GUIDELINE Inguinal Hernia Repair Toward Asian Guidelines

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Asian J Endosc Surg ISSN 1758-5902

GUIDELINE

Inguinal hernia repair: Toward Asian guidelines


Davide Lomanto,1 Wei-Keat Cheah,2 Jose Macario Faylona,3 Ching Shui Huang,4 Darin Lohsiriwat,5
Andy Maleachi,6 George Pei Cheung Yang,7 Michael Ka-Wai Li,7 Sathien Tumtavitikul,8 Anil Sharma,9
Rolf Ulrich Hartung,10 Young Bai Choi11 & Barlian Sutedja12
1 Minimally Invasive Surgery Centre, Department of Surgery, Yong Loo Lin School of Medicine, National University Health System, National University
Singapore, Singapore
2 Department of Surgery, Jurong General Hospital, Singapore
3 Department of Surgery, Philippines General Hospital, University of Philippines, Manila, Philippines
4 Department of Surgery, Taipei University, Taipei, Taiwan
5 Department of Surgery, Siriraj Hospital, Mahidol University, Bangkok, Thailand
6 Department of Digestive Surgery, Karyadi Hospital, Semarang, Indonesia
7 Department of Surgery, Pamela Youde Nethersole Eastern Hospital, Hong Kong
8 Department of Surgery, Vichaiyut Hospital, Bangkok, Thailand
9 Minimal Access and Bariatric Surgery Centre, Max Healthcare Hospital, New Delhi, India
10 Surgery, BR Medical Suites, Mediclinic City Hospital, Dubai, UAE
11 Department of Surgery, Assan University, Seoul, Korea
12 Department of Surgery, Gading Pluit Hospital, Jakarta, Indonesia

Keywords Abstract
Guidelines; hernia; inguinal hernia
Groin hernias are very common, and surgical treatment is usually recom-
Correspondence mended. In fact, hernia repair is the most common surgical procedure per-
Davide Lomanto, Minimally Invasive Surgical formed worldwide. In countries such as the USA, China, and India, there may
Centre, Department of Surgery, Yong Loo Lin
easily be over 1 million repairs every year. The need for this surgery has
School of Medicine, National University of
become an important socioeconomic problem and may affect health-care
Singapore, 5 Lower Kent Ridge Road,
119074 Singapore. providers, especially in aging societies. Surgical repair using mesh is recom-
Tel: +65 6772 2897 mended and widely employed in Western countries, but in many developing
Fax: +65 6774 6077 countries, tissue-to-tissue repair is still the preferred surgical procedure due to
Email: surdl@nus.edu.sg economic constraints. For these reason, the development and implementation
of guidelines, consensus, or recommendations may aim to clarify issues
Received 11 August 2014; accepted 20
related to best practices in inguinal hernia repair in Asia. A group of Asian
August 2014
experts in hernia repair gathered together to debate inguinal hernia treat-
DOI:10.1111/ases.12141 ments in Asia in an attempt to reach some consensus or develop recommen-
dations on best practices in the region. The need for recommendations or
guidelines was unanimously confirmed to help overcome the discrepancy in
clinical practice between countries; the experts decided to focus mainly on the
technical aspects of open repair, which is the most common surgery for hernia
in our region. After the identification of 12 main topics for discussion (indi-
cation, age, and sex; symptomatic and asymptomatic hernia: type of hernia;
type of treatment; hospital admission; preoperative care; anesthesia; surgical
technique; perioperative care; postoperative care; early complications; and
long-term complications), a search of the literature was carried out according
to the five levels of the Oxford Classification of Evidence and the four grades
of recommendation.

Introduction repair is the most common surgical procedure performed


worldwide. In countries such as the USA, China, and
Groin hernias are very common, and surgical treatment India, there may be as many as a million repairs every
is recommended for the majority of patients. Hernia year, with significant impact on the cost of health care

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16 © 2015 Japan Society for Endoscopic Surgery, Asia Endosurgery Task Force and Wiley Publishing Asia Pty Ltd.
D Lomanto et al. Inguinal hernia repair: Asian guidelines

Fig. 1. (a) Annual incidence of inguinal hernia in Asian countries. (b) Annual incidence of inguinal hernia in China and India. Data extrapolated based
on the assumption that hernia affects 15%–20% of the population.

Table 1 Prevalence of inguinal hernia by age group (1)


Age groups examined (years) 25–34 35–44 45–54 55–64 65–74 75 plus Total
Number of men examined 620 438 300 322 156 47 1883
Current prevalence (excluding successful repairs) 11.9% 15.1% 19.7% 26.1% 29.5% 34.1% 18.3%
Lifetime prevalence (including successful repairs) 15.2% 19.4% 28.0% 34.5% 39.7% 46.8% 24.3%

Table 2 Number and type of procedures for inguinal hernia repair in and laparoscopic techniques, and techniques with and
Western countries without the use of prosthesis, and there is still a debate
USA (2010) Europe (2010) over the best treatment today (4). The randomized con-
Total inguinal hernia repair 842 000 703 000 trolled trials have indicated the superiority of a tension-
Tension repair 41 000 (4.8%) 92 000 (13%) free mesh repair, performed either with the open method
Tension-free repair 801 000 (95.2%) 611 000 (87%) or laparoscopically, over a tissue repair. However, meta-
Open 635 000 (80.3%) 491 000 (69.8%) analyses have shown that a tension-free repair using
Laparoscopic 207 000 (19.7%) 120 000 (17%)
mesh must be performed routinely for it to have an
Source: Millennium Research Group. http://www.mrg.net advantage over tissue repair. Regardless, modern
tension-free repair methods enable patients to return to
(Figure 1). There have not been many studies on the normal activity following surgery (5–7). Similarly, lapa-
incidence and prevalence of hernia, especially in devel- roscopic surgery offers benefits in terms of early recovery,
oping countries. Scientific references show that preva- but it requires an experienced surgeon to avoid compli-
lence increases with age, making hernia repair an cations and recurrences. The technique also costs more
important socioeconomic problem that raises costs for than open methods for health services, and the proce-
health-care providers, especially in aging societies dure takes longer (8,9). Controversy extends as well to
(Table 1) (1). Surgery is recommended for all groin the best prosthetic material to implant, with debates over
hernias not only to relieve symptoms but also to reduce the merits of polypropylene compared to polyester and
the risk of serious complications. In the USA and Europe, lightweight mesh.
the use of mesh material as reinforcement of the groin For these reasons, the development and implementa-
region is very popular and is applied in up to 90% of tion of guidelines, a consensus, or recommendations may
procedures (Table 2) (2,3). In contrast, in many develop- clarify issues related to the best practice in inguinal
ing countries, tissue-to-tissue repair is still the preferred hernia repair. Under the auspices of the Asia Pacific
surgical procedure because of economic constraints; this Hernia Society, a group of Asian surgeons, experts in the
type of repair is used in the majority of total inguinal repair of hernia, recently gathered to debate inguinal
hernia repairs. hernia treatments in Asia in an attempt to reach some
Several randomized controlled trials have compared consensus or develop recommendations on best practices
surgical techniques using suture and mesh repair, open in the region. The need for recommendations and

Asian J Endosc Surg 8 (2015) 16–23


© 2015 Japan Society for Endoscopic Surgery, Asia Endosurgery Task Force and Wiley Publishing Asia Pty Ltd. 17
Inguinal hernia repair: Asian guidelines D Lomanto et al.

guidelines was unanimously confirmed because of the Recommendation (Grade B)


discrepancy in clinical practice from country to country. Mesh should be used in all adult patients. There is no
The experts decided to focus mainly on technical aspects difference in treatment between men and women.
of open repair, which is the most common surgery for However when a femoral hernia is detected in a female
hernia in our region. patient, the endo-laparoscopic approach is a better
option.
Material and Methods No consensus could be reached on the resection or
preservation of the round ligament because preservation
A brief questionnaire was sent by mail to collect initial
is sometimes difficult and resection can lead to pain and
data and to ask about willingness to participate in devel-
risk of prolapse.
oping guidelines. As a first step, the committee of experts
identified the objectives and topics for discussion. Then, a
search of the literature was carried out according to the Symptomatic and asymptomatic hernia
five levels of the Oxford Classification of Evidence and Conclusions (Level 1B)
the four grades of recommendation.
Watchful waiting may be an option for asymptomatic
The 12 main topics for discussion were as follows: (i)
patients, but this depends on a variety of factors, includ-
indication, age, and sex; (ii) symptomatic and asymptom-
ing an individual’s lifestyle, socioeconomic background,
atic hernia; (iii) type of hernia; (iv) type of treatment; (v)
and access to health-care facilities (13–17). However, in
hospital admission; (vi) preoperative care; (vii) anesthe-
most patients, symptoms will progress and surgical repair
sia; (viii) surgical technique; (ix) perioperative care; (x)
will be required eventually.
postoperative care; (xi) early complications; and (xii)
long-term complications.
Conclusions (Level 4)
The consensus meeting occurred in Singapore in April
2011, and a subsequent meeting was held in Hong Kong There was some debate about the definition of “asymp-
in November 2013. The recommendations that follow, tomatic.” Hernia was defined by Sir Astley Cooper (1804)
which were the result of these meetings, do not contrast as a protrusion of a viscus from its proper cavity (18).
or compete with the published European Hernia Society Even if a patient is asymptomatic, there is a very real
guidelines on the treatment of inguinal hernia in adults chance that he or she will develop a symptomatic hernia
(10). Instead, these recommendations are meant to in the future. The committee agreed that if hernia is
reflect the socioeconomic situation and clinical practice present, even without discomfort or pain, and protrud-
in the Asia–Pacific region. ing, it requires treatment, although treatment need not
necessarily be immediate (Grade D).
If a hernia is discovered during concomitant surgery,
Discussion, Results, and Recommendations
the local medico-legal regulations should be considered
Indications, age, and sex before the hernia is addressed (Grade D).
Adult hernia surgery should be performed as an elective
procedure to minimize surgical risk. There are no age Recommendation (Grade D)
restrictions if a patient’s general condition do not affect Symptomatic hernia should be repaired.
operative risk. Based on several studies, mesh repair We suggest that all symptomatic patients be treated.
seems to have better long-term clinical outcomes, espe- Surgical treatment may be recommended for asymptom-
cially in terms of recurrence. There are no differences atic patients, as most will develop symptoms over time.
with regard to gender, except that women seem to have
a higher reoperation rate due to high frequency of Type of hernia
femoral recurrence (11). Mesh should be used in adult
patients (10,12). Conclusions (Level 1B)
For primary unilateral hernia, tension-free mesh repair is
Conclusions (Level 2B–C) the treatment of choice. However, tissue/suture repair is
Mesh should be used in patients age 18 years and older still widely used in many Asian countries, and depending
(18–21 debated) if 60%–70% of natural growth has been on a country’s socioeconomic conditions, it should be
achieved. In cases where patients younger than 18 years considered as an option. Mesh repair is significantly
have very large defects, multiple recurrences, and weak superior because of lower recurrence rate, but socioeco-
tissues, mesh should also be used. Synthetic is preferred nomic aspects (e.g. cost, availability, and training) limit its
over biological mesh. usage.

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18 © 2015 Japan Society for Endoscopic Surgery, Asia Endosurgery Task Force and Wiley Publishing Asia Pty Ltd.
D Lomanto et al. Inguinal hernia repair: Asian guidelines

Suture repair remains an acceptable option for indirect Preoperative care


hernias smaller than 2 cm, young patients, and when Preoperative care should include the following: (i) the
surrounding tissue quality is good (19). positioning of a urinary catheter; (ii) antibiotic prophy-
laxis; and (iii) deep vein thrombosis prophylaxis.
Conclusions (Level 1A)
For bilateral and recurrent hernias, tissue repair is not Conclusions (Level 2B)
suitable; the endo-laparoscopic approach is suggested. A urinary catheter is not required in most patients. Pre-
For recurrent hernia with previous open suture repair, a operative voiding is recommended.
mesh repair is recommended. In cases of recurrent
hernia, the suggested approach depends on whether the Conclusions (Level 1B)
primary procedure is an anterior or posterior operation;
Routine antibiotic prophylaxis is not suggested except in
the hernia should be approached from the opposite site of
selected patients (31–36).
the previous surgical repair (5,20,21).
Recommendation (Grade B)
Recommendation (Grade A)
Routine antibiotic prophylaxis is not recommended.
For bilateral and recurrent hernias, endo-laparoscopic Antibiotic prophylaxis may be suggested depending on
repair is suggested, but open anterior mesh repair is an increased risk for infection.
acceptable option.
Anesthesia
Strangulated or obstructed hernia Conclusions (Level 1B)
For these complicated hernias, the open approach is sug- Hernia repair can be performed with the patient under
gested. However, the laparoscopic approach may have general, regional, or local anesthesia (37). The choice of
superior diagnostic value for conditions such as ischemic anesthesia should be made according to the patient’s
bowel and serosal tear (21,22). In a grossly contaminated choice, age, comorbidities, and operative risk. However,
surgical field, the use of mesh should be avoided. in open repair, local anesthesia may be preferred.
Local anesthesia is the most cost-effective (38–42).
Hernia classification
There are many classifications for inguinal hernia, but no Recommendation (Grade B)
worldwide consensus exists on the use of classification
All types of anesthesia are valid and accepted options.
for clinical purposes (23–25). The classification is mainly
The choice of anesthesia depends on the patient’s
for scientific purposes (e.g. publications, studies, and
condition.
clinical outcomes). The European Hernia Society Classi-
fication may be preferred (26).
Surgical technique
Patient position: conclusions (Level 1B)
Recommendation (Grade D)
Clinical data should include all parameters to identify the The supine position is recommended for all cases.
hernia (e.g. type, size, location, and presentation).
Type of incision: conclusions (Level 4)
Hospital admission The committee of experts suggests a lower lateral inci-
Conclusions (Level 2A) sion, about two fingers above and lateral to the pubis, to
allow direct access to the pubic area for fixation. An
Hernia repair can mostly be done as an ambulatory
adequate incision should be made; this may help reduce
surgery except in selected patients (27–29).
the amount of pain because the retractors can stretch less
during the procedure.
Recommendation (Grade A) Incision length depends on the patient’s body size and
For ASA I and II patients, hernia repair should generally hernia size. However, a 5–7-cm incision should be suffi-
be performed as a day surgery, although this should be cient with horizontal incision for a small hernia and with
assessed based on the type of anesthesia (30). oblique incision for a large hernia.
For ASA ≥ III patients, if surgery is performed under For an external oblique incision, a 6–7-cm medial inci-
local or general anesthesia, an overnight stay should be sion should be made in the direction opposite to the
required. fibers in order to preserve a wider inguinal ligament.

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© 2015 Japan Society for Endoscopic Surgery, Asia Endosurgery Task Force and Wiley Publishing Asia Pty Ltd. 19
Inguinal hernia repair: Asian guidelines D Lomanto et al.

There is no need to provide recommendations for space seem to improve the clinical outcome, but instead seems
dissection. to increase the risk for postoperative pain (45,46).
Sealant or glue may be considered for fixation (47–49).
Nerve identification The fixation of flat mesh should be over the pubic
tubercle with 1–2-cm overlap. Non-absorbable sutures
Conclusions (Level 2A)
should be used. For lateral fixation, either a running or
The dissection of the ilio-hypogastric nerve may be nec-
interrupted suture is suggested. If the mesh is slit around
essary to gain elasticity on the spermatic cord.
the spermatic cord, it should be closed adequately around
it to avoid recurrence and/or ischemia of the testicular
Recommendation (Grade B)
vessels (50,51).
The identification and isolation of the nerves are not
If posterior repair is performed, the mesh should be
strictly required. However, it is necessary to identify the
fixed using either sutures or sealant.
genital branch of ilio-inguinal and ilio-hypogastric nerve,
If self-gripping mesh is applied, a simple fixation over
but isolating the nerves are not required.
the pubic tubercle is required without lateral fixation.
This may reduce the risk of postoperative pain (52,53).
Hernia sac management
Conclusions (Level 2A) Recommendation (Grade B)
The transection of the hernia sac may increase postop- Mesh should be fixed, and the slit closed around the
erative pain. spermatic cord to avoid ischemia.
Self-gripping mesh should be fixed only to the pubic
Recommendation (Grade B) tubercle.
There is no need for transection except in cases of com- Either glue or sealant is an acceptable choice for
plicated hernias. fixation.

Mesh size Cord positioning

Conclusions (Level 1B) Conclusions (Level 4)


Depending on the size of the defect, the mesh should The cord should be preferably positioned under the
allow for a large coverage and overlap the pubic bone by external oblique aponeurosis.
at least 1–2 cm.
Recommendation (Grade D)
In open repair, the size of the mesh should adequately
No recommendation
cover the hernia defects and overlap the surrounding
area by more than 3 cm in all directions. Management of the round ligament
It is recommended that a minimum of 8 × 12-cm cov-
Conclusions (Level 2A)
erage be used for anterior repair and 10 × 15 cm for pos-
No consensus could be reached on the resection or pres-
terior repair.
ervation of the round ligament. Preservation is not fea-
sible most of the time, and resection may increase
Mesh type
postoperative pain and the risk of prolapse.
Conclusions (Level 1B)
A synthetic mesh is preferred over biological or Recommendation (Grade D)
semisynthetic prosthesis (43,44). No recommendation
There is no evidence regarding the superiority of light-
weight or heavyweight mesh in relation to pain or recur- Fascia closure/skin closure
rence (44). Recommendation (Grade D)
No recommendation
Recommendation (Grade A)
The use of a synthetic mesh with large pores is recom- Perioperative care
mended to reduce the shrinkage rate (43,44). Postoperative pain control is an essential aspect of
perioperative care.
Mesh fixation
Conclusions (Level 2B)
Conclusions (Level 2A)
In an anterior repair, the mesh should be fixed over the Pre-emptive local analgesia may be helpful for reducing
pubic tubercle. Lateral fixation of the mesh does not immediate postoperative pain, and non-steroidal

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20 © 2015 Japan Society for Endoscopic Surgery, Asia Endosurgery Task Force and Wiley Publishing Asia Pty Ltd.
D Lomanto et al. Inguinal hernia repair: Asian guidelines

anti-inflammatory drugs are optimal for pain control • chronic pain, which may be very subjective and related
during early recovery. In case of severe pain, opioids may to social and/or psychological influences (50,51,62,65–
be considered (54). 71)
• infertility
Recommendation (Grade D) • sexual dysfunction
• testicular atrophy.
Non-steroidal anti-inflammatory drugs or
There are several causes and risk factors for patients to
cyclooxygenase-2 and paracetamol (acetaminophen) are
develop long-term complications, and these may lead to
recommended for postoperative pain control (55).
a higher risk for recurrent hernia. Risk factors include the
presence of preoperative chronic pain and early sexual
Postoperative care activity in women, as women are more sensitive to pain.
Conclusions (Level 2B) Mesh repair is superior to tissue repair in terms of pre-
venting chronic pain, but there is no consensus on the
It is suggested that patients have an early return to
potential influence of mesh material. Nerve identification
normal activities (e.g. walking, driving, and light duties)
during the procedure may reduce the occurrence of post-
(28,56–58).
operative pain. A patient’s age does not appear to be a
It is also recommended that patients avoid heavy
risk factor.
lifting (i.e. more than 5 kg) for at least 2–3 weeks post-
Treatment for long-term complications should start as
operatively. They may resume heavy lifting after 4
early as possible after diagnosis. Nerve block may be
weeks.
considered initially for pain relief. Surgical exploration
(e.g. triple neurectomy) may be considered after failure
Recommendation (Grade D)
of less invasive options. A multidisciplinary approach
Patients may resume normal activities a few days after with a pain team is also an option.
surgery. However, they should wait 3–4 weeks to resume
participation in intensive sports.
Acknowledgments
Early complications We are grateful to Dr Dino Halim Liem for his generous
Possible postoperative complications include wound support and coordination in drafting the final paper.
infection or hematoma, scrotal hematoma, seroma, and The authors have no conflicts of interest to declare and
orchitis (59–62). received no financial support for this paper.
Draining a seroma may increase risks of infection (63).
If a seroma persists for 3–4 weeks, aspiration may be
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