Maller JJ, Welton T, Middione M, Callaghan FM, Rosenfeld JV, Grieve SM.

Revealing the
Hippocampal Connectome through Super-Resolution 1150-Direction Diffusion MRI. Sci
Rep. 2019;9(1):2418. Published 2019 Feb 20. doi:10.1038/s41598-018-37905-9
Method:
1. Subjects: one 42-year-old male + 94 healthy subjects
2. Image acquisition: The 1150-direction diffusion MRI sequence
3. Image Analysis: atlas of Destrieux (66 cortical and subcortical ROIs), FreeSurfer
brainstem generated custom pontine ROI, manually drawn mask of the mammillary
bodies,
Results:
1. Six long-range major hippocampal pathways connectivity from strongest to weakest (in
parentheses: target region):
a. inferior longitudinal fasciculus (ILF), (temporal pole); spinal-limbic pathway
(SLP), (strongest single connection: thalamus, 21.5% of total); anterior
commissure, (amygdala); cingulate bundle, (subcallosal gyrus); fornix,
(mammillary bodies); tapetum, (hippocampus - contralateral)
2. Connections of the left hippocampus within each lobe by track count from strongest to
weakest: Temporal (temporal pole); Limbic/Subcortical (Mammillary bodies); Occipital
(Medial lingual sulcus); Frontal (Subcallosal gyrus); Parietal lobe (parieto-occipital
sulcus)

Ritchey, M., & Cooper, R. A. (2020). Deconstructing the Posterior Medial Episodic
Network. Trends in cognitive sciences, 24(6), 451–465.
https://doi.org/10.1016/j.tics.2020.03.006

Chen, A. C., & Etkin, A. (2013). Hippocampal network connectivity and activation differentiates
post-traumatic stress disorder from generalized anxiety
disorder. Neuropsychopharmacology : official publication of the American College of
Neuropsychopharmacology, 38(10), 1889–1898. https://doi.org/10.1038/npp.2013.122
Methods:
1. fMRI data analysis: seed-based,