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Effects of Application of Elas
Effects of Application of Elas
H
Copyright 2018 American Nephrology Nurses Association.
clude hypotension, muscle
spasms, nausea, vomiting, Kim, H.J., & Kim, H.J. (2018). Effects of application of elastic compression stockings on
headache, chest pain, itching, blood pressure, pulse rate, and hypotensive symptoms in patients with intradialytic
and fever. Among the complications hypotension. Nephrology Nursing Journal, 45(5), 455-461.
of hemodialysis, hypotension is the
most common complication, occur- This study was conducted to identify the effect of elastic compression stockings on
ring in 25% to 50% of all hemodialy- hypotension in patients with intradialytic hypotension. Subjects of this study were 59
sis treatments (Flythe, Xue, Lynch, patients (29 in the experimental group, 30 in the control group). Elastic compression
Curthan, & Brunelli, 2014). This is stockings were applied to patients in the experimental group during hemodialysis. To
caused by various factors, such as sud- evaluate effects of treatment, systolic blood pressure, diastolic blood pressure, pulse rate,
den hypovolemia due to hyperfiltra- and hypotension symptom scores were measured. Results indicated the decrease in sys-
tion during hemodialysis, insufficient tolic blood pressure in the experimental group was less than that in the control group.
compensatory mechanisms, such as Hypotension symptom scores were significantly decreased in the experimental group.
left ventricular dysfunction, disorder Considering these results, the application of elastic compression stockings can be regard-
of plasma recharge, regulation of ed as an effective nursing intervention to help prevent intradialytic hypotension in
sympathetic nervous system, and patients undergoing hemodialysis.
arterial vascular stiffness (Yamamoto
et al., 2012). Key Words: Compression stocking, hemodialysis, hypotension, blood pressure.
Intradialytic hypotension is a sig-
nificant and independent risk factor
that decreases the efficiency of
hemodialysis treatment and is associat-
ed with poor survival outcomes for erfusion acting to reduce blood flow Several methods have been studied
patients on hemodialysis (McIntyre & rate and potentially lowering patient to control intradialytic hypotension,
Goldsmith, 2015). In addition, intradi- compliance, leading to early termina- such as sodium concentrations control
alytic hypotension may contribute sig- tion of hemodialysis (Bradshaw, (National Kidney Foundation [NKF],
nificantly to morbidity in patients on Bennett, Hutchinson, Ockerby, & Kerr, 2015), low-temperature dialysis, pre-
hemodialysis through subtle effects of 2017). Therefore, intradialytic hypoten- treatment with antihypertensive med-
organ damage due to localized hypop- sion should be prevented to perform ication, and control of ultrafiltration
and maintain proper hemodialysis rate over time (Palmer & Henrich,
treatment. In addition, even without 2008). However, despite these inter-
Hyun-Jung Kim, RN, is an Assistant Professor,
Gumi University, Department of Nursing, symptoms, sudden changes in blood ventions, intradialytic hypotension is
Gyungbuk, South Korea. pressure due to hypotension may cause the most frequent complication (Flythe
a decrease in health outcomes and et al., 2014).
Hee-Jung Kim, PhD, RN, is an Associate health-related quality of life, such as Active interventions by nephrology
Professor, The Catholic University of Daegu,
College of Nursing, Daegu, South Korea.
increased cardiovascular complications nurses are essential to prevent intradi-
and mortality in patients on hemodial- alytic hypotension. However intradia-
Statement of Disclosure: The authors reported ysis (Sasaki et al., 2005). Thus, it is nec- lytic hypotension often occurs sudden-
no actual or potential conflict of interest in rela- essary to identify the timing of intradi- ly, and some of these interventions
tion to this continuing nursing education activity. alytic hypotension and to develop a may require a physician’s order, which
Note: The Learning Outcome, additional state- strategic intervention plan for safe may require time to acquire. Mills,
ments of disclosure, and instructions for CNE hemodialysis (Kim, Choi, Won, & Kim, Fung, Travlos, and Krassioukov (2015)
evaluation can be found on page 462. 2015). found that physical counter maneu-
vers, such as pressing the abdomen or • Diastolic blood pressure of patients Exclusion criteria were as follows:
lower extremities using an abdominal with intradialytic hypotension. • Patients with cuts, redness, or skin
band or elastic stockings, or crossing • Pulse of patients with intradialytic diseases in the lower legs.
the legs, were effective in reducing hypotension. • Patients whose blood pressure-relat-
hypotension after hemodialysis. How- • Hypotension symptoms of patients ed medication was changed within
ever, the abdominal band has some with intradialytic hypotension. the prior month or were planning a
disadvantages, such as the need for therapeutic change that may affect
equipment and the need to measure hypotension during the study peri-
Methods
and maintain constant abdomen pres- od.
sure (Yamamoto et al., 2006). The leg- • Patients with heart failure.
crossing method was significantly Design • Patients who were pregnant.
effective in maintaining blood pres- This study was a quasi-experimen-
sure but did not relieve other symp- tal study by using a randomized con- Sample Size
toms (Kim et al., 2015). trolled trial with a non-equivalent The sample size was calculated
Some studies have been done to control group pretest-posttest design. using power analysis for the repeated
prevent hypotension by applying elas- measures ANOVA with an effect size
tic compression stockings. In a study Ethical Considerations of 0.25, a type error of 0.05, and
of pregnant women who underwent This study was reviewed and power of 95% using the G*Power
Cesarean section under spinal anes- approved by the university hospital’s 3.1.3 program. The number of sub-
thesia, wearing elastic compression Institutional Review Board. Before jects required in this study was 52,
stockings helped prevent hypotension the study, the researcher explained to with 26 assigned to each group. A
(Sutherland, Wee, Weston-Smith, participants the purpose and method total of 60 patients were included in
Skinner, & Tomas, 2004). Moreover, of the study, measurements to be this study in consideration of the
in a study in which hemodynamic taken, how to complete the question- potential dropout rate. During the
changes were observed by applying naire, participant confidentiality safe- study, one participant in the control
anti-embolization stockings during guards, and possible benefits and dis- group failed to receive all planned
hemodialysis, leg compression helped advantages of participating in the hemodialysis treatments due to
reduce intradialytic hypotension in study. Participants were assured their hypotension. Therefore, there were
patients (Kim, Lee, Kwon, Song, & refusal to participate in or withdrawal ultimately 30 patients in the experi-
Kim, 2010). This is thought to be from the study would not affect the mental group and 29 patients in the
caused by the elastic compression quality of care they would receive. control group.
stockings reducing the storage of Written consent was obtained from all
blood in the lower legs by applying participants. All participants received Measurements
constant pressure to the lower limbs, their elastic compression stockings Blood pressure and pulse. To
leading to increased central blood and hand cream as a reward for par- measure changes in blood pressure
flow (Sun et al., 2004). This approach ticipating in the study. and pulse, systolic blood pressure,
is non-invasive, has few side effects, diastolic blood pressure, and pulse
does not require additional equip- Participants were measured before the beginning
ment, is easy to apply, and has eco- Participants in this study were out- of hemodialysis; then at 1, 2, and 3
nomic advantages. Consequently, the patient patients on hemodialysis in hours after hemodialysis was begun;
application of elastic compression the hemodialysis unit of a university and again at the end of hemodialysis.
stockings would be expected to hospital in South Korea. Inclusion cri- Blood pressure and pulse rate were
reduce the discomfort caused by teria were: measured using an automatic blood
hypotension relatively easily and to be • Patients receiving hemodialysis pressure monitor mounted on a
an appropriate intervention method if three times a week for four hours hemodialyzer (Pheonix, GAMBRO,
symptoms are not severe. on an outpatient basis. Sweden).
Our study was conducted to • Patients aged 20 (the legal age of Hypotensive symptoms. Hypo-
develop a nursing intervention that majority in South Korea) to 80 tensive symptoms were measured
could prevent intradialytic hypoten- years. with a questionnaire developed for
sion by examining the effectiveness of • Patients who have had at least two this study to determine a hypotensive
elastic compression stockings on hypotensive episodes with a sys- symptom score. The questionnaire
reducing intradialytic hypotension tolic blood pressure lower than 20 consisted of six items: abdominal dis-
patients. Specific objectives were to mmHg during the last three comfort, yawning, nausea, muscle
determine the effectiveness of the hemodialysis sessions. spasms, sweating, and dizziness.
elastic compression stockings on the: • Patients who understand the pur- Items were based on a literature
• Systolic blood pressure of patients pose of this study and sign the writ- review of intradialytic hypotensive
with intradialytic hypotension. ten informed consent voluntarily. symptoms (K/DOQI Workgroup of
Table 1
Demographic and Clinical Characteristics of Participants
Exp. (n=30) Cont. (n=29)
(N=59)
Characteristics Categories n (%)/Mean(SD) n (%)/Mean(SD) c²/t p
Sex Male 17 (56.7) 17 (58.6) 0.02 0.544
Female 13 (43.3) 12 (41.4)
Age (years) ≤40 3 (10.0) 3 (10.3) 7.10 0.130
41-50 9 (30.0) 4 (13.8)
51-60 8 (26.7) 3 (10.3)
61-70 6 (20.0) 10 (34.5)
≥71 4 (13.3) 9 (31.0)
Level of education ≤ Elementary 11 (36.7) 6 (20.7) 4.79 0.188
Middle school 7 (23.3) 5 (17.2)
High school 9 (30.0) 9 (31.0)
≥ College 3 (10.0) 9 (31.0)
Duration of ≤12 5 (16.7) 4 (13.8) 7.22 0.204
hemodialysis (months)
13 to 24 10 (33.3) 3 (10.3)
25 to 36 1 (3.3) 5 (17.2)
37 to 48 5 (16.7) 5 (17.2)
49 to 60 4 (13.3) 4 (13.8)
≥61 5 (16.7) 8 (27.6)
Vascular access route AVF 25 (83.3) 27 (93.1) 4.40 0.111
AVG 4 (13.3) 0 (0.0)
Quinton catheter 1 (3.3) 2 (6.9)
Dry weight (Kg) 60.32 (11.98) 60.92 (9.23) 0.21* 0.831
Ultrafiltration volume (L) 2.70 (0.70) 2.55 (0.61) 0.92* 0.360
SBP (mmHg) 155.03 (17.45) 157.28 (17.50) 0.49 0.624
DBP (mmHg) 80.60 (13.01) 82.55 (10.43) 0.64 0.528
Pulse rate (/min) 73.53 (11.14) 76.83 (13.99) 1.00 0.320
Notes: Exp. = experimental group, Cont. = control group, AVF = arteriovenous fistula, AVG = arteriovenous graft, SBP = systolic
blood pressure, DBP = diastolic pressure.
*t test
Table 2
Effects of Elastic Compression Stockings on the Systolic Blood Pressure
Exp. (n=30) Cont. (n=29)
F (N=59)
Time Mean (SD) Mean (SD) p
At start 155.03 (17.45) 157.28 (17.50)
1 hour after starting hemodialysis 144.50 (17.13) 138.97 (15.16) G 0.21 0.650
2 hour after starting hemodialysis 135.33 (20.47) 136.31 (14.73) T 99.35 <0.001
3 hour after starting hemodialysis 132.87 (17.55) 132.55 (14.64) G*T 3.33 0.025
At finish 131.87 (19.79) 125.45 (13.35)
Table 4
Effects of Elastic Compression Stockings on the Pulse Rate
Exp. (n=30) Cont. (n=29)
(N=59)
Time Mean (SD) Mean (SD) F p
At start 75.53 (11.14) 76.83 (13.99)
1 hour after starting hemodialysis 72.17 (11.34) 76.48 (14.15) G 1.49 0.227
2 hours after starting hemodialysis 71.20 (11.78) 75.66 (13.92) T 4.27 0.011
3 hours after starting hemodialysis 72.93 (12.22) 75.83 (14.14) G*T 0.38 0.723
At finish 74.53 (12.88) 79.14 (14.20)
between groups (F=1.49, p=0.227); 2.77 ± 0.90 in the experimental group spinal anesthesia) showed results con-
however, there was a significant differ- and 3.21 ± 0.90 in the control group sistent with this study. It is thought
ence according to the time of measure- (z=2.05, p=0.041) (see Table 5). that storage of blood in the lower
ment (F=4.27, p=0.011) (see Table 4). limbs is reduced while blood flow to
the heart is increased, thereby pre-
Effects of Elastic Compression Discussion
venting hypotension (Sun et al., 2004;
Stockings on the Hypotensive This study was conducted to eval- Sutherland et al., 2001). Results of this
Symptom Scores uate the effects of the use of elastic study are very likely due to the same
The total score of hypotensive compression stockings on blood pres- mechanisms.
symptoms was 13.40 ± 2.04 in the sure, pulse, and hypotensive symp- Because a reduction of diastolic
experimental group and 15.03 ± 2.32 toms in patients on hemodialysis with blood pressure during hemodialysis
in the control group (t=2.87, p=0.006). intradialytic hypotension. leads to myocardial ischemia by
In the experimental group, the most In this study, wearing elastic com- decreasing myocardial perfusion pres-
severe symptoms were muscle spasm, pression stockings had a significant sure (Selby & McIntyre, 2007), control
dizziness, and nausea. In the control effect on the systolic blood pressure of of diastolic blood pressure is also
group, muscle spasms and vertigo patients with intradialytic hypoten- important for patients on hemodialy-
were severe. The differences between sion. In repeated measures ANOVA sis. Although not statistically signifi-
the two groups were significant in analysis, the significant interaction in cant in this study, changes in diastolic
three items: abdominal discomfort group*time indicates the significant blood pressures after hemodialysis in
was 1.40 ± 0.56 in the experimental difference between the two groups the experimental group were lower
group and 1.97 ± 0.78 in the control over time. Although studies on than those in the control group.
group (z=2.98, p=0.003), yawning was patients on hemodialysis were not Considering that diastolic blood pres-
1.67 ± 0.66 in the experimental group previously conducted, a study of com- sure is affected when the amount of
and 2.17 ± 0.71 in the control group pression stocking use in patients who blood ejected at the systolic phase is
(z=2.68, p=0.007), and dizziness was underwent Cesarean section (under small, or when the resistance of the
Table 5
Effects of Elastic Compression Stockings on the Hypotension Symptom Scores
Exp. (n=30) Cont. (n=29)
(N=59)
Classification Mean (SD) Mean (SD) z/t p
Abdominal discomfort 1.40 (0.56) 1.97 (0.78) 2.98 0.003
Yawn 1.67 (0.66) 2.17 (0.71) 2.68 0.007
Nausea 2.57 (0.94) 2.21 (0.82) 1.53 0.127
Muscle cramp 2.97 (0.85) 3.21 (0.82) 1.71 0.087
Dizziness 2.77 (0.90) 3.21 (0.90) 2.05 0.041
Cold sweating 2.03 (1.10) 2.21 (0.90) 0.88 0.382
Total 13.40 (2.04) 15.03 (2.32) 2.87* 0.006
* t test.
Notes: Exp. = experimental group, Cont.= control group, G = group, T = time.
peripheral blood vessel is decreased stocking was effective for both objec- ANOVA analysis, the significant inter-
(Kim et al., 2010), the pressure of the tive and subjective indicators. In par- action in group*time indicates the sig-
stockings applied in this study may ticular, considering negative effects of nificant difference between the two
have been insufficient to affect the hypotensive symptoms on the treat- groups over time. Moreover, elastic
diastolic blood pressure. Therefore, it ment adherence of patient on compression stockings are noninvasive
would be informative to repeat the hemodialysis (K/DOQI Workgroup and have fewer side effects. This inter-
study by applying stockings with high- of the NKF, 2005), the improvement vention can be applied to patients with
er than the 20 to 30 mmHg pressure of subjective symptoms may have a potential hypotension, as well as
utilized here. It may also be an effec- positive impact on the management patients with intradialytic hypotension.
tive and simple intervention in clinical of intradialytic hypotension in Based on these results, we suggest the
practice if it is used with other inter- patients on hemodialysis. However, following for further research: First, we
ventions that have been effective in some of these patients may not have suggest that a future study could meas-
maintaining diastolic blood pressure. hypotension symptoms, so careful ure the effect of using elastic compres-
In this study, the elastic compres- attention should also be paid to the sion stockings with higher pressures
sion stockings were effective for ame- degree, frequency, and duration of than the 20 to 30 mmHg in this study.
liorating symptoms of hypotension. In hypotension (K/DOQI Workgroup This is because the pressure of the
the experimental group, most symp- of the NKF, 2005). More effective stockings applied in this study may
toms (abdominal discomfort, yawning, intervention is anticipated if hypoten- have been insufficient to affect the dias-
muscle spasm, dizziness, and sweating) sive symptoms are more frequently tolic blood pressure to a statistically sig-
showed lower scores relative to the measured during hemodialysis and if nificant degree. Second, to try to pre-
control group. Abdominal discomfort, the timing of hypotensive symptoms dict changes in blood pressure, pulse,
yawning, and dizziness were scored is more predictable. However, most and hypotensive symptoms, we suggest
significantly lower in the experimental studies using elastic compression repeating the study by reducing the
group than in the control group. In stockings have never been interrupt- measurement interval.
several studies evaluating intradialytic ed by reported side effects (Cho, Kim,
hypotension, 64% to 80% of subjects Seol, Shin, & Choi, 2005; Kim et al., Conclusion
had one or more symptoms, such as 2010; Yamamoto et al., 2006).
dizziness, fatigue, and headache (Kim Consequently, this intervention of This study was conducted to
et al., 2015; Yamamoto et al., 2012). using elastic compression stockings is investigate the effect of wearing elas-
However, in these studies, the differ- considered to have relatively low dis- tic compression stockings on blood
ence in the degree of the subject’s comfort and side effects compared pressure, pulse, and hypotensive
symptoms was not compared because with other common interventions. symptoms in patients with intradialyt-
it was only measured by the number of This study confirmed the use of ic hypotension. There were 30 partic-
occurrences (Lee et al., 2007; elastic compression stockings was effec- ipants in the experimental group and
Yamamoto et al., 2006). tive in preventing the reduction of sys- 29 participants in the control group.
This study also reported the de- tolic blood pressure and hypotensive Results of this study showed that
gree of symptoms participants felt, symptoms in patients with intradialytic changes in systolic blood pressure
and results indicated elastic pressure hypotension. In repeated measures within the experimental group were
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