameters
Components with workplace control parameters

Substance CAS-No. Basis Type Value Ceiling Remarks
Limit
Value
n-Butyl acetate 123-86-4 TRGS 900 Listed.
n-Butyl acetate 123-86-4 TRGS 900 62 ppm 2 Y
300
mg/m3
n-Butyl acetate 123-86-4 TRGS 900 STEL Category II: substances
CL with a resorptive effect.
Exposition assessment value (EBW) per TRGS 430:Polyisocyanate content (HDI oligomers and/or
prepolymers) 90 %. Use an exposition assessment value of 0,5 mg/m³.
The regulations for the substances listed below must be observed when processing this product, particularly
if processing takes place at elevated temperatures.
Substance CAS-No. Basis Type Value Ceiling Remarks

Limit
Value
Hexamethylene-1,6-diis 822-06-0 TRGS 900 Listed.
ocyanate
Hexamethylene-1,6-diis 822-06-0 TRGS 900 0,005 ppm =2=
ocyanate 0,035
mg/m3
Hexamethylene-1,6-diis 822-06-0 TRGS 900 STEL Category I: substances
ocyanate CL for which the localized
effect has an assigned
OEL or for substances
with a sensitizing effect
in respiratory passages.
Hexamethylene-1,6-diis 822-06-0 TRGS 900 STEL 1 Substance listed with
ocyanate FAC both Peak factor and
STEL factor. The Peak
factor is supplied with the
AGW values.
Derived No Effect Level (DNEL)
Value type Route of Health Effects Value Remarks

exposure
Workers Inhalation Long-term systemic No hazard identified
effects
Workers Inhalation Acute systemic No hazard identified
effects
Workers Inhalation Long-term local 0,5 mg/m3 Most sensitive endpoint:
effects Irritation (respiratory tract)
Workers Inhalation Acute local effects 1 mg/m3 Most sensitive endpoint:
Irritation (respiratory tract)
Workers Dermal Long-term systemic No hazard identified
effects
Workers Dermal Acute systemic No hazard identified
effects
Workers Dermal Long-term local High hazard (no threshold
effects derived) Most sensitive
endpoint: Sensitisation (skin)
Workers Dermal Acute local effects High hazard (no threshold
derived) Most sensitive
endpoint: Sensitisation (skin)
Workers Eye contact Local effects No hazard identified
n-Butyl acetate
Value type Route of Health Effects Value Remarks

exposure
Workers Inhalation Long-term systemic 300 mg/m3 Most sensitive endpoint:
Workers Inhalation Acute systemic 600 mg/m3 Most sensitive endpoint:
Workers Inhalation Long-term local 300 mg/m3 Most sensitive endpoint:
Workers Inhalation Acute local effects 600 mg/m3 Most sensitive endpoint:
Workers Dermal Long-term systemic 11 mg/kg bw/day Most sensitive endpoint:
effects Neurotoxicity
Workers Dermal Acute systemic 11 mg/kg bw/day Most sensitive endpoint:
Workers Dermal Long-term local No hazard identified
effects
Workers Dermal Acute local effects No hazard identified
Workers Eye contact Local effects No hazard identified
Consumers Inhalation Long-term systemic 35,7 mg/m3 Most sensitive endpoint:

Consumers Inhalation Acute systemic 300 mg/m3 Most sensitive endpoint:
Consumers Inhalation Long-term local 35,7 mg/m3 Most sensitive endpoint:
Consumers Inhalation Acute local effects 300 mg/m3 Most sensitive endpoint:
Consumers Dermal Long-term systemic 6 mg/kg bw/day Most sensitive endpoint:
Consumers Dermal Acute systemic 6 mg/kg bw/day Most sensitive endpoint:
Consumers Dermal Long-term local No hazard identified
effects
Consumers Dermal Acute local effects No hazard identified
Consumers Oral Long-term systemic 2 mg/kg bw/day Most sensitive endpoint:

Consumers Oral Acute systemic 2 mg/kg bw/day Most sensitive endpoint:
Consumers Eye contact Local effects No hazard identified
Predicted No Effect Concentration (PNEC)
Compartment Value Remarks

Fresh water 0,127 mg/l
Fresh water sediment 266701 mg/kg dry weight
Marine water 0,0127 mg/l
Marine sediment 26670 mg/kg dry weight
Sewage treatment plant 88 mg/l
Air No hazard identified
Soil 53183 mg/kg dry weight
Oral Does not bioaccumulate.
Intermittent use/release 1,27 mg/l
n-Butyl acetate
Compartment Value Remarks

Fresh water 0,18 mg/l
Fresh water sediment 0,981 mg/kg dry weight
(d.w.)
Marine water 0,018 mg/l
Marine sediment 0,0981 mg/kg dry weight
(d.w.)
Sewage treatment plant 35,6 mg/l
Air No hazard identified
Soil 0,0903 mg/kg dry weight
(d.w.)
Oral Does not bioaccumulate.
Intermittent use/release 0,36 mg/l
8.2 Exposure controls
Respiratory protection
Respiratory protection required in insufficiently ventilated working areas and during spraying. An air-fed
mask, or for short periods of work, a combination of charcoal filter and particulate filter A2-P2 (EN529) is
recommended.
If applicable, further recommendations regarding respiratory protection can be found in the annex.
In case of hypersensitivity of the respiratory tract (e.g. asthmatics and those who suffer from chronic
bronchitis) it is inadvisable to work with the product.
Hand protection
Conditionally suitable materials for protective gloves; EN 374:
Nitrile rubber - NBR (>= 0.35 mm)
Only suitable as splash protection. Only suitable for brief exposure. In the event of contamination, change
protective gloves immediately.
Eye protection
Wear eye/face protection.
Skin and body protection

Wear suitable protective clothing.
In case of hypersensitivity of the skin it is inadvisable to work with the product.
SECTION 9: Physical and chemical properties
9.1 Information on basic physical and chemical properties
Appearance: liquid
Colour: colourless
Odour: solvent-like
Odour Threshold: not established
pH: not applicable
Softening point: ca. -48 °C
Boiling point/boiling range: ca. 127 °C
Flash point: ca. 50 °C DIN 53213
Evaporation rate: not established
Flammability (solid, gas): not applicable
Burning number: not applicable
Upper/lower flammability or explosive limits:
n-Butyl acetate upper: 7,5 %(V) / lower: 1,2 %(V)

Vapour pressure: not established
Vapour pressure of ingredients:
n-Butyl acetate ca. 12 hPa at 20 °C
Hexamethylene-1,6-diisocyanate ca. 0,007 hPa at 20 °C
Hexamethylene-1,6-diisocyanate < 0,0001 hPa at 20 °C
Homopolymer (vapor pressure balance/OECD No.104)
Vapour density: not established
Density: ca. 1,13 g/cm³ at 20 °C DIN 53217
Miscibility with water: immiscible at 15 °C
Water solubility of ingredients:
n-Butyl acetate ca. 10 g/l at 20 °C
Surface tension: not established
Partition coefficient not established
(n−octanol/water):
Auto-ignition temperature: not applicable
Ignition temperature: 370 °C
Decomposition temperature: not established
Viscosity, dynamic: ca. 500 mPa.s at 23 °C DIN EN ISO
3219/A.3
Explosive properties: not established
Dust explosion class: not applicable
Oxidising properties: not established
9.2 Other information

The indicated values do not necessarily correspond to the product specification. Please refer to the technical
information sheet for specification data.
SECTION 10: Stability and reactivity
10.1 Reactivity
This information is not available.
10.2 Chemical stability

10.3 Possibility of hazardous reactions

Exothermic reaction with amines and alcohols; reacts slowly with water forming CO2, in closed containers
risk of bursting owing to increase of pressure.
10.4 Conditions to avoid

10.5 Incompatible materials

10.6 Hazardous decomposition products

No hazardous decomposition products when stored and handled correctly.
SECTION 11: Toxicological information
Toxicological studies on the product are not yet available.
Toxicological studies on the product are not yet available.
Please find below the toxicological data available to us for the components (hazardous components).
Please find below the toxicological data available to us for the components (hazardous components).
11.1 Information on toxicological effects

Acute toxicity, oral
LD50 rat, female: > 2.500 mg/kg
Method: OECD Test Guideline 423
n-Butyl acetate
LD50 rat, female: 10.760 mg/kg
Acute toxicity, dermal

LD50 rat, male/female: > 2.000 mg/kg
LD50 rabbit, male/female: > 2.000 mg/kg
n-Butyl acetate
LD50 rat, male/female: 14.112 mg/kg
Acute toxicity, inhalation

ATEmix (inhal.): 1,67 mg/l, 4 h
Test atmosphere: dust/mist
Method: Calculation method
LC50 rat, female: 0,390 mg/l, 4 h
The test atmosphere generated in the animal study is not representative of workplace environments, how the
substance is placed on the market, and how it can reasonably be expected to be used. Therefore the test
result cannot be directly applied for the purpose of assessing hazard. Based on expert judgment and the
weight of the evidence, a modified classification for acute inhalation toxicity is justified.
Converted acute toxicity point estimate 1,5 mg/l

Method: Expert judgement
Assessment: Harmful if inhaled.
n-Butyl acetate
LC50 rat, male/female: > 21 mg/l, 4 h
Test atmosphere: vapour
Primary skin irritation

Species: rabbit
Exposure duration: 4 h
Result: slight irritant
Classification: No skin irritation
n-Butyl acetate
Species: rabbit
Result: non-irritant
Classification: No skin irritation
Species: Human experience

Classification: Repeated exposure may cause skin dryness or cracking.
Primary mucosae irritation

Species: rabbit
Classification: No eye irritation
n-Butyl acetate
Species: rabbit
Classification: No eye irritation
Sensitisation
Skin sensitization (local lymph node assay (LLNA)):
Species: Mouse
Result: positive
Classification: May cause sensitization by skin contact.
Skin sensitisation according to Magnusson/Kligmann (maximizing test):

Species: Guinea pig
Result: positive
Classification: May cause sensitization by skin contact.
Respiratory sensitization
Classification: No classification according to EC Directives 2006/121/EC or 1999/45/EC as respiratory

sensitizer.
No pulmonary sensitisation observed in animal tests.
No pulmonary sensitisation potential was observed in guinea pigs after either intradermal or inhalative
induction with polyisocyanate based on hexamethylene diisocyanate.
n-Butyl acetate
Skin sensitisation according to Magnusson/Kligmann (maximizing test):
Species: Guinea pig
Result: negative
Classification: Does not cause skin sensitization.
Sensitization of the respiratory airways
No data available.
Subacute, subchronic and prolonged toxicity

NOAEL: 3,3 mg/m³ air
Application Route: Inhalative
Species: rat, male/female
Dose Levels: 0 - 0,5 - 3,3 - 26,4 mg/m³
Exposure duration: 90 d
Frequency of treatment: 6 hours a day, 5 days a week
Test substance: as aerosol
Evidence of damage to organs other than the organs of respiration was not found.
n-Butyl acetate
NOAEL: 500 ppm
Application Route: inhalation (vapour)
Dose Levels: 500 - 1500 - 3000 ppm
Frequency of treatment: 6 hours a day, 5 days a week
Carcinogenicity
No data available.
n-Butyl acetate
No data available.
Reproductive toxicity/Fertility
Available data show no indications for reproductive toxicity.
n-Butyl acetate
Test type: Two-generation study
Animal testing did not show any effects on fertility.
Reproductive toxicity/Teratogenicity
Animal experiments on structurally similar compounds showed no indication of specific reproductive toxicity.
n-Butyl acetate
NOAEL (teratogenicity): 1500 ppm
Species: rat, female
Did not show teratogenic effects in animal experiments.
Genotoxicity in vitro
Test type: Salmonella/microsome test (Ames test)
Metabolic activation: with/without
Result: No indication of mutagenic effects.
Test type: Point mutation in mammalian cells (HPRT test)

Test system: Chinese hamster ovary (CHO) cells
Result: negative
Test type: Chromosome aberration test in vitro

Test system: Chinese hamster V79 cell line
Result: negative
n-Butyl acetate
Test type: Ames test
Result: negative
Test type: In vitro mammalian cell gene mutation test

Result: negative
Genotoxicity in vivo
No data available.
n-Butyl acetate
Test type: In vivo micronucleus test
Species: Mouse
Application Route: Oral
Result: negative
Studies of a comparable product.
STOT evaluation – one-time exposure

Route of exposure: Inhalative
May cause respiratory irritation.
n-Butyl acetate
May cause drowsiness or dizziness.
STOT evaluation – repeated exposure

Based on available data, the classification criteria are not met.
n-Butyl acetate
Aspiration toxicity
n-Butyl acetate
CMR Assessment
Carcinogenicity: Based on available data, the classification criteria are not met.
Mutagenicity: In vitro tests did not show mutagenic effects
Teratogenicity: Based on available data, the classification criteria are not met.
Reproductive toxicity/Fertility: Based on available data, the classification criteria are not met.
n-Butyl acetate
Carcinogenicity: No data available.
Mutagenicity: Based on available data, the classification criteria are not met.
Teratogenicity: Based on available data, the classification criteria are not met.
Reproductive toxicity/Fertility: Based on available data, the classification criteria are not met.
Toxicology Assessment
Acute effects: Harmful if inhaled.
Sensitization: May cause sensitization by skin contact.
n-Butyl acetate
Acute effects: Based on available data, the classification criteria are not met.
Sensitization: Based on available data, the classification criteria are not met.
Additional information
Special properties/effects: Over-exposure, especially when spraying coatings containing isocyanate without
the necessary precautions, entails the risk of concentration-dependent irritating effects on eyes, nose throat,
and respiratory tract. Delayed appearance of the complaints and development of hypersensitivity (difficult
breathing, coughing, asthma) are possible. Hypersensitive persons may suffer from these effects even at low
isocyanate concentrations, including concentrations below the occupational exposure limit. Prolonged
contact with the skin may cause tanning and irritant effects.
Animal tests and other research indicate that skin contact with diisocyanates can play a role in causing
isocyanate sensitization and respiratory reaction.
SECTION 12: Ecological information
Ecotoxicological studies of the product are not available.
Do not allow to escape into waterways, wastewater or soil.
Please find below the ecotoxicological data available to us for the components.
12.1 Toxicity
Acute Fish toxicity
LC50 > 100 mg/l
Test type: Acute Fish toxicity
Species: Danio rerio (zebra fish)
Method: Directive 67/548/EEC, Annex V, C.1.
n-Butyl acetate
LC50 18 mg/l
Species: Pimephales promelas (fathead minnow)
Chronic Fish toxicity

Study scientifically not justified.
n-Butyl acetate
No data available.
Acute toxicity for daphnia

EC50 > 100 mg/l
Species: Daphnia magna (Water flea)
Method: Directive 67/548/EEC, Annex V, C.2.
n-Butyl acetate
EC50 44 mg/l
Species: Daphnia (water flea)
Chronic toxicity to daphnia

Study scientifically not justified.
n-Butyl acetate
NOEC 23 mg/l
Species: Daphnia magna (Water flea)
Acute toxicity for algae

ErC50 > 1.000 mg/l
Test type: Growth inhibition
Species: scenedesmus subspicatus
Method: DIN 38412
n-Butyl acetate
EC50 675 mg/l
Species: Scenedesmus quadricauda (Green algae)
Acute bacterial toxicity

EC50 3.828 mg/l
Test type: Respiration inhibition
Species: activated sludge

n-Butyl acetate
EC50 356 mg/l
Species: activated sludge
Ecotoxicology Assessment
Acute aquatic toxicity: Based on available data, the classification criteria are not met.
Chronic aquatic toxicity: Based on available data, the classification criteria are not met.
Impact on Sewage Treatment: Because of the low bacterial toxicity, there is no risk of an adverse effect on the
performance of biological waste water treatment plants.
n-Butyl acetate
Acute aquatic toxicity: Harmful to aquatic life.
Chronic aquatic toxicity: Based on available data, the classification criteria are not met.
Impact on Sewage Treatment: Because of the low bacterial toxicity, there is no risk of an adverse effect on the
performance of biological waste water treatment plants.
12.2 Persistence and degradability

Biodegradability
Test type: aerobic
Inoculum: activated sludge
Biodegradation: 1 %, 28 d, i.e. not readily degradable
Method: Directive 67/548/EEC Annex V, C.4.E.
Test type: aerobic

Inoculum: activated sludge
Biodegradation: 0 %, 28 d, i.e. not readily degradable
n-Butyl acetate
Biodegradation: > 80 %, 5 d, i.e. readily biodegradable
Method: OECD Test Guideline 301 D
Stability in water
Test type: Hydrolysis
Half life: 7,7 h at 23 °C
The substance hydrolyzes rapidly in water.
Photodegradation
Test type: Phototransformation in air
Temperature: 25 °C
sensitizer: OH-radicals
Half-life indirect photolysis: 10,3 h
Method: SRC - AOP (calculation)
After evaporation or exposure to the air, the product will be rapidly degraded by photochemical processes.
Test type: Phototransformation in air

Temperature: 25 °C
sensitizer: OH-radicals
Half-life indirect photolysis: 3 h
Method: SRC - AOP (calculation)
After evaporation or exposure to the air, the product will be rapidly degraded by photochemical processes.
Studies of hydrolysis products.
Volatility (Henry's Law constant)

Calculated value = < 0,000001 Pa*m3/mol at 25 °C
Method: Bond-method
The substance has to be scored as non-volatile from water.
12.3 Bioaccumulative potential

Bioaccumulation
Bioconcentration factor (BCF): 3,2
Method: (calculated)
An accumulation in aquatic organisms is not to be expected.
Bioconcentration factor (BCF): 367,7

Method: (calculated)
An accumulation in aquatic organisms is not to be expected.
Studies of hydrolysis products.
12.4 Mobility in soil

Distribution among environmental compartments
Adsorption/Soil
not applicable
Environmental distribution
not applicable
12.5 Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and
toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
12.6 Other adverse effects

Isocyanate reacts with water at the interface forming CO2 and a solid insoluble product with high melting point
(polyurea). This reaction is accelerated by surfactants (e.g. detergents) or by watersoluble solvents. Previous
experience shows that polyurea is inert and non-degradable.
SECTION 13: Disposal considerations
Dispose in accordance with applicable international, national and local laws, ordinances and statutes. For
disposal within the EC, the appropriate code according to the European Waste Catalogue (EWC) should be
used.
13.1 Waste treatment methods

After final product withdrawal, all residues must be removed from containers (drip-free, powder-free or
paste-free). Packaging empty of usable product can be handed to a professional waste management
company; in the EU, this is done per packaging type at collection points run by the existing take-back systems
for the chemicals industry. The product and hazardous substance labelling must be left intact on the
packaging.
Alternatively, the product and hazardous substance labelling can be removed if the product residues adhering
to the sides are rendered non-hazardous. This packaging can also be handed to the collection points run by
the existing take-back systems for the chemicals industry for packaging type-specific recycling.
Containers must be recycled in compliance with national legislation and environmental regulations.
None disposal into waste water.
SECTION 14: Transport information
ADR/RID
14.1 UN number : 1866
14.2 UN proper shipping name : RESIN SOLUTION
14.3 Transport hazard class(es) : 3
Hazard Identification Number : 30
14.4 Packing group : III
14.5 Environmental hazards : no

Special regulation for 'viscous substances' applicable
ADN
14.1 UN number : 1866
Hazard Identification Number : 30
This classification data does not apply to transportation by tanker. If required, additional information can be
requested from the manufacturer.
IATA
14.1 UN number : 1866
IMDG
14.1 UN number : 1866
14.5 Marine pollutant : no
EmS Code : F-E - S-E
Segregation Group IMDG : not applicable
14.6 Special precautions for user

See section 6 - 8.
Additional information : Combustible. Keep dry.
Keep away from foodstuffs, acids and alkalis.
14.7 Transport in bulk according to Annex II of MARPOL73/78 and the IBC Code
Not applicable.
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
Directive 2012/18/EU on the control of major-accident hazards involving dangerous substances.
P5c Flammable liquids
Quantity1: 5.000 t Quantity2: 50.000 t
REACH - Restrictions on the manufacture, placing on the market and use of certain dangerous
substances, preparations and articles (Annex XVII)
Conditions of restriction for the following entries should be considered: 3
TA Luft List (Germany)

Type: Organic Substances
portion Class 1: 0,1 %
Fraction of other substances: 99,9 %
Water contaminating class (Germany)

1 slightly water endangering
Classification according to AwSV, Annex 1 (5.2)
Any existing national regulations on the handling of isocyanates must be observed.

Products containing solvent:
Any existing national regulations on the handling of solvents must be observed.
15.2 Chemical Safety Assessment

A Chemical Safety Assessment has been carried out for:
n-Butyl acetate
SECTION 16: Other information
Full text of the hazard statements of the CLP classification (1272/2008/CE) referred to under sections 2, 3
and 10.
H226 Flammable liquid and vapour.
H302 Harmful if swallowed.
H315 Causes skin irritation.
H317 May cause an allergic skin reaction.
H319 Causes serious eye irritation.
H330 Fatal if inhaled.
H332 Harmful if inhaled.
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled.
H335 May cause respiratory irritation.
H336 May cause drowsiness or dizziness.
The product is used mainly as a hardener in coating materials or adhesives. The handling of coating materials
or adhesives containing reactive polyisocyanates and residual monomeric HDI requires appropriate
protective measures referred to in this safety data sheet. These products may therefore be used only in
industrial or trade applications. They are not suitable for use in homeworker (DIY) applications.
Further details for safe handling of aliphatic isocyanates you find on the web page of ALIPA: ALIPA
Safeguard – We care that your care (www.alipa.org).
Abbreviations and acronyms

ADN Accord européen relatif au transport international des marchandises
Dangereuses par voie de Navigation intérieure
ADR Accord européen relatif au transport international des marchandises
Dangereuses par Route
ANSI American National Standards Institute
ASTM American Society of Testing and Materials (US)
ATE Acute Toxic Estimate
AwSv Verordnung über Anlagen zum Umgang mit wassergefährdenden Stoffen
BCF Bioconcentration Factor
CAS Chemical Abstract Service
CLP Regulation on Classification, Labelling and Packaging of Substances and
Mixtures
CMR Cancerogenic Mutagenic Reprotoxic
DIN Deutsches Institut für Normung
DNEL Derived No-Effect Level
EC… Effect Concentration ... %
EWC European Waste Catalogue
IATA International Air Transport Association
IBC Intermediate Bulk Container
ICAO International Civil Aviation Organization
IMDG International Maritime Dangerous Goods
IMO International Maritime Organization
ISO International Organization for Standardization
IUPAC International Union of Pure and Applied Chemistry
LOAEL Lowest Observable Adverse Effect Level
LC… Lethal Concentration, ...%
LD… Lethal Dose, ...%
MARPOL International Convention for the Prevention of Pollution From Ships
NOAEL No Observed Adverse Effect Level
NOEL/NOEC No Observed Effect Level/Concentration
OECD Organisation for Economic Co-operation and Development
PBT persistent, bioaccumulative, toxic
PNEC Predicted No-Effect Concentration
REACH Registration, Evaluation, Authorisation and Restriction of Chemicals
RID Règlement concernant le transport International ferroviaire de
marchandises Dangereuses
STOT Specific Target Organ Toxicity
TRGS Technische Regeln für Gefahrstoffe
vPvB very Persistent, very Bioaccumulative
WGK Wassergefährdungsklasse
Changes since the last version are highlighted in the margin. This version replaces all previous versions.
Further information
Classification of the mixture: Classification procedure:
Flam. Liq. 3 H226 Based on product data or assessment
Acute Tox. 4 H332 Calculation method
Skin Sens. 1 H317 Calculation method
STOT SE 3 H335 Calculation method
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and
belief at the date of its publication. The information given is designed only as a guidance for safe handling, use,
processing, storage, transportation, disposal and release and is not to be considered a warranty or quality
specification. The information relates only to the specific material designated and may not be valid for such
material used in combination with any other materials or in any process, unless specified in the text.
Annex
The operational conditions and the implementation of Risk Management Measures (RMM) are dependent
on the following priority-/lead substances for the respective exposure routes:
Lead substance(s), aquatic environment:
Not relevant
Lead substance(s), ozone layer:

Not relevant
Lead substance(s), Inhalation:

Not relevant
Lead substance(s), Dermal:

Not relevant
Lead substance(s), Oral:

Not relevant
Local effects, Skin:

Local effects, Inhalation:

Local effects, Eyes:

Not relevant
Exposure Scenario
Number Title
ES1 Formulation or re-packing

ES2 Use at industrial sites; Various sectors (SU12, SU13, SU19).
ES3 Widespread use by professional workers; Various sectors (SU12, SU13, SU19).
ES1: Formulation or re-packing
1.1. Title section
Structured Short Title : Formulation or re-packing
Worker
CS1 Use in closed process, no likelihood of exposure PROC1

[Hexamethylene-1,6-diisocyanate Homopolymer]
CS2 Use in closed, continuous process with occasional controlled PROC2, PROC3
exposure, Use in closed batch process (synthesis or formulation)
CS3 Use in batch and other process (synthesis) where opportunity for PROC4, PROC8b, PROC9
exposure arises, Transfer of substance or preparation (charging/
discharging) from/ to vessels/ large containers at dedicated facilities,
Transfer of substance or preparation into small containers
(dedicated filling line, including weighing)
CS4 Mixing or blending in batch processes for formulation of PROC5
preparations and articles (multistage and/ or significant contact)
CS5 Transfer of substance or preparation (charging/ discharging) from/ to PROC8a, PROC15
vessels/ large containers at non-dedicated facilities, Use as
laboratory reagent
1.2. Conditions of use affecting exposure
1.2.1. Control of worker exposure: Use in closed process, no likelihood of exposure (PROC1)
Product (article) characteristics
Concentration of the Substance in : <= 100%

Mixture/Article
Molar Mass : >= 168,19 g/mol Substance of unknown or variable composition,
complex reaction products or biological material (UVCB)
Vapour pressure : 0,0000246 hPa at 20 °C, calculated
Physical form of product : Liquid substance
Amount used, frequency and duration of use (or from service life)
General exposures : < 8 hours/day
Technical and organisational conditions and measures
Use in closed system for easy maintenance.

If possible keep equipment under negative pressure.
Provide a good standard of general ventilation (not less than 1 to 3 air changes per hour).
Personnel who work with the substance should have a pre-placement medical examination and periodic examinations
thereafter, including a pulmonary function test. Anyone with a medical history of chronic respiratory disease, asthmatic
or bronchial attacks, indications of allergic responses, recurrent eczema or sensitization conditions of the skin should
not handle or work with the substance. Anyone who develops chronic respiratory distress when working with the
substance should be removed from exposure and examined by a physician. Further exposure must be avoided in case
of pre-sensitisation to the substance (ALIPA, 2008).

Provide any measure to eliminate exposure.
Control staff entry to work area.
Ensure all equipment is well maintained.
General Permit to Work (PTW) for cleaning and maintenance activities
Regular cleaning of equipment, work area and clothing.
Supervision in place to check that the risk management measures in place are being used correctly and operation
conditions followed.
Training for staff on good practice.
Procedures and training for emergency decontamination and disposal.
Good standard of personal hygiene.
Sensitisers – pre-employment screening and appropriate health screening.
Handle substance within a closed system.
Conditions and measures related to personal protection, hygiene and health evaluation
All skin and mucous membranes with potential exposure protected with appropriate PPE.
Wear suitable gloves tested to EN374.
Other conditions affecting workers exposure
Indoor or outdoor use : Indoor

Temperature : <= 40 °C
1.2.2. Control of worker exposure: Use in closed, continuous process with occasional controlled exposure
(PROC2) / Use in closed batch process (synthesis or formulation) (PROC3)

Mixture/Article


Handle substance within a predominantly closed system.

1.2.3. Control of worker exposure: Use in batch and other process (synthesis) where opportunity for exposure
arises (PROC4) / Transfer of substance or preparation (charging/ discharging) from/ to vessels/ large
containers at dedicated facilities (PROC8b) / Transfer of substance or preparation into small containers
(dedicated filling line, including weighing) (PROC9)

Mixture/Article

Handle in semi-closed process with occasional controlled exposure.

1.2.4. Control of worker exposure: Mixing or blending in batch processes for formulation of preparations and
articles (multistage and/ or significant contact) (PROC5)

Mixture/Article


1.2.5. Control of worker exposure: Transfer of substance or preparation (charging/ discharging) from/ to
vessels/ large containers at non-dedicated facilities (PROC8a) / Use as laboratory reagent (PROC15)

Mixture/Article


1.3. Exposure estimation and reference to its source
1.3.1. Worker exposure: Use in closed process, no likelihood of exposure (PROC1)

Exposure route Exposure level RCR Remarks

long term, inhalative, local, 0,056 mg/m³ (ECETOC 0,112
TRA v2.0, Worker)
acute, inhalative, local, 0,056 mg/m³ (ECETOC 0,056

TRA v2.0, Worker)
long term, dermal, local, * (Qualitative assessment)
acute, dermal, local, * (Qualitative assessment)
Additional information on exposure estimation

*
Qualitative approach used to conclude safe use.
Local effects are assumed to be controlled by RMMs described.
Based on the applied RMMs the risk towards humans is sufficiently controlled (RCR ≤ 1).
1.3.2. Worker exposure: Use in closed, continuous process with occasional controlled exposure (PROC2) /
Use in closed batch process (synthesis or formulation) (PROC3)

long term, inhalative, local, 0,11 mg/m³ (ECETOC TRA 0,22
v2.0, Worker)
acute, inhalative, local, 0,11 mg/m³ (ECETOC TRA 0,11
v2.0, Worker)

*
1.3.3. Worker exposure: Use in batch and other process (synthesis) where opportunity for exposure arises
(PROC4) / Transfer of substance or preparation (charging/ discharging) from/ to vessels/ large containers at
dedicated facilities (PROC8b) / Transfer of substance or preparation into small containers (dedicated filling
line, including weighing) (PROC9)

v2.0, Worker)
v2.0, Worker)

*
1.3.4. Worker exposure: Mixing or blending in batch processes for formulation of preparations and articles
(multistage and/ or significant contact) (PROC5)

v2.0, Worker)
v2.0, Worker)

*
1.3.5. Worker exposure: Transfer of substance or preparation (charging/ discharging) from/ to vessels/ large
containers at non-dedicated facilities (PROC8a) / Use as laboratory reagent (PROC15)

v2.0, Worker)
v2.0, Worker)

*
1.4. Guidance to DU to evaluate whether he works inside the boundaries set by the ES
The risk management measures given in this exposure scenario apply to the specified substance in a concentration as
indicated in the scenario. The concentration of the substance in the product may differ. A downstream user should
evaluate if the risk management measures may be adapted accordingly.
Guidance is based on assumed operating conditions which may not be applicable to all sites; thus, scaling may be
necessary to define appropriate site-specific risk management measures.
Where other risk management measures/operational conditions are adopted, then users should ensure that risks are
managed to at least equivalent levels.
ES2: Use at industrial sites; Various sectors (SU12, SU13, SU19).
2.1. Title section
Exposure Scenario name : End Use

Structured Short Title : Use at industrial sites; Various sectors (SU12, SU13, SU19).
Worker
CS1 End Use PROC1

CS2 End Use PROC2
CS3 End Use PROC3
CS4 End Use PROC4
CS5 End Use PROC5
CS6 End Use PROC7
CS7 End Use PROC8a
CS8 End Use PROC8b
CS9 End Use PROC9
CS10 End Use PROC10
CS11 End Use PROC13
CS12 End Use PROC14
CS13 End Use PROC15
2.2.1. Control of worker exposure: Use in closed process, no likelihood of exposure (PROC1)

Mixture/Article
Remarks : This parameter is dependent on other Operational Conditions (OC) /
Risk Management Measures (RMM)., For safe combinations of OC /
RMM refer to section 3.

Duration of the acitivity : < 8 hours/day

A very high level of containment is required, except for short term exposures.
Recording of any "near miss" situations.
Handle substance within a closed system.
Indoor or outdoor use : Indoor use

Temperature : 140 °C
2.2.2. Control of worker exposure: Use in closed, continuous process with occasional controlled exposure
(PROC2)

Mixture/Article


Effective housekeeping processes in place.
Room ventilation rate of 1 air change per hour (ACH) is required.

Room size : 300 m³
Remarks : Room sizes only applicable where exposure estimation was calculated
with Advanced Reach Tool (ART).
2.2.3. Control of worker exposure: Use in closed batch process (synthesis or formulation) (PROC3)

Mixture/Article


Temperature : Above room temperature

Room size : 300 m³
arises (PROC4)

Mixture/Article


Room size : 100 - 300 m³

Mixture/Article



Room size : 300 m³
2.2.6. Control of worker exposure: Industrial spraying (PROC7)


Mixture/Article


Room ventilation rate of 3 air changes per hour (ACH) is required.
Local exhaust ventilation is required.

AND
Wear respiratory protection.
Wearing a spray protective overall with hood (Type 4, EN 14605) is required during spraying.
Furthermore, an air-fed mask or a combination of charcoal filter (type A/AX) and particulate filter (type P) must always
be worn if the appearance of vapours or aerosols cannot be excluded.

Temperature : 25 - 50 °C
Room size : 300 m³
vessels/ large containers at non-dedicated facilities (PROC8a)

Mixture/Article
Mixture/Article

<= 50 %
100%

OR

Remarks : <= 50 %
Remarks : 100%
Room size : 300 m³
Remarks : <= 50 %, Room sizes only applicable where exposure estimation was
calculated with Advanced Reach Tool (ART).
vessels/ large containers at dedicated facilities (PROC8b)

Mixture/Article

Room temperature (15-25 °C)
40 °C
120 °C
Provide the operation with a properly sited receiving hood.
Temperature : Room temperature (15-25 °C)

Room size : 300 m³
2.2.9. Control of worker exposure: Transfer of substance or preparation into small containers (dedicated filling
line, including weighing) (PROC9)

Mixture/Article


Room size : 300 m³
2.2.10. Control of worker exposure: Roller application or brushing (PROC10)


Mixture/Article
Mixture/Article
Mixture/Article


< 8 h/day
Indoor use

OR
< 4 h/day
Indoor use
Substance concentration
<= 30 %
OR
<= 50 %
< 2 h/day
Indoor use
Indoor or outdoor use : Indoor/Outdoor use

Remarks : no temperature indicated
2.2.11. Control of worker exposure: Treatment of articles by dipping and pouring (PROC13)

Mixture/Article


Room size : 300 m³
2.2.12. Control of worker exposure: Production of preparations or articles by tabletting, compression,

extrusion, pelletisation (PROC14)

Mixture/Article
Mixture/Article

Physical form of product : Powdered substance

<= 20 %
<= 100 %

OR

Room size : 300 m³

2.2.13. Control of worker exposure: Use as laboratory reagent (PROC15)


Mixture/Article


Room size : 300 m³
2.3.1. Worker exposure: Use in closed process, no likelihood of exposure (PROC1)


long term, inhalative, local, 0,07 mg/m³ (ECETOC TRA 0,14 <= 40 °C
v3.0, Worker)
acute, inhalative, local, 0,07 mg/m³ (ECETOC TRA 0,07 <= 40 °C
v3.0, Worker)
long term, inhalative, local, 0,07 mg/m³ (ECETOC TRA 0,14 140 °C
v3.0, Worker)
acute, inhalative, local, 0,28 mg/m³ (ECETOC TRA 0,28 140 °C
v3.0, Worker)
long term, dermal, local, ** (Qualitative assessment)
acute, dermal, local, ** (Qualitative assessment)

**
2.3.2. Worker exposure: Use in closed, continuous process with occasional controlled exposure (PROC2)

long term, inhalative, local, 0,016 mg/m³ (Advanced 0,032 20 °C, OR, 40 °C, OR, 140
REACH Tool (ART) v1.0) °C
acute, inhalative, local, 0,032 mg/m³ (Advanced 0,032 20 °C, OR, 40 °C, OR, 140
REACH Tool (ART) v1.0) °C

**
2.3.3. Worker exposure: Use in closed batch process (synthesis or formulation) (PROC3)

long term, inhalative, local, 0,13 mg/m³ (Advanced 0,26 Above room temperature,
REACH Tool (ART) v1.0) OR, 40 °C, OR, 140 °C
acute, inhalative, local, 0,26 mg/m³ (Advanced 0,26 Above room temperature,
REACH Tool (ART) v1.0) OR, 40 °C, OR, 140 °C

**
(PROC4)

long term, inhalative, local, 0,23 mg/m³ (Advanced 0,46
REACH Tool (ART) v1.5)
acute, inhalative, local, 0,46 mg/m³ (Advanced 0,46

**


**
2.3.6. Worker exposure: Industrial spraying (PROC7)


long term, inhalative, local, 0,27 mg/m³ (Advanced 0,54 Local exhaust ventilation
REACH Tool (ART) v1.5) (LEV): 95%, AND,
Respirator: 90% protection
acute, inhalative, local, 0,54 mg/m³ (Advanced 0,54 Local exhaust ventilation
REACH Tool (ART) v1.5) (LEV): 95%, AND,

**
containers at non-dedicated facilities (PROC8a)

long term, inhalative, local, 0,33 mg/m³ (Advanced 0,66 <= 50 %
acute, inhalative, local, 0,66 mg/m³ (Advanced 0,66 <= 50 %
long term, inhalative, local, 0,07 mg/m³ (ECETOC TRA 0,14 100%, Local exhaust
v3.0, Worker, *) ventilation (LEV): 90%, OR,
acute, inhalative, local, 0,07 mg/m³ (ECETOC TRA 0,07 100%, Local exhaust
v3.0, Worker, *) ventilation (LEV): 90%, OR,

*
The exposure estimates from ECETOC TRA assume that the conditions of use do not lead to formation of aerosol or
mists.
**
containers at dedicated facilities (PROC8b)

long term, inhalative, local, 0,26 mg/m³ (Advanced 0,52 Room temperature (15-25
REACH Tool (ART) v1.0) °C)
acute, inhalative, local, 0,52 mg/m³ (Advanced 0,52 Room temperature (15-25
REACH Tool (ART) v1.0) °C)
long term, inhalative, local, 0,26 mg/m³ (Advanced 0,52 40 °C, AND, LEV: 80%
REACH Tool (ART) v1.0) efficiency

acute, inhalative, local, 0,52 mg/m³ (Advanced 0,52 40 °C, AND, LEV: 80%
long term, inhalative, local, 0,18 mg/m³ (Advanced 0,36 120 °C, AND, LEV: 80%
acute, inhalative, local, 0,36 mg/m³ (Advanced 0,36 120 °C, AND, LEV: 80%

**
2.3.9. Worker exposure: Transfer of substance or preparation into small containers (dedicated filling line,
including weighing) (PROC9)


**
2.3.10. Worker exposure: Roller application or brushing (PROC10)


long term, inhalative, local, 0,227 mg/m³ (Measured 0,454 Indoor, 100%, < 2 h/day
value)
acute, inhalative, local, 0,454 mg/m³ (Measured 0,454 Indoor, 100%, < 2 h/day
value)
long term, inhalative, local, 0,27 mg/m³ (Measured 0,54 Indoor, <= 30 %, < 4 h/day
value)
acute, inhalative, local, 0,54 mg/m³ (Measured 0,54 Indoor, <= 30 %, < 4 h/day
value)
value)
value)
long term, inhalative, local, 0,091 mg/m³ (Measured 0,182 Indoor, 100%, < 8 h/day,
value) Local exhaust ventilation
(LEV): 90%, OR, Respirator:

90% protection
acute, inhalative, local, 0,18 mg/m³ (Measured 0,18 Indoor, 100%, < 8 h/day,
(LEV): 90%, OR, Respirator:
90% protection
long term, inhalative, local, 0,16 mg/m³ (Measured 0,32 Outdoor, 100%, < 8 h/day
value)
acute, inhalative, local, 0,32 mg/m³ (Measured 0,32 Outdoor, 100%, < 8 h/day
value)

**
2.3.11. Worker exposure: Treatment of articles by dipping and pouring (PROC13)



**
2.3.12. Worker exposure: Production of preparations or articles by tabletting, compression, extrusion,

pelletisation (PROC14)

long term, inhalative, local, 0,22 mg/m³ (Advanced 0,44 <= 100 %, Local exhaust
REACH Tool (ART) v1.0) ventilation (LEV): 90%, OR,
acute, inhalative, local, 0,44 mg/m³ (Advanced 0,44 <= 100 %, Local exhaust

**
2.3.13. Worker exposure: Use as laboratory reagent (PROC15)



**
If further details are needed, please contact us.
ES3: Widespread use by professional workers; Various sectors (SU12, SU13, SU19).
3.1. Title section
Exposure Scenario name : End Use

Structured Short Title : Widespread use by professional workers; Various sectors (SU12,
SU13, SU19).
Worker
CS1 End Use PROC3

CS2 End Use PROC4
CS3 End Use PROC5
CS4 End Use PROC8a
CS5 End Use PROC8b, PROC9
CS6 End Use PROC10
CS7 End Use PROC11
CS8 End Use PROC13
CS9 End Use PROC14
CS10 End Use PROC15
Further information
PROC 11 provides several contributing scenarios with variations of :

- Room size
- Spraying direction
- Generally 95% REP was used to calculate the exposure in each of these scenarios. Other mask efficiencies may also
be applied. Recalculation by rule of three is possible.
Downstream users may choose the scenario conditions that fit best to them.
3.2.1. Control of worker exposure: Use in closed batch process (synthesis or formulation) (PROC3)

Mixture/Article



Room size : 300 m³
arises (PROC4)

Mixture/Article


Room size : 300 m³

Mixture/Article


Room size : 300 m³
vessels/ large containers at non-dedicated facilities (PROC8a)

Mixture/Article
Mixture/Article

<= 50 %

100%

OR

Remarks : <= 50 %
Remarks : 100%
Room size : 300 m³
Remarks : <= 50 %, Room sizes only applicable where exposure estimation was
calculated with Advanced Reach Tool (ART).
vessels/ large containers at dedicated facilities (PROC8b) / Transfer of substance or preparation into small
containers (dedicated filling line, including weighing) (PROC9)

Mixture/Article



Room size : 300 m³
3.2.6. Control of worker exposure: Roller application or brushing (PROC10)


Mixture/Article
Mixture/Article
Mixture/Article

< 8 h/day
Indoor use

OR
OR
Substance concentration
<= 30 %
< 2 h/day
Indoor use
< 4 h/day
Indoor use

3.2.7. Control of worker exposure: Non industrial spraying (PROC11)

Concentration of the Substance in : 0 - 100%

Mixture/Article

or
Outdoor use
Wearing a spray protective overall with hood (Type 4, EN 14605) is required during spraying.
Furthermore, an air-fed mask or a combination of charcoal filter (type A/AX) and particulate filter (type P) must always
be worn if the appearance of vapours or aerosols cannot be excluded.
90% inhalation exposure reduction is the base assumption when using this REP. 95% inhalation exposure reduction
demands specific training in using this REP.

or
OR

Temperature : 25 - 50 °C
Room size : 100, 300, 1000 m³
3.2.8. Control of worker exposure: Treatment of articles by dipping and pouring (PROC13)

Mixture/Article

or
Outdoor use

Room size : 300 m³
3.2.9. Control of worker exposure: Production of preparations or articles by tabletting, compression,

extrusion, pelletisation (PROC14)

Mixture/Article
Mixture/Article
Physical form of product : Powdered substance


<= 100 %

OR
<= 20 %

Room size : 300 m³
3.2.10. Control of worker exposure: Use as laboratory reagent (PROC15)


Mixture/Article


Room size : 300 m³
3.3.1. Worker exposure: Use in closed batch process (synthesis or formulation) (PROC3)



*
(PROC4)


*


*
containers at non-dedicated facilities (PROC8a)

long term, inhalative, local, 0,33 mg/m³ (Advanced 0,66 <= 50 %, Above room
REACH Tool (ART) v1.0) temperature
acute, inhalative, local, 0,66 mg/m³ (Advanced 0,66 <= 50 %, Above room
REACH Tool (ART) v1.0) temperature
long term, inhalative, local, 0,14 mg/m³ (ECETOC TRA 0,28 100%, <= 40 °C, Local
v3.0, Worker) exhaust ventilation (LEV):
80%
acute, inhalative, local, 0,14 mg/m³ (ECETOC TRA 0,14 100%, <= 40 °C, Local
v3.0, Worker) exhaust ventilation (LEV):
80%
long term, inhalative, local, 0,07 mg/m³ (ECETOC TRA 0,14 100%, <= 40 °C, Respirator:
v3.0, Worker) 90% protection
acute, inhalative, local, 0,07 mg/m³ (ECETOC TRA 0,07 100%, <= 40 °C, Respirator:
v3.0, Worker) 90% protection

*
containers at dedicated facilities (PROC8b) / Transfer of substance or preparation into small containers
(dedicated filling line, including weighing) (PROC9)


*
3.3.6. Worker exposure: Roller application or brushing (PROC10)


long term, inhalative, local, 0,227 mg/m³ (Measured 0,454 Indoor, 100%, < 2 h/day
value)
acute, inhalative, local, 0,454 mg/m³ (Measured 0,454 Indoor, 100%, < 2 h/day
value)
value)
value)
value)
value)
(LEV): 80%
(LEV): 80%
value) Respirator: 90% protection
value) Respirator: 90% protection
long term, inhalative, local, 0,16 mg/m³ (Measured 0,32 Outdoor, 100%, < 8 h/day
value)
acute, inhalative, local, 0,32 mg/m³ (Measured 0,32 Outdoor, 100%, < 8 h/day
value)

*
3.3.7. Worker exposure: Non industrial spraying (PROC11)


long term, inhalative, local, 0,47 mg/m³ (Advanced 0,95 <= 11 %, < 8 h/day, 25-50
REACH Tool (ART) v1.5) °C, Room size < 100 m³,
Spraying in all directions.,
Surface spraying with no or
low compressed air use.,
acute, inhalative, local, 0,95 mg/m³ (Advanced 0,95 <= 11 %, < 8 h/day, 25-50
long term, inhalative, local, 0,39 mg/m³ (Advanced 0,78 <= 3%, < 8 h/day, Above
REACH Tool (ART) v1.5) room temperature, Room
size < 100 m³, Spraying in
all directions., Spraying with
high compressed air use,
acute, inhalative, local, 0,78 mg/m³ (Advanced 0,78 <= 3%, < 8 h/day, Above

long term, inhalative, local, 0,48 mg/m³ (Advanced 0,95 <= 34 %, < 8 h/day, Above
size < 100 m³, Only
horizontal or downward
spraying., Surface spraying
with no or low compressed
air use., Respirator: 90%
protection
acute, inhalative, local, 0,95 mg/m³ (Advanced 0,95 <= 34 %, < 8 h/day, Above
protection
spraying., Spraying with
all directions., Surface
spraying with no or low
compressed air use.,

protection
protection
protection
protection
protection
protection
protection
protection

protection
protection
protection
protection

protection
protection

protection
protection

*
3.3.8. Worker exposure: Treatment of articles by dipping and pouring (PROC13)


long term, inhalative, local, 0,01 mg/m³ (Advanced 0,02 Indoor
acute, inhalative, local, 0,02 mg/m³ (Advanced 0,02 Indoor
long term, inhalative, local, 0,024 mg/m³ (Advanced 0,048 Outdoor

acute, inhalative, local, 0,048 mg/m³ (Advanced 0,048 Outdoor

*
3.3.9. Worker exposure: Production of preparations or articles by tabletting, compression, extrusion,

pelletisation (PROC14)

long term, inhalative, local, 0,22 mg/m³ (Advanced 0,44 <= 100 %, Local exhaust
acute, inhalative, local, 0,44 mg/m³ (Advanced 0,44 <= 100 %, Local exhaust

*
3.3.10. Worker exposure: Use as laboratory reagent (PROC15)



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DESMODUR Ultra N 3390 BA

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DESMODUR Ultra N 3390 BA

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Safety Data Sheet according to Regulation (EU) No.

DESMODUR ultra N 3390 BA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifier

DESMODUR ULTRA N 3390 BA

Uses advised against:

1.3 Details of the supplier of the safety data sheet

Tel.: +49 214 6009 4068

1.4 Emergency telephone number

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

2.2 Label elements

Hazardous components which must be listed on the label

Supplementary hazardous characteristics and labeling elements:

2.3 Other hazards

SECTION 3: Composition/information on ingredients

Type of product: Mixture

ca. 90 % in n-butyl acetate

SECTION 4: First aid measures

4.1 Description of first aid measures

SECTION 5: Firefighting measures

5.1 Extinguishing media

Unsuitable extinguishing media: High volume water jet

5.2 Special hazards arising from the substance or mixture

5.3 Advice for fire-fighters

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

6.2 Environment related measures

6.3 Methods and material for containment and cleaning up

Decontamination solution 1: 8-10% sodium carbonate and 2% of liquid soap in water

Decontamination solution 3: 30 % commercial laundry detergent containing monoethanolamine, 70 % water

6.4 Reference to other sections

SECTION 7: Handling and storage

7.1 Precautions for safe handling

Products containing solvent: Explosion protection required.

7.2 Conditions for safe storage, including any incompatibilities

Storage class (TRGS 510) : 3: Flammable liquids

SECTION 8: Exposure controls/personal protection

Components with workplace control parameters

Substance CAS-No. Basis Type Value Ceiling Remarks

Derived No Effect Level (DNEL)

Value type Route of Health Effects Value Remarks

Value type Route of Health Effects Value Remarks

Workers Eye contact Local effects No hazard identified

Consumers Inhalation Long-term systemic 35,7 mg/m3 Most sensitive endpoint:

Consumers Oral Long-term systemic 2 mg/kg bw/day Most sensitive endpoint:

Predicted No Effect Concentration (PNEC)

Compartment Value Remarks

Intermittent use/release 1,27 mg/l

Compartment Value Remarks

8.2 Exposure controls

Skin and body protection

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

n-Butyl acetate upper: 7,5 %(V) / lower: 1,2 %(V)

9.2 Other information

SECTION 10: Stability and reactivity