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2020-08-24 Drug Discovery & Development
2020-08-24 Drug Discovery & Development
MK Pengembangan Obat
24 Agustus 2020
Medicine:
Global spending will reach
nearly $1.5 trillion by 2023
Preclinical testing
(1-3 years) Human clinical trials
(2-10 years)
Formulation
FDA approval
(2-3 years)
Lead: chemical compound that has pharmacological or biological activity and
whose chemical structure is used as starting point for chemical modification
in order to improve potency, selectivity, or pharmacokinetic parameters.
daryono hadi tjahjono - S e k o l a h F a r m a s i - I T B
VIRTUAL SCREENING
Using a computer to
predict activity
Isolate protein
US$ 1,778m
COMBINATORIAL CHEMISTRY
Rapidly producing vast numbers Find drug
of compounds
MOLECULAR MODELING US$ 873m
Computer graphics & models help improve activity
Preclinical testing
IN VITRO & IN SILICO ADME MODELS
Tissue and computer models begin to replace animal testing
daryono hadi tjahjono - S e k o l a h F a r m a s i - I T B
S.M. Paul, et al., Nature Reviews Drug Discovery, 2010, 9(3), 203–214.
+CADD
Classic
(in million US$)
Collective anual R&D spending: US$ 50 billion
Fig : R&D funding model to produce ONE New Molecular Entity (NME)
daryono hadi tjahjono - S e k o l a h F a r m a s i - I T B
Forbes
Pharma & Healthcare |8/11/2013 @ 11:10AM |
http://www.forbes.com/sites/matthewherper/2013/08/11/
daryono hadi tjahjono - S e k o l a h F a r m a s i - I T B
Personalized
Medicines
daryono hadi tjahjono - S e k o l a h F a r m a s i - I T B
Personalized
Medicines
daryono hadi tjahjono - S e k o l a h F a r m a s i - I T B
Terima Kasih
Hatur nuhun
daryono hadi tjahjono - S e k o l a h F a r m a s i - I T B