Student Guide: Cell Respiration – HS Handbook and STEM Case

Introduction: ​Jared, a CIA agent, has been poisoned by a criminal gang and has been
rescued by Navy SEALs. As a Medical Toxicologist, you will learn the concepts of cellular
respiration and perform an investigation to identify which poison was used to poison
Jared. You will then apply an antidote to save the agent.

Part 1: Directions: Launch the Gizmo and click on the ​Handbook tab. Use the arrows to navigate the
handbook and learn about Cellular Respiration. As you explore the handbook please answer the sequential
questions below.

Vocabulary​: As new vocabulary is introduced, the words are presented in the Gizmo as ​orange text - clicking
the orange text opens the glossary page for that term. You can use the glossary at any point.

1. Animals, such as humans, use the chemical energy in food to make what molecule? List and describe the
importance of this molecule below.

ATP givesourbodyenergy

2. Metabolism comes from the Greek work for “to change”. Describe the change that is occurring here.

energytoATP
breakingdownthefood energy

3. What is cellular respiration and what types of organisms use this process?

Allorganismsconvertfood glucose ATP

4. Describe the organelle in which cellular respiration occurs.

Mitochondria

2membranes

5. Sketch or insert a screen shot of the organelle below.

 outer
membrane

mmmm innermembrane

6. Insert the inputs or “reactants” and outputs or “products” of cellular respiration below.

+
sugar oxygen dioxide
carbon Oz waterH2O ATP
cHulk 02

7. Describe the 4 steps of cellular respiration on the table below.

Description Reactants Products Where does

this step
happen?

Glycolysis
splitglucoseinhalf pyrurates cytoplasm
glucose
tomakepyruvate

Kreb’s Cycle
movepyruvateinto
pyruvate NADH ATP mitochondria
mitochondria

tomakeNADH ATP CO2

Electron groupofproteins
Transport water innermembrane
NADHpassthrough NADH
Chain
chaintocomeout CO2 Atp
tomakeATP
ATP Synthase moleculesgoto H molecules ATP intermembrane
lowconcentration
Diphosphate
Ennymmakesam matrix

8. Which of the steps of cellular respiration is responsible for making the bulk of the ATP molecules?
 chain
ElectronTransport

9. By the end of Krebs cycle all the carbon brought in by glucose is gone. Where is it? How do YOU get rid
of it?

Add02tome getrid ofmeelectrons

Part 2: Directions: Launch the Gizmo and click on the ​Case tab. Use the arrows to navigate and answer the
sequential questions below.

1. Follow the instructions provided to collect data on Jared. The questions below are sequential.

2. What are Jared's symptoms?

muscleweakness

dizziness
shortness ofbreath

3. Fill in the table below

Poison What phase of How is cellular How would this affect
cellular respiration respiration impacted? ATP production?
is impacted by the
poison?

2-deoxyglucose Glycosis
attaches
tothefirstenzyme couldntmakeelectronswo
stopsglucosebeingused pyruvate
nopyruvateismade
arsenic attaches
enzyme
Krebscycle cantmovePMWAH tomakeNADH
stopspmuvalesonoNADH
isbeingmade socan'tmakeAIP
cyanide to
attaches last enzyme
ETC stopselectronsleavingnewelectrons cantpassNADHthroughchainsocant
enterchainstops
can't noHt
working makeATP
is moved
oligomycin ATPsynthase toholeinATPSun
attaches cant
molecules lowconcern
though
move
Htfrommovingthrough
blocks
tomakeenzymestoAtp

15. Why is it important to compare Jared's results to healthy muscle cell (control) data? Explain.

TocomparethedifferenceinAPmakingsoyoucanknowexactlywhatpoisoniscausingthis

16. On a separate piece of paper, make a concept map explaining how the four stages of cellular respiration are
related. Insert a photograph of your mind map here. Don't forget to give it a caption!

your photograph
Glucose
Glycosis splittomake
NADH pytuvate ATPsynthase
6 Krebs
cycle
my
sanitation
aeEiIrougn eieanniranspon.m
infinite enzymes

your caption
Relationofthe4 StagesofcellRespiration

Bogna Haddad @ OCDSB, January 2021