Cefuroxime is a second generation cephalosporin antibiotic used to treat mild to moderate bacterial infections. It works by interfering with bacterial cell wall synthesis. Common side effects include gastrointestinal issues like diarrhea and nausea. More serious adverse effects involve allergic reactions, hematologic issues, and colitis. Nursing responsibilities involve assessing for allergies, monitoring lab tests and symptoms, and educating patients about treatment and potential side effects. Dosing varies based on infection being treated, age, and renal function.
Cefuroxime is a second generation cephalosporin antibiotic used to treat mild to moderate bacterial infections. It works by interfering with bacterial cell wall synthesis. Common side effects include gastrointestinal issues like diarrhea and nausea. More serious adverse effects involve allergic reactions, hematologic issues, and colitis. Nursing responsibilities involve assessing for allergies, monitoring lab tests and symptoms, and educating patients about treatment and potential side effects. Dosing varies based on infection being treated, age, and renal function.
Cefuroxime is a second generation cephalosporin antibiotic used to treat mild to moderate bacterial infections. It works by interfering with bacterial cell wall synthesis. Common side effects include gastrointestinal issues like diarrhea and nausea. More serious adverse effects involve allergic reactions, hematologic issues, and colitis. Nursing responsibilities involve assessing for allergies, monitoring lab tests and symptoms, and educating patients about treatment and potential side effects. Dosing varies based on infection being treated, age, and renal function.
NAME OF DRUG CONTRAINDICATIONS SIDE EFFECTS ADVERSE EFFECTS NURSING RESPONSIBILITIES
MECHANISM OF ACTION
Cephalosporins exert Hypersensitivity to GI: Vomiting Before:
GENERIC NAME bactericidal activity by cefuroxime or to other Diarrhea, Abdominal pain Determine history interfering with bacterial cephalosporins. nausea, antibiotic- Colitis of hypersensitivity rea cell wall synthesis and associated colitis. Vaginal candidiasis ctions to Cefuroxime inhibiting cross-linking of Toxic nephropathy cephalosporins, the peptidoglycan. The Skin: Cholestasis penicillin, and history cephalosporins are also Rash, pruritus, Aplastic anemia of allergies, BRAND NAME thought to play a role in urticaria. Hemolytic anemia particularly to drugs, the activation of bacterial Hemorrhage. before therapy is cell autolysins which may Urogenital: initiated. contribute to bacterial cell Increased serum Lab tests: Perform Altoxime lysis. creatinine and culture and sensitivity BUN, decreased tests before initiation creatinine of therapy and clearance. periodically during CLASSIFICATION therapy if indicated. Therapeutic: Hematologic: Therapy may be Anti-infectives Hemolytic anemia instituted pending test results. Monitor Pharmacologic: MISC: periodically BUN and Second generation Anaphylaxis creatinine clearance. Cephalosporins During: Inspect IM and IV injection sites INDICATIONS frequently for signs of phlebitis. Susceptible mild to Monitor for moderate infections manifestations including of hypersensitivity (se pharyngitis/tonsillitis, e Appendix F). acute maxillary sinusitis, Discontinue drug and chronic bronchitis, acute report their otitis media, appearance promptly. uncomplicated skin and Monitor I&O rates skin structure, UTIs, and pattern: Especially gonorrhea, early Lyme important in severely disease. ill patients receiving high doses. Report any significant changes. Report onset of loose stools or diarrhea. Although pseudomembranous DOSAGE & FREQUENCY colitis (see Signs & Dosing in adults: Symptoms, Appendix Acute exacerbation F) rarely occurs, this of chronic potentially life- bronchitis: 250mg to threatening 500mg PO q12h x 10 complication should days be ruled out as the Uncomplicated UTI: cause of diarrhea 125mg - 250mg PO during and after q12h x 7-10 days antibiotic therapy. Gonorrhea: 1g PO x After: 1 dose Instruct patient to Lower respiratory take medication tract infection: around the clock at 750mg - 1.5g IV/IM evenly spaced times q8h and to finish the Bone/joint medication infection: 1.5 g completely, even if IV/IM q8h feeling better Advise patient to Dosing in pediatrics: report signs of PO: 30mg/kg/day superinfection and divided q12h allergy IV/IM: 50- Instruct patient to 100mg/kg/day notify health divided q6 to q8h professional if fever and diarrhea develop Disease state based dosing: Renal failure (IV dosing): CrCl > 20mL/min: Standard dosing CrCl 10-20mL/min: 0.75g q12h CrCl < 10mL/min: 0.75g q12h