Think inside

the cell
Think
breakthrough.
Think
PicoSure.
PicoSure continues to take picosecond laser technology to new levels.
With its unique ability to activate cell signaling to stimulate natural
skin-refreshing processes, PicoSure is the only picosecond laser with the
ability to effectively shatter all tattoo ink colors AND treat pigmented
lesions, wrinkles and acne scars1-4 with virtually no downtime.

There’s nothing quite like PicoSure. It gives your practice something

new and different to offer your patients.

Impressive results • Fewer treatments • Fewer side effects • Minimal downtime

 SKIN REVITALIZATION

Signaling a new day in

skin revitalization
When cells speak, the body listens.
Recent discoveries have begun to reveal the secret language of the body and how cells talk
to each other to keep us healthy. Known as cell signaling, this biological communication occurs
when cells are injured and release proteins, which are then detected by surrounding cells to
trigger a healing response.

Before

Focus™ Lens Array precisely

redistributes 755 nm energy to
revitalize skin.
After 4 Tx

Courtesy of Roy Geronemus, MD

Cell signaling: the principle behind PicoSure skin revitalization.

The PicoSure 755 nm wavelength and Focus Lens Array deliver energy that works with
the body, unleashing natural cell signaling processes to create brighter, healthier,
younger-looking skin—with virtually no downtime.

That’s breakthrough.
How PicoSure stimulates
cell signaling
Demonstrated science—and benefits.
Extensive scientific and clinical research5,6 has led to the discovery and understanding of how
specific 755 nm picosecond energy uniquely activates the body’s natural cell signaling processes—
helping patients achieve a more youthful appearance by increasing collagen and elastin.

Dermal Inflammation
LIOB

Treatment 10 Min Post 24 Hrs Post

Visual representation of treatment Histology courtesy of Emil Tanghetti, MD Histology courtesy of Emil Tanghetti, MD

The Focus Lens Array delivers
20x the energy density of a
normal PicoSure pulse to begin
activating cell signaling.
Intra-epidermal Laser Induced
Optical Breakdowns (LIOBs)
form and cause pressure waves
that propagate into the dermis,
triggering pressure injuries to
activate cells.
Cell signaling initiates an
enhanced inflammatory
healing response that leads to
increased collagen and elastin
and ultimately revitalizes skin.

PicoSure 755 nm and Focus

• Impressive results
• Minimal downtime
 TATTOO TREATMENT

Helping the body remove

ALL tattoo ink colors
Think inside the ink.
As the pioneers of picosecond technology, Cynosure physicists and engineers understood how
picosecond pulsewidths and wavelengths could uniquely combine to create a revolutionary new way
to safely and effectively remove tattoos.

Before

PicoSure shatters all ink colors. After 6 Tx

Courtesy of Roy Geronemus, MD

Selective signaling: the principle behind PicoSure tattoo removal.

PicoSure is the only picosecond aesthetic laser platform that effectively shatters ALL ink
colors with 755 nm/532 nm/1064 nm combination wavelengths – efficiently targeting ink
particles across all skin types, without harming surrounding tissue.

That’s breakthrough.
How PicoSure selectively
shatters ink
A natural process for better clearance.
During treatment with PicoSure, ultra-short pulses target ink particles with PressureWave™
technology—a pressure so powerful, the ink shatters into tiny dust-like particles. These
microscopic particles are more rapidly absorbed and eliminated naturally by the body.

PressureWave™ technology in action.

Untreated Ink Traditional Laser PicoSure Laser

Electron Microscopy courtesy of H.B. Jalian, MD

PicoSure 755 nm/532 nm/1064 nm

combination wavelengths
• Faster clearance of all colors

• Fewer treatments
 Only PicoSure techn
for you and
SKIN REVITALIZATION

Before After 4 Focus Tx

Courtesy of Robert Weiss, MD

Before After 5 Focus Tx

Courtesy of Shamshik Shin, MD

Before After 2 Focus Tx

Courtesy of R. Saluja, MD

• Lighten unwanted pigment AND increase collagen and elastin

• Convenient 15-minute treatments without the discomfort or
downtime of other laser options
• Treat pigment, acne scars and wrinkles in a way that differentiates
your practice

Cell signaling with PicoSure: a unique, compelling skin

revitalization conversation with your patients.
nology can do all this
your patients
TATTOO REMOVAL

Before After 5 Tx

Courtesy of Tataway

Before After 4 Tx

Courtesy of Ed Rohaly, MD

Before After 4 Tx

Courtesy of Tataway

• Faster clearance of all tattoo ink colors

95%
• Fewer treatments required
• Photomechanical efficacy
• Fewer side effects WORTH IT RATING
realself.com7
Tattoo removal with PicoSure: fewer treatments
for all colors—just what your patients want.
5 reasons
why PicoSure
makes sense
for your
practice
Real-world experience. As the world’s first
picosecond laser, only PicoSure has been
used to effectively treat more than 500,000
patients worldwide.

Exceptional reliability. Innovative and stable

technology platform enables consistently
excellent results and peace of mind.

Published studies. Proven clinical results

are established in well over a dozen peer-
reviewed publications.

Platform potential. Significant global user

network generates clinical best practices
and data for expanded indications.

Continued value. Dependable world-class

support from Cynosure plus the experience
and expertise of the picosecond innovator
protect your investment.
Think inside the cell.
Think PicoSure.
General Specifications

Nominal Wavelength 755 nm*

Pulse Duration 550-750 ps

Pulse Energy 165-200 mJ

Spot Sizes Zoom: 2.0 mm-6.0 mm, Fixed: 6.0 mm, 8.0 mm, 10.0 mm

Wavelength Options* 532 nm, 1064 nm

Electrical Power 200-240 V~, 4.5 kVA, 50/60 Hz, single phase
Electrical Service
30 Amp
Requirement

*PicoSure 755 and 1064 are FDA cleared to treat tattoos and pigmented lesions in skin types I-VI. PicoSure 755 with Focus is FDA cleared to treat pigmented lesions in skin
types I-VI and acne scars and wrinkles in skin types I-IV. PicoSure 532 is FDA cleared to treat tattoos in skin types I-III. Patient results will vary.

Contact your Cynosure consultant today. Call 800-886-2966. Visit www.cynosure.com/picosure

REFERENCES: IN
1. Treatment of Tattoos With a Picosecond Alexandrite Laser: A Prospective Trial. Saedi N, Metelitsa A, Petrell K, AVO
et al. Arch Dermatol. 2012;148(12):1360-1363. DIRE
EN 60825-
2. Successful and Rapid Treatment of Blue and Green Tattoo Pigment With a Novel Picosecond Laser. Brauer JA,
SOLID STAT
Reddy KK, Anolik R, et al. Arch Dermatol. 2012;148(7):820-823. Pulse Energy:
3. Use of a Picosecond Pulse Duration Laser With Specialized Optic for Treatment of Facial Acne Scarring. Pulse Width:
Wavelength:
Brauer JA, Kazlouskaya V, Alabdulrazzaq H, et al. JAMA Dermatol. Published online November 19, 2014.
4. Clearance of Yellow Tattoo Ink With a Novel 532-nm Picosecond Laser. Alabdulrazzaq H, Brauer JA, Bae YS,
Geronemus R. Lasers Surg Med. 2015;47:285-288.
5. The Histology of Skin Treated with a Picosecond Alexandrite Laser and a Fractional Lens Array. Tanghetti, E.
Lasers Surg Med. Published online June 1, 2016.
6. Safety of a Picosecond Laser with Diffractive Lens Array (DLA) in the Treatment of Fitzpatrick Skin Types IV to INVISIBLE LASER RADIATION
VI: a Retrospective Review. Haimovic A, Brauer JA, Bae YS, Geronemus RG. J Am Acad Dermatol. Published AVOID EYE OR SKIN EXPOSURE TO
online March 3, 2016. DIRECT OR SCATTERED RADIATION.
7. Based on rated reviews over 12 months. Accessed on October 7, 2016. EN 60825-1: 2007 CLASS 4 LASER PRODUCT
SOLID STATE LASER AIM LASER CLASS–3R
Pulse Energy: 200mJ Maximum Power: <5mW
Cover models used for illustrative purposes. Pulse Width: ≤ 900ps Wavelength: 630–690nm CW
Wavelength: 755nm
©2016 Cynosure, Inc. Cynosure and PicoSure are registered trademarks and Focus and Pressurewave are
trademarks of Cynosure, Inc. 921-0415-000 Rev. 8 10/16